Publications: 1981 – 1990



Mathiowitz, E., Kline, D., Langer, R. “Morphology of Poly(anhydride) Microsphere delivery systems”, J. Scanning Microscopy; 4: 329-340, 1990.

Staubli, A., Ron, E., Langer, R. “Hydrolytically degradable amino acid containing polymers”, J. Am. Chem. Soc.; 112: 4419-4424, 1990.

Kibat, P., Igari, Y., Wheatley, M., Eisen, H., Langer, R. “Microencapsulated liposomes: a system for enzymatically controlled pulsatile release of biologically active substances”, FASEB J.; 4: 2533-2539, 1990.

Moses, M., Sudhalter, J., Langer, R. “Identification of an inhibitor of neovascularization from cartilage”, Science; 248: 1408 – 1410, 1990.

Langer, R., Bernstein, H., Brown, L., Cima, L. “Medical reactors”, Chemical Eng. Sci.; 45: 1967- 1978, 1990.

Mathiowitz, E., Ron, E., Mathiowtiz, G., Amato, C., Langer, R. “Morphological characterization of bioerodible polymers. I. crystallinity of poly(anhydride) copolymers”, Macromolecules; 23: 3212-3218, 1990.

Kost, J., Langer, R. “Magnetically and ultrasonically modulated drug delivery systems”, Pulsed and Self-Regulated Drug Del.; pp. 3-16, 1990.

Ghodsian, F., Brown, L., Langer, R. “Solubility dependent controlled release systems”, Pulsed and Self-Regulated Drug Del.; pp. 201-214, 1990.

Laurencin, C., Pierre-Jacques, H., Langer, R. “Toxicology and Biocompatibility Considerations”, Eval. of Polymeric Mat. for Biomed. Appl.; 10: 549-570, 1990.

Chasin, M., Domb, A., Ron, E., Mathiowitz, E., Leong, K., Laurencin, C., Brem, H., Grossman, B., Langer, R. “Polyanhydrides as Drug Delivery Systems”, Biodegradable Polym. as Drug Del. Sys.; 43-70, 1990.

Aiken, J., Cima, L., Schloo, B., Mooney, D., Johnson, L., Langer, R., Vacanti, J. “Studies in Rat Liver Perfusion for Optimal Harvest of Hepatocytes”, J. Ped. Surg.; 25: 140-145, 1990.

Lucas, P., Laurencin, C., Syftestad, G., Domb, A., Goldberg, V., Caplan, A., Langer, R. “Ectopic Induction of Cartilage and Bone by Water-soluble Proteins from Bovine Bone using Polyanhydride Delivery Vehicle”, J. Biomed. Mat. Res.; 24: 901-911, 1990.

Langer, R. “New methods of drug delivery”, Science; 249: 1527-1533, 1990.

Cohen, S., Bano, M., Visscher, K., Chow, M., Allcock, H., Langer, R. “Ionically crosslinkable polyphosphazene: a novel polymer for microencapsulation”, J. Am. Chem. Soc.; 112: 7832-7833, 1990.

Laurencin, C., Domb, A., Morris, C., Brown, V., Chasin, M., McConnell, R., Langer, N., Langer, R. “Poly(anhydride) administration in high doses in vivo: studies of biocompatibility and toxicology”, J. Biomed. Mat. Res.; 1463-1481, 1990.

Mathiowitz, E., Dor, P., Amato, C., Langer, R. “Polyanhydride microspheres as drug carriers III. morphology and release characterization of microspheres made by solvent removal”, Polymer; 31, 547­556, 1990.

Siegel, R., Langer, R. “Mechanistic studies of macromolecular drug release from macroporous polymers. II: models for the slow kinetics of drug release”, J. Contr. Rel.; 14: 153-168, 1990.

Langer, R., Cima, L., Tamada, J., Wintermantel, E. “Future directions in biomaterials”, Biomaterials; 11, 738-745, 1990.

Vacanti, J., Ingber, D., Cima, L., Stein, J., Gilbert, J., Johnson, L., Schloo, B., Langer, R. “Hepatocyte tissue engineering using constructs of synthetic polymer networks and cultured cells.”, A World J. of Hepatic, Pancreatic and Biliary Surgery; 185-188, 1990.

Chasin, M., Hollenbeck, G., Brem, H., Grossman, S., Colvin, M., Langer, R. “Interstitial drug therapy for brain tumors: a case study”, Drug. Dev. Ind. Pharm.; 16: 2579-2594, 1990.

Igari, Y., Kibat, P., Langer, R. “Optimization of a microencapsulated liposome system for enzymatically controlled release of macromolecules”, J. Cont. Rel.; 14: 263-267, 1990.

Langer, R. “Novel drug delivery systems”, Chem. in Britain; 26: 232-238, 1990.

Domb, A., Laurencin, C., Israeli, O., Gerhart, R., Langer, R. “The step polymerization of poly(propylene fumarate) for use in bioerodible bone cement composites. “, J. Poly. Sci.; 28: 973-985, 1990.

