Publications: 2022-



Peppas, N. and Langer, R. A bright future in medicine for chemical engineering. Nature Chemical Engineering, 1, 10-12, 2024. DOI:

Lyu, Y., Huang, H., Su, Y., Ying, B., Liu, W., Dong, K., Langer, R., Gu, Z., Nan, K. Macroencapsulated bacteria for in vivo sensing and therapeutics, Matter, 2024. DOI:

Witten, J., Hu, Y., Langer, R., Anderson, D.G. Recent advances in nanoparticle RNA delivery systems, Proceedings of the National Academy of Sciences, 121 (11) e2307798120, 2024. DOI: 10.1073/pnas.2307798120

Alsaiari, S.K., Nadeef, S., Daristotle J.L., Rothwell, W., Du, B., Garcia, J., Zhang, L., Sarmadi, M., Forster, T., Menon, N., Lin, S.Q., Tostanoski, L.H., Hachmann, N., Wang, E.Y., Ventura, J.D., Barouch, D.H., Langer, R., Jaklenec, A. Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer. Science Advances 10, eadj6380, 2024. DOI:10.1126/sciadv.adj6380.

Collins, J., Han, J., Sarmadi, M., Allison-Logan, S., vander Straeten, A., Perkinson C.F., Acolaste, S., Kanelli, M., Daristotle, J., Karchin, A., Henderson, M., Cruz, M., Artzi, D., Alsaiari, S.K., Zhang, L., Levy, L., Wood, L., Jing, L., McHugh, K.J., Bawendi, M.G., Langer, R., Jaklenec A. On-Patient Temporary Medical Record for Accurate, Time-Sensitive Information at the Point of Care. Advanced Functional Materials , 2024. DOI:

Eshaghi, B., Schudel, A., Sadeghi, I., Chen, Z., Lee, A., Kanelli, M., Tierney, F., Ingalls, B., Francis, D., Li, G., Han, J., von Adrian, U., Langer, R., Jaklenec, A.The role of engineered materials in mucosal vaccination strategies, Nature Reviews Materials, 9, 29-45, 2024. DOI:

Clift, C.L., Blaser, M., Gerrits, W., Turner, M.E., Sonawane, A., Pham, T., Andresen, J.L., Fenton, O.S., Grolman, J.M., Buffolo, F., Schoen, F.J., Hjortnaes, J., Muehlschlegel, J.D., Mooney, D.J., Aikawa, M., Singh, S.A., Langer, R., Aikawa, E. Intracellular proteomics and extracellular vesiculomics as a metric of disease recapitulation in 3D bioprinted aortic valve arrays, Science Advances, 10: eadj9793, 2024. DOI: 10.1126/sciadv.adj9793.

Liu, G., Pickett, M., Kuosmanen, J., Ishida, K., Madani, W., White, G., Jenkins, J., Feig, V., Jimenez, M., Lopes, A., Morimoto, J., Fitzgerald, N., Cheah, J., Soule, C., Fabian, N., Hayward, A., Langer, R., Park, S., Karavasili, C., Lal, N., Murphy, M., Traverso, G. Drinkable, liquid in situ-forming and tough hydrogels for gastrointestinal therapeutics. Nature Materials, 2024. DOI:

Jeang, W.J., Bochenek, M.A., Bose, S., Zhao, Y., Wong, B.M., Yang, J., Liang, A.L., Langer, R., Anderson, D.G. Silicone cryogel skeletons enhance survival and mechanical integrity of hydrogel-encapsulated cell therapies. Science Advances, 10, eadk5949, 2024. DOI: 10.1126/sciadv.adk5949.

Bernstock, J., Johnston,B., Friedman, G., Chiocca, E., Langer, R., Srubuvasan, S., Leveraging next-generation materials for cancer neuroscience therapies in the central nervous system. Nature Reviews Materials, 2024. DOI 10:1038.




