Professor Robert S. Langer

Robert S. Langer is one of 9 Institute Professors at MIT; being an Institute Professor is the highest honor that can be awarded to a faculty member.  Dr. Langer has written more than 1,570 articles.  He also has over 1,400 issued and pending patents worldwide.  Dr. Langer’s patents have been licensed or sublicensed to over 400  pharmaceutical, chemical, biotechnology and medical device companies.  He is the most cited engineer in history (h-index 319 with more than 412,500 citations according to Google Scholar).

He served as a member of the United States Food and Drug Administration’s SCIENCE Board, the FDA’s highest advisory board, from 1995 — 2002 and as its Chairman from 1999-2002.

Dr. Langer has received over 220 major awards.   He is one of 3 living individuals to have received both the United States National Medal of Science (2006) and the United States National Medal of Technology and Innovation (2011).  He also received the 1996 Gairdner Foundation International Award, the 2002 Charles Stark Draper Prize, considered the equivalent of the Nobel Prize for engineers, the 2008 Millennium Prize, the world’s largest technology prize, the 2012 Priestley Medal, the highest award of the American Chemical Society, the 2013 Wolf Prize in Chemistry, the 2014 Breakthrough Prize in Life Sciences and the 2014 Kyoto Prize.    In 2015, Dr. Langer received the Queen Elizabeth Prize for Engineering.  Among numerous other awards Langer has received are the Dickson Prize for Science (2002), the Heinz Award for Technology, Economy and Employment (2003), the Harvey Prize (2003), the John Fritz Award (2003) (given previously to inventors such as Thomas Edison and Orville Wright), the General Motors Kettering Prize for Cancer Research (2004), the Dan David Prize in Materials Science (2005), the Albany Medical Center Prize in Medicine and Biomedical Research (2005), the largest prize in the U.S. for medical research, induction into the National Inventors Hall of Fame (2006), the Max Planck Research Award (2008), the Prince of Asturias Award for Technical and Scientific Research (2008), the Warren Alpert Foundation Prize (2011), the Terumo International Prize (2012), the Benjamin Franklin Medal in Life Science (2016), the Kabiller Prize in Nanoscience and Nanomedicine (2017),  the Dreyfus Prize in Chemical Science (2019), the Medal of Science (Portugal’s highest honor, 2020), the Maurice-Marie Janot Award (2020), the BBVA Foundation Frontiers of Knowledge Award in Biology and Biomedicine (2021) and the Balzan Prize for Biomaterials for Nanomedicine and Tissue Engineering (2022).  In 1998, he received the Lemelson-MIT prize, the world’s largest prize for invention for being “one of history’s most prolific inventors in medicine.”  In 1989 Dr. Langer was elected to the National Academy of Medicine,  in 1992 he was elected to both the National Academy of Engineering and to the National Academy of Sciences, and in 2012 he was elected to the National Academy of Inventors.

Forbes Magazine (1999) and Bio World (1990) have named Dr. Langer as one of the 25 most important individuals in biotechnology in the world.  Discover Magazine (2002) named him as one of the 20 most important people in this area.  Forbes Magazine (2002) selected Dr. Langer as one of the 15 innovators worldwide who will reinvent our future.  Time Magazine and CNN (2001) named Dr. Langer as one of the 100 most important people in America and one of the 18 top people in science or medicine in America (America’s Best).  Parade Magazine (2004) selected Dr. Langer as one of 6 “Heroes whose research may save your life.”  Dr. Langer has received 41 honorary doctorates.   They include degrees from Harvard University, the Mt. Sinai School of Medicine, Yale University, Columbia University, the Memorial Sloan Kettering Cancer Center Gerstner Graduate School, the University of Maryland, the University of Western Ontario (Canada), ETH (Switzerland), the Technion (Israel), the Hebrew University of Jerusalem (Israel), the Universite Catholique de Louvain (Belgium), Rensselaer Polytechnic Institute, Willamette University, the University of Liverpool (England), Bates College, the University of Nottingham (England), Albany Medical College, Pennsylvania State University, Northwestern University, Uppsala University (Sweden), Tel Aviv University (Israel), Boston University, Ben Gurion University (Israel), the University of Laval (Canada), Carnegie Mellon University, Drexel University, Hanyang University (South Korea), the University of New South Wales (Australia), Karolinska Institutet (Sweden), Hong Kong University of Science and Technology (Hong Kong),  the National Institute of Astrophysics, Optics and Electronics (Mexico), the University of Limerick (Ireland), the University of Illinois, Ohio State University, Olin College of Engineering, Alfred University, Macau University of Science and Technology, the Universidad de Santiago de Compostela, Maastricht University, and the University of California – San Francisco Medal.  He received his Bachelor’s Degree from Cornell University in 1970 and his Sc.D. from the Massachusetts Institute of Technology in 1974, both in Chemical Engineering.

News

2023

– Robert Langer wins the 2023 Dr. Paul Janssen Award (12/2023)

2022

Robert Langer wins the 2022 Balzan Prize (9/14/22)

Bob Langer Wins BBVA Foundation Frontiers of Knowledge Award in Biology and Biomedicine! (1/26/22)

2021

Bob Langer and colleagues analyze how the surfaces of silicone breast implants affect the immune system

2020

– Bob Langer receives the 2020 Maurice Marie-Janot Award

2019

Robert Langer wins the 2019 Dreyfus Prize in the Chemical Sciences

AIChE announces Langer Prize for Innovators and Entrepreneurs

2017

Bob Langer named #1 Master of the Bench, Medicine Maker “Power List”

2016

– Bob Langer received an Honorary Doctor of Medicine, Karolinska Institutet
– Bob Langer named World’s Most Influential Scientific Minds list, 2016 Thomson Reuters

2015

Bob Langer helps to create an ingestible sensor that measures heart and breathing rates – November 18, 2015

Bob Langer received the Queen Elizabeth Prize for Engineering – October 26, 2015

Langer and colleagues develop a pH-responsive polymer gel that could create swallowable devices – July 27, 2015

Bob Langer’s Microchips Biotech signs deal to commercialize implantable drug-delivery devices – June 29, 2015

Bob Langer – 2015 Medicine Maker Power List – May 12, 2015

– Langer lab has designed implantable device to allow cancer drug testing in patients – April 22

Langer lab develops a self-healing nanogel to aid drug delivery – February 19

Profs. Anderson and Langer work to help control diabetes – February 9

– Bob Langer’s Controlled Drug Release Technology featured in IBiology video series. February 2015, [Watch Video – III parts]

Bob Langer wins Queen Elizabeth Prize for Engineering – February 3, 2015

2014

Bob Langer named Cornell Entrepreneur of the Year 2015 – December 16

Bob Langer profiled on Chemical Heritage Foundation’s “Scientists You Must Know” video – September 2

Bob Langer receives Kyoto Prize – June 20

2013

Bob Langer receives the 2014 Breakthrough Prize in Life Sciences – December 13

Bob Langer unlocks a new means of growing intestinal stem cells – December 1

The Langer lab designs drug-carrying nanoparticles that can be taken orally – November 27

Professors Anderson and Langer develop an injectable nanogel to help fight diabetes – May 16

Profs Anderson, Hammond and Langer practice medicine at the nanoscale – March 11

Professors Jensen and Langer find a way to deliver RNA, proteins and nanoparticles by “squeezing” cells – January 23

Bob Langer wins Israel’s Wolf Prize in Chemistry – January 2, 2013

2012

Bob Langer to receive the 2013 National Medal of Technology and Innovation – December 21, 2012

NYTimes profiles the Langer lab – November 24, 2012

Bob Langer wins the Wilhelm Exner Medal, considered the “Austrian Nobel Prize.” – November 8, 2012

Using ultrasound waves, Professors Blankschtein and Langer have found a way to enhance the permeability of skin to drugs, making transdermal drug delivery more efficient – September 14, 2012

Bob Langer’s new tissue scaffold could be used for drug development and implantable therapeutic devices – August 27, 2012

Bob Langer designs nanoparticles that deliver high doses of antibiotics directly to bacteria – May 4, 2012

Bob Langer wins 2012 Perkin Award, the highest honor for the US industrial chemical industry – April 25, 2012

Bob Langer and Dan Anderson have developed nanoparticles that could manufacture cancer drugs at tumor sites – April 9, 2012

Bob Langer’s targeted nanoparticles show success in clinical cancer trials – April 4, 2012

The Tech interviews Institute Professor Robert Langer – December 13, 2011

Bob Langer wins Priestley Medal, chemistry’s top awardJune 21, 2011

Bob Langer’s work highlighted on NOVA’s Feb. 9 “Making Stuff: Smarter” (minute 40:35) – February 9, 2011

Professor Robert Langer ’74’s controlled drug release technology a “baby boomer invention that changed the world” – December 30, 2010

Professor Bob Langer develops nanoparticle to improve cancer drug delivery. MIT News, October 5, 2010

Professor Bob Langer receives NAE Founders Award. MIT News, october 1, 2010

Professor Bob Langer works to help Julie Andrews sing again, guardian.co.uk, October 22, 2009

Dr. Lisa E. Freed’s research featured on NIH and Stories of Recovery. [Watch the video] October 2009

Nature shares a day in the life of Professor Bob Langer, Nature News, March 4, 2009

Prof. Langer wins the 2008 Millennium Technology Prize, June 11, 2008

Langer won the $1.2 million Millennium Technology Prize, Boston Herald, “The Ticker” by staff and wire reports, June 12, 2008 

MIT professor Robert Langer wins $1.2M technology prize, Boston Herald, by Associated Press, June 11, 2008

Prof. Langer wins the 2008 Prince of Asturias Award for Technical and Scientific Research for the creation of new materials for the benefit of mankind, June 5, 2008

Prof. Langer wins top German science award, March 18, 2008

Prof. Langer and ChemE students develop a gecko-inspired bandage, Feb. 18, 2008

Professor Langer demonstrates drug delivery by nanoparticle, February 13, 2008

Three from MIT win top U.S. science, technology honors, July 16, 2007 | Photos

Langer throws out the ceremonial first pitch at Fenway Park, July 28, 2006

Langer honored for his 30 years of innovation, July 14-16, 2006 (Event Detail)

Langer inducted into the Inventors Hall of Fame, May 6, 2006

Prof. Langer won the ACS Award in Chemistry of Materials C&EN News, Jan. 1, 2007

Cancer Smart Bomb, ScienCentral News, May 11, 2006

Langer has been named Institute Professor, March 2, 2005

A dab relieves pain of the jab, August 18, 2004

Langer award cites cancer work, June 2004

Langer wins two prestigious prizes for biomedical advances, December 3, 2003

Stem cells ‘seeded’ on polymer scaffold, October 22, 2003

MIT, California Schools receive $50M grant for Army research, September 10, 2003

Technology Licensing Office has terrific year, ‘Super Week’, March 19, 2003

Julie Andrews hopes to sing praises of research team, June 18, 2002

‘Biorubber’ opens doors for tissue engineering, June 5, 2002

MIT World videos now streaming from WGBH web site, June 5, 2002

MIT affiliates dominate Technology Review’s TR100 list, June 5, 2002

MIT’s biorubber ushers in new possibilities in tissue engineering, May 31, 2002

Facts on Cambridge, MIT and the biotech industry, May 6, 2002

Smart suture is first application of novel MIT polymer, April 25, 2002

Here & There: A Truly Beautiful Mind, April 10, 2002

Langer team reports source of cells for engineered human blood vessels, April 3, 2002

Team reports source of human cells for engineered blood vessels, March 28, 2002

Langer awarded $500,000 Draper Prize for engineering, February 27, 2002

Charles Stark Draper Prize
MIT Bioengineering Professor Awarded 2002 Draper Prize
The 2002 Draper Prize

Lemelson-MIT Program
Robert S. Langer Wins 1998 Lemelson-MIT Prize

Inventor of the Week, June 2002

Scientific American Frontiers
Body Building Episode Premiered, May 28, 2002
How to Make a Nose Segement
Science Hotline

MIT ChemE News and Events
Smart Fibers May Improve Future For Sutures Langer Awarded 2002 Draper Prize

MIT World
Lecture: Biomaterials and How They Will Change our Lives,
March 28, 2002

Boston Globe Magazine
For top scientists, prizes a growing source of income, June 22, 2004
Prizes Honor Local Scientists,December 2, 2003
Stem ” cells” grown into tissues, October 28, 2003
Terrified of needles? Help is on the horizon, August 19, 2004
Speak Up, Stem Cell advocates, July 19, 2004
Changing the World, June 29, 2003

The Crusader: MIT scientist Robert Langer doesn’t believe in science for science’s sake. He sees it as a means to change the world – and he has, May 25, 2003

Boston Herald
FDA OK’s needle-free injection device , August 19, 2004

CNN/Time Magazine
America’s Best: Science and Medicine
, 2001

Forbes Magazine
Plastic Man : 85 Years of Ideas, December 23,2002
Biotechnology All-Stars, May 31, 1999

Red Herring
MIT’s Robert Langer proves nice guys deliver the goods, January 15, 2002

The Tech
MIT Professor Wins ’Engineering Nobel’, February 22, 2002

The Daily Gazette, NY
Speakers cite promise of biotech field, April 4, 2003

New York Times
How Much Of the Body Is Replaceable? November 11, 2003

National Institute of Health
MIT’s Langer Offers Blue Sky view of Biomaterial Potential, July, 22  2003

Newsweek, U.S. Edition
Sci-Fi War Uniforms?, February 24,  2003

MIT News Office Tech Talk
Three MIT scientists among Time’s best, August 29, 2001
Research Firsts and Teaching Firsts at MIT

Beyond Discovery (National Academy of Sciences)
Polymers and People, 1999

Lemelson-MIT Program
Inventor of the Week, April 1998

The Tech
Bob Langer: Quest of Curiosity  July 11, 2001
Good Speakers, Good Company At Biotechnology Conference, March 3, 2001
Lemelson Winner Discusses Innovation, Education, April 28, 1998

Publications: 2020-

2020

2020

Raman, R., Hua, T., Gwynne, D., Collins, J., Tamang, S., Zhou, J., Esfandiary, T., Soares, V., Pajovic, S., Hayward, A., Langer, R., Traverso, G. Light-degradable hydrogels as dynamic triggers for gastrointestinal applications. Science Advances, 6:eaay0065, 2020. PMID32010768; PMC6968934; DOI: 10.1126/sciadv.aay0065

Yu, J., Wang, J., Zhang, Y., Chen, G., Mao, W., Ye, Y., Kahkoska, A., Buse, J., Langer, R., Gu, Z. Glucose-responsive smart insulin patch for blood glucose regulation in mice and pigs, Nature Biomedical Engineering, 499–506, 2020. DOI:10.1038/s41551-019-0508-y

Sarmadi, M., Behrens, A.M., McHugh, K.J., Contreras, H., Tochka, Z., Lu, X., Langer, R., Jaklenec, A. Modeling, design, and machine learning-based framework for optimal injectability of microparticle-based drug formulations. Science Advances, 2020.

Volpatti, L., Matranga, M.A., Cortinas, A.B., Delcassian, D., Daniel, K., Langer, R., Anderson, D., Glucose-responsive nanoparticles for rapid and extended self-regulated insulin delivery, ACS Nano, 14 (1): 488-497, 2020. DOI: 10.1021/acsnano.9b06395. PMID: 31765558

Mirvakili, S., Sim, D., Hunter, I., Langer, R. Magnetically induced thermal pneumatic artificial muscles. Science Robotics, 2020.

Yang, K., O’Cearbhaill, E., Liu S., Zhou, A., Hamilos, A., Chitnis, G., Xu, J., Giraldo, J., Verma, M., Pop, R., Langer, R., Melton, D.,. Greiner, D., Karp, J. SUbA therapeutic convection enhanced macroencapsulation device for enhancing β cell viability and insulin secretion. Science Advances,

Mirvakili, S., Ngo, Q.P., Langer, R. Polymer nanocomposite microactuators for on-demand chemical release via high-frequency magnetic field excitation. Nano Letters, 2020, 4816-4822 DOI: 10.1021/acs.nanolett.0c00648 PMC7349659; PMID: 32479730

Srinivasan, S., Ramadi. K., Vicario, F., Gwynne, D., Hayward, A., Lagier, D., Langer, R., Frassica, J., Baron, R., Traverso, G. A rapidly deployable individualized system for augmenting ventilator capacity. Science Translational Medicine, 2020. PMID32424018; PMC7259824; DOI: 10.1126/scitranslmed.abb9401

Roberts, T., Langer, R., Wood, M. Advances in oligonucleotide drug delivery. Nature Reviews Drug Discovery, 2020. DOI: 10.1038/s41573-020-0075-7

Lu, X., Miao, L., Gao, W., Chen, Z., McHugh, K., Sun, Y., Tochka, Z., Tomasic, S., Sadtler, K., Hyacinthe, A., Huang, Y., Graf, T., Hu, Q., Sarmadi, M., Langer, R., Anderson, D., Jaklenec, A. Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy. Science Translational Medicine, 2020. DOI: 10.1126/scitranslmed.aaz6606

Sadtler, , Collins, J., Byrne, J., Langer, R. Parallel evolution of polymer chemistry and immunology: integrating mechanistic biology with materials design. Advanced Drug Delivery Reviews, 2020. doi.org/10.1016/j.addr.2020.06.021

Patel, A, Kaczmarek, J, Bose, S, Kauffman, K, Mir, F, Heartlein, M, DeRosa, F, Langer, R, and Anderson, D, Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium, Advanced Materials, PMID: 30609147 DOI: 1002/adma.201805116

Von Erlach, T., Saxton, S., Shi, Y., Minahan, D., Reker, D., Javid. F., Lee, Y.L., Schoellhammer, C., Esfandiary, T., Cleveland, C., Booth, L. Lin, J. Levy, H., Blackburn, S., Hayward, A., Langer, R., Traverso, G. Robotically handled whole-tissue culture system for the screening of oral drug formulations. Nature Biomedical Engineering, 4, 544–559, 2020. DOI:10.1038/s41551-020-0545-6

Reker, D., Shi, Y., Kirtane, A.R.., Hess, K., Zhong, G.J., Crane, E., Lin, C., Langer, R., Traverso, G. Machine learning uncovers food-and-excipient-drug interactions. Cell Reports, 30, 3710–3716, 2020. DOI:1016/j.celrep.2020.02.094 PMID: 32187543 PMCID: PMC7179333

Li, J., Liang, Y.J., Laken, S., Langer, R., Traverso, G. Clinical opportunities for continuous biosensing and closed-loop therapies. Trends in Chemistry, 2 (4): 319-340, 2020. DOI:10.1016/j.trechm.2020.02.009

Rudra, A., Li, J., Shakur, R., Bhagchandani, S., Langer, R. Trends in therapeutic conjugates: bench to clinic, Bioconjugate Chemistry, 31 (3), 462-473, 2020. DOI: 10.1021/acs.bioconjchem.9b00828

Verma, M., Chu, J., Salama, J., Faiz, M., Eweje, F., Gwynne, D., Lopes, A., Hess, K., Soares, V., Steiger, C., McManus, R., Koeppen, R., Hua, T., Hayward, A., Collins, J., Tamang, S.M., Ishida, K., Miller, J., Katz, S., Slocum, A.H., Sulkowski, M.S., Thomas, D.L., Langer, R., Traverso, G. Development of a long-acting direct-acting antiviral system for Hepatitis C virus treatment in swine. Proceedings of the National Academies of Sciences, 117 (22) 11987-11994, 2020. DOI: 10.1073/pnas.2004746117

Sarmadi, M., Behrens, A., Kevin J. McHugh, K., Contreras, H., Tochka, Z., Lu, X., Langer, R., Jaklenec, A. Modeling, design, and machine learning-based framework for optimal injectability of microparticle-based drug formulations. Science Advances, 6:8, eabb6594, 2020. DOI: 10.1126/sciadv.abb6594

Haley RM, Gottardi R, Langer R, Mitchell MJ. Cyclodextrins in drug delivery: applications in gene and combination therapy. Drug Delivery Translational Research, 10:661- 677, 2020. PMID32077052 DOI:10.1007/s13346-020-00724-5

Wei, T., Cheng, Q., Farbiak, L., Anderson, D.G., Langer, R., Siegwart, D.J. Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing. ACS Nano, 2020, DOI: 10.1021/acsnano.0c04707

Saunders N.R.M., Paolini M.S., Fenton O.S., Poul L., Devalliere J., Mpambani F., Darmon A., Bergere M., Jibault O., Germain M., Langer R. A Nanoprimer to Improve the Systemic Delivery of siRNA and mRNA. Nano Letters, 20:4264-4269, 2020. PMID32357299; DOI: 10.1021/acs.nanolett.0c00752

Ramadi, K., Dagdeviren, C., Bhagchandani, P.; Nunez-Lopez, C., Kim, M. Langer, R., Graybiel, A., Cima, M. Simultaneous recording and marking of brain microstructures. Journal of Neural Engineering, 17: 044001, 2020. DOI:10.1088/1741-2552/aba161

Bose, S., Volpatti, L., Thiono, D., Yesilyurt, V., McGladrigan, C., Tang, Y., Facklam, A., Wang, A., Jhunjhunwala, S, Veiseh, O., Hollister-Lock, J., Bhattacharya, C., Weir, G., Greiner, D., Langer, R., Anderson, D. A retrievable implant for the long-term encapsulation and survival of therapeutic xenogeneic cells. Nature Biomedical Engineering, 4: 814-826, 2020. DOI:10.1038/s41551-020-0538-5

Schwerdt, H., Amemori, K., Gibson, D., Stanwicks, L., Yoshia, T., Bichot, N., Amemori, S., Desimone, R., Langer, R., Cima, M., Graybiel, A. Dopamine and beta-band oscillations differentially linked to striatal value and motor control, Science Translation Medicine, in press.

Abramson, A., Della, D., Kong, Y.L., Zhou, J., Gao, Y., Collins, J., Tamang, S., Wainer, J., McManus, R., Hayward, A., Frederiksen, M.R., Water, J.J., Jensen, B., Roxhed, N., Langer, R., Traverso, G. Ingestible transiently anchoring electronics for microstimulation and conductive signaling. Science Advances, in press, 2020.

Tang, Z., Kong, N., Zhang, X., Liu,Y. Ping Hu, P., Mou, S., Liljeström, P., Shi, P.J.,  Tan, W., Kim,  J.S., Cao,  Y., Langer, R., Leong,  K., O Farokhzad, O., Tao, W. Responding to COVID-19: What can materials scientists do?  Nature Review Materials, 2020, in press.

Raman, R., Rousseau, E.B., Wade, M. ,Tong, A., Cotler, M.J., Kuang, J., Aponte Lugo, A., Zhang, E., Graybiel, A.M., White, F.M, Langer, R., Cima, M.J. Platform for micro-invasive membrane-free biochemical sampling of brain interstitial fluid, Science Advances, 2020, in press.

Yin, H., Bogorad, R., Barnes, C., Zhuang, I., Nonaka, H., Ruda, V., Kuchimanchi, S., Nechev, L., Akinc, A., Zerial, M., Langer, R., Anderson, D. and Koteliansky, V., Efficient multiplex knockdown mediated control of organ size and its application for rapid analyses of molecular interactions in vivo, Proceedings of the National Academy of Sciences,

Han, M., Cha, Y., Jeong, H., Zoldan, J., Burkart, A., Kim, C., Kim, H., Cho, S., Kim, B., Langer, R., Kahn, R., Cha, H., Guarente, L. and Kim, K., Metabolic control of human pluripotent stem cell fate and function by deacetylase SIRT2, Science, submitted.

Taylor, L., Arner, K., Kolewe, M., Pritchard, C., Hendy, G., Langer, R. and Ghosh, F., Tissue stabilization in vitro using surface modification of poly(glycerol-co-sebacic acid) membranes in adult porcine retinal explants, Biomaterials, submitted.

Mizrahi, B., Khoo, X., Chiang, H., Sher, K., Feldman, R., Irusta, S., Langer, R. and Kohane, D., Multi-armed prepolymer for antifouling coatings, Journal of the American Chemical Society, submitted.

Fenton, O., Kauffman, K., McClellan, R., Appel, E., Dorkin, J., Tibbitt, M., Heartlein, M., DeRosa, F., Langer, R. and Anderson, D., Bioinspired alkenyl amino alcohol ionizable lipid materials for highly potent in vivo mRNA delivery, Journal of the American Chemical Society, submitted.

Indolfi, L., Ligorio, M., Ting, D., Xega, K., Tzafriri, A., Bersani, F., Aceto, N., Deshpande, V., Ferrone, C., Haber, D., Langer, R., Clark, J. and Edelman, E., A local drug delivery platform to enhance cytotoxic effects of chemotherapy in pancreatic cancer, Proceedings of the National Academy of Sciences, submitted.

Lin, J., Dargazany, R., Zhang, S., Jafari, M., Lee, Y., Hurowitz, H., Langer, R. and Traverso, G., Corona molecular dynamics of poly(ethylene glycol)-coated nanoparticles, Nano Letters, submitted.

Kahn, O., Tsosie, J., Spanoudaki, V., Zaia, E., Chiu, A., Tang, K., Siebert, S., Bader, A., Aresta-Dasilva, S., Langan, E., Langer, R., Anderson, D., Implant surface modifications modulate blood vessel geometry and vascular organization at the material-host interface, Journal of the American Chemical Society, submitted

McAvoy, M., Tsosie, J, Vyas, K, Khan, O, Sadtler, K, Anderson, D, and Langer, R, Stretchable Multielectrode Array for Skeletal Muscle Conditioning, Acetylcholine Receptor Stabilization and Epimysial Recording After Critical Peripheral Nerve Injury, Biomaterials, submitted.

Ferreira, M., Neubert, J., Atala, A., Breuer, C., Collins, S., Keating, A., Langer, R., Rapoza, M., Reeve, B., Russell, A., Roberts, M., Parsons-Wingerter, P., Stoudemire, J., Gobel, D., Harper, L., Hunsberger, J., Naughton, G., Moldovan, N., Solorzano, R., Pereira, T., Roadmap to ending the organ shortage: Research strategies, challenges and opportunities, Nature Biotechnology, submitted.