Leong, K., Domb, A., Ron, E., Langer, R. “Polyanhydrides”, Second Ed. of the Encycl. Poly. Sci. Eng.; 648-665, 1990.



Brem, H., Kader, A., Epstein, J., Tamargo, R., Domb, A., Langer, R., Leong, K. “Biocompatibility of a biodegradable controlled-release polymer in the rabbit brain”, Selective Cancer Therap.; 5: 55-65, 1989.

Levy, D., Kost, J., Meshulam, Y., Langer, R. “Effect of ultrasound on transdermal drug delivery to rats and guinea pigs”, J. Clin. Invest.; 83: 2074-2078, 1989.

Siegel, R., Kost, J., Langer, R. “Mechanistic studies of macromolecular drug release from macroporous polymers. I. experiments and preliminary theory concerning completeness of drug release”, J. Cont. Rel.; 8: 223-236, 1989.

Howard, M., Gross, A., Grady, M., Langer, R., Mathiowitz, E., Winn, R., Mayberg, M. “Intracerebral drug delivery in rats with lesion-induced memory deficits. “, J. Neurosurgery; 71: 105-112, 1989.

Cima, L., Mooney, D., Vacanti, JP., Langer, R. “Three Dimensional Culture of Primary Mammalian Cells in Porous Biodegradable Polymer Matrices for in vivo Organ Regeneration.”, American Instititute of Chemical Engineers. Microfiche Proceedings of Annual Conference; , 1989.

Domb, A., Gallardo, C., Langer, R. “Poly(anhydrides) 3. Poly(anhydrides) based on aliphaticaromatic diacids”, Macromolecules; 22: 3200-3204, 1989.

Yu, H., Langer, R. “Pseudopoly(amino acids): A study of the synthesis and characterization of poly(acyl-hydroxyproline-esters)”, Macromolecules; 22: 3250-3255, 1989.

Langer, R. “Biomaterials in Controlled Drug Delivery: New perspectives from biotechnological advances”, Pharm. Techn.; 13: 22-30, 1989.

Domb, A, Langer, R. “Solid state and solution stability of poly(anhydrides) and poly(esters)”, Macromolecules; 22: 2117-2122, 1989.

Kost, J., Leong, K., Langer, R. “Effects of ultrasound on polymer degradation and release of incorporated substances”, PNAS; 86: 7663-7666, 1989.

Comfort, A., Berkowitz, S., Albert, E., Langer, R. “Immobilized enzyme cellulose hollow fibers: I. immobilization of heparinase”, Biotech. Bioeng.; 34: 1366-1373, 1989.

Comfort, A., Albert, E., Langer, R. “Immobilized enzyme cellulose hollow fibers: II. kinetic analysis”, Biotech. Bioeng.; 34: 1374-1382, 1989.

Comfort, A., Berkowitz, S., Albert, E., Langer, R. “Immobilized enzyme cellulose hollow fibers: III. physical properties and in vitro biocompatibility”, Biotech. Bioeng.; 34: 1383-1390, 1989.

Mullon, C., Tosone, C., Langer, R. “Simulation of bilirubin detoxification in the newborn using an extracorporeal bilirubin oxidase reactor”, Pediatric Res.; 26: 452-457, 1989.

Yang, V., Bernstein, H., Langer, R. “Heparinase immobilization”, Enzyme Engin.; 9: 515-520, 1989.

Saltzman, W. Langer, R. “Transport rates of proteins in porous materials with known microgeometry”, Biophys. J.; 55: 163-171, 1989.

Freese, A., Sabel, B., Saltzman, W., During, M., Langer, R. “Controlled release of dopamine from a polymeric brain implant: in vitro characterization”, Exp. Neur.; 103: 234-238, 1989.

During, M., Freese, A., Sabel, B., Saltzman, W., Deutch, A., Roth, R., Langer, R. “Controlled release of dopamine from a polymeric brain implant: in vivo characterization”, Ann. Neur.; 25: 351-356, 1989.



Kohn, J., Langer, R. “Backbone modifications of synthetic poly-alpha amino acids”, Peptides, Chem. and Biology; pp. 658-661, 1988.

Brown, L., Langer, R. “Transdermal drug delivery systems”, Ann. Rev. of Med.; 39: 221-229, 1988.

Mullon, C., Klibanov, A., Langer, R.. “Kinetics of bilirubin oxidase and modeling of an immobilized bilirubin oxidase reactor for bilirubin detoxification”, Biotech. Bioeng.; 31: 536-546, 1988.

Domb, A., Ron, E., Langer, R. “Polyanhydrides II. One step polymerization using phosgene or diphosgene as coupling agents”, Macromolecules; 21: 1925-1929, 1988.

Ghodsian, F., Brown, L., Mathiowitz, E., Brandenburg, D., Langer, R. “Enzymatically controlled drug delivery”, Proc. Nat. Acad.Sci.; 85: 2403-2406, 1988.