Gao, J., Karp, J., Langer, R., Joshi, N. The future of drug delivery. Chemistry of Materials, 35: 359-363, 2023. DOI:

Liu, J., Spruift, E., Miserez, A., Langer, R. Peptide-based liquid droplets as emerging delivery vehicles. Nature Reviews Materials, 2023.DOI: 10.1038/s41578-022-00528-8, 2023.

Segar, D.J., Bernstock, J., Arnout, O., Bi, W.L., Friedman, G., Langer, R., Traverso, G., Rampersad, S.M. Modeling of intracranial tumor treating fields for the treatment of complex high-grade gliomas. Scientific Reports. 12: 1636, 2023. DOI: PMID: 36717682 PMCID: PMC9886948

Zhong, R., Talebian, S., Mendes, B., Wallace, G., Langer, R., Shi, K., Conde, J. Hydrogels for RNA delivery. Nature Materials, 2023. DOI:

Conde, J., Langer, R., Rueff, J. When genetics meets nanomedicine: The mRNA therapy as a breakthrough to all of us. Nature Nanotechnology, 2023. DOI:

Li, B., Manan, R.S., Liang, S., Gordon, A., Jiang, A., Varley, A., Gao, G., Langer, R., Xue, W., Anderson, D. Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing. Nature Biotechnology, 2023. DOI: PMID: 36997680. PMC10544676

Cao, Y., Langer, R., Ferrara, N. Targeting angiogenesis in oncology, ophthalmology and beyond. Nature Reviews Drug Discovery, 2023. DOI: PMID: 37041221

Raimondo, T.R., Reed, K., Shi, D., Langer, R., Anderson, D.G. Delivering the next generation of cancer immunotherapies with RNA. Cell, 186:8, 1535-1540, 2023. PMID: 37059063. DOI:

Vander Straeten, A., Sarmadi, M., Daristotle, J.L., Kanelli, M., Tostanoski, L.H., Collins, J., Pardeshi, A., Han,. J., Varsheny, D., Eshaghi, B., Garcia, J., Forster, T.A., Li, G., Menon, N., Pyon, S.L., Zhang, L., Jacob-Dolan, C., Powers, O., Hall, K., Alsaiari, S., Wolf, M., Tibbit, M.W., Farra, R., Barouch, D.H., Langer, R., Jaklenec, A. A microneedle vaccine printer enables decentralized manufacturing of thermostable COVID-19 mRNA vaccines. Nature Biotechnology, 2023. DOI: PMID: 37095347

Bhagchandani, S.H., Vohidov, F., Milling, L., Tong, E.Y., Brown, C.M., Ramseier, M.L., Liu, B., Fessenden, T., Nguyen, H.V.T., Kiel, G.R., Won, L., Langer, R., Spranger, S., Shalek, A.K., Irvine, D.J., Johnson, J.A. Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation. Science Advances, 2023. 9(16): eadg2239. DOI: 10.1126/sciadv.adg2239 PMID: 37075115. PMCID: PMC10115420

Guimarães, P., Figueroa-Espada, C., Riley, R., Sewastianiak, T., Dennis, P., Loebel, C., Shepherd, S.J., Haley. R., Wang, K., Langer. R., Anderson, D.G., Carrasco, R.D., Mitchell, M. In Vivo bone marrow microenvironment siRNA delivery using lipid-polymer nanoparticles for multiple myeloma therapy. Proceedings of the National Academy of Sciences, 120 (25) e2215711120, 2023. DOI:1073/pnas.2215711120.