Hlavaty, K., Booty, M., Stockman, A., Tian, L., How, E., Subramanya, D., Venkitaraman, A., Yee, C., Ozay, E., Pryor, O., Smith, C., Volk, K., Blagovic, K., Vicente-Suarez, I., Yarar, D., Myint, M., Merino, A., Chow, J., Pomerance, L., Abdeljawad, T., An, H., Stokes, B., Liu, S., Mao, S., Heimann, M., von Adrian, U., Jensen, K., Langer, R., Knoetgen, H., Trumpfheller, C., Bernstein, H., Sharei, A., Loughhead, S., Microfluidic squeezing enables antigen presentation by diverse immune cell types to elicit CD8+ T cell responses, Nature Biomedical Engineering, submitted.

Ramadi, K., Bashyam, A., Frangieh, C., Rousseau, E., Cotler, M., Langer, R., Graybiel, A., Cima, M., Computationally guided intracerebral drug delivery via chronically implanted microdevices, Cell Reports, submitted.

Talebian, S., das Neves, J., Sarmento, B., Langer, R., Conde, J. Facts and figures about nanotechnology in the past 20 years. Nature Nanotechnology, submitted.

Volpatti, L., Facklam, A., Cortinas, A., Matranga, M., Hill, M. Langer, R., Anderson, D. Microgel encapsulated nanoparticles for glucose-responsive insulin delivery. Biomaterials, submitted

Kirtane, A.R. , Karavasili, C., Wahane, A. , Dao Le, T.H., Hua, T., Scala, C., Lopes, A., Hess, K., Collins, J., Tamang, S., Ishida, K., Rajesh, N., Phan, N., Li, J., Hayward, A., Langer, R., Traverso, G. Molecular gastronomy-inspired drug delivery systems for paediatric applications. Nature Communications, submitted.

Schwerdt, H., Amemori, K., Gibson, D., Stanwicks, L., Yoshia, T., Bichot, N., Amemori, S., Desimone, R., Langer, R., Cima, M., Graybiel, A. Dopamine and beta-band oscillations differentially linked to striatal value and motor control, Science Translation Medicine,

Li, W., Qiu, J., Li, X., Aday, S., Zhang, J., Conley, G., Xu, J., Langer, R., Mannix, R., Karp, J.M., Joshi, N. BBB pathophysiology independent delivery of siRNA in traumatic brain injury. Science Advances, submitted.

Caffarel-Salvador, E., Kim, S., Soares, V., Tian, R.Y., Stern, S.R., Minahan, D., Yona, R., Lu, X., Zakaria, F.R., Collins, J., Wainer, J., Wong. J., McManus, R., Tamang, S., McDonnell, S., Ishida, K., Hayward, A. Liu, X., Hubàlek, F., Vegge, A., Frederiksen, M., Rahbek U., Yoshitake, T., Fujimoto, J., Roxhed, N., Langer, R., Traverso, G., A microneedle platform for buccal macromolecule delivery. Science Advances, submitted.

McLean, W.J., Hinton, A.S., Herby, J., Yang-Hood, A., Schrader, A.D., Ohlemiller, K.K., Salt, A.N., Hartsock, J.J., Wilson, S., Lucchino, D., King, S., Jackson, L.E., Rosenbloom, J., Atiee, G., Bear, M., Runge, C., Gifford, R., Rauch, S., Lee, D., Langer, R., Karp, J., Loose, C., LeBel, C. Improved speech intelligibility in subjects with stable sensorineural hearing loss following intratympanic dosing of FX-322. Otology & Neurotology, submitted.

Sadtler, K., MacIsaac, C., Zepeda, F., Langer, R., Anderson, D.G. The clotting cascade: a link between scar formation and the foreign body response. Science Translational Medicine, submitted.

Mitchell, M., Billingsley, M., Haley, R., Wechsler, M., Peppas, N.A., Langer, R. Engineering precision nanoparticles for drug discovery. Nature Reviews Drug Discovery, submitted.

 

Publications: 1991 – 2000

2000

2000

Fu, K., Klibanov, A., Langer, R. “Protein stability in controlled release systems”, Nature Biotech.; 18: 24-25, 2000.

Kost, J., Mitragotri, S., Gabbay, R., Pishko, M., Langer, R. “Transdermal monitoring of glucose and other analytes using ultrasound”, Nature Medicine; 6: 347-350, 2000.

Kim, B., Langer, R., Hrkach, J. “Biodegradable photo-crosslinked poly (ether-ester) networks for lubricious coatings”, Biomaterials; 21: 259-265, 2000.

Langer, R. “Tissue engineering”, Mol. Therapy; 1:12-15, 2000.

Mitragotri, S., Farrell, J., Tang, H., Terahara, T., Kost, J., Langer, R. “Determination of the threshold energy for ultrasound-induced transdermal drug delivery”, Journal of Controlled Release; 63: 41-52, 2000.

Tobio, M., Schwendeman, S., Guo, Y., McIver, J., Langer, R., Alonoso, M. “Improved immunogenicity of a core-coated tetanus toxoid delivery system”, Vaccine; 18: 618-622, 2000.

Fu, K., Pack, D., Klibanov, A., Langer, R. “Visual evidence of acidic environment within degrading PLGA microspheres”, Pharmaceutical Research; 17: 100-106 , 2000.

Elisseeff, J., McIntosh, W., Anseth, K., Riley, S., Ragan, P., Langer, R. “Potoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks”, Journal of Biomedical Materials Research; 51: 164-171, 2000.

Langer, R. “Biomaterials, Status, Challenges, and Perspectives”, AIChE Journal; 46: 1286-1289, 2000.

Shastri, V., Martin, I., Langer, R. “Macroporous polymer foams by hydrocarbon templating”, Proc. Nat. Acad. Sci.; 97: 1970-1975, 2000.

Santini, J., Richards, A., Scheidt, R., Cima, M., Langer, R. “Microchips as controlled release devices”, Angewandte Chemie; 39: 2396-2407, 2000.

Santini, J., Richards, A., Scheidt, R., Cima, M., Langer, R. “Microchip technology in drug delivery”, Annals of Medicine; 32: 377-379, 2000.

Mitragotri, S., Coleman, M., Kost, J., Langer, R. “An analysis of ultrasonically extracted interstitial fluid as a predictor of blood glucose levels”, J. Appl. Physiol.; 89: 961-966, 2000.

Lu, L., Peter, S., Lyman, M., Lai, H., Leite, S., Tamada, J., Vacanti, J., Langer, R., Mikos, A. “In vitro degradation of porous poly(L-lactic acid) foams”, Biomaterials; 21: 1595-1605, 2000.

Lu, L., Peter, S., Lyman, M., Lai, H., Leite, S., Tamada, J., Uyama, S., Vacanti, J., Langer, R., Mikos, A. “In vitro and in vivo degradation of porous poly(DL-lactic-co-glycolic acid) foams”, Biomaterials; 21: 1837-1845, 2000.

Langer, R. “Biomaterials in drug delivery and tissue engineering: one laboratory’s experience”, Accounts of Chemical Research; 33: 94-101, 2000.

Langer, R. “New tissues for old”, Chemistry in Britain; 36: 32-34, 2000.

Mitragotri, S., Kost, J., Langer, R. “Enhancement of transdermal transport through a synergistic effect of ultrasound and other enhancers, in “, Handbook of Pharm. Cont. Rel. Tech.; Wise, D. ed., Marcel Dekker, 607-616, 2000.

Mitragotri, S., Langer, R., Kost, J. “Ultrasound for modulation of skin transport properties, in “, Biomaterials Engineering and Devices: Human Applications; Wise, D., ed., Trantolo, D., Altobeli, D., Yazemski, M., Wnek, G., and Gresser, J. Marcel Dekker, 843-854, 2000.

Mitragotri, S., Ray, D., Farrell, J., Tang, H., Yu, B., Kost, J., Blankschtein, D., Langer, R. “Synergistic effect of low-frequency ultrasound and Sodium Lauryl Sulfate on transdermal transport”, Journal of Pharmaceutical Sciences; 89, 892-900, 2000.

Mitragotri, S., Kost, J., Langer, R. “Non-invasive drug delivery and diagnostics using low-frequency sonophoresis”, Recent Advances and Research Updates in Medicine, 1, 43-48, 2000.

Mitragotri, S., Coleman, M., Kost, J., Langer, R. “Transdermal Extraction of Analytes Using Ultrasound”, Pharmaceutical Research; 17, 466-470, 2000.

Schaefer, D., Martin, I., Shastri, P., Padera, R., Langer, R., Freed, L., Vunjak-Novakovic” In vitro generation of osteochondral composites”, Biomaterials; 21: 2599-2606, 2000.

Lynn, D., Langer, R. “Degradable poly(b-amino esters): synthesis, characterization, and self-assembly with plasmid DNA”, J. Am. Chem. Soc.; 122: 10761-10768, 2000.

Chen, T., Langer, R., Weaver, J. “Transdermal Drug Delivery by Skin Electroporation, in”, Handbook of Pharm. Cont. Rel. Tech. Wise, D. ed., Marcel Dekker, 597-605, 2000.

Langer, R. “Tissue engineering: Status and challenges”, The Journal of Regen. Med.; 1: 5-6, 2000.

Mitragotri, S., Coleman, M., Kost, J., Langer, R. “Non-invasive blood analyte extraction using ultrasound”, Pharmaceutical Research; 17: 467-470, 2000.

Kohane, D., Lipp, M., Kinney, R., Lotan, N., Langer, R. “Sciatic Nerve Blockade with Lipid-Protein-Sugar Particles Containing Bupivacaine”, Pharmaceutical Research; 17: 1243-1249, 2000.

Patel, N., Bhandari, R., Shakesheff, K.M., Cannizzaro, S., Davies, M., Langer, R., Roberts, C., Tendler, S., Williams, P. “Printing Patterns for Biospecifically Adsorbed Proteins”, Journal of Biomaterials Science Polymer Edition; 11: 319-331, 2000.

1999

1999

Moses, M., Weiderschain, D., Wu, I., Fernandez, C., Ghazizadeh, V., Lane, W., Flynn, E., Sytkowski, A., Tao, T., Langer, R. “Troponin I is present in human cartilage and inhibits angiogenesis”, PNAS; 96: 2645-2650, 1999.

Stading, M., Langer, R. “Mechanical shear properties of cell-polymer cartilage constructs”, Tissue Engineering; 5: 3, 241-250, 1999.

Chen, T., Langer, R., Weaver, J. “Charged microbeads are not transported across the human stratum corneum in vitro by short high-voltage pulses”, Bioelectrochemistry and Bioenergetics; 48: 181-192, 1999.

Ben-Jebria, A., Chen, D., Eskew, M., Vanbever, R., Langer, R., Edwards, D. “Large porous particles for sustained protection from carbachol-induced bronchoconstriction in guinea pigs”, Pharmaceutical Research; 16: 555-561, 1999.

Ma, P., Langer, R. “Morphology and mechanical function of long-term in vitro engineered cartilage”, Journal of Biomedical Matericals Research; 44: 217-221, 1999.

Caponetti, G., Hrkach, J., Kriwet, B., Poh, M., Lotan, N., Colombo, P., Langer, R. “Microparticles of novel poly(lactic acid-co-amino acid) graft copolymers: preparation and characterization”, Journal of Pharmaceutical Science; 88:1, 136-141, 1999.

Ando, S., Putnam, D., Pack, D., Langer, R. “PLGA microspheres containing plasmid DNA: preservation of supercoiled-DNA via cryopreparation and carbohydrate stabilization”, Journal of Pharmaceutical Science; 88:1, 126-130, 1999.

Santini, J., Cima, M., Langer, R. “A Controlled-release Microchip”, Nature; 397: 335-338, 1999.

Ameer, G., Grovender, E., Obradovic, B., Cooney, C., Langer, R. “RTD Analysis of a novel taylor-couette flow device for blood detoxification”, AIChE Journal; 45: 3, 633-638, 1999.

Zewert, T., Pliquett, U., Vanbever, R., Langer, R., Weaver, J. “Creation of transdermal pathways fro macromolecule transport by skin electroporation and a low toxicity, pathway-enlarging molecule”, Bioelectrochem. Bioenerget; 49: 11-20, 1999.

Ameer, G.A., Harmon, W., Sasisekharan, R., Langer, R. “Investigation of a whole blood fluidized bed taylor-couette flow device for enzymatic heparin neutralization”, Biotechnology and Bioengineering; 62: 5, 602-608, 1999.

Kohane, D., Kuang, Y., Nu, T., Langer, R., Strichartz, G., Berde, C. “Vanilloid receptor agonists potentiate the in vivo local anesthetic activity of percutaneously injected site 1 soldium channel blockers”, Anesthesiology; 90: 2, 524-534, 1999.

Pack, D., Putnam, D., Langer, R. “Design of imidazole-containing endosomolytic biopolymers for gene delivery”, Biotechnology and Bioengineering; 67: 217-223, 1999.

Elisseff, K., Anseth, D., Sims, W., McIntosh, W., Randolph, M., Langer, R. “Transdermal photopolymerization for minimally invasive implantation”, PNAS; 96: 3104-3107, 1999.

Niklason, L., Gao, J., Abbot, W., Hirschi, K., Houser, S., Marini, R., Langer, R. “Functional arteries grown in vitro”, Science; 284: 489-493, 1999.

Anseth, K., Shastri, V., Langer, R. “Photopolymerizable degradable polyanhydrides with osteocompatibility”, Nature Biotechnology; 17: 156-159, 1999.

Vunjak-Novakovic, G., Martin, I., Obradovic, B., Treppo, S., Grodzinsky, A., Langer, R., Freed, L. “Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue engineered cartilage”, Journal of Orthopaedic Research; 17: 1, 130-138, 1999.

Sinisterra, R., Shastri, V., Najjar, R., Langer, R. “Encapsulation and release of rhodium (II) citrate and its association complex with hydroxypropyl-B-cyclodextrin from biodegradable polymer Microspheres”, Journal of Pharmaceutical Science; 88:5, 574-576, 1999.

Ameer, G., Barabino, G., Sasisekharan, R., Harmon, W., Cooney, C., Langer, R. “Ex vivo evaluation of a novel taylor-couette flow, immobilized heparinase I device for clinical application”, Proc. Nat. Acad. Sci.; 96: 2350-2355, 1999.

Fu, K., Griebenow, K., Hsieh, L., Klibanov, A., Langer, R. “FTIR characterization of the secondary structure of proteins encapsulated within PLGA mircrospheres”, Journal of Controlled Release; 58: 3, 357-366, 1999.

Zelikin, A., Shastri, V., Langer, R. “Facile synthesis of 3-alkylpyrroles”, Journal of Organic Chemistry; 64: 9, 3379-3380, 1999.

Langer, R., Vacanti, J. “Tissue engineering: the challenges ahead”, Scientific American; 280: 62-65, 1999.

Putnam, D., Langer, R. “Poly(4-hydroxy-L-proline ester): low-temperature polycondensation and plasmid DNA complexation”, Macromolecules; 32: 11, 3658-3662, 1999.

Shakesheff, K., Davies, M., Langer, R. “Surface characterization methods”, J. Biomat. Sci.; 9: 507-518, 1999.

Attawia, M., Herbert, K., Uhrich, K., Langer, R., Laurencin, C. “Proliferation, morphology, and protein expression by osteoblasts cultured on poly(anhydride-co-imides)”, Journal of Biomedical Materials Research; 48: 322-327, 1999.

Kost, J., Mitragotri, S., Langer, R. “Phonophoresis, in “, Percutaneous Absorption: Drugs-Cosmetics-Mechanisms-Method, edited by Robert L. Bronaugh, Howard I. Maibach, Vol. 97, 3rd Edition, p. 615-631, 1999.

Dillow, A., Dehghani, F., Hrkach, J., Foster, N., Langer, R. “Bacterial inactivation by using near- and supercritical carbon dioxide”, Proceedings of the National Academy of Sciences; 96: 10344-10348, 1999.

Elisseeff, J., Winnette, M., Anseth, K., Langer R. “Cogelation of hydrolyzable cross-linkers and poly(ethylene oxide) dimethacrylate and their use as controlled release vehicles, in”, Intelligent Mat. for Cont, Rel: ACS Symp. Ser. 728: 1-13, Dinh, S., DeNuzzio, J., Comfort, A., eds., 1999.

Vanbever, R., Ben-Jebria, A., Mintzes, J., Langer, R., Edwards, D. “Sustained release of insulin from insoluble inhaled particles”, Drug Delivery Research48: 178-185, 1999.

Vacanti, J., Langer, R. “Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation”, Lancet; 354: 32-34, 1999.

Carrier, R., Papadaki, M., Rupnick, M., Schoem, F.J., Bursac, N., Langer, R., Freed, L., Vunjak-Novakovic, G. “Cardiac tissue engineering: cell seeding, cultivation parameters, and tissue construct characterization”, Biotechnology & Bioengineering; 64: 580-589, 1999.

Vanbever, R., Mintzes, J., Wang, J., Nice, J., Chen, D., Batycky, R., Langer, R., Edwards, D. “Formulation and physical characterization of large porous particles for inhalation”, Pharmaceutical Research; 16: 1735-1742, 1999.

Weaver, J., Langer, R. “Electrochemical creation of large aqueous pathways: an approach to transdermal drug delivery”, Progress in Dermatology 33: 1-10, 1999.

Mitragotri, S., Johnson, M., Blankschtein, D., Langer, R. “A theoretical analysis of solute partitioning, diffusion, and permeation across lipid bilayers”, Biophysical Journal; 77: 1268-1283, 1999.

Langer, R. “Selected advances in drug delivery and tissue engineering”, Journal of Controlled Release; 62: 7-11, 1999.

Uhrich, K., Cannizzaro, S., Langer, R., Shakesheff, K. “Polymeric systems for controlled drug release”, Chemical Reviews; 99: 3181-3198, 1999.

Ameer, G., Raghavan, S., Sassisekharan, R., Cooney, C., Harmon, W., Langer, R. “Regional heparinization via Simultaneous separation and reaction in a novel taylor-couette flow device”, Biotechnology and Bioengineering; 63: 618-624, 1999.

Papadaki, M., Langer, R. “Cardiomyoplasty: Cellular tissue engineering approaches”, Basic and Appl. Myology; 9: 151-159, 1999.

Stading, M., Langer, R. “Rheological properties and microstructure of tissue engineered cartilage”, The Wiley Poly. Network. Group Rev. Series 32: 405-414, 1999.

Elisseeff, J., Anseth, K., Sims, D., McIntosh, W., Randolph, M., Yaremchuk, M., Langer, R. “Transdermal Photopolymerization of PEO-based injectable hydrogels for tissue engineered cartilage”, Plastic and Reconstructive Surgery; 104: 1014-1022, 1999.

Weaver, J., Pliquett, U., Zewart, T., Vanbever, R., Herndon, T., Gowrishankar, T., Chen, T., Prausnitz, M., Vaughan, T., Chizmadzhev, Y., Preat, V., Langer, R. “Recent advances in skin electroporation: mechanism and efficacy. In”, Elec. And Magnetism in Bio. And Med. F. Bersani, ed. New York: Plenum Press, 149-152, 1999.

Patel, N., Sanders, G.H.W., Shakesheff, K.M, Cannizzaro, S.M., Davies, M.C., Langer, R., Roberts, C.J., Tendler, S.J.B., Williams, P.M. “Atomic force microscopy analysis of highly defined proteins formed by microfluidic networks”, Langmuir; 15: 7252-7257, 1999.

Shakesheff, K.M, Davies, M.C., Langer, R. “The use of XPS in surfactant surface analysis”, Surfactant Science Series, 87: 143-172, 1999.

Black, R., Hartshorne, M., Davies, M., Roberts, C., Tendler, S., Williams, P., Shakesheff, K., Cannizzaro, S., Kim, I., Langer, R. “Surface engineering and surface analysis of a biodegradable polymer with biotinylated end-groups”, Langmuir; 15: 3157-3161, 1999.

Shum-Tim, D., Stock, U., Hrkach, J., Shinoka, T., Lien, J., Moses, M., Stamp, A., Taylor, G., Moran, A., Landis, W., Langer, R., Vacanti, J., Mayer, J.E. “Tissue engineering of autologous aorta using a new biodegradable polymer”, Annals of Thoracic Surgery; 68: 2298-304, 1999.

Mitragotri, S., Johnson, M., Blankschtein, D., Langer, R. “On the origin of size selectivity of biological membranes to non-electrolytes”, Biophysical Journal; 77, 1268-1283, 1999.

1998

1998

Gao, J., Niklason, L., Zhao, X., Langer, R. “Surface modification of polyanhydrides microsphere”, Journal of Pharmaceutical Science; 87: 2, 246-248, 1998.

Evora, C., Soriano, I., Rogers, R., Hanes, J., Shakesheff, K., Langer, R. “Relating the phagocytosis of microparticles by alveolar macrophages to surface chemistry: The effect of 1, 2-dipalmitoylphosphatidylcholine”, Journal of Controlled Release; 51: 143-152, 1998.

Langer, R. “Drug delivery and targeting”, Nature; 392 (Supp): 5-10, 1998.

Shinoka, T., Shum-Tim, D., Ma, P., Tanel, R., Isogai, N., Langer, R., Vacanti, J., Mayer, J.E. “Creation of viable pulmonary artery autografts through tissue engineering”, J. Thor. and Cardiovasc. Surg; 115:3, 536-546, 1998.

Vunjak-Novakovic G., Obradovic B., Bursac P., Martin, I., Langer R. Freed L. “Dynamic cell seeding of polymer scaffolds for cartilage tissue engineering”, Biotechnol. Prog.; 14: 193-202, 1998.

Freed, L., Hollander, A., Martin, I., Barry, J., Langer, R., Vunjak-Novakovic, G. “Chondrogenesis in a cell-polymer-bioreactor system”, Exper. Cell Res.; 240: 58-65, 1998.

Pollock, J., Kluth, D., Cusick, R., Lee, H., Utsunomiya, H., Ma, P., Langer, R., Broelsch, C., Vacanti, J. “Formation of spheroidal aggregates of hepatocytes on biodegradable polymers under countinuous-flow bioreactor conditions”, European Journal of Pediatr. Surg.; Vol. 8: 195-199, 1998.

Hanes, J., Chiba, M., Langer, R. “Degradation of porous poly(anydride-co-imide) microspheres and implications for controlled macromolecule delivery”, Biomaterials; 19: 163-172, 1998.

Cannizzaro, S., Padera, R., Langer, R., Rogers, R., Black, F., Davies, M., Tendler, S., Shakesheff, K. “A novel biotinylated degradable polymer for cell-interactive applications”, Biotechnology and Bioengineering; 58: 529-535, 1998.

Kohane, D., Yieh, J., Lu, N., Langer, R., Strichartz, G., Berde, C. “A re-examination of tetrodotoxin for prolonged duration local anesthesia”, Anesthesiology; 89: 119-131, 1998.

Schwendeman, S., Tobio, M., Joworowicz, M., Alonso, J., Langer, R. “New strategies for the microencapsulation of tetanus vaccine”, J. Microencapsulation; 15: 299-318, 1998.

Costantino, J., Schwendeman, S., Langer, R., Klibanov, A. “Deterioration of lyophilized pharmaceutical proteins”, Biochem.; 63: 357-363, 1998.

Ibim, S., Uhrich, K., Bronson, R., El-Amin, S.F., Langer, R., Laurencin, C. “Poly(anhydride-co-imides): in vivo biocompatibility in a rat model”, Biomaterials; 19: 944-951, 1998.

Hadlock, T., Elisseeff, J., Langer, R., Vacanti, J., Cheney, M. “A tissue-engineered conduit for facial nerve repair”, Arch. Otolaryngol Head Neck Surg; 124(10): 1081-1086, 1998.

Shakesheff, K., Cannizzaro, S., Langer, R. “Creating biomimetic micro-environments with synthetic polymer-peptide hybrid molecules”, Journal of Biomaterials Science-Polymer Edition; 9: 507-518, 1998.

Shastri, V., Padera, R., Tarcha, P., Langer, R. “Biocompatibility of Orthocure TM Photopolymerizable Anahydride Networks”, Journal of Biomedical Materials Research; 530: 93-98, 1998.

Marler, J., Upton, J., Langer, R., Vacanti, J. “Transplantation of cells in matrices for tissue regeneration”, Adv. Drug Del. Rev.; 33: 165-182, 1998.

Riesle, J., Hollander, A., Langer, R., Freed, L., Vunjak-Novakovic, G. “Collagen in tissue-engineered cartilage: types, structure, and crosslinks”, J. Cell. Biochem.; 71: 313-327, 1998.

Chen, H., Langer, R. “Oral particulate delivery: status and future trends”, Adv. Drug Del; 34, 339-350, 1998.

Gao, J., Niklason, L., Langer, R. “Surface hydrolysis of poly(glycolic acid) meshes increases the seeding density of vascular smooth muscle cells”, Journal of Biomedical Materials Research; 42: 417-424, 1998.

Ma, P., Langer, R. “Fabrication of bioegradable polymer foams for cell transplantation and tissue engineering”, Methods in Molecular Medicine 18: 47-56, J. Morgan and M.L. Yarmush (eds), Humana Press, Totowa, NJ, 1998.

Ibim S., Uhrich K., Attawia M, Shastri V., El-Amin S., Bronson R., Langer R., Laurencin CT”Preliminary in vivo report on the osteocompatibility of poly(anaydride-co-imides) evaluated in a tibial model”, Journal of Biomedical Materials Research; 43: 374-379, 1998.

Tobio, M., Gref, R., Sanchez, A., Langer, R., Alonso, M. “Stealth PLA-PEG nanoparticles as protein carriers for nasal administration”, Pharmaceutical Research; 15: 2, 270-275, 1998.

Chen, T., Langer, R., Weaver, J. “Skin electroporation causes molecular transport across the stratum corneum through localized transport regions”, Journal of Investigative Dermatology; 3: 159-165, 1998.