Bernstein, H., Yang, V., Cooney, C., Langer, R. “An immobilized heparinase system for blood deheparinization”, Meth. Enz.; 137: 515-529, 1988.

Domb, A., Langer, R. “Polyanhydrides: stability and novel composition”, Makromol. Chem. Macromol. Symp.; 19: 189-200, 1988.

Comfort, A., Mullon, C., Langer, R. “The influence of bond chemistry on immobilized enzyme systems for ex vivo use”, Biotech. and Bioeng.; 32: 554-563, 1988.

Bindschacdler, C., Leong, K., Mathiowitz, E. Langer, R. “Polyanydride microsphere formulation by solvent extraction”, J. Pharm. Sci.; 77: 696-698, 1988.

Domb, A., Cravalho, E.G., Langer, R. ” The synthesis of poly(hydroxamic) from poly(Acrylamide)”, J. Poly. Sci.; 26: 2623-2630, 1988.

Kost, J., Leong, K., Langer, R. “Ultrasonically controlled colymeric drug delivery”, Makromol. Chem. Macromol. Symp.; 19: 275-285, 1988.

Comfort, A., Mullon, C., Koh, J., Albert, E., Tosone, C., Hall, P., Langer, R. “Stability and immunologic activity of immobilized heparinase and bilrubin oxidase”, ASAIO Transactions; 34: 538-2542, 1988.

Freed, L., Vunjak, G., Drinker, P., Langer, R. “A novel bioreactor based on suspended particles of agarose-immobilized species”, ASAIO Transactions; 34: 732-738, 1988.

Mullon, C., Saltzman, W., Langer, R. “Computer based visualization for quantitative and analysis of the distribution of matrix-bound proteins”, Bio/Technology; 6: 927-929, 1988.

Rosen, H., Kohn, J., Leong, K., Langer, R. “Bioerodible polymers for controlled release systems”, Cont. Rel. Sys.: Fab. Tech.; Vol. II, Chap. 5, 84-110, 1988.

Yang, V., Bernstein, H., Cooney, C., Langer, R. “The development of an immobilized heparinase reactor in bioreactors, immobilized enzymes and cells, and fundamentals in the applications”, Elsevier Applied Science; pp. 83-94, 1988.

Bernstein, H., Langer, R. “Ex vivo model of an immobilized enzyme reactor”, PNAS; 85: 8751-8755, 1988.

Klein, M., Arensman, R., Weber, T., Mottaghy, K., Langer, R., Nolte, S.H. “Pediatric ECMO: directions for new developments”, Trans. Am. Soc. Artif. Intern. Organs.; 34: 978-985, 1988.

Karel, M., Langer, R. “Controlled release of food additives”, Flavor Encapsulation; ACS Symp. Ser. 370. 177-191, 1988.

Langer, R. “Controlled release systems”, Chem. Eng. Ed. in a Changing Environment; 115-124, 1988.

Leong, K. Langer, R. “Polymeric controlled drug delivery”, Adv. Drug Del. Rev.; I, 199- 233, 1988.

Langer, R. “Biodegradable polymers for drug delivery to the brain”, ASAIO Transactions; 34: 945-946, 1988.

Larsen, A., Rice, K., Linhardt, R., Wogan, G., Langer, R. “Resistance of heparinase-derived heparin fragments to biotransformation”, J. Biol. Chem.; 264: 1570-1577, 1988.

Vacanti, J., Morse, M., Saltzman, M., Domb, A., Perez-Atayde, A., Langer, R. “Selective Cell Transplantation Using Bioabsorbable Artificial Polymers as Matrices”, J. Ped. Surg.; 23: 3-9, 1988.

Mathiowitz, E., Saltzman, M., Domb, A., Dor, P, Langer, R. “Polyanhydride Microspheres as Drug Carriers. II Microencapsulation by Solvent Removal”, J. Appl. Polym. Sci.; 35: 755-774, 1988.

Chasin, M., Lewis, D., Langer, R. “Polyanhydrides for controlled release”, Biopharm. Manuf.; 1: 33-46, 1988.



Yang, V., Bernstein, H., Langer, R. “Heparinase immobilization: characterization and optimization”, Methods in Enzymology; 515-520, 1987.

Kohn, J., Langer, R. “Polymerization reactions involving the side chains of a-L-amino acids”, J. Am. Chem. Soc.; 109: 817-820, 1987.

Edelman, E., Brown, L., Langer, R. “In vitro and in vivo kinetics of regulated drug release from polymer matrices by oscillating magnetic fields”, J. Biomed. Mat. Sci.; 21: 339-353, 1987.

Yang, V., Bernstein, H., Langer, R. “Large scale purification of catalytically pure heparinase”, Biotech. Prog.; 3: 27-30, 1987.

Yang, V., Langer, R. “A simple and economic technique for pI measurements”, Biotechniques; 5: 138-144, 1987.

Leong, K., Simonte, V., Langer, R. “Synthesis of polyanhydrides: melt-polycondensation, dehydrochlorination, and dehydrative coupling”, Macromolecules; 20: 705-712, 1987.