Li, Z., Zhang, S., Zuber, F., Altenried, S., Jaklenec, A., Langer, R., Ren, Q. Topical application of Lactobacilli successfully eradicates Psuedomonas aeruginosa biofilms and promotes wound healing in chronic wounds. Microbes and Infection, 2023. DOI: 10.1016/j.micinf.2023.105176 PMID: 37406851

Doloff, J., Ma, M., Sadraei, A., Tam, H. H., Farah, S., Hollister-Lock, J., Vegas, A., Veiseh, O., Quiroz, V., Rakoski, A., Aresta-Dasilva, S., Bader, A., Griffin, M., Weir, G., Brehm, M., Shultz, L., Langer, R., Greiner, D. Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response. Science Advances 9, eade9488, 2023. PMID: 37327334 PMCID: PMC10275594 DOI: 10.1126/sciadv.ade9488

Herrera-Mora, G., Solis-Chaves, P., Hernandez-Aviles, G., Graham, E., Clausen-Oreamyno, C., Castro-Cespedes, J.A., Andres, J.,Haupt, J., Jamiel, M., Veiseh, O., Sforza, M., Hancock, J., Kinney, B., De Mezerville, R., Langer, R., Doloff, J., Chacon-Quiros, M. Ultrasonographic identification of shell surface types in commercially available silicone gel-filled breast implants. Plastic and Reconstructive Surgery, 2023. PMID: 37224221 DOI: 10.1097/PRS.0000000000010758

Srinivasan, S., Gfrerer, L., Karandikar, P., Som, A., Alshareef, A., Liu, S., Higginbotham, H., Ishida, K., Hayward, A., Kalva, S.P., Langer, R., Traverso, G. Adaptive conductive electrotherapeutic scaffolds for enhanced peripheral nerve regeneration and stimulation. Med, 2023.DOI:

Kanelli, M., Bardhan, N.M., Sarmadi, M., Alsaiari, S., Rothwell, W.T., Pardeshi, A., De Fiesta, D.C., Mak, H., Spanoudaki, V., Henning, N., Han, J., Belcher, A.M., Langer, R., Jaklenec, A. A machine learning-optimized system for on demand, pulsatile, photo-and chemotherapeutic treatment using near-infrared responsiveness MoS2 based microparticles in a breast cancer model. BioRxiv PMID: 37090507 PMCID: PMC10120681 DOI: 10.1101/2023.04.16.536750

McHugh, K., Baryakova, T., Pogostin, B., Langer, R. Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems. Nature Reviews Drug Discovery, 22, 387-409, 2023. PMID: 36973491

Chauhan, V., Sharp, P.A., Langer, R. Altered DNA repair pathway engagement by engineered CRISPR-Cas9 nucleases, Proceedings of the National Academies of Science. 120: 11, e2300605120, 2023. DOI: 10.1073/pnas.2300605120 PMID: 36881621 PMCID: PMC10242711

Liu, G., Guzman, E.B., Menon, N., Langer, R. Lipid nanoparticles for nucleic acid delivery to endothelial cells. Pharmaceutical Research, 40 (1), 3-25, 2023. PMID: 36735106. PMCID: PMC9897626 DOI: 10.1007/s11095-023-03471-7

Conde, J., Langer, R., and Rueff, J., mRNA therapy at the convergence of genetics and nanomedicine, Nature Nanotechnology, 18: 537-540, 2023.

Abbasalizadeh, S., Babaee, S., Kowsari-Esfahan, R., Mazidi, Z., Shi, Y., Wainer, J., Cabral, J.M.S., Langer, R., Traverso, G., Baharvand, H. Continuous production of highly functional vascularized hepatobiliary organoids from pluripotent stem cells using a scalable microfluidic platform Advanced Functional Materials,2023. DOI: 10.1002/adfm.202210233

Li, B., Jiang, A., Raji, I., Atyeo, C., Raimondo, T.M., Gordon, A., Rhym, L., Samad, T., MacIsaac, C., Witten, J., Mughal, H., Chicz, T.M., Xu, Y., McNamara, R.P., Bhatia, S., Alter, G., Langer, R., Anderson, D.G. Enhacing the immunogencity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA. Nature Biomedical Engineering, 2023. DOI:

Wang, E.Y., Sarmadi, M.Ying, B., Jaklenec, A., Langer, R. Recent advances in micro- and nanoscale carrier systems for controlled delivery of vaccines. Biomaterials, 303:122345, 2023. PMID: 37918182 DOI: 10.1016/j.biomaterials.2023.122345

Navamajiti, N., Reker, D., Langer, R., Traverso, G. Silk fibroin-based coatings for pancreatin-dependent drug delivey. JPharmSci. , 2023. DOI: PMID: 37690778

Rousseau, E., Raman, R., Tamir, T., Bu, A., Srinivasan, S., Lynch, N., Langer, R., White, F., Cima, M. Actuated tissue engineered muscle grafts restore functional mobility after volumetric muscle loss. Biomaterials, 302: 122317, 2023. DOI:

Krishnan, S.R., Liu, C., Bochenek, M., Bose, S., Khatib, N., Walters, B., O’Keefe, L., Facklam, A., Langer, R., Anderson, D.G. A wireless, battery-free device enables oxygen generation and immune protection of therapeutic xenotransplants in vivo. Proceedings of the National Academy of Sciences,120 (40) e2311707120, 2023. DOI: PMID: 37738292; PMCID: PMC10556620.

Traverso, G., Finomore, V., Mahoney, J., Kupec, J., Stansbury, R., Bachwr, D, Pless, B., Schuetz, S., Hayward, A., Langer, R., Rezai, A. First-in-human trial of an ingestible vitals monitoring pill. Device, 1, 100125, 2023. DOI:

Jiang, A.Y., Witten, J., Raji, I.O., Eweje, F., MacIsaac, C., Meng, S. Oladimeji. F.A., Hu. Y., Manan, R.S., Langer, R., Anderson, D.G. Combinatorial development of nebulized mRNA delivery formulations for the lungs. Nature Nanotechnology, 19: 364–375, 2023. DOI:

Ralvenius, W.T., Andresen, J.L., Huston, M.M., Penney, J., Bonner, J.M., Fenton, O.S., Langer, R., Tsai, L. Nanoparticle-mediated delivery of anti-PU.1 siRNA via localized intracisternal administration reduces neuroinflammation. Advances Materials, 2023. DOI:

Salem, A.,Kim, H., Kirtane, A.R., Kim, N.K., Rajesh, N.U., Tang, C., Ishida, K., Hayward, A., Langer, R., Traverso, G. Gastrointestinal delivery of an mRNA vaccine using immunostimulatory polymeric nanoparticles. American Association of Pharmaceutical Scientists Journal, 2023, DOI: 10.1208/s12248-023-00844-z.

Som, A., Rosenboom, J., Wehrenberg-Flee, E., Chandler, A., Ndakwah, G., Chen, E., Suggs, J., Morimoto, J., Kim, J., Mustafa, A.R., Marcos-Vidal, A., Fintelman, F.J., Basu, A., Langer, R., Traverso, G., Mahmood, U. Percutaneous intratumoral immunoadjuvant gel increases the abscopal effect of cryoablation for checkpoint inhibitor resistant cancer. Advanced Healthcare Materials, 2023. DOI:



Booty, M.G., Hlavaty, K.A., Stockmann, A., Ozay, E.I., Smith, C., Tian, L., How, E., Subramanya, D., Venkitaraman, A., Yee, C., Pryor, O., Volk, K., Blagovic, K., Vicente-Suarez, I., Yarar, D., Myint, M., Merino, A., Chow, J., Abdeljawad, T., An,, H., Liu, S., Mao, S., Heiman, M., Talarico, L., Jacques, M.K., Chong, E., Pomerance, L., Gonzalez, J.T., von Adrian, U., Jensen, K.F., Langer, R., Knoetgen, H., Trumpfheller, C., Umaña, P., Bernstein, H., Sharei, A., Loughhead, S.M. Microfluidic squeezing enables MHC-I antigen presentation by diverse immune cells to elicit CD8+ T cell responses with anti-tumor activity. The Journal of Immunology, 2022. DOI:

Ferdosi, S., Tangeysh, B., Brown, T.R., Everley, P., Figa, M., McLean, M., Elgierari, E.M., Zhao, X., Garcia, V.J., Wang, T., Chang, M.E.K., Riedesel. K., Chu, J., Mahony, M., Xia, H., O’Brien, E., Stolarczyk, C., Harris, D., Platt, T., Ma, P., Goldberg, M., Langer, R., Flory, M.R., Siddiqui, A., Benz, R., Tao, W., Cruz Cuevas, J., Batzoglou, S., Blume, J.E., Hornburg, D., Farokhzad, O. Engineered nanoparticles enable deep proteomics studies at scale by leveraging tunable nano-bio Interactions. Proceedings of the National Academy of Sciences, 119 (11) e2106053119., 2022.

Chen, W., Wainer, J., Ryoo, S.W., Qi, X., Chang, R., Li, J., Lee, S., Wentworth, A., Collins, J.E., Tamang, S., Ishida, K., Hayward, A., Langer, R., Traverso, G. Dynamic omni-directional adhesive microneedle system for oral macromolecular drug delivery. Science Advances, 8: eabk1792, 2022.PMID: 34985942PMCID: PMC8730401DOI: 10.1126/sciadv.abk1792

Kim, H., Lee, S., Wentworth, A., Babaee, S., Wong, K., Collins, J.E., Chu, J., Ishida, K., Kuosmanen, J., Jenkins, J., Hess, K., Lopes, A., Morimoto, J., Wan, Q., Potdar, S.B., McNally, R., Tov, C., Kim, N.Y., Haywards, A., Wollin, D., Langer, R., Traverso, G. Biodegradable ring-shaped implantable device for intravesical therapy of bladder disorders. Biomaterials, 2022. PMID: 36030104PMCID: PMC10485746. DOI: 10.1016/j.biomaterials.2022.121703

Rosenboom, J., Langer, R., Traverso, G. Bio-based polymers for a circular economy. Nature Reviews Materials, 7(2): 117–137, 2022.Doi: 10.1038/s41578-021-00407-8. PMCID: PMC8771173. PMID: 35075395

Abramson, A., Kirtane, A., Shi, Y., Zhong, G. Collins, J.E., Tamang, S., Ishida, K., Hayward, A., Wainer, J., Rajesh, N.E., Lu, X., Gao, Y., Karandikar, P., Tang, C., Lopes, A., Wahane, A., Reker, D., Revsgaard, Frederiksen, M., Jensen, B., Langer, R., Traverso, G. Oral mRNA delivery using capsule-mediated gastrointestinal tissue injections. Matter, 2022. DOI:10.1016/j.matt.2021.12.022

Sarmadi, M., Krishnan, S.R., Ramadi, K.B., Langer, R. The road ahead for application of mechanics in drug delivery. Mechanics Research Communications, 125, 2022 DOI: 10.1016/j.mechrescom.2022.103956.

Mead, B.E., Hattori, K., Levy, L., Imada, S., Goto, N., Vukovic, M., Sze, D., Kummerlowe, C., Matute, J.D., Duan, J., Langer, R., Blumberg, R.S., Ordovas-Montanes, J., Yilmaz, O.H., Karp, J.M., Shalek, A.K. Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation. Nature Biomedical Engineering 6, 476–494, 2022.

Kirtane, A.R., Karavasili, C., Wahane, A., Freitas, D. Booz, K., Thi, D., Le, H., Hua, T., Scala, S., Lopes, A., Hess, K., Collins, J., Tamang, S., Ishida, K., Kuosmanen, J.L.P., Rajesh, N.U., Phan, N.V., Li, J., Krogmann, A., Lennerz, J.K., Hayward, A., Langer, R., Traverso, G. Development of oil-based gels as versatile drug delivery systems for pediatric applications. Science Advances, 2022. 8(21):eabm8478. DOI: 10.1126/sciadv.abm8478. Epub 2022 May 27. PMID: 35622910; PMCID: PMC9140966.