Patel, N., Padera, R., Sanders, G., Cannizzaro, S., Davies, M., Langer, R., Roberts, C., Tendler, S., Williams, P., Shakesheff, K. “Spatially controlled cell engineering on biodegradable polymer surfaces”, FASEB Journal; 12: 1447-1457, 1998.

Chen, T., Segall, E., Langer, R., Weaver, J. “Skin electroporation: rapid measurements of the transdermal voltage and the flux of four fluorescent molecules show a transition to large fluxes near 50v”, Journal of Pharmaceutical Science; 87: 1368-1374, 1998.

Uhrich, K., Ibim, S., Larrier, D., Langer, R., Laurencin, C. “Chemical changes during in vivo degradation of poly(anhydride-imide) matrices”, Biomaterials; 19, 2045-2050, 1998.

Riesle, J., Hollander, A., Langer, R., Freed, L., Vunjak-Novakovic, G. “Collagen in tissue-engineered cartilage: types, structure and crosslinks”, Journal of Cellular Biochemistry71, 313-327, 1998.

1997

1997

Costantino, H., Liauw, S., Mitragotri, S. Langer, R., Klibanov, A., Sluzky, V. “The pharmaceutical development of insulin: Historical perspectives and future directions ACS Symposium Series”, Therapeutic Protein and Peptide Form. and Del. Shahrokh, Z., Sluzky, V., Cleland, J.., Shire, S., Randolph, T., Eds., American Chemical Society, Washington, DC, 29-66, 1997.

Peter, S., Yaszemski, M., Suggs, L., Payne, R., Langer, R., Hayes, W., Unroe, M., Alemany, L., Engel, P., Mikos, A. “Characterization of partially saturated poly(propylene fumarate) for orthopaedic application”, J. Biomater. Sci.; 8: 893-904, 1997.

Langer, R. “Tissue engineering: A new field and its challenges”, Pharmaceutical Research; 14, 840-841, 1997.

Chaignaud B., Langer, R., Vacanti, J. “History of tissue engineering with synthetic scaffolds”, Synth. Biodegradable Poly. Scaffolds, 1-14, Atala, A., Langer, R., Mooney, D., Vacanti, J., eds., Boston: Birkhauser, 1997.

Kim, T., Lee, H., Utsunomiya, H., Ma, P., Langer, R., Schmidt, E., Vacanti, J. “Enhanced survival of transgenic hepocytes expressing hepatocyte growth factor in heptocyte tissue engineering”, Transplant Prot. 29, 858-860, 1997.

Chen, H., Langer, R. “Magnetically-responsive liposomes as potential oral delivery vehicles”, Pharmaceutical Research; 14, 537-50, 1997.

Costantino, H., Griebenow, K., Langer, R., A. Klibanov”On the pH memory of lyophilized compounds containing protein functional groups”, Biotechnology and Bioengineering; 53: 345-348, 1997.

Uhrich, K., Thomas, T., Laurencin, C., Langer, R. “In vitro degradation characteristics of poly(anhydride imides) containing trimellitylimidoglycine”, Journal of Applied Polymer Science; 63: 1401-1411, 1997.

Costantino, H., Shieh, L., Klibanov, A., Langer, R. “Heterogeneity of serum albumin samples with respect to solid-state aggregation via thiol-disulfide interchange-Implications for sustained release from polymers”, Journal of Controlled Release; 44: 255-261, 1997.

Shakesheff, K., Evora, C., Soriano, M., Langer, R. “The adsorption of poly(vinyl alcohol) to biodegradable microparticles studied by x-ray photoelectron spectroscopy (XPS)”, Journal of Colloid and Interface Science; 185: 538-547, 1997.

Ernst, S., Garro, O., Winkler, S., Venkataraman, G., Langer, R., Cooney, L., Sasisekharan, R. “Process simulation for recombinant protein production: Cost estimation and sensitivity analysis for heparinase I expressed in Escherichia coli”, Biotechnology and Bioengineering; 53: 575-582, 1997.

Cook, A., Hrkach, J., Gao, N., Johnson, I., Pajvani, U., Cannizzaro, S., Langer, R. “Characterization and development of RGD-peptide-modified poly(lactic acid-co-lysine) as an interactive, resorbable biomaterial”, Journal of Biomedical Materials Research; 35: 513-523, 1997.

Mader, K., Bacic, G., Domb, A., Elamalak, O, Langer, R., Swartz, H. “Noninvasive in vivo monitoring of drug release and polymer erosion from biodegradable polymers by EPR spectroscopy and NMR imaging”, Journal of Pharmaceutical Science; 86: 126-134, 1997.

Narasimhan, B., Langer, R. “Zero-order release of micro- and macromolecules from polymeric devices: The role of the burst effect”, Journal of Controlled Release; 47: 13-20, 1997.

Peracchia, M., Gref, R., Minamintake, Y., Domb, A, Lotan, N., Langer, R. “PEG-coated nanospheres form amphiphilic diblock and multiblock copolymers: Investigation of their drug encapsulation and release characteristics”, Journal of Controlled Release; 46: 223-231, 1997.

Elisseeff, J. Anseth, K, Langer, R., Hrkach, J. “Synthesis and characterization of photocrosslinked polymers based on poly(L-lactic acid-co-L-aspartic acid)”, Macromolecules; 30: 2182-2184, 1997.

Edwards, D., Hanes, J., Caponetti, G., Hrkach, J., Ben-Jebria, A, Eskew, M., Mintzes, J. Deaver, D., Lotan, N., Langer, R. “Large porous aerosols for pulmonary drug delivery”, Science; 276: 1868-1871, 1997.

Chiba, M., Hanes, J., Langer, R. “Controlled Protein Delivery from Biodegradable Tyrosine-Containing Poly(anhydride-co-imide) Microspheres”, Biomaterials; 18: 893-901, 1997.

Zund, G., Breuer, C., Shinoka, T., Ma, P., Langer, R., Mayer J., Vacanti, J. “A novel approach for construction of a bioprosthetic heart valve”, Eur. J. Cardio-thoracic Surg.; 11: 493-497, 1997.

Schmidt, C., Shastri, V., Vacanti, J., Langer, R. “Stimulation of neurite outgrowth using an electrically conducting polymer”, PNAS; 94: 8948-8953, 1997.

Chen, H., Langer, R., Edwards, D. “A film tension theory of phagocytosis”, J. Colloid and Interfac. Sci.; 190: 118-133, 1997.

Cook, A., Pajvani, U., Hrkach, J., Cannizzaro, S., Langer, R. “Colorimetric analysis of surface reactive amino groups on poly(lactic acid-co-lysine): poly(lactic acids) blends”, Biomaterials; 18: 1417-1424, 1997.

Gupta, R., Alroy, J., Alonso, M., Langer, R., Siber, G. “Chronic local tissue reactions, long term immunogenicity and immunologic priming of mice and guinea pigs to tetanus toxoid encapsulated in biodegradable polymer microspheres composed of poly lactide-co-glycolide polmers”, Vaccine; 15: 1716-1723, 1997.

Cusick, R., Lee, H., Sano, K., Pollok, J., Utsunomiya, H, Ma, P., Langer, R., Vacanti, J. “The effect of donor and recipient age on engraftment of tissue engineered liver”, J. Pediatr. Surg.; 32: 357-360, 1997.

Shinoka, T., Shum-Tim, S., Ma, P., Tanel, R., Langer, R., Vacanti, J., Mayer, J., Jr. “Tissue-engineered heart valve leaflets. Does cell origin affect outcome?”, Circulation; 96 (suppl II): II-102-II-107, 1997.

Freed, L., Langer, R., Martin, I., Pellis, N., Vunjak-Novakovic, G. “Tissue engineering of cartilage in space”, PNAS; 94: 13885-13890, 1997.

Hanes, J., Cleland, J., Langer, R. “New advances in microsphere-based single-dose vaccine”, Adv. Drug Del. Rev.; 28: 97-120, 1997.

Uhrich, K., Larrier, D., Laurencin, C., Langer, R. “In vitro degradation characteristics of poly(anhydride imides) containing pyromellitylimidoalanine”, J. Poly. Sci.; 34: 1261-1269, 1997.

Mooney, D., Langer, R. “Engineering biomaterials for tissue engineering to 10-100 micron scale”, Bio. Engin. Handbook; Bronzino, J., ed., CRC Press, Boca Raton, FL, pp. 1609-1618, 1997.

Batycky, R., Hanes, J., Langer, R., Edwards, D. “Theoretical model of erosion and macromolecular drug release from biodegrading microspheres”, Journal of Pharmaceutical Science; 86: 1464-1477, 1997.

Mooney, D., Sano, K., Kaufmann, P., Majahod, K., Schloo, B., Vacanti, J., Langer, R. “Long-term engraftment of hepatocytes transplanted on biodegradable polymer sponges”, Journal of Biomedical Materials Research; 37: 413-420, 1997.

Johnson, M., Blankschtein, D., Langer, R. “Evaluation of solute permeation through the stratum corneum: lateral bilayer diffusion as the primary transport mechanism”, Journal of Pharmaceutical Science; 86: 1162-1172, 1997.

Mitragotri, S., Blankschtein, D., Langer, R. “An explanation for the variation of the efficacy of sonophoresis from drug to drug”, Journal of Pharmaceutical Science; 86: 1190-1192, 1997.

Niklason, L., Langer, R. “Advances in tissue engineering of blood vessels and other tissues”, Transplant Immun.; 5: 303-306, 1997.

Constantino, R., Liauw, S., Mitragotri, S., Klibanov, A., Langer, R., Sluzky, V. “Pharm. developments of insulin, in” Therapeutic Protein and Peptide Form. and Del. ACS Symposium Series, Shahrokh, Z., Sluzky, V., Cleland, J., Shrine, S., Randolph, T., Eds., 29-66, 1997.

Shastri, V.R., Hildgen, P., Langer, R. Najajrah, Y., Ringel, I., Domb, A. “Other polyesters, in”, Handbook of Biodegrad. Poly. A. Domb, J. Kost, D. Wiseman, eds. Harwood Academic Publishers, 119-134, 1997.

Domb, A., Elmalak, O., Shastri, V., Ta-Shma, Z., Masters, D., Ringel, I., Teomim, D., and Langer, R. “Polyanhydrides, in”, Handbook of Biodegradable Poly. A. Domb, J. Kost, D. Wiseman, eds., Harwood Academic Publishers, 135-159, 1997.

Mitragotri, S., Blankschtein, D., Langer, R. “An Explanation for the Variation of the Sonophoretic Transdermal Transport Enhancement from Drug to Drug”, Journal of Pharmaceutical Science; 86: 10, 1190-92, 1997.

Shastri, V., Tarcha, P., Padera, R., Langer, R. “Biocompatibility of photo-cured polyanhydrides for othopedic and dental applications”, Proceeding of Surfaces in Biomaterials 52-56, 1997.

Dillow, A., Dehghani, F., Foster, N., Hrkach, J., Langer, R. “Production of polymeric support materials using a supercritical fluid gas anti-solvent process”, ISSF Proceedings A: 247-250, 1997.

1996

1996

Mitragotri, S., Blankschtein, D., Langer, R. “Transdermal drug delivery using low-frequency sonophoresis”, Pharm. Res.; 13: 411-420, 1996.

Breuer, C., Shinoka, T., Tanel, R., Zund, G., Mooney, D., Ma, P., Miura, T., Colan, S., Langer, R., Mayer, J., Vacanti, J. “Tissue engineering lamb heart valve leaflets”, Biotech and Bioeng.; 50: 562-567, 1996.

Vunjak-Novakovic, G., Freed, L., Biron, R., Langer, R. “Effects of mixing on tissue engineered cartilage”, Am. Inst. of Ch. Eng. J.; 42: 850-860, 1996.

Hrkach, J., Peracchia, M., Domb, A., Lotan, N., Langer, R. “Nanotechnology for biomaterials engineering: structural characterization of amphiphilic polymeric nanoparticles by 1H NMR spectroscopy”, Biomaterials; 18: 27-30, 1996.

Uhrich, K.; Thomas, T.; Gupta, A.; Laurencin, C. Langer, R. “In vitro degradation of poly(anhydride-imides) containing trimellitylimidoglycine”, J. Appl. Polym. Sci.; 34: 1261-69, 1996.

Attawia, M.; Uhrich, K.; Botchwey, E.; Langer, R., Laurencin, C. “In vitro bone biocompatibility of poly(anhydride-co-imides) containing pyromellitylimidoalanine”, J. Ortho. Res.; 14: 445-454, 1996.

Curley, J., Castillo, J., Hotz, J., Uezono, M., Hernandez, S., Lim, J., Tigner, J., Chasin, M., Langer, R., Berde, C. “Prolonged regional nerve blockade: injectable biodegradable bapivacaine-polyester microspheres”, Anesthesiology; 84: 1401-1410, 1996.

Shastri, V., Schmidt, C, Kim, T., Vacanti, J., Langer, R. “Polypyrrole: a potential Candidate for Stimulated Nerve Regeneration”, Matierials Research Society ProceedingsVol. 414, 113-118, 1996.

Vunjak-Novakovic, G., Freed, L., Langer, R. “Culture de chondrocytes sur des polymeres biodegradables”, Synoviale J. de Rhum. 12: 4-5, 1996.

Edwards, D., Gooch, K., Zhang, I., McKinley, G., Langer, R. “The nucleation of receptor-mediated endocytosis”, PNAS; 93: 1786-1791, 1996.

Sanchez, A., Gupta, R., Alonso, M., Siber, G., Langer, R. “A pulsed controlled release system for potential use in vaccine delivery”, J. Pharm. Sci.; 85: 547-552, 1996.

Langer, R. “Controlled release of a therapeutic protein”, Nat. Med.; 2: 742-743, 1996.

Mooney, D, Kaufman, P., . Sano, K., Schwendeman, S., McNamara, K., Schloo, B., Vacanti, J., Langer, R. “Localized delivery of epidermal growth factor improves the survival of transplanted hepatocytes”, Biotech. and Bioeng.; 50: 422-429, 1996.

Sano, K., Cusick, R., Lee, H., Pollok, J., Kaufmann, P., Uyama, S., Mooney, D., Langer, R., Vacanti, J. “Regenerative signals for hetertopic hepatocyte transplantation”, Trans. Proc. 28: 1857-1858, 1996.

Ibarra, C., Langer, R., Vacanti, J. “Tissue engineering: cartilage, bone, and muscle”, 235-245, Lanza R., Chick W., eds. The Netherlands: Kluwer Academic Publishers, 1996.

Brem, H., Langer, R. “Polymer-Based Drug Delivery to the Brain”, Sci. and Med. 3: 52-61, 1996.

Johnson, M., Mitragotri, S., Patel, A., Blankschtein, D., Langer, R. “Synergistic Effects of Chemical Enhancers and Therapeutic Ultrasound on Transdermal Drug Delivery”, J. Pharm. Sci.; 85: 7, 670-679, 1996.

Mooney, D., Mazzoni, C., Breuer, C., McNamara, K., Hern, D., Vacanti, J., Langer, R. “Stabilized polyglycolic acid fiber-based devices for tissue engineering”, Biomaterials; 17: 115-124, 1996.

Kost, J., Pliquett, U., Mitragotri, S., Yamamoto, A., Langer, R., Weaver, J. “Synergistic Effect of Electric Field and Ultrasound on Transdermal Transport”, Pharm. Res.; 13: 4, 633-638, 1996.

Edwards, D., Schneck, F., Zhang, I., Davis, A., Chen. H., Langer, R. “Spontaneous vesicle formation at lipid bilayer membranes”, Biophys. J.; 71: 1208-1214, 1996.

Schwendeman, S., Cardamone, M., Brandon, M., Klibanov, A., Langer, R. “Stability of proteins and their delivery from biodegradable polymer microspheres”, Microspheres/ Microparticulates Charact. and Pharm. App. 1-49, H. Bernstein, S. Cohen, eds. Marcel Dekker, Inc., N.Y , 1996.

Sasisekharan, R., Venkataraman, G., Godavarti, R., Ernst, S., Cooney, C., Langer, R. “Heparinase I from Flavobacterium heparinum: The mapping and characterization of the heparin binding domain”, J. Bio. Chem.271: 3124-31, 1996.

Schwendeman, S., Costantino, H., Gupta, R., Tobio, M., Chang, A., Alonso, M., Siber, G., Langer, R. “Strategies for stabilizing tetanus toxoid toward the development of a single-dose tetanus vaccine”, Dev. in Bio. Standardization 87: 293-306, 1996.

Li, W., Perzl, M., Heyder, J., Langer, R., Brain, J., Englemeir, K.H., Niven, R., Edwards, D. “Aerodynamics and Aerosol Particle Deaggreation Phenomena in Model Oral-Pharyngeal Cavities”, J. Aerosol Sci. 27, 1269-1286, 1996.

Langer, R. “Polymeric drug delivery systems”, Idea to Product: The ProcessElsevier Publishers, N. Alexander, Wentz, A. eds., 53-67, 1996.

Venkataraman, G., Sasisekharan, V., Herr, A., Ornitz, D., Waksman, G., Cooney, C., Langer, R. Sasisekharan, R. “Preferential self-association of fibroblast growth factor is stabilized by heparin during receptor dimerization and activation”, PNAS; 93: 845-50, 1996.

Ernst, S., Venkataraman, G., Winkler, S., Godavarti, R., Langer, R., Cooney, C., Sasisekharan, R. “Expression in Escherichia coli, purification, and characterization of heparinase I from flavobacterium heparinum”, Biochem. J.; 315: 589-97, 1996.

Johnson, M., Berk, D., Blankschtein, D., Golan, D., Jain, R., Langer, R. “Lateral diffusion of small compounds in human stratum corneum and model lipid bilayer systems”, Biophvs. J.; 71: 2656-2668, 1996.

Chen, H. and Langer, R. “Polymerized liposomes as oral vaccine carriers: Stability and bioavailability”, J. Cont. Rel.; 42: 263-272, 1996.

Yaszemski, M., Payne, R, . Hayes, W., Langer, R., Mikos, A. “Evolution of bone transplantation: molecular, cellular and tissue strategies to engineer human bone”, Biomaterials; 17: 2, 175-185, 1996.

Mooney, D., Kim, B-S, Vacanti, J., Langer, R. “Tissue engineering: Urogenital systems”, Textbook of Tissue Engineering, 587-596, Lanza, R., Chick, W., R. Langer, eds. Textbook of Tiss. Eng., Springer-Verlag, Berlin, Germany, 1996.

Pliquett, U., Zewert, T., Chen. T., Langer, R., Weaver, J. “Imaging of fluorescent molecule and small ion transport through human stratum corneum during high-voltage pulsing: Localized transport regions are involved”, J. Biophvs. Chem 58: 185-204, 1996.

Prausnitz, M., Gimm, J., Weaver, J., Guy, R., Langer, R., Cullander, C. “Imaging regions of transport across human stratum corneum during high-voltage and low-voltage exposures”, J. Pharm. Sci.; 85: 1363-1370, 1996.

Edelman, E., Brown, L., Langer, R. “Quantification of insulin release from implantable polymer-based delivery systems and augmentation of therapeutic effect with simultaneous release of somatostatin”, J. Pharm. Sci.; 85: 1271 -75, 1996.

Brown, L., Edelman, E., Fischel-Ghodsian, F., Langer, R. “Characterization of glucose-mediated insulin release from implantable polymers”, J. Pharm. Sci.; 85: 1341-45, 1996.

Costantino, H., Schwendeman, S., Griebenow, K., Klibanov, A., Langer, R. “The Secondary Structure and Aggregation of Lyophilized Tetanus Toxoid”, J. Pharm. Sci.; 85: 1290-93, 1996.

Schwendeman, S., Costantino, H., Gupta, R., Langer, R. “Progress and challenges for peptide, protein and vaccine delivery from implantable polymeric systems”, Cont. Drug Del.: The Next Generation Park, K., ed., The American Chemical Society, Washington, 1996.

Kohn, J., Langer, R. “Bioresorbable and bioerodible materials”, Bio. Sci., An Introduction to Materials in Medicine Ratner, B., Hoffman, A., Schoen, F., Lemons, J., eds., 64-72, Academic Press, New York, NY, 1996.

Chen, H., Langer, R. “Lectin-bearing polymerized liposomes as potential oral vaccine carriers”, Pharm. Research; 13: 1378-1383, 1996.

Hanes, J., Langer, R. “Polymeric controlled release vaccine delivery systems”, Reproductive Immunology R. Bronson, N. Alexander, D. Anderson, D., Branch, Kutteh, W., eds., Blackwell Scientific Publications, Inc., Boston, 647-664, 1996.

Moses, M., Marikovsky, M. Harper, J., Vogt, P., Eriksson, E., Klagsbrun, M., Langer, R. “Temporal study of the activity of matrix metalloproteinases and their endogenous inhibitors during wound healing”, J. Cell. Biochem.; 60: 379-386, 1996.

Prausnitz, M., Lee, C., Liu, C., Pang, J., Singh, T., Weaver, J., Langer, R. “Transdermal transport efficiency during skin electroporation and iontophoresis”, J. Contr. Rel.; 38: 205-217, 1996.

Mooney, D., Baldwin, D., Suh, N., Vacanti, H., Langer, R. “A novel approach to fabricate porous sponges of poly(D, L-lactic-co-glycolic acid) without the use of organic solvents”, Biomaterials; 17: 1417-1422, 1996.

Hrkach, J., Ou, J., Lotan, N., Langer, R. “Poly(L-lactic acid-co-amino acid) Graft Copolymers: a class of functional, biodegradable biomaterials”, Hydrogels and Biodegrad. Poly. for Bioapp. 8: 93-102, Ottenbrite, R., Huang, S., Park, K., eds. ACS Symposium Series 627; ACS: Washington, DC , 1996.

Shinoka, T., Ma, P., Shum-Tim, D., Breuer, C., Cusick, R., Zund, G., Langer, R., Vacanti, J., Mayer, J. “Tissue-engineered heart valves: autologous valve leaflet replacement study in a lamb model”, Sup. II Circulation 94: 164-168, 1996.

Kline, D.F., Hanes, J., Langer, R. “Adjuvant-active polymeric microparticles vaccine-delivery systems”, Microparticulate Systems for the Delivery of Protiens and Vaccines Cohen, S., and Bernstein, H., eds., Marcel Dekker, Inc. , New York, 349-380, 1996.

Hanes, J., Chiba, M., Langer, R. “Synthesis and characterization of degradable (anhydride-co-imide) terpolymers containing trimellitylimido-L tyrosine: novel polymers for drug delivery”, Macromolecules; 29: 5279-5287, 1996.

Cohen, S., Bano, M. Cima, L., Allcock, H., Vacanti, J., Vacanti, C., Langer, R. “Design of synthetic polymeric structures for cell transplantation and tissue engineering”, Clinic. Mat.13: 3-10, 1996.

488. Castillo J., Curley, J., Hotz, J., Uezono M., Tigner, J., Chasin, M., Langer, R., Berde C. “Glucocorticoids prolong rat sciatic nerve blockade in vivo from bupivacaine microspheres”, Anesthesiology; 85: 1157-1166, 1996.

Godavarti, R., Cooney, C., Langer, R., Sasisekharan, R. “Heparinase I from Flavohacterium heparinum, Identification of a critical histidine residue essential for catalysis as probed by chemical modification and site directed mutagenesis”, Biochemistry; 35: 6846-6852, 1996.

Kost, J., Pliquet, U., Mitragotri, S., Yamamoto, A., Langer, R., Weaver, J. “Synergistic Effect of Ultrasound and Electroporation on Transdermal Drug Delivery”, Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 23, 1996.

Mitragotri, S., Blankschtein, D., Langer, R. “Transdermal Drug Delivery Using Low-Frequency Sonophoresis”, Pharmaceutical Research; 13: 3, 411-420, 1996.

Mitragotri, S., Blankschtein, D., Langer, R. “Sonophoresis: Enhanced Transdermal Drug Delivery by Application of Ultrasound”, Encl. Of Pharm. Tech. Swarbrick, J., Boylan, J., Eds., 14: 103-122, 1996.

Anseth, K., Shastri, V., Laurencin, C., Langer, R. “Photo-polymerization of novel degradable networks for orthopaedic applications”, ACS Polymer Materials Society Science Proceedings 74: 385-386, 1996.

Godavarti, R., Davis, M., Venkataraman, G., Conney, C., Langer, R., Sasisekharan, R. “Cloning and recombinant expression of Heparinases I, II, and III from flavobacterium heparinum”, Biochemistry and Biophysical Research Community 225: 751-758, 1996.

Schwendeman, S., Costantino, H., Gupta, R., Klibanov, A., Langer, R. “Peptide, protein and vaccine delivery from implantable polymer systems”, Controlled Drug Del.: Challenges and Strategies 229-267. K Park, ed., American Chemical Society, Washington, DC, 1996.

1995

1995

Shefer, S., Breslau, J., Langer, R. “Computer Simulation of LDL removal in the Presence of a Bioreactor Containing Phospholipase A2”, Biotech. Prog.; 11: 133-139, 1995.

Hubbell, J., Langer, R. “Tissue engineering”, Chem. & Eng. News; 42-54, 1995.

Yaszemski, M., Payne, R., Hayes, W., Langer, R. Aufdemorte, T., Mikos, A. “The ingrowth of new bone tissue and initial mechanical properties of a degrading polymeric composite scaffold”, Tiss. Eng.; 1: 41-45, 1995.

Mitragotri, S., Edwards, D., Blankschtein, D., Langer, R. “A Mechanistic Study of Ultrasonically Enhanced Transdermal Drug Delivery”, J. Pharm. Sci.; 84: 697-706, 1995.

Goepferich, A., Langer, R. “Modeling monomer release from bioerodible polymers”, J. Cont. Rel.; 33: 5569, 1995.

Uhrich, K., Gupta, A., Thomas, T., Laurencin, C., Langer, R. “Synthesis and characterization of degradable poly(anhydride-co-imides)”, Macromolecules; 28: 2184-2193, 1995.