Linhardt, R., Langer, R. “New approaches for anticoagulation in extracorporeal therapy”, Biomat. Art . Cells, Art. Org.; 15: 91-100, 1987.

Langer, R. “Bioengineering: its role in the changing face of chemical engineering”, Biotech. Progress; 3:02, 1987.

Laurencin, C., Langer, R. “Drug delivery systems”, Clinics in Lab. Med.; 7: 301-323, 1987.

Kost, J. Langer, R. “Equilibrium swollen hydrogels in controlled release applications”, Hydrogels in Med. Pharm.; pp. 95-108, 1987.

Bernstein, H., Yang, V., Langer, R. “The distribution of heparinase covalently immobilized to agarose: experimental and theoretical studies”, Biotech. Bioeng.; 30; 196-207, 1987.

Bernstein, H., Yang, V., Langer, R. “Immobilized heparinase in vitro reactor model”, Biotech. Bioeng.; 30: 239-250, 1987.

Mathiowitz, E., Langer, R. “Polyanhydride microspheres as drug carriers”, J. Cont. Rel.; 1.126388889, 1987.

Saltzman, W., Pasternack, S., and Langer, R. “Microstructural models for diffusive transport in porous polymers”, Recent Adv. in Cont. Rel. Tech.; 348: 16-33, 1987.

Saltzman, W., Pasternak, S., Langer, R. “Quantitative image analysis for developing microstructural descriptions of heterogeneous materials”, Chem. Eng. Sci.; 42: 1989-2004, 1987.

Bernstein, H., Yang, V., Randawa, M., Lund, D., Harmon, W., Langer, R. “Extracorporeal enzymatic heparin removal: use in a sheep dialysis model”, Kidney Int.; 32: 452-463, 1987.

Mathiowitz, E., Cohen, M., Langer, R. “Novel microcapsules for delivery systems”, Reactive Poly. Ion Exchange Sorbents; 6: 275-283, 1987.

Mullon, C., Langer, R. “A new method for measuring conjugated and total bilirubin in neonate plasma using bilirubin oxidase”, Clin Chem.; 33: 1822-1825, 1987.

Domb, A., Langer, R. “Polyanhydrides: I. preparation of high molecular weight polyanhydrides”, J. Poly. Sci.; 25: 3373-3386, 1987.

Kost, J., Wolfrum, J., Langer, R. “Magnetically controlled insulin release in diabetic rats”, J. Biomed. Mat. Res.; 21: 1367-1373, 1987.

Levy, R., Golomb, G., Langer, R. “Prevention of Cardiovascular calcification with controlled release diphosphate, in Artificial Organs: The W.F. Kolff Festschrift”, J. Andrade; p. 657- 670, 1987.

Bernstein H., Langer, R. “An immobilized enzyme system for heparin removal”, Art. Organs; p. 333-342, 1987.

Cuenoud, H., Joris, I., Langer, R., Majno, G. “Focal arteriolar insudation: A response of arterioles to Chronic Non-Specific Irritation”, Amer. J. Path.; 127: 592-604, 1987.

Laurencin, C., Koh, H., Neenan, T., Alcock, H., Langer, R. “Controlled release using a new bioerodible polyphosphazene matrix system”, J. Biomed. Mater. Res.; 21: 1231-1246, 1987.

Yang, V., H. Bernstein, C. Cooney, Langer, R. “Large scale preparation and characterization of mucopolysaccharase contamination free heparinase”, Appl. Biochem. Biotech.; 16: 35-50, 1987.

Wheatley, M., Langer, R. “Particles as drug delivery systems”, Particulate Sci. and Tech.; 5: 53-65, 1987.

Langer, R., Leong, K., Edelman, E., Siegel, R., Bawa, R. “Zero order release, magnetic control, and polypeptide release”, Cont. Drug Del. Sys.; 146-160, 1987.

Thompson, R.W., Folkman, J., Langer, R., Ingber, D. Sudhalter, J. D’Amore, P. “Angiogenic vascular grafts”, Endothelizilization of Vascular Grafts; 167-176, 1987.

Bernstein, H., Yang, V., Langer, R. “An investigation of heparinase immobilization”, Applied Biochem. and Biotech.; 129-143, 1987.



Leong, K., D’Amore, P., Marletta, M., Langer, R. “Bioerodible polyanhydrides as drug-carrier matrices: II: biocompatibility and chemical reactivity”, J. Biomed. Mat. Res.; 20: 51-64, 1986.

Brown, L., Edelman, E., Siemer, L., Langer, R. “Controlled-release systems for macromolecules: methods and applications”, Adv. in Carriers and Adjuvants for Veterinary Biologics; 133-141, 1986.

Siegel, R., Langer, R. “A new monte carlo approach to diffusion in constricted porous geometrics”, J. Colloid Interfacial Sci.; 109: 426-440, 1986.