Sarmadi, M., Ta, C., VanLonkhuyzen, A.M., De Fiesta, D.C., Kanelli, M., Sadeghi, I., Behrens, A.M.,, Ingalls, B., Menon, N., Daristotle, J.L., Langer, R., Jaklenec, A. Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles. Science Advances, 8, eabn5315, 2022. PMID: 35857507. PMCID: PMC9278852. DOI: 10.1126/sciadv.abn5315

Labouta, H.I., Langer, R., Cullis, P.R. Merkel, O.M., Prausnitz, M.R., Gomaa, Y., Noguiera, S.S., Kumeira, T. Role of drug delivery technologies in the success of COVID-19 vaccines: a perspective. Drug Delivery and Translational Research 12, 2581–2588 (2022). PMID: 35290656. PMCID: PMC8923087. DOI: 10.1007/s13346-022-01146-1

Byrne, J.D., Gallo, D., Boyce, H., Becker, S.L., Mitchell, K.M., Cotoia, A.T., Feig, V.R., Lopes, A., Ciszmadia, E., Longhi, M.S., Lee, J.S., Kim, H., Wentworth, A.J., Shankar, S., Ishida, K., Hayward, A., Kuosmanen, J.L.P., Jenkins, J., Wainer, J., Aragon, A., Wong, K., Steiger, C., Jeck, W.R., Tift, M., Langer, Otterbein, L.E., Traverso, G. Delivery of therapeutic carbon monoxide by gas entrapping materials. Science Translational Medicine, 2022. DOI: 10.1126/scitranslmed.abl4135

Subramanian, D.A., Langer, R., Traverso, G. Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems. Journal of Nanobiotechnology, 20: 362, 2022.

Srinivasan, S.M., Alshareef, A., Hwang, A.,V., Kang, J., Kuosmanen, J., Ishida, K., Jenkins, J., Liu, S., Madani, W., A., M., Lennerz, J., Hayward, A., Morimoto, J., Fitzgerald, N., Langer, R., Traverso, G. RoboCap: Robotic mucus-clearing capsule for enhanced drug delivery in the gastrointestinal tract. Science Robotics, 2022. PMID: 36170378. DOI: 10.1126/scirobotics.abp9066. PMC10034646

Huang, X., Kong, N., Zhang, X., Cao, Y., Langer, R., Tao, W. The landscape of mRNA nanomedicine. Nature Medicine, 28: 2273-2287, 2022.

Tang, W., Zhuang, J., Anselmo, A., Xu, X., Duan, A., Zhang, R., Sugarman, J.L., Zeng, Y., Rosenberg, E., Graf, T., McHugh, K., Tzeng, S.Y., Behrens, A.M., Freed, L.E., Jing, L., Jayawarden, S., Weinstock, S., Le, X., Sears, C., Oxley, J., Daristotle, J., Collins, J., Langer, R., Jaklenec, A. Enhanced stability and clinical absorption of a new form of encapsulated vitamin A for food fortification. Proceedings of the National Academy of Sciences, 2022. DOI: 10.1073/pnas.2211534119

Shafiee, A., Ghadiri, E., Langer, R. Fabricating human tissues: How physics can help. Physics Today, 75, 12, 38 2022. DOI: 10.1063/PT.3.5138

Volpatti, L.R., Bochenek, M.A., Facklam, A.L., Burns, D.M., MacIsaac, C., Morgart, A., Walters, B., Langer, R., Anderson, D.A. Partially oxidized alginate as a biodegradable carrier for glucose-responsive insulin delivery and islet cell replacement therapy. Advanced Healthcare Materials, 20221822, 2022. PMID: 36325648. DOI: 10.1002/adhm.202201822