Mooney, D., Sano, K., Kaufmann, P., McNamara, K., Vacanti, J., Langer R. “Intergating Cell Transplantation and Controlled Drug Deliverly Technologies to Engineer Liver Tissue”, Materials Research Society Proceedings; Vol. 394: 83-89, 1995.

Cao, Y., Vacanti, J., Ma, P., Paige, K., Upton, J., Langer, R., Vacanti, C. “Tissue Engineering of Tendon”, Materials and Research Society Proceedings; Vol. 394: 91-97, 1995.

Edwards, D., Prauznitz, M., Langer, R., Weaver, J. “Analysis of enhanced transdermal transport by skin electroporation”, J. Cont. Rel.; 34: 211-221, 1995.

Venkataraman, G., Sasisekharan, V., Cooney, C., Langer, R., Sasiskharan, R. “Complex Flexibility of TGF-13 Super Family”, PNAS; 92: 5406-5410, 1995.

Mylonas, C., Tabata, Y., Langer, R., Zohar, Y. “Preparation and evaluation of polyanhydride microspheres containing gonadotropin-releasing hormone (GnRH), for inducing ovulation and spermiation in fish”, J. Cont. Rel.; 35: 23-34, 1995.

Cohen, S., Langer, R. “Long-term protein delivery from microencapsulated liposome systems”, Liposomes, New Sys. and New Trends in Their Appl.; R. Puisieux, P. Couvreur, J. Delattre, J-P. Devissaguet, eds., Editions de Sante, Paris, France, 275-291, 1995.

Thomson, R., Ishaug, S., Mikos, A., Langer, R. “Polymer for Biological Systems”, The Encyclopedia of Molec. Biol. and Biotech; R. Meyer, ed. VCH Publishers, New York, NY, 717-724, 1995.

Ishaug, S.L., Thomson, R.C., Mikos, A., Langer, R. “Biomaterials for Organ Regeneration”, The Encyc. of Molec. Biol. and Biotech; R.A. Meyer, ed. VCH Publishers, NY, NY, pp. 86-93, 1995.

Hanes, J., Chiba, M., Langer, R. “Polymer Microspheres for Vaccine Delivery”; M. Powell, M. Newman, eds. 16: 389-412, Plenum, New York, 1995.

Cao, Y., Vacanti, J., Ma, X., Paige, K., Upton, J., Chowanski, Z., Schloo, B., Langer, R., Vacanti, C. “Generation of neo-tendon using synthetic polymers seeded with tenocytes”, Transplant. Proc.; 26: 3390-3391, 1955.

Sakata, J., Vacanti, C., Schloo, B., Healy, G., Langer, R., Vacanti, J. “Tracheal composites tissue engineered from chondrocytes, tracheal epithelial cells, and synthetic degradable scaffolding”, Transplant. Proc.; 26: 3309-3310, 1995.

Langer, R. “Biomaterials: New Polymers and Novel Applications”, MRS Bulletin; 20: 18-22, 1995.

Zewert, T., Pliquett, U., Langer, R., Weaver, J. “Transdermal Transport of DNA Antisense Oligonucleotides by Electroporation”, Biochem. and Biophys. Res. Comm.; 212: 286-292, 1995.

Hrkach, J., Ou, J., Lotan, N., Langer, R. “Synthesis of Poly(L-lactic acid-co -L-Lysine) Graft Copolymers”, Macromolecules; 28: 4736-4739, 1995.

Mitragotri, S., Blankschtein, D., Langer, R. “Ultrasound-mediated transdermal protein delivery”, Science; 269: 850-853, 1995.

Langer, R., Vacanti, J. “Artificial Organs”, Sci. Amer.; 273: 130-133, 1995.

Johnson, M., Blankschtein, D., Langer R. “Permeation of steroids through human skin”, J. Pharm. Sci.; 84: 1144-1146, 1995.

Langer, R., Vunjak, G., Freed, L., Atala, A., Vacanti, C., Vacanti, J. “Tissue Engineering: Biomedical Applications”, Tissue Engin.; 1: 151-162, 1995.

Mooney, D., Breuer, C., McNamara, K, Vacanti, J., Langer R. “Fabricating tubular devices from polymers of lactic and glycolic acid for tissue engineering”, Tissue Engin.; 1: 107-118, 1995.

Cohen, S., Langer, R. “Novel liposome-based formulations for prolonged delivery of proteins and vaccines”, J. Liposome Res.; 5: 813-828, 1995.

Payne, L., Jenkins, S., Andrianov, A., Langer, R., Roberts, B. “Xenobiotic Polymers as Vaccine Vehicles”, Adv. in Exper. Med. and Biol.; 1475-1480, 1995.

Okada, J., Cohen, S., Langer, R. “In vitro evaluation of polymerized liposomes as an oral drug delivery system”, Pharm. Res.; 1/7/2002 12:04, 1995.

Laurencin, C., Sobrasua, E., Ibim, M., Langer, R. “Biomedical Applications of Synthetic Biodegradable Polymers”, CRC Press; J.Hollinger, ed., New York, pp. 59-102, 1995.

Shefer, S., Rosenberger, V., Vahanian, G., Wong, W., Langer, R. “Implantable hollow fiber bioreactor as a potential treatment for hypercholesterolemia: characterization of the catalytic unit”, Biotech & Bioeng; 48: 36-41, 1995.

Goepferich, A., Langer, R. “Modeling of Polymer Erosion in Three Dimensions”, AIChE J.; 41: 289-299, 1995.

Prausnitz, M., Corbett, J., Gimm, J., Golan, D., Langer, R., Weaver, J. “Millisecond measurement of transport during and after an electroporation pulse”, Biophys. J.; 68: 1864-1870, 1995.

Wake, M., Mikos, A., Sarakinos, G., Vacanti, J., Langer, R. “Dynamics of fibrovascular tissue ingrowth in hydrogel foams”, Cell Transpl.; 4: 275-2791995, 1995.

Langer, R. “1994 Whitaker Lecture: Polymers for drug delivery and tissue engineering”, Annals of Biomed. Eng.; 23: 101-111, 1995.

Ma, P., Schoo, B, Mooney, D., Langer, R. “The development of biomechanical properties and morphogenesis of in vitro tissue engineered cartilage”, J. Biomed. Mat. Res.; 29: 1587-1595, 1995.

Schwendeman, S., Costantino, H., Gupta, R., Siber, G., Klibanov, A., Langer, R. “Stabilization of tetanus and diptheria toxoids against moisture-induced aggregation”, PNAS; 92: 11234- 11238, 1995.

Prausnitz, M., Edelman, E., Gimm, J., Langer, R., Weaver, J. “Transdermal delivery of heparin by skin electroporation”, Bio/Tech.; 13: 1205-1209, 1995.

Ma, P., Langer, R. “Degradation, structure and properties of fibrous nonwoven poly(glycolic acid) scaffolds for tissue engineering”, Poly. in Med. Pham.; Mikos, A., Leong, K., Radomsky, M., Tamada, J., Yaszemski, M., eds., 394: 99-104, 1995.

Shinoka, T., Breuer, C., Tanel, R., Zund, G., Miura, T., Ma, P., Langer, R., Vacanti, J., Mayer, J. “Tissue engineering heart valves: valve leaflet replacement study in a lamb model”, Annals of Thoracic Surg.; 60: S513-516, 1995.

Costantino, H., Langer, R., Klibanov, A. “Aggregation of a lyophilized pharm. protein, recombinant human albumin: effects of moisture and stabilization by excipients”, Bio/Techn.; 13: 493-496, 1995.

Weaver, J., Langer, R., Potts, R. ” Tissue electroporation for localized drug delivery”, Enviro. Elec. and Magnet. Fields; Blank, M., ed. American Chemical Society, 301-316, 1995.

Sasisekharan, R., Leckband, D., Godavarti, R., Venkataraman, G., Cooney, C., Langer, R. “Heparinase I from flavobacterium heparinum: The role of cysteine residue in catalysis as probed by chemical modification and site-directed mutagenesis”, Biochemistry; 34: 14441-14448, 1995.

Langer, R. “Biomaterials and biomedical engineering”, Chem. Eng. Sci.; 50: 4109-4121, 1995.

Pliquett, W., Langer, R., Weaver, J. “Changes in the passive electrical properties of human stratum corneum due to electroporation”, Biochim. Biophys. Acta; 1239: 111-121, 1995.

Cusick, R., Sano, K., Lee, H., Pollok, J., Mooney, D., Langer, R., Vacanti, J. “Heterotopic fetal rat hepatocyte transplantation on biodegradable polymers”, Am. Coll. of Surgeons Surg. Forum; 46: 658-661, 1995.

Prausnitz, M., Bose, V., Langer, R., Weaver, J. “Electroporation”, Percutaneous Penetration Enhancers; H. Maibach, E. Smith, eds., CRC Press, Boca Raton, FL, 393-405, 1995.

Costantino, H., Griebenow, K., Mishra, P., Langer, R., Klibanov, A. “Fourier-transform infrared (FTIR) spectroscopic investigation of protein stability in the lyophilized form”, Biochim. Biophys. Acta; 1253:69-74, 1995.

Ernst, S., Langer, R., Cooney, C., Sasisekharan, R. “Enzymatic degradation of glycosaminoglycans”, CRC Critical Rev. Biochem. Mol. Biol.; 30: 387-444, 1995.

Mooney, D., Langer, R., Ingber, D. “Cytoskeletal filament assembly and the control of cell shape and function by extracellular matrix”, J. Cell Sci.; 108: 2311-2320, 1995.

Barrera, D., Zylstra, E., Lansbury, P., Langer, R. “Copolymerization and degradation of poly(lactic Langer, R., Polymers for Drug Delivery and Tissue Engineering”, Macromolecules; 28: 425-432, 1995.

Hrkach, J., Ou, J., Lotan, N., Langer, R. “Poly(L-Lactic acid-co-aspartic acid): Interactive Polymers for Tissue Engineering”, Mat. Res. Soc. Symp. Proc.; 394: 77-82, 1995.

Goepferich, A., Karydas, D., Langer, R. “Predicting drug release from cylindric polyanhydride matrix discs”, European J. of Pharm. and Biopharm.; 41(2): 81-87, 1995.

Mitragotri, S., Edwards, D., Blankschtein, D., Langer, R. “Quantitative Prediction of Ultrasonically Enhanced Transdermal Drug Delivery”, Proceed. Intern. Symp. Control. Rel. Bioact. Mater.; 22, 1995.

Attawia, M., Uhrich, K., Botchwey, B., Fan, M., Laurencin, C., Langer, R. “Cytotoxicity testing of poly(anhydride-co-imides) for orthopedic applications”, J. Biomed. Mat. Res.; 29, 1233-1240, 1995.

1994

1994

Cleland, J., Langer, R. “Formulation and delivery of proteins and peptides: Design and development strategies”, ACS Symps. Ser; 567: l-19, 1994.

Sasisekharan, R., Moses, M., Nugent, A., Cooney, C., Langer, R. “Heparinase inhibits neovascularization”, PNAS; 91: 1524-1528, 1994.

Wu, M., Tamada, J., Brem, H., Langer, R. “In vivo versus in vitro degradation of controlled release polymers for intracranial surgical therapy”, J. Biomed. Mat. Res.; 28: 387-395, 1994.

Gref, R., Minamitake, Y., Peracchia, M., Trubetshoy, V. Torchillin, V., Langer, R. “Biodegradable long- circulating polymeric nanospheres”, Science; 263: 1600-1603, 1994.

Wong, J., Langer, R., Ingber, D. “Novel applications for electrically conducting polymers: Control of cell shape on polypyrrole thin films”, Proc. Nat. Acad. Sci.; 91: 3201-3204, 1994.

Shieh, L., Tamada, J., Tabata, Y., Domb, A., Langer, R. “Drug Release from a New Family of Biodegradable Polyanhydrides”, J. Cont. Rel.; 29: 73-82, 1994.

Freed, L., Vunjak-Novakovic, G., Marquis, J., Langer, R. “Kinetics of Chondrocyte Growth in Cell- Polymer Implants”, Biotech. Bioengin.; 43: 597-604, 1994.

Alonso, M., Gupta, R., Min, C., Siber, G., Langer, R. “Biodegradable Microspheres as Controlled Release Tetanus Toxoid Delivery Systems”, Vaccine; 12: 299-306, 1994.

Freed, L., Marquis, J., Emmanual, J., Vunjak-Novakovic, G., Marquis, J., Langer, R. “Composition of Cell-Polymer Cartilage Implants”, Biotech. Bioeng.; 43: 605-614, 1994.

Mikos, A., Freed, L., Langer, R. “Wetting of poly(L-lactic acid) and poly(DL-lactic-co-glycolic acid) foams for tissue culture”, Biomaterials; 15: 55-58, 1994.

Peppas, N., Langer, R. “New Challenges in Biomaterials”, Science; 263, 1715-1720, 1994.

Cohen, S., Langer, R. “Pulsatile Liposomes”, J. Liposome Res.; 4: 349-360, 1994.

Mikos, A., Thorsen, A., Czerwonka, L., Bao, Y., Winslow, N., Vacanti, J., Langer, R. “Preparation and Characterization of Poly(L-Lactic Acid) Foams for Cell Transplantation”, Polymer; 35: 1068-1077, 1994.

Prausnitz, M., Milano, C., Gimm, J., Langer, R., Weaver, J. “Quantitative Study of Molecular Transport Due to Electroporation: Uptake of Bovine Serum Albumin by Erythrocyte Ghosts”, Biophys. J.; 66: 1522-1530, 1994.

Tabata, Y., Langer, R”Polyanhydride Granules Provide Near-Constant Release of Water-Soluble Drugs”, J. Pharm. Sci.; 83: 5-11, 1994.

Freed, L., Grande, D., Emmanual, J., Kwan, M., Marquis, J., Lingbin, Z., Dunkelman, N., Langer, R. “Joint Resurfacing Using Allograft Chondrocytes and Synthetic Biodegradable Polymer Scaffolds”, J. Biomed. Mat. Res.; 28: 891-899, 1994.

Freed, L., Vunjak-Novakovic, G., Biron, R., Eagles, D., Lesnoy, D., Barlow, S., Langer, R. “Biodegradable Polymer Scaffolds for Tissue Engineering”, Bio/Tech.; 12: 689-693, 1994.

Liu, L., Kost, J., Ferreira, J., Langer, R. “Enhanced Protein Blotting from PhastGel Media to Membranes by Irradiation of Low Intensity Ultrasound”, Anal. Biochem.; 216: 27-32, 1994.

Venkataraman, G., Sasisekharan, V., Cooney, C., Langer, R., Sasisekharan, R. “A Stereochemical approach to pyranose ring flexibility. Its implications on the conformation of dermatan sulfate”, PNAS; 91: 6171-6175, 1994.

Kost, J., Liu, L., Gabelnick, H., Langer, R. “Ultrasound as a Potential Trigger to Terminate the Activity of Contraceptive Delivery Implants”, J. Cont. Rel.; 30: 77-81, 1994.

Johnson, L., Aiken, J., Mooney, D., Schloo, B., Cima, L., Langer, R., Vacanti, J. “The Mesentery as a Laminated Vascular Bed for Hepatocyte Transplantation”, Cell Transpl.; 3: 273-281, 1994.

Goepferich, A., Gref, R., Minamitake, Y., Shieh, L., Alonso, M., Tabata, Y., Langer, R. “Drug Delivery from Bioerodible Polymers: Systemic and Intravenous Administration”, Formulation and Del. of Proteins and Peptides; ACS Press, Washington, D.C., ACS Symp. Series 567, J. Cleland, R. Langer, eds., 242-277, 1994.

Cohen, S. Langer, R. “Inter and Intracellular Targeting of Drugs”, Homing Mech. and Cell. Targeting; 217-231, 1994.

Mooney, D., Mazzoni, C., Organ, G., Puelacher, W., Vacanti, J., Langer, R. “Stabilizing fiber based cell delivery devices by physically bonding adjacent fibers”, Mat. Res. Soc. Proc.: Biomat. for Drug and Cell Del.; 331: 47-52, 1994.

Ferreira, J., Sasisekharan, R., Louie, O., Langer, R. “A study on the functional sub-units of phospholipase A2 by enzyme immobilization”, Biochem. J.; 303: 527-530, 1994.

Puelacher, W., Mooney, D., Langer, R., Vacanti, J., Vacanti, C. “Design of nasoseptal cartilage replacement synthesized from biodegradable polymers and chondrocytes”, Biomaterials; 15: 774-778, 1994.

Ferreira, J., Sasisekharan, R., Louie, O., Langer, R. “Carbodiimide Modification Enhances Activity of Pig Pancreatic Phospholipase A2”, Eur. J. of Biochem.; 223: 611-616, 1994.

Edwards, D., Langer, R. “A linear theory of transdermal transport phenomena”, J. Pharm. Sci.; 83: 1315-1334, 1994.

Sakata, J., Vacanti, C., Schloo, B., Healy, G., Langer, R., Vacanti, J. “Tracheal composite tissue engineered from chondrocytes, tracheal epithelial cells and synthetic degradable scaffolding”, Transplant Proc.; 26: 3309-3310, 1994.

Costantino, H., Langer, R., Klibanov, A. “Solid-Phase Aggregation of Proteins under Pharmly Relevant Conditions”, J. Pharm. Sci.; 83: 1662-1666, 1994.

Goepferich, A., Alonso, M., Langer, R. “Development and characterization of microencapsulated microspheres”, Pharm Res.; 11: 1568- 1574, 1994.

Cohen, S., Langer, R. “Novel Approaches to controlled release antigen delivery”, Internat. J. of Techn. Assessm. in Health Care; A. Robbins, P. Freeman, eds. Cambridge University Press, 10:1, 121-130, 1994.

Rosenthal, R., Moses, M., Shintani, Y., Megyesi, J., Langer, R., Folkman, J. “Purification and Characterization of a Mouse Sarcoma 180-Derived Collagenase Inhibitor which also Inhibits Endothelial Cell DNA Synthesis”, J. Cell Biochem.; 56: 97-105, 1994.

Park, T., Alonso, M., Langer, R. “Controlled release of proteins from poly (L-lactic acid) coated poly (isobutylcyanoacrylate) microcapsules”, J. Appl. Poly. Sci.; 52: 1797-1807, 1994.

Andrianov, A., Payne, L., Visscher, K., Allcock, H., Langer, R. “Hydrolytic degradation of tonically cross-linked polyphosphazene microspheres”, J. Appl. Poly. Sci.; 53: 1573-78, 1994.

Vacanti, C., Vacanti, J., Langer, R. “Tissue Engineering Using Synthetic Biodegradable Polymers”, Poly. of Bio. and Biomed. Signif.; ACS Symposium Series 540, Chicago, IL., 16-34, 1994.

Costantino, H., Langer, R., Klibanov, A. “Moisture-Induced Aggregation of Lyophilized Insulin”, Pharm. Res.; 11: 21-29, 1994.

Prausnitz, M., Pliquett, U., Langer, R., Weaver, J. “Rapid temporal control of transdermal drug delivery by electroporation”, Pharm. Res.; 11: 1834-1837, 1994.

Langer, R. “Polymer systems for controlled release of macromolecules, immobilized enzyme medical bioreactors, and tissue engineering”, Adv. in Chem. Eng.; 19: 1-50, 1994.

Mooney, D., Organ, G., Vacanti, J., Langer, R. “Design and fabrication of biodegradable polymer devices to engineer tubular tissues”, Cell Transplant.; 3: 203-210, 1994.

Brem, H., Walter, K., Tamargo, R. Olivi, A., Langer, R. “Drug Delivery to the brain”, Poly. Site Spec. Pharm.; 117-139, John Wiley & Sons, New York, 1994.

Takeda, T., Kim, T., Lee, S., Langer, R., Vacanti, J. “Hepatocyte transplantation in biodegradable polymer scaffolds using the Dalmation dog model of hyperuricosuria”, Transplant. Proc.; 27: 635-636, 1994.

Shieh, L., Tamada, J., Chen, I., Pang, J., Domb, A., Langer, R. “Erosion of a New Family of Biodegradable Polyanhydrides”, J. Biomed. Mat. Res.; 28: 1465-1475, 1994.

Mooney, D., Kaufmann, P., Sano, K., McNamara, K., Vacanti, J., Langer, R. “Transplantation of hepatocytes using porous biodegradable sponges”, Transplant. Proc.; 26: 3425-26, 1994.

Puelacher, W., Mooney, D., Langer, R., Vacanti, J., Vacanti, C. “Tissue engineered growth of cartilage: The effect of varying the concentration of chondrocytes seeded onto synthetic materials”, Int. J. Oral Maxillofacial Surg.; 23: 49-53, 1994.

Mooney, D., Hansen, L., Langer, R., Vacanti, J., Ingber, D. “Extracellular matrix controls tubulin monomer levels by regulating protein turnover”, Mol. Biol. Cell.; 5: 1281-1288, 1994.

Mooney, D., Park. S., Kaufmann, P., Sano, K., McNamara, K, . Vacanti, J., Langer, R. “Biodegradable sponges for hepatocyte transplantation”, J. Biomed. Mat. Res.; 29: 959-966, 1994.

Mooney, D., Kaufmann, P., Sano, K., McNamara, K., Vacanti, J., Langer, R. “Transplantation of Hepatocytes Using Porous, Biodegradable Sponges”, Transplant. Proc.; 26: 6, 3425-3426, 1994.

1993

1993

Freed, L., Vunjak-Novakovic, G., Bernstein, H., Cooney, C., Langer, R. “The Kinetics of Immobilized Heparinase in Human Blood”, Annals of Biomed. Eng.; 21: 67-76, 1993.

Mikos, A., Bao, Y., Ingber, D., Vacanti, J. Langer, R. “Preparation of poly(glycolic acid) bonded fiber structures for cell transplantation”, J. Biomed. Med. Res.; 27: 183-189, 1993.

Tamada, J., Langer, R. “Erosion Kinetics of Hydrolytically Degradable Polymers”, PNAS; 90: 552-556, 1993.

Gross, A., Langer, R., Mathiowitz, E., Mayberg, M. “Sustained Release of Acetylcholine in Rat Hippocampus Using a Polyanhydride Drug Delivery System”, Poly. for Adv. Tech.; 3: 331-335, 1993.

Freed, L., Marquis, J., Nohria, A., Mikos, A., Emmanual, J., Langer, R. “Neocartilage formation in vitro and in vivo using Cells Cultured on Synthetic Biodegradable Polymers”, J. Biomed. Mat. Res.; 27: 11-23, 1993.

Shefer, S., Ferreira, J., Mullon, C., Langer, R. “Extracorporeal Enzymatic Removal of Low density Lipoproteins in Rabitts: Efficacy and Safety”, The Inter. J. Artif. Organs; 16: 115-125, 1993.

Wald, H.L., Sarakinos, G., Mikos, A., Vacanti, J., Langer, R. “Cell seeding in porous transplantation devices”, Biomaterials; 14: 270-278, 1993.

Tabata, Y., Langer, R. “Polyanhydride Microspheres that Display Near-constant Release of Water soluble drugs”, Pharm. Res.; 10: 391-399, 1993.

Tabata, Y., Gutta, S., Langer, R. “Controlled Delivery Systems for Proteins Using polyanhydride Microspheres”, Pharm. Res.; 10: 487-496, 1993.

Brem, H., Walter, K., Langer, R. “Polymers as Controlled Drug Delivery Devices for the treatment of Malignant Brain Tumors”, Eur. J. Pharm. and Biopharm.; 39: 2-7, 1993.

Mikos, A., Sarakinos, G., Leite, S., Vacanti, J., Langer, R. “Laminated Three-dimensional Biodegradable Foams for Use in Tissue Engineering”, Biomaterials; 14: 323-330, 1993.

Sasisekharan, R., Bulmer, M., Moremen, K.W., Cooney, C., Langer, R. “Cloning and expression of heparinase I gene from flavobacterium heparinum”, PNAS; 90: 3660-3664, 1993.

Gilbert, J., Takeda, T., Stein, J., Langer, R., Vacanti, J. “Cell Transplantation of Genetically Altered Cells on Biodegradable Polymer Scaffolds in Syngeneic Rats”, Transplantation; Vol. 56, No. 2: 423-427, 1993.

Labeque, R., Mullon, C., Ferreira, J., Lees, R., Langer, R. “Enzymatic modification of plasma low density dipoproteins: a potential treatment for hypercholesterolemia”, PNAS; 90: 3476-3480, 1993.

Laurencin, C., Gerhart, T., Witschger, P., Satcher, R., Domb, A., Hanff, P., Edsberg, L., Hayes, W., Langer, R. “Bioerodible poly(anhydrides) for antibiotic drug delivery: in vivo osteomyelitis treatment in a rat model system”, J. Orthoped. Res.; 11: 256-262, 1993.

Ron, E., Turek, T., Mathiowitz, E., Chasin, M., Hageman, M., Langer, R. “Release of Polypeptides from Polyanhydrides”, PNAS; 90: 4176-4180, 1993.

Fontaine, M., Hansen L., Thompson, S., Uyama S., Ingber, D., Mulligan, R., Langer, R., Vacanti, J. “Transplantation of genetically altered hepatocytes using cell-polymer constructs leads to sustained human growth hormone secretion in vivo”, Transplant. Proc.; 25: 1002-1004, 1993.

Langer, R., Vacanti, J. “Tissue Engineering“, Science; 260: 920-926, 1993.
Abstract / Full-text (pdf)

Bhagat, H., Langer, R. “Implants and Implantation Technology”, Encyclopedia of Pharm. Tech.; 8: 53-82, 1993.

Gupta, R., Siber, G., Alonso, M., Langer, R. “Development of a Single-dose tetanus toxoid based on controlled release from biodegradable and biocompatible polyester microspheres”; 93: 391-396, 1993.

Cima, L., Langer, R. “Tissue Engineering”, Chem Eng. Progress; 6: 54-46, 1993.