Murray, J., Allison, K., Sudhalter, J., Langer, R. “Purification and partial amino acid sequence of a collagenase Inhibitor from Bovine Cartilage”, J. Biol. Chem.; 261: 4154-4159, 1986.

Kost, J., Langer, R. “Magnetically modulated delivery systems”, Pharm. International; 7: 60-63, 1986.

Cerbelaud, E., Conway, L., Galliher, P., Langer, R., Cooney, C. “Sulfur regulation of heparinase and sulfatases in Flavo-bacterium heparinum”, Appl. and Envir. Microbiol.; 51: 640-646, 1986.

Kohn, J., Langer, R. “Poly(Iminocarbonates) as Potential New Biomaterials”, Biomaterials; 7: 176-182, 1986.

Larsen, A., Lund, D., Langer, R., Folkman, J. “Oral heparin results in the appearance of heparin fragments in the Plasma of Rats”, PNAS; 83: 1-5, 1986.

Brown, L., Siemer. L., Langer, R. “Controlled release of insulin from polymer matrices: in vitro kinetics”, Diabetes; 35: 684-691, 1986.

Brown, L., Siemer, L, Munoz, C., Edelman, E., Langer, R. “Controlled release of insulin from polymer matrices: control of diabetes in rats”, Diabetes; 35: 692-697, 1986.

Edelman, E., Linhardt, R., Bobeck, H., Kost, J., Rosen, H., Langer, R. “Polymer based drug delivery: magnetically nodulated and bioerodible systems”, Poly. as Biomat.; p. 279-292, 1986.

Langer, R. “Biopolymers in controlled release systems”, Polymeric Biomat.; p. 161-169, 1986.

Klein, M., Langer, R. “Immobilized enzymes in clinical medicine: a new approach to the treatment of disease”, Trends in Biotech.; 4: 179-186, 1986.

Sung, S., Lavin, A., Klibanov, A., Langer, R. “An immobilized enzyme reactor for the detoxification of bilirubin”, Biotech. Bioeng.; 28: 1531-1539, 1986.

Leong, K., Kost, J., Mathiowitz, E., Langer, R. “Polyanhydrides for the controlled release of bioactive agents”, Biomaterials; 7: 364-371, 1986.

Kohn, J., Albert, E., Wilchek, M., Langer, R. “Identification and colorimetric determination of organic cyanates (R-O-C=N) in nanomolar quantities”, Anal. Chem.; 58: 3184-3188, 1986.

Kohn, J., Niemi, S., Albert, E., Murphy, J., Langer, R., Fox, J. “Single-step immunization using a controlled release, biodegradable polymer with sustained adjuvant activity”, J. Immuno. Methods; 95: 31-38, 1986.

Langer, R., Blackshear, P., Chang, T., Klein, M., Schultz, J. “Enzyme and drug delivery systems”, ASAIO Trans.; 9: 639-645, 1986.

Blackshear, P., Robbins, D., Rohde, T., Langer, R., Moses, A., Massey, E. “Insulin replacement: current concepts”, ASAIO Trans.; 9: 646-655, 1986.

Yang, V., Bernstein, H. Kadam, J., Cooney, C., Langer, R. “Removal of the anticoagulant activities of the low molecular weight heparin fractions and fragments with flavobacterial heparinase”, Thrombosis Res.; 44: 599-610, 1986.

Golomb, G., Langer, R., Schoen, F., Smith, M., Choi, Y., Levy, R. “Controlled release of diphosphonate to inhibit bioprosthetic heart valve calcification: dose-response and mechanistic studies”, J. Cont. Rel.; 4: 181 – 194, 1986.

Kost, J., Leong, K., Langer, R. “Ultrasonic modulated drug delivery systems in polymers”, Med., Biom. and Pharm. Appl.; 387-396, 1986.

Langer, R., Siegel, R., Brown, L., Leong, K., Kost J., Edelman, E. “Controlled release systems: three mechanisms”, Chemtech; 16: 108-110, 1986.



Balazs, A., Calef, D., Deutch, J., Siegel, R., Langer, R. “The role of polymer matrix structure & interparticle interactions in diffusion limited drug release”, Biophys. J.; 47: 97-104, 1985.

Folkman, J., Ausprunk, D., Langer, R. “Connective tissue: small blood vessels and capillaries”, Textbook of Rheumatology; 197-210, 1985.

Yang, V., Linhardt, R., Bernstein, H., Cooney, C., Langer, R. “Purification and characterization of heparinase from flavobacterium heparinum”, J. Biol. Chem.; 260: 1849-1857, 1985.

Edelman, E., Kost, J., Bobeck, H., Langer, R. “Regulation of drug release from porous polymer matrices by oscillating magnetic fields”, J. Biomed. Mat. Res.; 19: 67-83, 1985.

Hsu, T., Langer, R. “Polymers for the controlled release of macromolecules: effect of molecular weight of ethylene-vinyl acetate copolymer”, J. Biomed. Mat. Res.; 19: 445-460, 1985.