Prausnitz, M., Lau, B., Milano, C., Conner, S., Langer, R., Weaver, J. “A quantitative study of electroporation showing a plateau in net molecular transport”, Biophys. J.; 65:414-422, 1993.

Edelman, E., Langer, R. “Optimization of release from magnetically controlled polymeric drug release devices”, Biomaterials; 14: 8, 621-626, 1993.

Prausnitz, M., Bose, V., Langer, R., Weaver, J. “Transtissue Molecular Transport Due to Electroporation of Skin”, Electricity and Magnetism in Bio. and Med.; M. Blank, ed. San Francisco Press, San Francisco, CA, 122-124, 1993.

Lau, B., Milano, C., Prausnitz, M., Langer, R., Weaver, J. “Quantitative Determination of Molecular Transport Across Erythrocyte Ghost Membranes by Electroporation”, Electricity and Magnetism in Bio. and Med.; M. Blank, ed. San Francisco Press, San Francisco, CA, 141-143, 1993.

Mikos, A., Sarakinos, G., Leite, S., Vacanti, J., Langer, R. “Preperation of Poly(glycolic acid) Bonded Fiber Structures for Cell Attachment and Transplantation”, J. Biomed. Mater. Res.; Vol. 27, No. 2: 183-189, 1993.

Mikos, A., Sarakinos, G., Leite, S., Vacanti, J., Langer, R. “Laminated Three Dimensional Biodegradable Foams for use in Tissue Engineering”, Biomaterials; Vol. 14, No. 5: 323-330, 1993.

Alonso, M., Cohen, S., Park, T., Gupta, R., Siber, G., Langer R. “Determinants of release rate of tetanus vaccine from polyester microspheres”, Pharm Res.; 10: 945-953, 1993.

Goepferich, A., Langer, R. “The influence of microstructure and monomer properties on the erosion mechanism of a class of polyanhydrides”, J. Poly. Sci.; 31: 2445-2458, 1993.

Goepferich, A., Langer, R. “Modeling of Polymer Erosion”, Macromolecules; 22: 4105-4112, 1993.

Mikos, A., Sarakinos, G., Lyman, M., Ingber D., Vacanti, J., Langer, R. “Prevascularization of biodegradable polymer scaffolds for hepatocyte transplantation”, Biotech. & Bioeng.; 42: 716-723, 1993.

Ferreira, J., Sasisikharan, R., Louie, O., Langer, R. “Influence of chemistry in immobilization of cobra venom phospholipase A2 – Implications as to mechanism”, Biochemistry; 32: 8098-8102, 1993.

Masters, D., Berde, C., Dutta, S., Turek, T., Langer, R. “Sustained local anesthetic release from bioerodible polymer matrices: A potential method for prolonged regional anesthesia”, Pharm. Res.; 10: 1527-1532, 1993.

Masters, D., Berde, C., Dutta, S., Griggs, C., Hu, D., Kupsky, W., Langer, R. “Prolonged Regional Nerve Blockage by Controlled Release of Local Anesthetic from a Biodegradable Polymer Matrix”, Anesthesiology; 79: 340-346, 1993.

Andrianov, A., Cohen, S., Visscher, K., Payne L., Allcock, H., Langer, R. “Controlled Release Using Ionotropic Polyposphazene Hydrogels”, J. Contr. Rel.; 27: 69-77, 1993.

Langer, R. “Polymer Controlled Drug Delivery Systems”, Accts. of Chem. Res.; 26: 537-542, 1993.

Shefer, S., Payne, R., Langer, R. “Design of a biomedical reactor for plasma Low Density Lipoprotein removal”, Biotech. and Bioeng.; 42: 1252-1262, 1993.

Barrera, D., Zylstra, E., Lansbury, P., Langer, R. “Synthesis and RGD Peptide Modification of a New Biodegradable Copolymer System: Poly(Lactic Acid-co-Lysine)”, J. of Amer. Chem. Soc.; 115: 11010-11011, 1993.

Prausnitz, M., Langer, Weaver, J. “Electroporation of mammalian skin: A new mechanism to enhance transdermal drug delivery”, PNAS; 90: 10504-10508, 1993.

Prausnitz, M., Seddick, D., Kon, A., Bose, V., Frankenburg, S., Klaus, S., Langer, R., Weaver, J. “Methods for in vivo tissue electroporation using surface electrodes”, Drug Del.; 1: 125-131, 1993.

Cohen, S., Bano, M., Cima, L., Allcock, H., Vacanti, J., Vacanti, C., Langer, R. “Design of synthetic polymeric structures for cell transplantation and tissue engineering”, Clinical Mat.; 0.881944444, 1993.

Gilbert, J., Takeda, T., Stein, J., Langer, R., Vacanti, J. “Cell transplantation of genetically altered cells on biodegradable polymer scaffolds in syngeneic rats”, Transplantation; 56: 423-427, 1993.

Kost, J., Langer, R. “Ultrasound-mediated transdermal drug delivery”, Topical Drug Bioavailiability Bioequivalence. Penetration, ; Plenium Press, NY, V. Shah, H. Maibach, eds., 91-104, 1993.

Freed, L., Vunjak-Novakovic, G., Langer, R. “Cultivation of cell-polymer cartilage implants in bioreactors”, J. Cell. Biochem.; 51: 257-64, 1993.

Freed, L., Vunjak-Novakovic, G., Drinker, P., Langer, R. “A Bioreactor based on Suspended Particles of Immobilized Enzyme”, Annals of Biomed. Eng.; 21: 57-65, 1993.

Sheppard, N., Langer, R. “The Use of Ultrasound Attenuation to Characterize Release of Proteins from Polymer Matrix Devices”, J. Cont. Rel.; 22: 245-242, 1992.

Cohen, S., Allcock, H., Langer, R. “Cell and Enzyme Ionotropic Synthetic Hydrogels”, Recent Adv. in Pharm. and Indust. Biotech.; 3648, 1992.

Wintermantel, E., Cima, L., Schloo, B., Langer, R. “Angiopolarity of cell carriers: directional angiogenesis in resorbable liver cell transplantation devices”, Angiogenesis: Key Principles- Science Technology, Medicine; 331-334, 1992.

1992

1992

Park, T., Cohen, S., Langer, R. “Poly(L-lactic acid)/Pluronic Blends: Characterization of Phase Separation Behavior, degradation, Morphology and as Protein Releasing Matrices”, Macromolecules; 25: 116-122, 1992.

During, M., Freese, A., Deutch, A., Kibat, P., Sabel, B., Langer, R., Roth, R. “Biochemical and Behavioral Recovery in a Rodent Model of Parkinson’s Disease following Stereotactic Implantation of dopamine-Containing Liposomes”, Exper. Neurology; 115: 193-199, 1992.

Mathiowitz, E., Bernstein, H., Giannos, S., Dor, P., Turek, T., Langer, R. “Polyanhydride Microspheres. IV. Morphology and characterization of systems made by spray drying”, J. Applied Polym. Sci.; 45: 125-134, 1992.

Alonso, M., Langer, R. “Biodegradable controlled release microspheres for macromolecules and proteins”, Profiles on Biotech.; T.G. Villa, J. Abalde, Eds, in Servicio de Publicacions, Universidad de Santiango, 555-564, 1992.

Cady, S., Langer, R. “Overview of protein formulations for animal health applications”, J. Agric. and Food Chem.; 40: 332-336, 1992.

Park, T., Cohen, S., Langer, R. “Controlled protein release from polyethyleneimine coated poly(lactic acid)/pluronic blend matrices”, Pharm. Res.; 9: 37-39, 1992.

Mooney, D., Hansen, L., Vacanti, J., Langer, R., Farmer, S., Ingber, D. “Different extracellular matrix molecules share a common mechanism for control of hepatocyte growth and differentiation”, J. Cell Physiol.; 3: 315-353, 1992.

Langer, R., Peppas N. “New drug delivery systems”, Bioeng. Sci. News; 16: 3-7, 1992.

Liu, L., Kost, J., D’Emanuele, A., Langer, R. “Experimental approach to elucidate the mechanism of ultrasound-enhanced polymer erosion and release of incorporated substances”, Macromolecules; 25: 123-128, 1992.

Kost, J., Langer, R. “Responsive polymer systems for controlled delivery of therapeutics”, Trends in Biotech.; 10: 127-131, 1992.

Mooney, D.J., Johnson, L., Cima, L., Hansen, L., Ingber, D., Langer, R., Vacanti, J. “Principles of tissue engineering and reconstruction using polymer-cell constructs”, Tissue-Inducing Biomat; 252: 345-352, 1992.

Mooney, D., Langer, R, Hansen, L., Vacanti, J., Ingher, D. “Induction of hepatocyte differentiation by the extracellular matrix and an RGD-containing synthetic peptide”, Tissue-Inducing Biomat.; 252: 199-204, 1992.

Tamada, J., Langer, R. “The development of polyanhydrides for drug delivery applications”, J. Biomat. Sci. Poly. Ed.; 3: 315-353, 1992.

Sheppard, N., Madrid, M., Langer, R. “Polymer matrix controlled release systems: influence of polymer carrier and temperature on water uptake and protein release”, J. Appl. Polym. Sci.; 46: 19-26, 1992.

Simons, M., Edelman, E., DeKeyser, J, Langer, R., Rosenberg, R. “Antisense c-myb oligonucleotides Inhibit arterial smooth muscle proliferation in vivo”, Nature; 359: 67-70, 1992.

Soltys, P., Mullon, C., Langer, R. “Oral treatment for jaundice using immobilized bilirubin oxidase”, Artificial Organs; 16: 331-335, 1992.

Moses, M., Sudhalter, J., Langer, R. “Isolation and characterization of an inhibitor of neovascularization for the conditioned media of scapular chondrocytes”, J. Cell Biol.; 119: 475-482, 1992.

Edelman, E., Fiorino, A., Grodzinsky, A., Langer, R. “Mechanical deformation of polymer matrix controlled release devices modulates drug release”, J. Biomed. Mat. Res.; 26: 1619, 1992.

Sluzky, V., Klibanov, A., Langer, R. “Mechanism of insulin Aggregation and Stabilization”, Agitated Aqueous Solutions, Biotech., and Bioeng.; 40: 895-903, 1992.

Shefer, S., Shefer, A., Kost, J., Langer, R. “Structural characterization of starch networks in the solid state by cross-polarization magic-angle-spinning 13C-NMR spectroscopy and wide angle x-ray diffraction”, Macromolecules; 25: 6756-6760, 1992.

Mooney, D., Hansen, L., Vacanti, J., Langer, R., Farmer, S., Ingber., D. “Switching from differentiation to growth in hepatocytes: Control by extracellular matrix”, J. Cell Physiol.151: 497-505, 1992.

Mathiowitz, E., Langer, R. “Polyanhydride Microspheres as Drug Delivery Systems”, Microcapsules in Med. and Pharm.; pp. 100-123, 1992.

D’Emanuele, A., Kost, J., Hill, J., Langer, R. “An Investigation of the Effects of Ultrasound on Degradable Polyanhydride Matrices”, Macromolecules; 25: 511-515, 1992.

Sheppard, N., Langer, R. “The Use of Ultrasound Attenuation to Characterize Release of Proteins from Polymer Matrix Devices”, J. Cont. Rel.; 22: 245-242, 1992.

Cohen, S., Allcock, H., Langer, R. “Cell and Enzyme Ionotropic Synthetic Hydrogels”, Recent Adv. in Pharm. and Indust. Biotech.; 3648, 1992.

Wintermantel, E., Cima, L., Schloo, B., Langer, R. “Angiopolarity of cell carriers: directional angiogenesis in resorbable liver cell transplantation devices”, Angiogenesis: Key Principles- Science Technology, Medicine; 331-334, 1992.

1991

1991

Langer, R. “Pharmacology”, 1991 McGraw-Hill Yearbook of Sci. and Tech.; pp. 299-301, 1991.

Kost, J., Langer, R. “Responsive polymeric delivery systems”, Adv. Drug Del. Rev.; 6: 19-50, 1991.

Davies, M., Khan, M., Domb, A., Langer, R., Watts, J., Paul, A. “The analysis of the surface chemical structure of biomedical aliphatic polyanhydrides using XPS and ToF-SIMS”, J. Applied Poly. Sci.; 42: 1597-1605, 1991.

Langer, R. “Polymeric delivery systems”, Targeting of Drugs: 2 Optimization Strategies; 165-174, 1991.

Ron, E., Mathiowitz, E., Mathiowitz, G., Domb, A., Langer, R. “NMR Characterization of erodible copolymers”, Macromolecules; 24: 2278-2282, 1991.

Leckband, D., Langer, R. “An approach for the stable immobilization of proteins”, Biotech. Bioeng.; 37: 227- 237, 1991.

Cima, L., Ingber, D., Vacanti, J., Langer, R. “Hepatocyte culture on biodegradable polymeric substrates”, Biotech. Bioeng.; 38: 145-158, 1991.

Moses, M., Langer, R. “Biocompatible controlled release polymers for delivery systems of polypeptides and growth factors”, J. Cell. Biochem; 45: 340-345, 1991.

Staubli, A., Mathiowitz, E., and Langer, R. “Characterization of hydrolytically degradable amino acid containing poly(anhydride-co-imides)”, Macromolecules; 24: 2283-2290, 1991.

Staubli, A., Mathiowitz, E., Langer, R. “Sequence distribution and its effect on glass transition temperature of poly(anhydride-co-amides) containing asymmetric monomers”, Macromolecules; 24: 2291-2298, 1991.

Cima, L., Vacanti, J., Vacanti, C., Ingber, D., Mooney, D., Langer, R. “Tissue Engineering by Cell Transplantation Using Degradable Polymer Substrate”, J. Biomech. Eng.; 113: 143-151, 1991.

Cohen, S., Bano, M., Chow, M., Langer, R. “Lipid-alginate interactions render changes in phospholipid bilayer Permeability”, Biochim. Biophys. Acta.; 1063: 95-102, 1991.

Bano, M., Cohen, S., Visscher, K., Allcock, H., Langer, R. “A Novel Synthetic Method for Hybridoma Cell Encapsulation”, Bio/Tech.; 9: 468-471, 1991.

Cohen, S., Yoshioka, T., Lucarelli, M., Hwang, L., Langer, R. “Controlled Delivery Systems for proteins based on poly(Lactic/Glycolic Acid) Microspheres”, Pharm. Res.; 8: 713-720, 1991.

Langer, R. “Polymer implants for drug delivery in the brain”, J. Cont. Rel.; 16: 53-60, 1991.

Mikos, A., Mathiowitz, E., Langer, R. Peppas, N. “The interaction of Polymer microspheres with Mucin Gels as a Means of characterizing polymer retention on Mucus”, J. Colloid Inter. Sci.; 143: 366-373, 1991.

Moses, M., Langer, R. “Inhibitors of Angiogenesis”, Bio/Technology; 9: 630-634, 1991.

Ron, E., Langer, R. “Erodible systems”, Treatise on Cont. Drug Del.; pp. 199-224, 1991.

Edelman, E., Mathiowitz, E., Langer, R., Klagsburn, M. “Controlled and Modulated Release of Basic Fibroblast Growth Factor”, Biomaterials; 12: 619-626, 1991.

Sluzky, V. Tamada, J.A., Klibanov, A., Langer, R. “Kinetics of Insulin Aggregation in Aqueous Solutions upon Agitation in the Presence of Hydrophobic Surfaces”, PNAS; 88: 9377-9381, 1991.

Madrid, Y., Brem, H., Langer, R. “New Directions in the Delivery of Drugs and Other Substances to the Central Nervous System”, Adv. in Pharm.; 22: 299-324, 1991.

Wheatley, M., Chang, M., Park, E., Langer, R. “Coated Alginate Microspheres: Factors Influencing the Controlled Delivery of Macromolecules”, J. Appl. Poly. Sci.; 43: 2123-2135, 1991.

Wintermantel, E., Cima, L., Schloo, B., Langer, R. “Angiopolarity: a new design parameter for cell transplantation devices and its application to degradable systems”, ASAIO Trans.; 37: m334-m336, 1991.

Zimmerman, J., Langer, R., Cooney, C. “The release of heparinase from the Periplasmic space of flavobacterium heparinum by Three Step Osmotic Shock”, Appl. Biochem. and Biotech.; 30: 137-148, 1991.

Moses, M., Langer, R. “A metalloproteinase Inhibitor as an Inhibitor of Neovascularization”, J. Cell. Biochem; 47: 230-235, 1991.

Langer, L., Brem, H., Langer, R. “New technologies for fighting Brain Disease”, Tech. Rev.; 94: 62-71, 1991.

Liu, R., Klibanov, A., Langer, R. “Moisture-Induced Aggregation of Lyophilized Proteins in the Solid State”, Biotech. Bioeng.; 37: 177-184, 1991.

Langer, R., Kost, J. “Real Time Response polymeric delivery systems in Temporal Control of Drug Delivery”, Annals of the New York Academy of Sciences; 618: 330-334, 1991.

Cohen, S., Bernstein, H., Hewes, C., Chow, M., Langer, R. “The Pharmacokinetics of and humoral responses to antigen delivered by microencapsulated Liposomes”, PNAS; 10440-10444, 1991.

Vacanti, C., Langer, R., Schloo, B., Vacanti, J. “Synthetic Polymers Seeded with Chondrocytes Provide a Template for New Cartilage Formation”, J. Plastic Surg.; 88: 753-759, 1991.

Tudor, A., Church, S., Domb, A., Hendra, P., Langer, R., Celia, C., Davies, M. “The Application of Fourier-Transform Raman Spectroscopy to the Analysis of Poly(Anhydride) Homo and Co-Polymers”, Spectrochimica Act.; 47A: 1335- 1343, 1991.

Langer, R. Drug delivery systems”Drug delivery systems”, Mat. Res. Bulletin; Materials Research Society, 1: 47-49, 1991.

Cima, L., Langer, R., Vacanti, J. “Polymers for tissue and Organ culture”, J. Bioactive and Compatible Poly.; 6: 232-239, 1991.

Domb, A., Mathiowitz, E., Ron, E., Giannos, S., Langer, R. “Polyanhydrides IV: Unsaturated and cross- Linked Polyanhydrides”, J. Poly. Sci.; 29: 571-579, 1991.

Volkin, D., Staubli, A., Langer, R., Klibanov, A. “Enzyme Thermoinactivation in AnLydrous Organic Solvents”, Biotech. Bioeng.; 37: 843-853, 1991.

Freed, L., Vunjak-Novakovic, G., Obradovic, B., Drinker, P., Langer, R. “A bioreactor for blood detoxification: fluid dynamic and ex vivo modeling Studies”, Macroscopic & Microscopic Heat & Mass Transfer in Biomed. Eng.; 55-66, 1991.

Publications: 2001 – 2010

2010

2010

Cho, S., Goldberg, M., Son, S., Xu, Q., Yang, F., Mei, Y., Bogatyrev, S., Langer, R. and Anderson, D., Lipid-like nanoparticles for small interfering RNA delivery to endothelial cells, Advanced Functional Materials, 19:  3112-3118, 2010 PMCID: N/A.

Yang, F., Cho, S., Son, S., Bogatyrev, S., Singh, D., Green, J., Mei, Y., Park, S., Bhang, S., Kim, B., Langer, R., and Anderson, D., Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles, Proceedings of the National Academy of Sciences, 107: 3317-3322, 2010. PMID: 19805054, PMCID: PMC2840438.

Hook, A., Williams, P., Anderson, D. and Langer, R. High throughput methods applied in biomaterial development and discovery, Biomaterials, 31:  187-198, 2010, PMID: 19815273, PMCID: Exempt from PMC—Non-NIH/PHS Funding.

Kolishetti, N., Shar, S., Valencia, P., Lin, L., Karnik, R., Lippard, S., Langer, R. and Farokhzad, O., Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy, Proceedings of the National Academy of Sciences, 107:  17939-17944, 2010.

Hudson, S., Langer, R., Fink, G. and Kohane, D., Injectable in situ cross linking hydrogels for local antifungal therapy, Biomaterials, 31:  1444-1452, 2010, PMID: 19942285, PMCID: PMC2813953.

Love, K., Mahon, K., Levins, C., Whitehead, K., Querbes, W., Dorkin, J., Qin, J., Cantley, W., Qin, L., Racie, T., Frank-Kamenetsky, M., Yip, K., Alvarez, R., Sah, D., de Fougerolles, A., Fitzgerald, K., Koteliansky, V., Akinc, A., Langer, R. and Anderson, D., Lipid-like materials for low dose, in vivo gene silencing, Proceedings of the National Academy of Sciences, 107:  1864-1869, 2010, PMID: 20080679, PMCID: PMC2804742.

Gerecht, S., Ferreira, L.S., Langer, R., Vascular differentiation of human embryonic stem cells in bioactive hydrogel-based scaffolds, Methods in Molecular Biology, 584: 333-354, 2010, PMID: 19907986, PMCID: Exempt from PMC—Non-NIH/PHS Funding.

Cao, Y, and Langer, R., Optimizing the delivery of cancer drugs that block angiogenesis, Science Translational Medicine, 2:  15ps3, 2010, PMCID: Exempt from PMC—Review.

Chan, J., Zhang, L., Tong, R., Ghosh, D., Gao, W., Liao, G., Yuet, K., Gray, D., Rhee, J., Cheng, J., Golomb, G., Libby, P., Langer, R., and Farokhzad, O., Spatiotemporal controlled delivery of nanoparticles to injured vasculature, Proceedings of the National Academy of Sciences, 107:  2213-2218, 2010, PMID: 20133865, PMCID: PMC2836709.

Zoldan, J., Kraehenbuehl, T., Lytton-Jean, A., Langer, R. and Anderson, D., Tissue engineering for stem cell mediated regenerative medicine, in Human Stem Cell Technology and Biology, 2010, 377-399, G. Stein, M. Borowski, M. Luong, M.J. Shao, K. Smith and P. Vasquez eds., Wiley-Blackwell, Hoboken, NJ, PMCID: Exempt from PMC—Book Chapter.

Park, H., Karajanagi, S., Wolak, K., Aanestad, J., Deheron, L., Kobler, J., Lopez-Guerra, G., Heaton, J., Langer, R. and Zeitels, S., 3D hydrogel model using adipose-derived stem cells for vocal fold augmentation, Tissue Engineering Part A, 16: 535-543, 2010, PMID: 19728785, PMCID: PMC Journal—In Process.

Burgess, P., Hutt, P., Farokhzad, O., Langer, R., Minick, S. and Zale, S., On firm ground:  IP protection of therapeutic nanoparticles, Nature Biotechnology, 28:  1267-1270, 2010. PMID: 21139609, PMCID: PMC Exempt—Non-NIH/PHS Funding.

Schroeder, A., Levins, C., Cortez, C., Langer, R., and Anderson, D., Lipid-based nanotherapeutics for siRNA delivery, Journal of Internal Medicine, 267: 9-21, 2010, PMID: 20059641, PMCID: N/A.

Dvir, T., Banghart, M., Timko, B., Langer, R., and Kohane, D., Photo-targeted nanoparticles, Nano Letters, 10: 250-254, 2010, PMID: 19904979, PMCID: PMC2806491.

Hoare, T., Zurakowski, D., Langer, R., Kohane, D., Rheological blends for drug delivery. I. Characterization in vitro, Journal of Biomedical Materials Research Part A, 92A: 575-585, 2010, PMID: 19235215, PMCID: Exempt from PMC—Non-NIH/PHS Funding.

Mamo, T., Moseman, E., Kolishetti, N., Salvador-Morales, C., Shi, J., Kuritzkes, D., Langer, R., von Andrian, U. and Farokhzad, O., Emerging nanotechnology approaches for HIV/AIDS treatment and prevention, Nanomedicine, 5:  269-285, 2010, PMID: 20148638, PMCID: PMC2861897.

Seto, J., Polat, B., Lopez, R., Blankschtein, D. and Langer, R., Effects of ultrasound and sodium lauryl sulfate on the transdermal delivery of hydrophilic permeants:  Comparative in vitro studies with full-thickness and split-thickness pig and human skin, Journal of Controlled Release, 145:  26-32, 2010. PMID: 20346994, PMCID: PMC2916660.

Lahann, J. and Langer, R., Nanobiomaterials:  The interface of nanotechnology and biomaterials, IQT Quarterly, 1:  11-15, 2010, PMCID: Exempt from PMC—Review.

Pritchard, C., Woodard, E, Langer, R. and Reynolds, F., Establishing a model spinal cord injury in the African Green Monkey for the preclinical evaluation of biodegradable polymer scaffolds seeded with human neural stem cells, Journal of Neuroscience Methods, 188: 258-269, 2010; PMID: 20219534, PMCID: PMC Journal—In Process.

Cheng, H., Kastrup, C., Ramanathan, R., Siegwart, D., Ma, M., Bogatyrev, S., Xu, Q., Whitehead, K., Langer, R. and Anderson, D., Nanoparticulate cellular patches for cell-mediated tumoritropic delivery, ACS Nano, 4:  625-631, 2010. PMID: 20121215, PMCID: PMC2836800.

Mu, C., LaVan, D., Langer, R. and Zetter, Z., Self-assembled gold nanoparticle molecular probes for detecting protelytic activity in vivo, ACS Nano, 4: 1511-1520, 2010; PMID: 20146506, PMCID: PMC2847389.

Park, H., Yip, M., Kost, J., Kobler, J., Langer, R. and Zeitels, S., Indirect low-intensity ultrasonic stimulation for tissue engineering, Journal of Tissue Engineering, advanced web publication doi:10.4061/2010/973530, 2010. PMID: 21350648, PMCID: PMC3039491.

Pritchard, C., Arnér, K., Neal, R., Neeley, W., Bojo, P., Bachelder, E., Holz, J., Watson, N., Botchwey, E., Langer, R., Ghosh, F., The use of surface modified poly(glycerol-co-sebacic acid) in retinal transplantation, Biomaterials, 31: 2153-2162, 2010; PMID: 19962754, PMCID: PMC Journal—In Process.