Levy, R., Wolfrum, J., Schoen, F., Hawley, M., Lund, S., Langer, R. “Inhibition of calcification of bioprosthetic heart valves by local controlled release diphosphonate”, Science; 228: 190-192, 1985.

Yang, V., Langer, R. “A rapid method for isoelectric point estimation”, Anal. Bio. Chem.; 147: 148-155, 1985.

Langer, R., Brown, L., Edelman, E. “Controlled release and magnetically modulated release systems for macromolecules”, Drug and Enz. Targeting. Meth. in Enzym.; 112: 399-423, 1985.

Langer, R., Siegel, R., Brown, L., Leong, K., Kost, J., Edelman, E. “Controlled release and magnetically modulated systems for macromolecular drug”, Ann. of the New York Acad. of Sci.; 446: 1-13, 1985.

Bawa, R., Siegel, R., Marasca, B., Karel, M., Langer, R. “An explanation for the sustained release of macromolecules from polymers”, J. Cont. Rel.; l: 259-267, 1985.

Langer, R. “Biomaterials: new perspectives on their use in the controlled delivery of polypeptides”, Pharm. Techn.; 9: 37-39, 1985.

Lavin, A., Sung, C., Klibanov, A., Langer, R. “Enzymatic removal of bilirubin from blood: a potential treatment for neonatal jaundice”, Science; 230: 543-546, 1985.

Kost, J., Noekker, R., Kunica, E., Langer, R. “Magnetically controlled release systems: effect of polymer composition”, J. Biomed. Mat. Res.; l9: 935-940, 1985.

Leong, K., Brott, B., Langer, R. “Bioerodible polyanhydrides as drug-carrier matrices: I. characterization, degradation and release characteristics”, J. Biomed. Mat. Res.; 19: 941-955, 1985.

Yang, V., Morgan, L., McCarthy, M., Langer, R. “Isoelectric points of the polysaccharide degrading enzymes in flavobacterium heparinum”, Carbo. Res.; 143: 1-6, 1985.

Langer, R., Larsen, A., Bernstein, H., Yang, V., Lund, D., Tapper, D. “Enzymatic control of anticoagulation”, ASAIO J.; 8: 213-214, 1985.

Linhardt, R., Merchant, Z., Rice, K.G., Kam, Y., Fitzgerald, G., Grant, A., Langer, R. “Evidence of random structural features of the heparin polymer”, Biochemistry; 24: 7805-7810, 1985.

Levy, R., Golomb, G., Wolfrum, J., Lund, S.A., Schoen, F., Langer, R. “Local controlled release of diphosphonates from ethylenevinyl acetate matrices prevents bio-prosthetic heart valve calcification”, Am. Soc. Artif. Intern. Organs; 31: 459-463, 1985.

Sung, C., Lavin, A., Klibanov, A., Langer, R. “An immobilized enzyme reactor for treatment of severe neonatal jaundice”, ASAIO J.; 31: 264-268, 1985.

Langer, R., Lund, D., Leong, K., Folkman, J. “Controlled release of macromolecules: biological studies”, J. Cont. Rel.; 2: 331-341, 1985.

Niemi, S., Fox, J., Brown, L., Langer, R. “Evaluation of ethylene-vinyl acetate copolymer as a noninflammatory alternative to Freund’s complete adjuvant in rabbits”, Lab. Animal Sci.; 35: 609-612, 1985.

Langer, R. “Bioavailability of macromolecular drugs and its control in controlled drug bioavailability”, Bioavailability Cont. by Drug Del. Sys. Design; 3: 307-364, 1985.



Siegel, R. Langer, R. “Controlled release of polypeptides and other macromolecules”, Pharm. Research; 1: 2-10, 1984.

Grant, A., Linhardt, R., Fitzgerald, G., Park J., Langer, R. “Metachromatic activity of heparin and heparin fragments”, Anal. Biochem.; 137: 25-28, 1984.

Lee, A., Langer, R. “Shark cartilage contains an inhibitor of tumor neovascularization”, Biotech. and Genetic Engin. in the Marine Sci.; 215-220, 1984.

Larsen, A., Linhardt, R., Klein, M., Tapper, D., Langer, R. “Extracorporeal enzymatic deheparinization and its effect on formed blood components”, Art. Organs; 8: 198-203, 1984.

Langer, R. “Polymers and drug delivery systems”, Long-Acting Contraceptive Del. Sys.; 23-32, 1984.

Murray, J., Brown, L., Langer, R. “Controlled release of nanogram or microgram quantities of macromolecules”, Cancer Drug Del.; 1: 119-123, 1984.

Lee, A., Von Beuzekom, M., Glowacki, J., Langer, R. “Inhibitors enzymes, and growth factors from shark cartilage”, Comp. Physiol & Biochem.; 78B: 609-616, 1984.

Linhardt, R., Cooney, C., Zannetos, C., Larsen, A., Tapper, D., Langer, R. “An immobilized microbial heparinase for blood deheparinization”, Appl. Biochem. and Biotech.; 9: 41-55, 1984.

Kost, J., Langer, R. “Controlled release of bioactive agents”, Trends in Biotech.; 2: 47-51, 1984.

Siegel, R., Cohen, J., Brown, L., Langer, R. “Sintered polymers for sustained macromolecular drug release”, Rececnt Adv. in Drug Del. Sys.; 315-320, 1984.

Langer, R., Brown, L., Edelman, E. “Controlled release and magnetically modulated systems for macromolecules: recent advances”, Rec. Adv. in Drug Del. Sys.; 249-258, 1984.

Cohen, J., Siegel, R., Langer, R. “Sintering technique for preparation of polymer matrices for the sustained release of macromolecules”, J. Pharm. Sci.; 73: 1034-1037, 1984.

Langer, R. “Macromolecular delivery systems for therapeutic applications of controlled drug release”, Contemp. Biomat.; 560-572, 1984.

Larsen, A., Hetelekidis, S., Langer, R. “Disposition and anticoagulant activity of biologically active heparin fragments in the rat”, J. Pharm. & Exper. Ther.; 231: 373-378, 1984.

Edelman, E., Brown, L., Kost, J., Taylor, J., Langer, R. “Modulated release from polymeric drug delivery systems using oscillating magnetic fields: in vitro and in vivo characteristics=”, Trans. Amer. Soc. Art. Int. Organs; 30: 445-447, 1984.

Larsen, A., Hetelekidis, S., Langer, R. “Enzymatic extracorporeal deheparinization: effects of subchronic exposure to heparin fragments”, Trans. Amer. Soc. Art. Int. Organs; 30: 298-302, 1984.

Wheatley, M., Langer, R. “Polymeric microsphere for controlled drug delivery”, Microspheres and drug therapy; 341-345, 1984.

Sefton, M., Brown, L., Langer, R. “Ethylene-vinyl acetate microspheres for controlled release of macromolecules”, J. Pharm. Sci.; 73: 1859-1861, 1984.

Kohn, J., Langer, R. “A new approach to the development of Bioerodible Polymers for controlled release applications employing naturally occurring amino acids”, Proc. ACS Div. Poly. Mat.: Sci. Eng. American Chemical Society; 51: 119-121, 1984.



Langer, R., Murray, J. “Angiogenesis inhibitors and their delivery systems”, Appl. Biochem. and Biotech; 8: 9-24, 1983.

Hsich, D., Rhine, W., Langer, R. “Zero-order controlled release polymer matrices for micromolecules and macromolecules”, J. Pharm. Sci.; 72: 17-22, 1983.

Rosen, H., Chang, J., Wnek, G., Linhardt. R., Langer, R. “Bioerodible polyanhydrides for controlled drug delivery”, Biomaterials; 4: 131-133, 1983.

Langer, R. Edelman, E., Hsieh, D. “Magnetically controlled polymeric delivery systems”, Biocompatible Poly.: Sci. and Tech.; 585-596, 1983.

Langer, R. “New drug delivery systems”, Drug Therapy; 13: 217-231, 1983.

Hsieh, D., Langer, R. “Zero-order drug delivery systems with magnetic control”, Cont. Rel. of Bioactive Mat.; 121-131, 1983.

Langer, R. “Implantable controlled release systems”, Pharm. and Therapeutics; 21: 35-51, 1983.

Langer, R., Peppas, N. “Chemical and physical structure of polymers as carriers for controlled release of bioactive agents: a review”, J. Macromol. Sci.; 23: 61-126, 1983.

Brown, L., Wei, C., Langer, R. “In vitro and in vivo release of macromolecules from polymeric drug delivery systems”, J. Pharm. Sci.; 72: 1181-1185, 1983.

Lee, A., Langer, R. “Shark cartilage contains inhibitors of tumor angiogenesis”, Science; 221: 1185-1187, 1983.

Kupchik, H., Langer, R., Haberern, C., El Deriny, S., O’Brien, M. “A new method for the three dimensional in vitro growth of human cancer cells”, Exper. Cell. Res.; 147: 454-459, 1983.

Folkman, J., Langer, R., Linhardt, R., Haudenschild, C., Taylor, S. “Angiogenesis inhibition and regression of large tumour masses caused by heparin or a heparin fragment in the presence of cortisone”, Science; 221: 719-725, 1983.

Murray, J., Brown, L., Klagsbrun, M., Langer, R. “A micro sustained release system for epidermal growth factor”, In Vitro; 19: 743-748, 1983.

Klein, M., Drongowski, R., Linhardt, R., Cooney, C., Langer, R. “Heparinase: in vivo activity and immunogenicity in rabbits”, J. Lab. and Clin. Med.; 102: 828-837, 1983.



Langer, R., Linhardt, R., Klein, M., Flanagan, M., Galliher, P., Cooney, C. “A system for heparin removal”, Biomaterials: Interfacial Phenomena and Applications; 493-509, 1982.

Berman, M., Winthrop, S., Ausprunk, D., Rose, J., Langer, R., Gage, J. “Plasminogen activator (urokinase) causes vascularization of the cornea”, Invest. Ophthal.; 22: 191-199, 1982.