Shapiro, M., Westmeyer, G., Romero, P., Szablowski, J., Kuster, B., Shah, A., Otey, C., Langer, R., Arnold, F. and Jasanoff, A., Directed evolution of a MRI contrast agent for noninvasive imaging of dopamine, Nature Biotechnology, 28:  264-270, 2010. PMID: 20190737, PMCID: PMC Journal—In Process.

Levenberg, S., Ferreira, L., Chen-Konak, L., Kraehenbuehl, T., and Langer, R., Isolation, differentiation and characterization of vascular cells derived from human embryonic stem cells, Nature Protocols, 5:  1115-1126, 2010, PMID: 20539287, PMCID: N/A.

Kohane, D. and Langer, R., Biocompatibility and drug delivery systems, Chemical Science, 1:  441-446, 2010.

Valencia, P., Basto, P., Zhang, L., Rhee, M., Langer, R. Farokhzad, O. and Karnik, R., Single-step assembly of homogenous lipid-polymeric and lipid-quantum dot nanoparticles enabled by microfluidic rapid mixing, ACS Nano, 4:  1671-1679, 2010, PMID: 20166699, PMCID: PMC2923464.

Gao, W., Langer, R., Farokhzad, O., Poly(ethylene glycol) with observable shedding, Angewandte Chemie International Edition, 49:   6567-6571, 2010. PMID: 20677297, PMCID: PMC Journal—In Process.

Guillemette, M.D., Park, H., Hsiao, J.C., Jain, S.R., Larson, B.L., Langer, R. and Freed, L.E., Combined technologies for microfabricating elastomeric cardiac tissue engineering scaffolds, Macromolecular Bioscience, 10:  1330-1337, 2010. PMID: 2071854, PMCID: N/A.

Fisher, O., Khademhosseini, A., Langer, R. and Peppas, N., Bioinspired materials for controlling stem cell fate, Accounts of Chemical Research, 43:  419-128, 2010, PMID: 20043634, PMCID: PMC2840210.

Mei, Y., Saha, K. Bogatyrev, S., Yang, J., Hook, A., Kalcioglu, Z., Cho, S., Mitalipova, M., Pyzocha, N., Rojas, F., Van Vliet, K., Davies, M., Alexander, M., Langer, R., Jaenisch, R. and Anderson, D., Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells, Nature Materials,  9:  768-778, 2010. PMID: 20386609, NIHMSID: NIHMS216987.

Bratlie, K., Dang, T., Lyle, S., Nahrendorf, M., Weissleder, R., Langer, R., and Anderson, D., Rapid biocompatibility analysis of materials via in vivo fluorescence imaging of inflammatory responses, Plos. One, 5:  1-8, 2010. PMID: 20386609, PMCID: PMC2850367.

Shi, J., Votruba, A., Farokhzad, O. and Langer, R., Nanotechnology in drug delivery and tissue engineering:  From discovery to applications, Nano Letters, 10:  3223–3230, 2010. PMID: 20726522, PMCID: PMC2935937.

Tekin, H., Anaya, M., Brigham, M. Nauman, C., Langer, R. and Khademhosseini, A., Stimuli-responsive microwells for formation and retrieval of cell aggregates, Lap on a Chip, 10:  2411-2418, 2010. PMID: 20664846, PMCID: PMC Journal—In Process.

Luo, Y., Kobler, J., Heaton, J., Jia, X., Zeitels, S., Langer, R., Injectable hyaluronic acid-dextran hydrogels and effects of implantation in ferret vocal fold, Journal of Biomedical Materials Research Part B, 93B:  386-393, 2010, PMID: 20151459, PMCID: N/A.

Pritchard, C., Arner, K., Langer, R. and Ghosh, R., Retinal transplantation using surface modified poly(glycerol-co-sebacic acid) membranes, Biomaterials, 31:  7978-7984, 2010. PMID: 20656341, PMCID: N/A.

Yang, F., Cho, S., Son, S., Hudson, S., Bogatyrev, S., Keung, L., Langer, R. and Anderson, D., Combinatorial development of 3D extracellular matrices for human embryonic stem cell differentiation, Biomacromolecules, 11:  1909-1914, 2010. PMID: 20614932, PMCID: PMC2946176.

Polat, B., Blankschtein, D. and Langer, R., Low-frequency sonophoresis:  Application to the transdermal delivery of macromolecules and hydrophilic drugs, Expert Opinion on Drug Delivery, 7:  1415-1432, 2010.

Davies, M., Alexander, M., Hook, A., Yang, J., Mei, Y., Taylor, M., Urquhart, A., Langer, R., and Anderson, D., High throughput surface characterization:  A review of a new tool for screening prospective biomedical material arrays, Journal of Drug Targeting, 18:  741-751, 2010. PMID: 20945971, PMCID: PMC Exempt—Review.

Polat, B., Figueroa, P., Blankschtein, D. and Langer, R., Transport pathways and enhancement mechanisms within localized and non-localized transport regions in skin treated with low-frequency sonophoresis and sodium lauryl sulfate, Journal of Pharmaceutical Sciences, 100:  512-529, 2010. PMID: 20740667, PMCID: PMC3032395.

Maloney, J., Nikova, D., Latuenschlaeger, F., Clarke, E., Langer, R., Guck, J., Van Vliet, K., Mesenchymal stem cell mechanics from the attached to the suspended state, Biophysical Journal, 99:  2479-2487, 2010. PMID: 20959088, PMCID: PMC2955350.

Abrahamsson, C., Yang, F., Brunger, J., Valonen, P., Langer, R., Welter, J., Caplan, A., Guilak, F. and Freed, L., Chondrogenesis and mineralization with long term in vitro culture of human mesenchymal stem cells on 3D woven scaffolds, Tissue Engineering, 16:  3709-3718, 2010.

Huang, Y., Cozzitorto, J., Eltoukhy, A., Langer, R., Anderson, D., Brody, J. and Sawicki, J., CanScript, an 18-base pair DNA sequence, boosts tumor cell-specific promoter activity, Cancer Biology and Therapy, 10:  882-888, 2010.

Wang, A. Yuet, K., Zhang, L., Gu, F., Huynh-Le, M., Radovic-Moreno, A., Kantoff, P., Bander, N., Langer, R. and Farokhzad, O., ChemoRad nanoparticles:  A novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation, Nanomedicine, 5:  361-368, 2010.

Yang, J., Mei, Y., Hook, A., Taylor, A., Bogatyrev, S., Langer, R., Anderson, D., Davies, M. and Alexander, M., Polymer surface functionalities that control human embryoid body cell adhesion revealed by high throughput surface characterization of combinatorial material microarrays, Biomaterials, 31: 8827-8838, 2010.

DeSousa, F., Guerreiro, J., Ma., M., Anderson, D., Drum., C., Sinisterra, R., and Langer, R., Photo-response behavior of electrospun nanofibers based on spiropyran-cyclodextrin modified polymer, Journal of Materials Chemistry, 20:  9910-9917, 2010.

Mei, Y., Hollister-Lock, J. Bogatyrev, S., Cho, S., Weir, G., Langer, R., and Anderson, D., A high throughput micro-array system of polymer surfaces for the manipulation of primary pancreatic islet cells, Biomaterials, 31:  8989-8995, 2010.

Green, J., Langer, R., and Anderson, D., Combinatorial polymer and lipidoid libraries for nanomedicine, in Hanbook of Materials for Nanomedicine, 1, 291-312, 2010, Pan Stanford Publishing, Chicago, Il..

Bruggeman, J., Bettinger, C. and Langer, R., Biodegradable xylitol-based elastomers:  In vivo behavior and biocompatibility, Journal of Biomedical Materials Research, 95A:  92-104, 2010.

Mahon, K., Love, K., Whitehead, K., Qin,, J., Akinc, A., Leshchiner, E., Leshchiner, I., Langer, R. and Anderson, D., A combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery, Bioconjuagte Chemistry, 21:  1448-1454, 2010.

Seto, J., Polat, B., Langer, R., and Blankschein, D., Application of the aqueous porous pathway model to quantify the effect of sodium lauryl sulfate on ultrasound-induced skin structural perturbation, Journal of Pharmaceutical Sciences, Epub ahead of print, 2010. PMID: 20963845, NIHMSID: NIHMS261783.

2009

2009

Green, J., Zugates, G., Langer, R. and Anderson D., Poly(b-amino esters):  Procedures for synthesis and gene delivery, Methods in Molecular Biology, 480:  53-63, 2009, PMID: 19085119, PMCID: Exempt from PMC—Non-NIH/PHS Funding.

Farokhzad, O. and Langer, R., Impact of Nanotechnology on drug delivery, ACS Nano, 3:  16-20, 2009, PMID: 19206243, PMCID: Exempt from PMC—Non-NIH/PHS Funding.

Whitehead, K., Langer, R. and Anderson, D., Knocking down barriers:  Advances in siRNA delivery, Nature Reviews:  Drug Discovery, 8:  129-138, 2009, PMID: 19180106, PMCID: Exempt from PMC—Non-NIH/PHS Funding.

Xu, Q., Hashimoto, M., Dnag, T., Hoare, T., Kohane, D., Whitesides, G. Langer,R., and Anderson, G., Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery, Small, 5:  1575-1581, 2009, PMID: 19296563, PMCID: PMC2789598.

Khademhosseini, J., Vacanti, J. and Langer, R., Progress in tissue engineering, Scientific American, 300:  64-71, 2009, PMCID: Exempt from PMC—Magazine Article.

Nguyen, D., Green, J., Chan., J., Anderson, D. and Langer, R., Polymeric materials for gene delivery and DNA vaccination, Advanced Materials, 21: 847-867, 2009, PMCID: Exempt from PMC—Review.

Taylor, M., Urquhart, A., Anderson, D., Langer, R., Davies, M. and Alexander, M., Partial least squares regression as a powerful tool for investigating large combinatorial polymer libraries, Surface and Interface Analysis (Spec. Iss.), 41: 127-135, 2009, PMCID: N/A.

Langer, R., Perspectives and challenges in tissue engineering and regenerative medicine, Advanced Materials, 21:  3235-3236, 2009, PMCID: Exempt from PMC—Editorial.

Khademhosseini, A., Rajalingam, B., Jinno, S. and Langer, R. Nanoengineered systems for tissue engineering and regeneration, in Nanotechnology, 2009, 361-384. Ed., Vogel, V., Wiley-Vch Verlag GmbH and Co., KGaA, Weinheim, Germany, PMCID: Exempt from PMC—Book Chapter.

Huang, Y.H., Bao, Y., Peng, W., Goldberg, M., Love, K., Bumcrot, D., Cole, G., Langer, R., Anderson, R. and Sawicki, J., Claudin-3 gene silencing with small interfering RNA suppresses ovarian tumor growth and metastasis, Proceedings of the National Academy of Sciences, 106:  3426-3430, 2009, PMID: 19208807, PMCID: PMC2651300.

Chang, J., Zhang, F., Yuet, K., Liao, G., Rhee, J., Langer, R. and Farokzhad, O., PLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery, Biomaterials, 30:  1627-1634, 2009, PMID: 19111339, NIHMSID: NIHMS92982.

Salavador-Morales, C., Zhang, F., Langer, R. and Farokzhad, O., Immunocompatibilty properties of lipid-polymer hybrid nanoparticles with heterogeneous surface functional groups, Biomaterials, 30:  2231-2240, 2009, PMID: 19167749, PMCID: PMC2699891.

Gu, F., Langer, R. and Farokhzad, O., Formulation/Preparation of functionalized nanoparticles for in vivo targeted drug delivery, Methods in Molecular Biology, 544: 589-598, 2009, PMID: 19488725, PMCID: Exempt from PMC—Book Chapter.

Lu, J., Langer, R. and Chen, J., A novel mechanism is involved in cationic lipid-mediated functional siRNA delivery, Molecular Pharmaceutics, 6:  763-771, 2009, PMID: 19292453, PMCID: PMC2688906.

Daniel, K., Duc, H.L.H, Cima, M., and Langer,R., Controlled release microchips, in Chronopharmaceutics:  Science and technology for biological rhythm guided therapy and prevention of diseases, 2009, 187-215, Bi-Botti C. Youan, eds., John Wiley and Sons, Hoboken, NJ, PMCID: Exempt from PMC—Book Chapter.

Pridgen, E., Alexis, F., Farokhzad, O. and Langer, R., Biodegradable, targeted polymeric nanoparticle drug delivery formulation for cancer therapy, in Methods of Bioengineering:  Nanoscale bioengineering and nanomedicine, 2009, 197-235, Rege, K. and Medintz, I., eds., Artech House, Boston, PMCID: Exempt from PMC—Book Chapter.

Akinc, A., Goldberg, M., Qin, J., Dorkin, R., Gamba-Vitalo, C., Maier, M., Jayaprakash, K., Jayaraman, M., Rajeev, K., Manoharan, M., Kotelianski, V., Rohl, I., Leshchiner, E., Langer, R. and Anderson, D., Development of lipioid-siRNA formulations for systemic delivery to the liver, Molecular Therapy, 17:  872-879, 2009, PMID: 19259093, PMCID: PMC2653762.

Guerrini, M., Zhang, Z., Shriver, Z., Naggi, A., Masuko, S., Langer, R., Casu, B., Lindhardt, R., Torri, G. and Sasisekharan, R., Orthogonal analytical approaches to detect potential contaminants in heparin, Proceedings of the National Academy of Sciences, 106:  16956-16961, 2009, PMID: 19805108, PMCID: PMC2749844.

George, P., Saigal, R., Lawlor, M., Moore, M., LaVan, D., Marini, R., Selig, M., Makhni, M., Burdick, J., Langer, R. and Kohane, D., Three-dimensional conductive constructs for nerve regeneration, Journal of Biomedical Materials Research, 91:  519-527, 2009, PMID: 18985787, PMCID: N/A.

Bettinger, C., Bruggeman, J., Borenstein, J and Langer, R., In vitro and in vivo degradation of poly (1,3-diamino-2-hydroxypropane-co-polyol sebacate) elastomers, Journal of Biomedical Materials Research, 91:  1077-1088, 2009, PMID: 19107786, PMCID: Exempt from PMC—Non-NIH/PHS Funding.

Bettinger, C., Kulig, K., Vacanti, J., Borenstein, J. and Langer, R., Nanofabricated collagen-inspired synthetic elastomers for primary rat hepatocyte culture, Tissue Engineering, 15:  1321-1329, 2009, PMID: 18847357, PMCID: PMC2789736.

Dang, T., Xu, Q., Bratlie, K., O’Sullivan, E., Chen, X., Langer, R. and Anderson, D., Microfabrication of homogenous, asymmetric cell-laden hydrogel capsules, Biomaterial, 30:  6896-6902, 2009, PMID: 19800116, NIHMSID147749.

Bettinger, C., Langer, R., Borenstein, J., Engineering substrate topography at the micro- and nanoscale to control cell funcation, Angewandte Chemie, 48:  5406-5415, 2009, PMID: 19492373, NIHMSID: NIHMS148783.

Harris, T., Green, J., Fung, P., Langer, R., Anderson, D., Bhatia, S., Tissue-specific gene delivery via nanoparticle coating, Biomaterials, 30:  3926-3933, 2009, PMID: 19850333, PMCID: PMC2796451.

Yang, F., Green, J., Dinio, T., Keung, L., Cho, S., Park, H.,  Langer, R. and Anderson, D., Gene delivery to human adult and embryonic cell-derived stem cells using biodegradable nanoparticulate polymeric vectors, Gene Therapy, 16:  533-546, 2009, PMID: 19129861, PMCID: PMC2688702.

Bettinger, C., Bruggeman, J., Misra, A., Borenstein, J., and Langer, R., Biocompatibility of biodegrable semiconducting melanin films for nerve tissue engineering, Biomaterial, 30:  3050-3057, 2009, PMID: 19286252, PMCID: PMC Journal—In Process.

Zhou, M., Liu, H., Kilduff, J., Langer, R., Anderson, D., and Belfort, G., High-throughput membrane surface modification to control NOM fouling, Environ. Sci. Technology, 43: 3865-3871, 2009, PMID: 19544900, PMCID: Exempt from PMC—Non-NIH/PHS Funding.

Bhang, S., Cho, S., Lim., J., Kang, J., Lee, T., Yang, H., Song, Y., Park, M., Kim, H., Langer, R., Anderson, D. and Kim, B., Locally delivered growth factor enhances the angiogenic efficacy of adipose derived stromal cells transplanted to ischemic limbs, Stem Cells, 27: 1976-1986, 2009, PMID: 19544425, PMCID: PMC Journal—In Process.

Lee, J., Green, J., Love, K., Sunshine, J., Langer, and Anderson, D., Gold, poly (beta-amino ester) nanoparticles for siRNA delivery, Nanoletters, 9:  2402-2406, 2009.

Ghosh, F., Neeley, W., Langer, R. and Karin, A., Selective removal of photoreceptor cells in vivo using the biodegradable elastomer poly(glycerol sebacate), Tissue Engineering Part A, in press (advance web pub: 10.1089/ten.tea.2008.0450), PMID: 19191667, PMCID: PMC Journal—In Process.

Yang, F., Mei, Y., Langer, R. and Anderson, D., High-throughput optimization of stem cell microenvironments, Combinatorial Chemistry and High Throughput Screening, 12: 554-561, 2009, PMID: 19601753, PMCID: PMC2748120.

Shapiro, M., Szablowski, J., Langer, R. Jasanoff, A., Protein nanoparticles engineered to sense kinase activity in MRI, JACS, 131: 2484-2486, 2009, PMID: 19199639, PMCID: PMC2662502.

Epstein-Barash, H., Shichor, I., Kwon, A., Hall, S., Lawlor, H., Langer, R. and Kohane, D., Prolonged duration local anesthesia with minimal toxicity, Proceedings of the National Academy of Sciences, 106: 7125-7130, 2009, PMID: 19365067, PMCID: PMC2678453.

Kraehenbuehl, T., Ferreira, L., Zammaretti, P., Hubbell, J., and Langer, R., Cell-responsive hydrogel for encapsulation of vascular cells, Biomaterials, 30: 4318-4324, 2009, PMID: 19500842, PMCID: PMC Journal—In Process.

Nguyen, D., Chen, S., Lu, J., Goldberg, M., Kim, P., Sprague, A., Novobrantseva, T., Sherman, J., Shulga-Morskaya, S., de Fougerolles, A., Chen, J., Langer, R., and Anderson, D., Drug delivery medicated control of RNA immunostimulation, Molecular Therapy,  17:  1555-1562, 2009.

Huang, Y., Zugates, G., Peng, W., Holtz, D., Dunton, C., Green, J., Hossain, N., Padera, R., Langer, R., Anderson, D., Sawicki, J., Nanoparticle-delivered suicide gene therapy effectively reduces ovarian tumor burden in mice, Cancer Research, 69:  6184-6191, 2009. PMCID: PMC2735403.

Nguyen, D., Kim,  P., Martinez-Sobrido, L., Beitzel, B., Garcia-Sastre, A., Langer, R. and Anderson, D., A novel high-throughput cell-based method for integrated quantification of type I interferons and in vitro screening of immunostimulatory RNA drug delivery, Biotechnology and Bioengineering, 103:  664-675, 2009.

Sunshine, J., Green, J., Mahon, K., Yang, F., Eltoukhy, A., Nguyen, D., Langer, R., and Anderson D., Small molecule end group of linear polymer determines cell-type gene delivery efficacy, Advanced Materials, 21:  4947-4951, 2009.

Stone, G., Barzee, S., Snarsky, V., Santucci, C., Tran, B., Zugates, G., Langer, R., Anderson, D., and Kornbluth, Nanoparticle-delivered multimeric soluble CD40L DNA combined with toll-like receptor agonists as a treatment for melanoma, PLoS One, 4: e7334, 1-14, 2009.

2008

2008

Neeley, W., Redenti, S., Klassen, H., Tao, Sarah, Desai, T., Young, M. and Langer, R., Microfabricated scaffold for retinal progenitor cell grafting, Biomaterials, 29:  418-426, 2008.

Karnik, R., Gu, F., Basto, P., Cannizzaro, C., Dean, L., Kyei-Manu, W., Langer, R. and Farokhzad, O., Microfluidic platform for controlled synthesis of polymeric nanoparticles, Nano Letters, 8:  2906-2912, 2008.

Urquhart, A., Taylor, M., Anderson, D., Langer, R., Alexander, M., Davies, M., TOF-SIMS analysis of a 576 micro-patterned co-polymer array reveals surface moieties that control wettability, Analytical Chemistry, 80:  135-142, 2008.

Fuller, J., Zugates, G., Ferreira, L., Ow, H., Nguyen, N., Wiesner, U. and Langer, R., Intercellular delivery of core-shell fluorescent silica nanoparticles, Biomaterials, 29:  1526-1532, 2008

Alexis, F., Rhee, J. Richie, J., Radovic-Moreno, A., Langer, R. and Farokhzad, O., New frontiers in nanotechnology for cancer treatment, Urol. Oncol., 26:  74-85, 2008.

Wright, D., Rajalingam, B., Karp, J., Selvarasah, S., Ling, Y., Yeh, J., Langer, R., Dokmeci, M., Khademhosseini, A., Reusable, reversibly sealable parylene membranes for cell and protein patterning, Journ. Biomed. Mat. Res., 85:  530-538, 2008.

Chau, Y., Luo, Y., Cheung, A., Nagai, Y., Zhang, S., Kobler, J., Zeitels, S. and Langer, R., Incorporation of a matrix metalloproteinase-sensitive substrate info self-assembling peptides:  A model for biofunctional scaffolds, Biomaterials, 29:  1713-1719, 2008.

Radisic, M., Park, H., Salazar-Lazaro, J., Geng, W., Wang, Y., Langer, R., Freed, L. and Vunjak-Novakovic, G., Pre-treatment of synthetic elastomeric scaffolds by cardiac fibroblasts improves engineered heart tissue, J. Biomed. Mat. Rsch, 86:  713-724, 2008.

Parsa, S., Wang, Y., Fuller, J., Langer, R. and Pfeifer, B., A comparison between polymeric microsphere and bacterial vectors for macrophage P388D1 gene delivery, Pharm. Res., 25:  1202-1208, 2008.

Moss, J., Langer, R., Drug Delivery Modalities, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, Second Edition, Chap. 54, pp. 935-941, Lippincott Williams & Wilkins, Baltimore, MD, 2008.

Wood, K., Azarin, S., Arap, W., Pasqualini, R., Langer, R., and Hammond, P., Tumor-targeting gene delivery using molecularly engineering hybrid polymers functionalized with a tumor-homing peptide, Bioconjugate Chemistry, 19:  403-405, 2008.

Gu, F., Zhang, F., Teply, B., Mann, N., Wang, A., Radovic-Moreno, A., Langer, R., and Farokhzad, O., Precise engineering of targeted nanoparticles using self-assembled biointegrated block copolymers, Proceedings of the National Academy of Sciences, 105:  2586-2591, 2008.

Mahdavi, A., Ferreira, L., Sundback, C., Nichol, J., Chan, E., Carter, D., Bettinger, C., Patanavanich, S., Chignozha, L., Joseph, E., Galakatos, A., Pryor, A., Pomerantseva, I., Masiakos, P., Faquin, W., Zumbuehl, A., Hong, S., Borenstein, J. Vacanti, J., Langer, R., and Karp, J., A biodegradable and biocompatible Gecko-inspired adhesive, Proceedings of the National Academy of Sciences, 105:  2307-2312, 2008.

Kochling, J., Rott, Y., Arndt, S., Green, J., Anderson, D., Langer, R., Stripecke, R., Schmidt, M., Henze, G. and Bucsky, P., Prevention of Ph+ acute lymphoblastic leukaemia by DNA vaccination using a non-viral vector system and nanoparticle delivery, European Journal of Pediatrics, 167:  371, 2008.

Kang, L., Chung, B.G., Langer, R. and Khademhosseini, A., Microfluidics for drug discovery and development:  From target selection to product lifecycle management, Drug Discovery Today, 13:  1-13, 2008.

Koechling, J., Rott, Y., Arndt, S., Green, J., Anderson, D., Langer, R., Stripecke, R., Wittig, B and Schmidt, M., Prevention of Ph+ acute lymphoblastic leukemia by nanoparticulate delivery of a DNA vaccine in syngeneic mice, Blood, 110:  366b, 2008.

Teply, B., Tong, R., Jeong, S.Y., Luther, G., Sherifi, I., Yim. C. Khademhosseini, A., Farokhzad, O., Langer, R. and Cheng, J., The use of charge-coupled polymeric microparticles and micromagnets for modulating the bioavailability of orally delivered macromolecules, Biomaterials, 29:  1216-1223, 2008.

Kushner, J., Blankschtein, D. and Langer, R., Heterogeneity in skin treated with low-frequency ultrasound, Journal of Pharmaceutical Sciences, 97:  4119-4128, 2008.

Karnik, R., Hong, S. Zhang, H. Mei, Y., Anderson, D., Karp, J. and Langer, R., Nanomechanical control of cell rolling in two dimensions through surface patterning of receptors, Nano Letters, 8:  1153-1158, 2008.

Bettinger, C., Zhang, Z, Gerecht, S., Borenstien, J. and Langer, R., Enhancement of in vitro capillary tube formation by substrate nanotopography, Advanced Materials, 20:  99-103, 2008.

Karp, J., Mahdavi, A., Hong, S., Khademhosseini, A., and Langer, R., Microscale approaches for bone tissue engineering, in Micro and nanoengineering of the cell microenvironment:  Technologies and applications, 2008, 417-430, Khademhosseini, A., Borenstein, J., Toner, M., Takayama, S., eds., Artech House, Boston, US and London, UK.

Bettinger, C., Bruggeman, J. Borenstein, J. and Langer, R., Amino alcohol-based degradable poly(ester amide) elastomers, Biomaterials, 29:  2315-2325, 2008.