Langer, R., Hsich, D., Brown, L. “Polymeric delivery systems for macromolecules: approaches for studying in vivo release kinetics and designing constant rate dsystems”, Biol. Activities of Polymers; 186: 95-197, 1982.

Linhardt, R., Fitzgerald, G., Cooney, C., Langer, R. “Mode of action of heparin lyase E.C. 4227 on heparin”, Biochem. Biophys. Acta.; 702: 197-203, 1982.

Langer, R. “Controlled release of macromolecules”, Chemtech; 12: 98-105, 1982.

Langer, R., Linhardt, R., Cooney, C., Tapper, D., Klein, M. “Immobilized heparinase: production, purification and application in extracorporeal therapy”, Enzyme Eng.; 6: 433-441, 1982.

Klein, M., Drongowski, R., Linhardt, R., Langer, R. “A colorimetric assay for chemical heparin in plasma”, Anal. Biochem.; 124: 59-64, 1982.

Linhardt, R., Grant, A., Cooney, C., Langer, R. “Differential anticoagulation activity of heparin fragments prepared using microbial heparinase”, J. Biol. Chem.; 257: 7310-7313, 1982.

Langer, R., Linhardt, R., Hoffberg, S., Larsen, A., Cooney, C., Tapper, D., Klein, M. “An enzymatic system for removing heparin in extracorporeal therapy”, Science; 217: 261-263, 1982.

Cooney, C. Galliher, P., Langer, R., Linhardt, R., Conway, L. “Regulation of heparinase synthesis in flavobacteria heparinum”, Europ. J. Appl. Microbiol.; 15: 252-257, 1982.

Langer, R., Linhardt, R., Larsen, A., Cooney, C., Tapper, D., Klein, M. “In vivo activity of microbial heparinase”, Trans. Am. Soc. Art. Int. Organs; 28: 387-390, 1982.



Folkman, J., Ausprunk, D., Langer, R.”Connective tissue: small blood vessels and capillaries”, Textbook of Rheumatology; 210-220, 1981.

Conn, H., Langer, R.”Iodine disinfection of hydrophilic contact lenses”, Ann. Ophthal.; 13: 361-364, 1981.

Langer, R.”Polymers for sustained release of macromolecules: their use in a single-step method of immunization”, Immunological Techniques, Methods in Enz.; 73: 57-75, 1981.

Hsich, D., Langer, R., Folkman, J.”Magnetic modulation of release of macromolecules from Polymers”, PNAS; 78: 1863-1867, 1981.

Galliher, P., Cooney, C., Langer, R., Linhardt, R.”Heparinase production by flavobacteria”, Appl. Env. Microbiology; 41: 360-365, 1981.

Langer, R., Brem, H., Tapper, D.”Biocompatibility of polymeric delivery systems for macromolecules”, J. Biomed. Mat. Res.; 15: 267-277, 1981.

Langer, R.”Controlled Release: A new approach to drug delivery”, Tech. Rev.; 83: 26-34, 1981.

Langer, R., Karel, M.”Controlled release technology: polymers in medicine, food and agriculture”, Poly. News; 7: 250-258, 1981.

Langer, R., Hsieh, D., Brown, L., Rhine, W.”Polymers for the sustained release of macromolecules: controlled and magnetically modulated systems”, Better Therapy With Existing Drugs: New Uses and Del. Sys.; 179-216, 1981.

Hsieh, D., Langer, R.”Experimental approaches for achieving both zero-order and modulated controlled release from polymer matrix systems”, Cont. Rel. of Pesticides and Pharm.; 16-May, 1981.

Langer, R., Folkman, J. “Angiogenesis Inhibitors in molecular actions and targets for cancer chemotherapeutic agents” 511-525, 1981.

Langer, R., Hsich, D., Peil, A., Bawa, R., Rhine, W.”Polymers for sustained macromolecular release: kinetics, applications, external control”, Cont. and Topical Rel. of Drugs to the Body; 206: 10-20, 1981.

Mayberg, M., Langer, R., Zervas, N., Moskowitz, M.”Perivascular meningeal projections from at trigeminal ganglia: possible pathway for vascular headaches in man”, Science; 213: 228-230, 1981.

Moskowitz, M., Mayberg, M., Langer, R.”Controlled release of horseradish peroxidase from polymers: a method to improve histochemical localization and sensitivity”, Brain Res.; 212: 460-465, 1981.

Langer, R., Peppas, N.”Present and future applications of biomaterials in controlled drug delivery systems”, Biomaterials; 2: 195-210, 1981.

Langer, R., Urquhart, J. Blackshear, P.”Implantable drug delivery systems”, Trans. Am. Soc. Art. Int. Organs; 27: 648-654, 1981.

Peil, A., Barrett. F., Rha, C., Langer, R.”Retention of micro-nutrients by polymer coatings used to fortify rice”, J. Food Science; 47: 260-262, 1981