Akinc, A., Zumbuehl, A., Goldberg, M., Leshchiner, E., Busini, V., Hossain, N., Bacallado, S., Nguyen, D., Fuller, J., Alvarez, R., Borodovsky, A. Borland, T., Constein, R., de Fougerolles, A., Dorkin, J., Jayaprakash, K., Jayaraman, M., John, M., Kotelianski, V., Manoharan, M., Nechev, L., Qin, J., Racie, T., Raitcheva, D., Rajeev, K., Sah, D., Soutschek, J., Toudjarska, I, Vornlocher, H.P., Zimmermann, T., Langer, R. and Anderson, D., A combinatorial library of lipid-like materials for delivery of RNAi therapeutics, Nature Biotechnology, 26:  561-569, 2008.

Yang, F., Neeley, W., Moore, M., Karp, J., Shukla, A. and Langer, R., Tissue engineering:  The therapeutic strategy of the 21st century, Nanotechnology and Tissue Engineering:  The Scaffold, CRC Press/Francis Group, pp: 3-32, 2008.

Levy-Nissenbaum, E., Radovic-Moreno, A., Wang, Z. Langer, R. and Farokhzad, Nanotechnology and aptamers:  Applications in drug delivery, Trends Biotechnol., 26:  442-449, 2008.

Bettinger, C., Borenstein, J., and Langer, R. Tissue engineering:  Microfabrication techniques in scaffold development, Nanotechnology and Tissue Engineering:  The Scaffold, CRC Press/Francis Group, pp: 87-119, 2008.

Guerrini, M., Beccati, D., Shriver, Z., Naggi, A., Viswanathan, K., Bisio, A., Capila,I., Lansig, J., Guglieri, S., Fraser, B., Al-Hakim, A.,  Gunay, N., Zhang, Z., Robinson, L., Buhse, L., Nasr, M., Woodock, J., Langer, R., Venkataraman, G., Linhardt, R., Casu, B., Torri, G., Sasisekharan, R., Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events, Nature Biotechnology, 26:  669-675, 2008.

Kishimoto, T., Viswanathan, K., Ganguly, T., Elankumaran, S., Smith, S., Pelzer, K., Lansing, J., Sriranganathan, N., Zhao, G., Galcheva-Gargova, Z., Al-Hakim, A., Bailey, G., Fraser, B., Roy, S., Rogers-Cotrone, T., Buhse, L., Whary, M., Fox, J., Nasr, M., Dal Pan, G., Shriver, Z., Langer, R., Venkataraman, G., Austen, F., Woodcock, J., Sasisekharan, R., Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System, New England Journal of Medicine, 358:  2457-2467, 2008.

Blossom, D., Kallen, A. Patel, R., Elward, A., Robinson, L., Gao, G., Langer, R., Perkins, K., Jaeger, J., Kurkjian, K., Jones, M., Schillie, S., Shehab, N., Ketterer, D., Venkataraman, G., Kishimoto, T., Shriver, Z., McMahon, A., Austen, K., Kozlowski, S., Srinivasasn, A., Turabelidze, G., Gould, C. Arduino, M. and Sasisekharan, R., Outbreak of adverse reactions associated with contaminated heparin, New England Journal of Medicine, 359:  2674-2684, 2008.

Kohane, D. and Langer, R., Polymeric biomaterials in tissue engineering, Pediatric Research, 63:  487-491, 2008.

Ferreira, L., Squire, T., Park, H., Choe, H., Kohane, D. and Langer, R., Human embryoid bodies containing nano- and micro-particulate delivery vehicles, Advanced Materials, 20:  2285-2291, 2008.

Park, H., Bhalla, R., Saigal, R., Radisic, M., Watson, N., Langer, R., Vunjak-Novakovi, G., Effects of the electrical stimulation in C2C12 muscle constructs, Journal of Tissue Engineering and Regenerative Medicine, 2: 279-287, 2008.

Zhang, L., Gu, F., Chan., J., Wang, A., Langer, R. and Farokhzad, O., Nanoparticles in medicine:  Therapeutic applications and developments, Clinical Pharmacology and Therapeutics, 83:  761-769, 2008.

Kushner, J., Blankschtein, D. and Langer, R., Evaluation of hydrophilic permeant transport parameters in the localized and non-localized transport regions of skin treated simultaneously with low-frequency ultrasound and sodium lauryl sulfate, Journal of Pharmaceutical Sciences, 97:  906-918, 2008.

Nguyen, D. Raghavan, S., Tashima, L., Lin, E., Fredette, S., Langer, R. and Wang, C., Enhancement of poly(orthoester) microchips for DNA vaccine delivery by blending with poly(ethylenimine), Biomaterials, 29:  2783-2793, 2008.

Brito, L., Little, S., Langer, R., Amiji, M., Poly(β-amino ester) and Cationic Phospholipid-Based Lipopolyplexes for Gene Delivery and Transfection in Human Aortic Endothelial and Smooth Muscle Cells, Biomacromolecules, 9:  1179-1187, 2008.

Bruggeman, J., deBruin, B-J., Bettinger, C. and Langer, R., Biodegradable poly(polyol sebacate) polymers, Biomaterials, 29:  4726-4735, 2008.

Cao, Y. and Langer, R., A review of Judah Folkman’s remarkable achievement in biomedicine, Proceedings of the National Academy of Sciences, 105:  13203-13205, 2008.

Green, J., Zhou, Y., Mitalipova, M., Beard, C., Langer, R., Jaenisch, R. and Anderson, D., Nanoparticles for gene transfer to human embryonic stem cell colonies, Nano Letters, in 8:  3126-3130, 2008.

Green, J., Langer, R., and Anderson, D., A combinatorial polymer library approach yields insights into non-viral gene delivery, Accounts of Chemical Research, 41:  749-759, 2008.

Ferreira, L., Karp, J., Nobre, L. and Langer, R., New opportunities:  The use of nanotechnologies to manipulate and track stem cells, Cell Stem Cell, 3:  136-146, 2008.

Wang, Z., Guimaraes, A., Zhang, L., Gu, F., Langer, R., Weissleder, R. and Farokhzad, O., Development of novel multifunctional nanoparticles for combined imaging and targeted delivery of chemoradiotherapy, Int. Journal of Radiation Oncology Biology Physics (Spe. Iss.), 72:  S707, 2008.

Auguste, D., Furman, K., Wong, A., Fuller, J., Armes, S., Deming, T. and Langer, R., Poly(ethylene glycol) protected, pH-dependent liposomes enhance RNAi delivery, Journal of Controlled Release, 130:  266-274, 2008.

Dhar, S., Gu, F., Langer, R., Farokhzad, O. and Lippard, S., Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized pt (IV) prodrug-PLGA-PEG nanoparticles, Proceedings of the National Academy of Sciences, 105:  17356-17361, 2008.

Prausnitz, M. and Langer, R., Transdermal drug delivery, Nature Biotechnology, 26:  1261-1268, 2008.

Nguyen, D., Green, J., Chan., J., Anderson, D. and Langer, R., Polymeric materials for gene delivery and DNA vaccination, Advanced Materials, 20:  1-21, 2008.

Wang, A., Bagalkot, V., Vasilliou,l C., Gu, F., Alexis, F., Zhang, L., Shaikh, M., Yuet, K., Cima, M., Langer, R., Kantoff, P., Bander, N., Jon, S. and Farokhzad, O., Superparamagnetic iron oxide nanoparticle aptamer bioconjugate for combined prostrate cancer imaging and therapy, ChemMedChem, 3:  1311-1315, 2008.

Bruggeman, J., Bettinger, C., Nijist, C., Kohane, D. and Langer, R., Biodegradable xylitol-based polymers, Advanced Materials, 20:  1922-1927, 2008.

Park, H., Williams, G., Goldman, N., Choe, H., Kobler, .J., Lopez Guerra, G., Heaton, J., Langer, R. and Zeitels, S., Comparison of effects of two harvesting methods on fat autograft, The Laryngoscope, 118:  1493-1499, 2008.

Adams, D., Toner, M., and Langer, R., Microflow and crack formation patterns in drying sessile droplets of liposome suspensions in trehalose solutions, Langmuir, 24:  7688-7697, 2008.

Showalter, S., Huang, Y., Witkiewicz, A., Constantino, C., Yeo, C., Green, J., Langer, R., Anderson, D., Sawicki, J. and Brody, J., Nanoparticle delivery of diphtheria toxin DNA effectively kills mesothelin expressing pancreatic cancer cells, Cancer Biology and Therapy, 7:  1584-1590, 2008.

Mei, Y., Cannizzaro, C., Park, H., Xu, Q., Bogatyrev, S., Yi, K., Goldman, N., Langer, R. and Anderson, D., Cell-compatible, multicomponent protein arrays with subcellular feature resolution, Small, 4:  1600-1604, 2008.

Hudson, S., Padera, R., Langer, R. and Kohane, D., The biocompatibility of mesoporous silicates, Biomaterials, 29:  4045-4055, 2008.

Zhang, L, Chan, J., Gu, F., Rhee, J., Wang, A., Radovic-Moreno, A., Alexis, F., Langer, R. and Farokhzad, O., Self-assembled lipid-polymer hybrid nanoparticles:  A robust drug delivery platform, ACS Nano, 2:  1696-1702, 2008.

Frank-Kamenetsky, M., Grefhorst, A., Anderson, A., Racie, T., Bramlage, B., Akinc, A., Butler, D., Charisse, K., Dorkin, R., Fan, Y. Gamba-Vitalo, C., Hadwiger, P., Jayaraman, M., John, M., Jayaprakash, K., Maier, M., Nechev, L., Rajeev, K., Read, T., Rohl, I., Soutschek, J., Tan, P., Wong, J., Wang, G., Zimmerman, T., de Fougerolles, A., Vornlocher, H., Langer, R., Anderson, D., Manoharan, lM., Koteliansky, V., Horton, J. and Fitzgerald, K., Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates, Proceedings of the National Academy of Sciences, 105:  11915-11920, 2008.

Engelmayr, G., Cheng, M., Bettinger, C., Borenstein, J. Langer, R. and Freed, L., Accordian like honeycombs for tissue engineering cardiac anisotropy, Nature Materials, 7:  1003-1010, 2008.

Taylor, M., Urquhart, A., Williams, P., Anderson, D., Langer, R, Alexander, M. and Davies, M., A method for investigating protein adhesion and adsorption to microarrayed combinatorial polymers, Macromolecular Rapid Communications, 29:  1298-1302, 2008.

Cho, S., Hartle, L., Son, S., Yang, F., Goldberg, M., Xu, Q., Langer, R. and Anderson, D., Delivery of small interfering RNA for inhibition of endothelial cell apoptosis by hypoxia and serum deprivation, Biochemical & Biophysical Research Communications, 376:  158-163, 2008.

Svensson, R., Shey, M., Ballas, Z., Dorkin, R., Goldberg, M., Akinc, A., Langer, R., Anderson, D., Bumcrot, D. and Henry, M., Assessing siRNA pharmacodynamics in a luciferase expressing mouse, Molecular Therapy, 16: 1995-2001, 2008.

Sawicki, J., Anderson, D. and Langer, R., Nanoparticle delivery of suicide DNA for epithelial ovarian cancer therapy, Advances in Experimental Medicine and Biology, Vol. 767:  Ovarian Cancer, Springer Verlag, New York, 622: 209-19, 2008.

2007

2007

Langer, R., Tissue engineering: Perspectives, challenges and future directions, Tissue Engineering, 13: 1-2, 2007.

Khademhosseini, A., Ling, Y., Karp, J. and Langer, R., Micro- and nanoscale control of cellular environment for tissue engineering. Nanobiotechnology II, Mirkin, C. and Niemeyer, C., Eds., 2007, Wiley-VCH Verlag, Weinheim.

Moss, J.D. and Langer, R., Drug Delivery Modalities, in Principles of Pharmacology:  The pathophysiologic basis of drug therapy 2nd Ed, 2007, 935-941, E. Golan, ed.in chief, Lippincott Williams & Williams, Baltimore.

Farokhzad, O., Jon, S. and Langer, R., Aptamers and cancer nanotechnology. Nanotechnology for cancer therapy, pp. 289-313, Amiji, M., Ed, 2007.

Goldberg, M., Langer, R. and Jia, X., Nanostructured materials for applications in drug delivery and tissue engineering, Journal of Biomaterials Science Polymer, 18:  241-268, 2007.

Green, J., Chiu, E., Leshchiner, E., Shi, J., Langer, R., Anderson, D., Electrostatic ligand coatings of nanoparticles enable ligand-specific gene delivery to human primary cells, Nano Letters,7: 874-879, 2007.

Peng, W., Anderson, D., Bao, Y., Padera, R., Langer, R., Sawicki, Nanoparticulate delivery of suicide DNA to murine prostate and prostate tumors, The Prostate, 67: 855-862, 2007.

Ferreira, L., Langer, R., Vunjak-Novakovic, G., Gerecht-Nit, S., Fuller, J., Shieh, H., Bioactive hydrogel scaffolds for controllable vascular differentiation of human embryonic stem cells, Biomaterials, 28: 2706-2717, 2007.

Ward, M.S., Khoobei, A., Lavik, E.B., Langer, R., Young, M.J., Neuroprotection of retinal ganglion cells in DBA/2J mice with GDNF-loaded biodegradable microspheres, Journal of Pharmaceutical Sciences, 96: 558-568, 2007.

Choleris, E., Little, S., Mong, J., Puram, S., Langer, R., Pfaff, D., Microparticle-based delivery of oxytocin receptor antisense DNA in the medial amygdala blocks social recognition in female mice, Proc. Nat. Acad. Sci., 104: 4670-4675, 2007.

Gu, F., Karnik, R., Wang, A., Alexis, F., Levy-Nissenbaum, E., Seungpyo, H., Langer, R., Farokhzad, O., Targeted nanoparticles for cancer therapy, Nano Today, 2: 14-21, 2007.

Langer, R., A bioengineer sees a future for safe gene-silencing therapies, Nature, 447:  757, 2007.

Karp, J., Yeh, J., Eng, G., Fukuda, J., Blumling, J., Suh, K., Cheng, J., Mahdavi, A., Borenstein, J., Langer, R., Khademhosseini, A., Controlling size, shape, and homogeneity of embryoid bodies using poly(ethylene glycol) microwells, Lab on a Chip, 7:786-794, 2007.

Figallo, E., Cannizzaro, C., Gerecht, S., Burdick, J., Langer, R., Elvassore, N., Vunjak-Novakovic, G., Micro-bioreactor array for controlling cellular microenvironments, Lab on a Chip, 7: 710-719, 2007.

Gerecht, S., Burdick, J., Ferreira, L., Townsend, S., Langer, R., Vunjak-Novakovic, G., Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells, PNAS, 104: 11298-11303, 2007.

Yeo, Y., Bellas, E., Highleye, C.B., Langer, R., Kohane, D.S., Peritoneal adhesion prevention with an in situ cross-linkable hyaluronan gel containing tissue-type plasminogen activator in a rabbit repeated-injury model, Biomaterials, 28: 3704-3713, 2007.

Cheng, J., Teply, B.A., Sherifi, I., Sung, J., Luther, G., Gu, F.X., Levy-Nissenbaum, E., Radovic-Moreno, A., Langer, R., Farokhzad, O.C., Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery, Biomaterials, 28: 869-876, 2007.

Loose, C., Langer, R. and Stephanopoulos, G., Optimization of protein fusion partner length for maximizing in vitro translation of peptides, Biotechnology Progress, 23: 444-451, 2007.

Gerecht, S., Bettinger, C., Zhang, Z., Borenstein, J., Vunjak-Novakovic, G., Langer, R., The effect of actin disrupting agents on contact guidance of human embryonic stem cells, Biomaterials, 28: 4068-4077, 2007.

Ferreira, L., Gerecht, S., Sheih, H., Watson, N., Rupnick, M., Dallabrida, S., Vunjak-Novakovic, G., Langer, R., Vascular progenitor cells isolated from human embryonic stem cells give rise to endothelial and smooth muscle-like cells and form vascular networks in vivo, Circulation Research, 101: 286-294, 2007.

Levenberg, S., Basevitch, Y., Zoldan, J. and Langer, R., Review:  Endothelial potential of human embryonic stem cells, Blood, 110: 806-814, 2007.

Zumbuehl, A., Ferreira, L., Kuhn, D., Astashkina, A., Long, L., Yeo, Y., Iaconis, T., Ghannoum, M. Langer, R., Kohane, D. and Fink, G., Antifungal hydrogels, Proceedings of the National Academy of Sciences, 104: 12994-12998, 2007.

Ng, T., Lavik, E., Keino, H., Taylor, A., Langer, R., Young, M., Creating an immune privileged site using retinal progenitor cells and biodegradable polymers, Stem Cells,25: 1552-1559, 2007.

Park, H., Cannizzaro, C., Vunjak-Novakovic, G., Langer, R., Vacanti, C., Farokhzad, O., Nanofabrication and microfabrication of functional materials for tissue engineering, Tissue Engineering, 13: 1867-1877, 2007.

Zugates, G., Peng, W., Zumbuehl, A., Jhunjhunwala, S., Huang, Y., Langer, R., Sawicki, J., Anderson, D., Rapid optimization of gene delivery by parallel end-modification of poly(β-amino ester)s, Molecular Therapy, 15: 1306-1312, 2007.

Radisic, M., Park, H., Gerecht-Nir, S., Cannizzaro, C., Langer, R., Vunjak-Novakovic, G., Biomimetic approach to cardiac tissue engineering, Philos. Trans. R. Soc. Lond. Biol. Sci., 362: 1357-1368, 2007.

Gerecht, S., Townsend, S., Pressler, H., Zhu, H., Nijist, C., Bruggeman, J., Nichol, J. and Langer, R., A porous photocurable elastomer for cell encapsulation and culture, Biomaterials, 28: 4826-4825, 2007.

Little, S., Anderson, D. and Langer, R., Nonviral genetic vaccines for cancer, Gene Therapy for Cancer, ed., Hunt, K., Vorburger, S. and Swisher, S., Humana Press, Totowa, NJ, 2007.

Jiang, C., Moore, M., Zhang, X., Klassen, H., Langer, R., Young, M., Intravitreal injections of GDNF-loaded biodegradable microspheres are neuroprotective in a rat model of glaucoma, Molecular Vision, 13: 1783-1792, 2007.

Zugates, G., Anderson, D. and Langer, R., High-throughput methods of screening polymeric transfection reagents, Gene transfer: Delivery and expression of DNA and RNA, pg 547-554, eds, Friedmann, t. and Rossi, Ji, Cold Spring Harbor Laboratory Press, New  York, NY., 2007

Karp, J., Langer, R., Development and therapeutic applications of advanced biomaterials, Current Opinion in Biotechnology, 18: 1-6, 2007.

Daniel, K., Kim, G., Vassiliou, C., Jalali-Yazdi, F., Langer, R., Cima, M., Multi-Reservoir Device for Detecting a Soluble Cancer Biomarker, Lab on a Chip, 7: 1288-1293, 2007.

Urquhart, A., Anderson, D., Taylor, M., Alexander, M., Langer, R., Davies, M., High throughput surface characterization of a combinatorial material library, Advanced Materials, 19: 2486-2491, 2007.

Park, S., Lee, K., Choi, I., Langer, R., Jon, S., Dual functional, polymeric, self-assembled monolayers as a facile platform for construction of patterns of biomolecules, Langmuir, 23: 10902-10905, 2007.

Townsend, S., Evrony, G., Gu, F., Shulz, M., Brown Jr., R., Langer, R., Tetanus toxin C fragment conjugated nanoparticles for targeted drug delivery to neurons, Biomaterials, 28:  5176-5184, 2007.

Bettinger, C., Cyr, K., Matsumoto, A., Langer, R., Borenstein, J., Kaplan, D., Silk fibroin microfluidic devices, Advanced Materials, 19:  2847-2850, 2007.

Khademhosseini, A and Langer, R., Microengineered hydrogels for tissue engineering, Biomaterials, 28:  5087-5092, 2007.

John, M., Constien, R., Akinc, A., Goldberg, M., Moon, Y., Spranger, M., Hadwiger, P., Soutschek, J., Vornlocher, H., Manoharan, M., Stoffel, M., Langer, R., Anderson, D., Horton, J., Koteliansky, V., Bumcrot, D., Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway, Nature, 449: 740-744, 2007.

Farokhzad, O., Zhang, L., Kantoff, P., Langer, R., Jon, S., Bagolkot, V., Quantum dot-aptamer conjugates for synchronous cancer imagin, therapy, and sensing of drug delivery based on bi-flourescence resonance energy transfer, Nano Letters, 7:  3065-3070, 2007.

Kim, G., Josephson, L., Langer, R., Cima, M., Magnetic relaxation switch detection of human chorionic gonadotrophin, Bioconjugate Chemistry, 18:  2024-2028, 2007.

Nijst, C., Bruggeman, J., Karp, J., Ferreira, L., Zumbuehl, A., Bettinger, C., Langer, R., Synthesis and characterization of photocurable elastomers from poly(glycerol-co-sebacate), Biomacromolecules, 8:  3067-3073, 2007.

Green, J., Zugates, G., Tedford, N., Huang, Y., Griffith, L., Lauffenburger, D., Sawicki, J., Langer, R., Anderson, D., Combinatorial modification of degradable polymers enables transfection of human cells comparable to adenovirus, Advanced Materials, 19:  2836-2842, 2007.

Kushner, J., Deen, W., Blankschtein, D. and Langer, R., First-principles, structure-based transdermal transport model to evaluate lipid partition and diffusion coefficients of hydrophobic permeants solely from stratum corneum permeation experiments, Journal of Pharmaceutical Sciences, 96:  3236-3251, 2007.

Kushner, J., Kim, D., So, P., Blankschtein, D., Langer, R., Dual-Channel two-photon microscopy study of transdermal transport in skin treated with low-frequency ultrasound and a chemical enhancer, Journal of Investigative Dermatology, 127:  2832-2846, 2007.

Zugates, G., Tedford, N., Zumbuehl, A., Jhunjhunwala, S., Kang, C., Griffith, L., Lauffenburger, D., Langer, R., Anderson, D., Gene delivery properties of end-modified poly(β-amino ester)s, Bioconjugate Chemistry, 18:  1887-1896, 2007.

Peer, D., Karp, J., Hong, S., Farokhzad, O., Margalit, R., Langer, R., Nanocarriers: Emerging platforms for cancer therapy, Nature Nanotechnology, 2:  751-760, 2007.

Kushner, J., Blankschtein, D. and Langer, R., Evaluation of the porosity, the tortuosity, and the hindrance factor for the transdermal delivery of hydrophilic permeants in the context of the aqueous pore pathway hypothesis using dual-radiolabeled permeability experiments, Journal of Pharmaceutical Sciences, 96:  3263-3282, 2007.

Adams, D., Toner, M., and Langer, R., Role of trehalose in prevention of giant vesicle adsorption and encapsulated solute leakage in anhydrobiotic preservation, Langmuir, 23:  13013-13023, 2007.

Hong, S., Lee, D., Zhang, H., Zhang, J., Resvick, J., Khademhosseini, A., King, M., Langer, R., Karp, J., Covalent immobilization of P-selectin enhances cell rolling, Langmuir, 23:  12261-12268, 2007.

Evgenov, O., Kohane, D., Bloch, K., Stasch, J., Volpatol, G., Bellas, E., Evgenov, N., Buys, E., Gnoth, M., Graveline, A., Liu, R., Hess, D., Langer, R., Zapol, W., Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation, American Journ. of Resp. and Crit. Care Med., 176:  1138-1145, 2007.

Kim, G., Tyler, B., Tupper, M., Karp, J., Langer, R., Brem, H., Cima, M., Resorbable polymer microchips releasing BCNU inhibit tumor growth in the rat 9L flank model, Journal of Controlled Release, 123:  172-178, 2007.

2006

2006

Bettinger, C.J., Weinberg, E.J., Kulig, K.M., Vacanti, P., Wang, Y., Borenstein, J. and Langer, R., Three-dimensional microfluidic tissue-engineering scaffolds using a flexible biodegradable polymer, Advanced Materials, 18:  165-169, 2006.

Burdick, J., Ward, M., Liang, E., Young, M., Langer, R., Stimulation of neurite outgrowth by neurotrophins delivered from degradable hydrogels, Biomaterials, 27:  452-459, 2006.

Radisic, M., Park, H., Chen, F., Salazar-Lazzaro, J., Wang, Y., Dennis, R., Langer, R., Freed, L. and Vunjak-Novakovic, G., Biomimetic approach to cardiac tissue engineering:  Oxygen carriers and channeled scaffolds, Tissue Engineering, 12: 2006.

Fukuda, J., Khademhosseini, A., Yeh, J., Eng, G., Cheng, J., Farokhzad, O. and Langer, R., Micropatterned cell co-cultures using layer-by-layer deposition of extracellular matrix components, Biomaterials, 27:  1479-1486, 2006.

Levenberg, S., Khademhosseini, A. and Langer, R., Embryonic Stem Cells in Tissue Engineering, in Essentials of Stem Cell Biology, 2006, pp457-462, R. Lanza, E.D. Thomas, J. Thomson, R. Pederson, J. Gearhart, B. Hogan, D. Melton, M. West, eds., Elsevier.

Lavik, E. and Langer, R., Nerve Regeneration, in Scaffolding in Tissue Engineering, 2006, pp 481-499, Ma, P. and Elisseeff, J., eds., CRC Press.

Khademhosseini, A., Vacanti, J., Borenstein, J. and Langer, R., Microscale technologies for tissue engineering and biology, Proceedings of the National Academy of Sciences, 103:  2480-2487, 2006.

Kohane, D., Tse, J., Yeo, Y., Padera, R., Shubina, M. and Langer, R., Biodegradable polymeric microspheres and nanospheres for drug delivery in the peritoneum, J. Biomed Mat. Rsch., 77A:  351-361, 2006.

Shmulewitz, A. and Langer, R., The ascendance of combination products, Nature Biotechnology, 24:  277-280, 2006.

Peppas, N., Hilt, Z., Khademhosseini, A. and Langer, R., Hydrogels in biology and medicine:  From molecular properties to bionanotechnology, Advanced Materials, 18:  1345-1360, 2006.

George, P., LaVan, D., Burdick, J., Chen, C.-Y., Liang, E. and Langer, R., Electrically controlled drug delivery from biotin-doped condutive polypyrrole, Advanced Materials, 18:  577-581, 2006.

Gerecht-Nir, S., Radisic, M., Park, H., Cannizzaro, C., Boublik, J., Langer, R. and Vunjak-Novakovic, G., Biophysical regulation during cardiac development and application to tissue engineering, Int. J. Dev. Biol., 50:  233-243, 2006.

Yin, Y., Henzl, M, Lorber, B., Nakazawa, T., Thomas, T., Jiang, F., Langer, R. and Benowitz, L., Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells, Nature Neuroscience, 9:  843-852, 2006.

Devalapally, H., Shenoy, D., Little, S., Langer, R. and Amiji, M., Poly(ethylene oxide)-modified poly(b-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs Part III: Therapeutic efficacy and safety studies in ovarian cancer xenograft model, Cancer Chemotherapy and Pharmacology, DI 10.1007/s00280-006-0287-5, 2006.

Farokhzad, O, Karp, Jeffrey, Langer, R, Nanoparticle–aptamer bioconjugates for cancer targeting, Expert Opinion in Drug Delivery 3:3, 311-324, 2006.

Berry, D., Lynn, D.M., Berry, E., Sasisekharan, R. and Langer, R., Heparin localization and fine structure regulate Burkitt’s lymphoma growth, Biochemical and Biophysical Rsch Comm., 348:  850-856, 2006.

Langer, R., Biomaterials for drug delivery and tissue engineering, MRS Bulletin, 31:  477-485, 2006.
Bettinger, C.J., Orrick, B., Misra, A., Langer, R. and Borenstein, J., Microfabrication of poly (glycerol-sebacate) for contact guidance applications, Biomaterials, 27: 2558-2565, 2006.

Farokhzad, O., Cheng, J., Teply, B., Sherifi, I., Jon, S.Y., Kantoff, P., Richie, J.P. and Langer, R., Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo, Proceedings of the National Academy of Sciences, 103:  6315-6320, 2006.

Staples, M., Daniel, K., Cima, M. and Langer, R., Application of micro- and nano-electromechanical devices to drug delivery, Pharmaceutical Research, 23:  847-863., 2006.

Yeo, Y., Highley, C. B., Bellas, E., Ito, T., Marini, R., Langer, R., Kohane, D.S., In situ cross-linkable hyaluronic acid hydrogels prevent post-operative abdominal adhesions in a rabbit model, Biomaterials, 27: 4698-4705, 2006.

Mahmood, T., Shastri, V.P., Van Blitterswijk, C.A., Langer, R., and Riesle, J., Evaluation of chondrogenesis within PEGT:PBT scaffolds with high PEG content. Journal of Biomedical Materials Research, 79A: 216-222, 2006.

Fukuda, J., Khademhosseini, A., Yeo, Y., Yang, X., Yeh, J., Eng, G., Blumling, J., Wang, C.-F., Kohane, D. and Langer, R., Micromolding of photocrosslinkable chitosan hydrogel for spheroid microarray and co-cultures Biomaterials, 27: 5259-5267, 2006.

Anderson, D.G., Tweedie, C.A., Hossain, N., Navarro, S.M., Brey, D.M., Van Vliet, K.J., Langer, R., Burdick, J.A., A Combinatorial Library of Photocrosslinkable and Degradable Materials, Advanced Materials, 18: 2614-2618, 2006.

Hahn, M., Teply, B., Stevens, M., Zeitels, S. and Langer, R., Collagen composite hydrogels for vocal fold lamina propria restoration, Biomaterials, 27: 1104-1109, 2006.

Hoffman, S., Knecht, S., Langer, R., Kaplan, D.L., Vunjak-Novakovic, G., Merkle, H. and Meinel, L., Cartilage-like tissue engineering using silk scaffolds and mesenchymal stem cells, Tissue Engineering, 12:  2729-2738, 2006.

Karp, J., Ferreira, L, Khademhosseini, A., Kwon, A., Yeh, J. and Langer, R., Cultivation of human embryonic stem cells without the embryoid body step enhances osteogensis in vitro, Stem Cells, 24: 835 – 843, 2006.

Yoshida, M., Langer, R., Lendlein, A. and Lahann, J., From advanced biomedical coatings to multi-functionalized biomaterials, Polymer Reviews, Vol.46, 4: 347-375, 2006.

Mahmood, T., Miot, S., Frank, O., Martin, I., Riesle, J., Langer, R., and Van Blitterswijk, C.A., Modulation of chondrocyte phenotype for tissue engineering by designing the biologic-copolymer carrier interface.  Biomacromolecules, 7: 3012-3018, 2006.

Teng, Y., Liao, W., Choi, H., Konya, D., Sabharwal, S., Langer, R., Sidman, R., Snyder, E., Frontera, W., Physical activity mediated functional recovery after spinal cord injury:  Potential roles of neural stem cells, Future Medicine, 1:  763-776, 2006.

Watanabe, W., Thomas, M., Clarke, R., Klibanov, A., Langer, R., Katstra, J., Fuller, G., Griel, L., Fiegel, J., Edwards, D., Why inhaling salt water changes what we exhale.  Journal of Colloid and Interface Science, 9:16 1-8, 2006.

Bellin, I., Kelch, S., Langer, R. and Lendlein, A., Polymeric triple shape materials, Proceedings of the National Academy of Sciences., 103:  18043-18047, 2006.

Meinel, L., Hofmann, S., Betz, O., Fajardo, R., Merkle, H., Langer, R., Evans, C., Vunjak-Novakovic, G. and Kaplan, D., Osteogenesis by human mesenchymal stem cells cultured on silk biomaterials:  Comparison of adenovirus mediated gene transfer and protein delivery of BMP-2, Biomaterials, 27:  4993-5002, 2006.

Bagalkot, V., Farokhzad, O., Langer, R., Jon, S., An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform, Angewandte Chemie International Edition, 45: 8149-8152, 2006.

Jia, X., Yeo, Y., Clifton, R., Jiao, T., Kohane, D., Kobler, J., Zeitels, S., Langer, R., Hyaluronic acid-based microgels and microgel networks for vocal fold regeneration, Biomacromolecules, 7:  3336-3344, 2006.

Yeh, J., Ling, Y.,  Karp, J., Gantz, J., Chandawarkar, A., Eng, G., Blumling, J., Langer, R. and Khademhosseini, A., Micromolding of shape-controlled, harvestable cell-laden hydrogels, Biomaterials, 27:  5391-5398. 2006.

Suh, K.Y., Khademhosseini, A., Jon, S. and Langer, R., Direct confinement of individual viruses within polyethylene glycol (PEG) nanowells, Nano Letters, 6:  1196-1201, 2006.

Piantino, J., Burdick, J., Goldberg, D., Langer, R. and Benowitz, L., An injectable, biodegradable hydrogel for trophic factor delivery enhances axonal rewiring and improves performance after spinal cord injury, Experimental Neurology, 201: 359-367, 2006.

Khademhosseini, A., Karp, J., Bettinger, C., Borenstein, J., Yeh, J., Ling, Y., Fukuda, J. and Langer, R., Interplay of biomaterials and micro-scale technologies for advancing biomedical applications, Journal of Biomaterials Science:  Polymer Edition, 17: 1221-1240, 2006.

Green, J. J., Shi, J., Chiu, E., Leshchiner, E. S., Langer, R. and Anderson, D.G., Biodegradable polymeric vectors for gene delivery to human endothelial cells, Bioconjugate Chemistry, 17: 1162-1169, 2006.

Yeo, Y., Burdick, J., Highley, C., Marini, R, Langer, R. and Kohane, D.S., Peritoneal application of chitosan and UV-cross-linkable chitosan, J. Biomed. Mats. Rsch., 78A: 668-675, 2006.

Zugates, G.T., Anderson, D.G., Little, S.R., Lawhorn, I.E.B. and Langer, R., Synthesis of poly(b-amino ester)s with thiol-reactive side chains for DNA delivery, J. Amer. Chem. Soc., 128: 12726-12734, 2006.

Mahmood, T., van Blitterswijk, C., Shastri, P., Riesle, J. and Langer, R., Chondrogenesis within PEGT:PBT scaffolds with high PEG content, J. Biomed Mats Rsch, 79A: 216-222, 2006.

Farokhzad, O. and Langer, R., Nanomedicine:  Developing smarter therapeutic and diagnostic modalities, Advanced Drug Delivery Reviews, 58: 1456-1459, 2006.

Chau, Y., Dang, N., Tan, F., Langer, R., Investigation of targeting mechanism of new dextran-peptide-methotrexate conjugates using biodistribution study in matrix-metalloproteinase-overexpressing tumor xenograft model, Journal of Pharmaceutical Sciences, 95: 542-551, 2006.

Luo, Y., Kobler, J., Zeitels, S., Langer, R., Effects of growth factors on extracellular matrix production by vocal fold fibroblasts in 3-dimensional culture, Tissue Engineering, 12: 3365-3374, 2006.

Khademhosseini, A., Ferreira, L., Blumling, J., Yeh, J., Karp, J., Fukuda, J., Langer, R., Co-culture of human embryonic stem cells with murine embryonic fibroblasts on microwell-patterned substrates, Biomaterials, 27: 5968-5977, 2006.

Karp, J., Yeo, Y., Geng, W., Cannizarro, C., Yan, K., Kohane, D., Vunjak-Novakovic, G., Langer, R., Radisic, M., A photolithographic method to create cellular micropatterns, Biomaterials, 27: 4755-4764, 2006.

Mitragotri, S., Tang, H. Blankschtein, D., Langer, R. Transdermal delivery:  Sonophoresis, Encl. Of Pharm. Tech., pp. 3828-3842, Swarbrick, J., Boylan, J., Eds., Informa Healthcare, 2006.

2005

2005

Burdick, J., Chung, C., Jia, C., Randolph, M. and Langer, R., Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks, Biomacromolecules, 6:  386-391, 2005.

Moss, J.D. and Langer, R., Drug Delivery Mechanisms, in Principles of Pharmacology: The pathophysiologic basis of drug therapy, 2005, 781-787, E. Golan, ed. in chief, Lippincott Williams & Williams, Baltimore.

Meinel, L., Hofmann, S., Kareourgiou, V., Kirker-Head, C., Zichner, L., McCool, J.C., Langer, R., Vunjak-Novakovic, G. and Kaplan, D., The inflammatory reponses to silk films in vivo and in vitro, Biomaterials, 26:  147-155, 2005.

Wood, K.C., Little, S.R., Langer, R., and Hammond, P.T., A family of hierarchically self-assembling linear-dendritic hybrid polymers for highly efficient targeted gene delivery, Angewandte Chemie, 44:  2-7, 2005.

Sundback, C., Shyua, J., Wang, Y. Faquinc, W., Langer, R., Vacanti, J. and Hadlock, T., Biocompatibility analysis of poly(glycerol sebacate)as a nerveguide material, Biomaterials, 26: 5454-5464, 2005.

Anderson, D., Akinc, A., Hossain, N. and Langer, R., Structure/property studies of polymeric gene delivery using a library of poly(b-amino esters), Molecular Therapy, 11: 426-434, 2005.

LaVan, D., Padera, R., Friedmann, T., Sullivan, J., Langer, R., and Kohane, D., In vivo evaluation of tetrahedral amorphous carbon, Biomaterials, 26: 465-473, 2005.

Pfeifer, B., Burdick, J. and Langer, R., Formulation and surface modification of poly(ester-anhydride) micro- and nanospheres, Biomaterials, 26: 117-124, 2005.

Lynn, D., Anderson, D.G., Akinc, A. and Langer, R., Degradable poly(b-amino ester)s for gene delivery, Polymeric Gene Delivery:  Principles And Applications, ed: Mansoor M. Amiji, CRC Press, 1st ed., 2005, p. 227-241.

Grayson, A.C.R., Cima, M. and Langer, R., Size and temperature effects on poly(lactic acid-co-glycolic acid) degradation and microreservoir device performance, Biomaterials, 26:  2137-2145, 2005.

Kim, P., Kim, D.H., Kimb, B, Choi, S.K., Lee, H., Khademhosseini, A., Langer, R. and and Suh, K.Y., Fabrication of nanostructures of polyethylene glycol for applications to protein adsorption and cell adhesion, Nanotechnology, 16: 1-7, 2005.

George, P., Lyckman, A., LaVan, D., Hedge, A., Leung, Y., Avasare, R., Testa, C., Alexander, P., Langer, R. and Sur, M., Fabrication and biocompatibility of polypyrrole implants suitable for neural prosthetics, Biomaterials, 26:  3511-3519, 2005.

Johnson, A.M., Sadoway, D.R., Cima, M.J. and Langer, R., Design and testing of an impedance-based sensor for monitoring drug delivery, J. of the Electrochem. Soc., 152:  H6-H11, 2005.

Lahann, J. and Langer, R., Smart materials with dynamically controlled surfaces, MRS Bulletin, 30: 185-188, 2005.

Levenberg, S., Huang, N. and Langer, R., Derivation of endothelial cells from human embryonic stem cells, in Human Embryonic Stem Cells., 2005, pp137-152, G.P. Schatten, eds., Odorico, J., Zhang, S., Pedersen, R., Garland Science/BIOS Scientific Publishers.

Anderson, D., Putnam, D., Lavik, E., Mahmood, T. and Langer R., Biomaterial microarrays: Rapid, microscale screening of polymercell interaction, Biomaterials, 26:  4892-4897, 2005.

Fidkowski, C., Kaazempur-Mofrad, M., Borenstein, J., Vacanti, J., Langer, R. and Wang, Y., Endothelialized microvasculature based on a biodegradable elastomer, Tissue Engineering, 11:  302-309, 2005.

Radisic, M., Deen, W., Langer, R. and Vunjak-Novakovic, G., Mathematical model of oxygen distribution in engineered cardiac tissue with parallel channel array perfused with culture medium containing oxygen carriers, AJP:  Heart & Circulatory Physio., 288:  H1278-H1289, 2005.

Levenberg, S., Burdick, J.A., Kraehenbuehl, T. and Langer, R., Neurotrophin induced differentiation of human embryonic stem cells on three-dimensional polymeric scaffolds, Tissue Engineering, 11: 506-512, 2005.

Lendlein, A., Jiang, H., Junger, O. and Langer, R., Light-induced shape memory polymers, Nature, 434: 879-882, 2005.

Stevens, M., Mayer, M., Weibel, D., Anderson, D., Whitesides, G. and Langer, R., Direct patterning of mammalian cells onto porous tissue engineering substrates using agarose stamps, Biomaterials, 26: 7636-7641, 2005.

Langer, R., Outlook on health care and life science strategies, Greenwich Roundtable Quarterly, 2:  29-34, 2005.

Akinc, A., Thomas, M., Klibanov, A. and Langer, R., Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis, Journal of Gene Medicine, 7:  657-663, 2005.]

Levenberg, S., Rouwkema, J., Macdonald, M., Garfein, E., Kohane, D., Darland, D., Marini, R., Mulligan, R., DAmore, P. and Langer, R., Engineering vascularized skeletal muscle tissue, Nature Biotech., 23: 879-884, 2005.

Little, S., Lynn, D., Puram, S. and Langer, R., Formulation and characterization of poly-b amino ester microparticles for genetic vaccine delivery, Journal of Controlled Release, 107:  449-462, 2005.

Stevens, M., Marini, R, Schaefer, D, Aronson, J., Langer, R. and Shastri, V., In vivo engineering of organs:  The bone bioreactor, Proceedings of the National Academies of Science, 102: 11450-11455, 2005.

Yeo Y., Bellas E., Firestone, W., Langer, R and Kohane D.S., Complex coacervates for thermally sensitive controlled release of flavor compounds, Journal of Agricultural and Food Chemistry, 53: 7518-7525, 2005.

Mahmood, T., Riesle, J., Shastri, V., Van Blitterswijk, C. and Langer, R., Tissue engineering of bovine articular cartilage within porous poly(ether ester) co-polymer scaffols with different structures, Tissue Engineering, 11: 1244-1253, 2005.

Khademhosseini, A, Yeh, J., Eng, G., Karp, J., Kaji, H., Borenstein, J., Farokhzad, O. and Langer, R., Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays, Lab on a Chip, 5: 1380-1386, 2005.

Warfvinge, K., Kiilgaard, J., Lavik, E., Scherfig, E., Langer,R., Klassen, H. and Young, M., Retinal progenitor cell xenografts to the pig retina, Arch Opthalmol, 123: 1385-1393, 2005.

Khademhoseini et al., Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays, Lab on a Chip, 12: 1380-1386, 2005.

Tweedie, C.A, Anderson, D.G., Langer, R. and Van Vliet, K.J., Combinatorial material mechanics:  High-throughput polymer synthesis and nanomechanical screening, Advanced Materials, 12: 2599-2604, 2005.

Bettinger, C.J., Weinberg, E.J., Kulig, K.M., Vacanti, P., Wang, Y., Borenstein, J. and Langer, R., Three-dimensional microfluidic tissue-engineering scaffolds using a flexible biodegradable polymer, Advanced Materials, D01: 10.1002/adma.200500438.

2004

2004

Langer, R., Transdermal drug delivery:  Past progress, current status and future prospects, Adv. Drug Del. Rev., 56:  557-558, 2004.

Suh, K.Y., Seong, J., Khademhosseini, A., Laibinis, P. and Langer, R., A simple soft lithographic route to fabrication of poly(ethyleneglycol) microstructures for protein and cell patterning, Biomaterials, 25:  557-563, 2004.

Prausnitz M., Mitragotri S., Langer R., Current status and future potential of transdermal drug delivery, Nature Reviews Drug Discovery, 3:  115-124, 2004.

Stevens, M., Qanadilo, H., Langer, R., and Shastri, V., A rapid-curing alginate gel system: utility in periosteum-derived cartilage tissue engineering, Biomaterials, 25:  887-894, 2004.

Pouliot, R., Azhari, R., Qanadilo, H.F., Mahmood, T., Triantafyllou, S. and Langer R., Tissue engineering of fish skin:  Behavior of fish cells on PEGT/PBT copolymers in relation to the composition of the polymer substrate as an initial step in constructing a robotic/living tissue hybrid, Tissue Engineering, 10:  7-21, 2004.

Shastri, V.P., Padera, R.F., Tarcha, P.J. and Langer, R., A preliminary report on the biocompatibility of OrthoCure photopolymerization anhydride networks, Biomaterials, 25:  715-721, 2004.

Grayson, A., R., Johnson, A., Flynn, N., Li, Y., Cima, M., Langer, R., A bioMEMS review:  MEMS technology for physiologically integrated devices, Proceedings of the IEEE, 92:  6-21, 2004.

Radisic, M., Yang, M., Boublik, J., Cohen, R., Langer, R., Freed, L., Vunjak-Novakovic, G., Medium perfusion enables engineering of compact and contractile cardiac tissue, Am. J. Physiol. Heart Cir Physiol, 286:  H507-H516, 2004.

Meinel, L., Kareourgiou, V., Fajardo, R., Snyder, B., Shinde-Patil, V., Zichner, L., Kaplan, D., Langer, R. and Vunjak-Novakovic, G., Bone tissue engineering using human mesenchymal stem cells:  Effects of scaffold material and medium flow, Annals of Biomed. Eng., 32:  112-122, 2004.

Colombo, G., Langer, R. and Kohane, D.S., Effect of excipient composition on the biocompatibility of bupivacaine-containing microparticles at the sciatic nerve, Journal of Biomed. Mats. Rsch., 68A:  651-659, 2004.

Peppas, N. and Langer, R., Origins and development of biomedical engineering within chemical engineering, AIChE J., 50:  536-546, 2004.

Stevens, M., Flynn, N., Wang, C., Tirrell, D. and Langer, R., Coiled-coil peptide based assembly of gold nanoparticles, Adv. Materials, 16:  915-918, 2004.

Radisic, M., Park, H., Shing, H., Consi, T., Schoen, F., Langer, R., Freed, L., Vunjak-Novakovic, G., Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds, Proceedings of the National Academy of Sciences, 101:  18129-18134, 2004.

Little, S.R., Lynn, D.A., Ge, Q., Anderson, D.G., Puram, S., Chen, J., Eisen, H.N., Langer, R., Poly-b amino ester containing microparticles enhance the activity of non-viral genetic vaccines, Proceedings of the National Academy of Sciences, 101:  9534-9539, 2004.

Burdick, J., Khademhosseini, A. and Langer, R., Fabrication of gradient hydrogels using a microfluidics/ photopolymerization process, Langmuir, 20:  5153-5156, 2004.

Jia, X., Burdick, J., Kobler, J., Clifton, R., Rosowski, J., Zeitels, S and Langer, R., Synthesis and characterization of in Situ crosslinkable hyaluronic acid-based hydrogels with potential application for vocal fold regeneration, Macromolecules, 37:  3239-3248, 2004.

Khademhosseini, A., Jon, S., Suh, K.Y., Tran, T., Eng, G., Yeh, J., Seong, J. and Langer, R., Direct patterning of protein- and cell-resistant polymeric monolayers and microstructures, Advanced Materials, 15: 1995-2000, 2004.

Suh, K.Y., Khademhosseini, A., Yang, J.M., Eng, G. and Langer, R., Soft lithographic patterning of hyaluronic acid on hydrophilic substrates using molding and printing, Advanced Materials, 16:  584-588, 2004.

Wang, C., Ge, Q., Ting, D., Nguyen, D., Shen, H., Chen, J., Eisen, H., Heller, J., Langer, R. and Putnam, D., Molecularly engineered poly(ortho ester) microspheres for enhanced delivery of DNA vaccines, Nature Materials, 3:  190-196, 2004.

Langer, R. and Tirrell, D., Designing materials for biology and medicine, Nature, 428:  487-492, 2004.

Qi, Y., Zhao, G., Liu, D., Shriver, Z., Sundaram, M., Sengupta, S., Venkataraman, G., Langer, R. and Sasisekharan, R., Delivery of therapeutic levels of heparin and low-molecular-weight heparin through a pulmonary route, Proceedings of the National Academy of Sciences, 101:9867-9872, 2004.

Suh, K., Khademhosseini, A., Eng, G. and Langer, R., Single nanocrystal arrays on patterned poly(ethylene glycol) copolymer microstructures using selective wetting and drying, Langmuir, 20:  6080-6084, 2004.

Khademhosseini, A., Suh, K.Y., Yang, J.M., Eng, G., Yeh, J., Levenberg, S. and Langer, R., Layer-by-layer deposition of hyaluronic acid and poly-L-lysine for patterned cell co-cultures, Biomaterials, 25:  3583-3592, 2004.

Thomas, T., Kohane, D., Wang, A. and Langer, R., Microparticulate formulations for the controlled release of interleukin-2, J. of Pharm. Sci., 93:  1100-1109, 2004.

Anderson, D.G., Levenberg, S. and Langer, R., Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells, Nature Biotechnology, 22:  863 – 866, 2004.

Farokhzad, O., Jon, S., Khademhosseini, A., Tran, T., LaVan, D. and Langer, R., Nanoparticle-aptamer bioconjugates:  A new approach for targeting prostate cancer cells, Cancer Research, 64:  7668-7672, 2004.

Jia, X., Colombo, G., Padera, R., Langer, R. and Kohane, D.S., Prolongation of sciatic nerve blockade by in situ crosslinked hyaluronic acid, Biomaterials, 25:  4797-4804, 2004.

Grayson, A., Cima, M. and Langer, R., Molecular release from a polymeric microreservoir device:  Influence of chemistry, polymer swelling, and loading on device performance, J. Biomed. Mat. Rsch, 69:  502-512, 2004.

Yue, I., Poff, J., Cortes, M.E., Sinisterra, R., Faris, C.B., Hildgen, P., Langer, R. and Shastri, R., A novel polymeric chlorhexidine delivery device for the treatment of periodontal disease, Biomaterials, 25:  3743-3750, 2004.

Berry, D., Lynn, D.M., Sasisekharan, R. and Langer, R., Internalized heparin using poly(b-amino ester)s promote cellular uptake of heparin and cancer cell death, Chemistry & Biology, 11:  487-798, 2004.

Chen, P.C., Park, Y.J., Chang, L.C., Kohane, D.S., Bartlett, R.H., Langer, R. and Yang, V.C., Injectable microparticle-gel system for prolonged and localized lidocaine release. I:  In vitro characterization, Journal of Biomedical Materials Research, 412-419, 2004.

Lavik, E. and Langer, R., Tissue engineering:  Current state and perspectives, Applied Microbiol & Biotech., 65:  1-8, 2004.

Voskerician, G., Shawgo, R.S., Hiltner, A.P., Anderson, J.M., Cima, M.J. and Langer, R., In vivo inflammatory and wound healing effects of gold electrode voltammetry for MEMS micro-reservoir drug delivery device, IEEE Trans. Biomed. Eng., 51:  627-635, 2004.

Kushner, J., Blankschtein, D. and Langer, R., Experimental demonstration of the existence of highly permeable localized transport regions in low-frequency sonophoresis, J. Pharm. Sci, 93:  2733-2745, 2004.

Chau, Y., Tan, F. and Langer, R., Synthesis and characterization of dextran-peptide-methotrexate conjugates for tumor targeting via mediation by matrix-metalloproteinase II and matrix-metalloproteinase IX, Bioconjug. Chemistry, 15:  931-941, 2004.

Wang, C., Flynn, N. and Langer, R., Controlled structure and properties of thermoresponsive nanoparticle-hydrogel composites, Adv. Materials, 16:  1074-1079, 2004.

Langer, R., Improving drug delivery, The Scientist, 18:  44-45, 2004.

Khademhosseini, A. Yeh, J., Jon, S., Eng, G., Suh, K., Burdick, A. and Langer, R, Molded polyethylene glycol microstructures for capturing cells within microfluidic channels, Lab on a Chip, 4:  425-430, 2004.

Chen, P.C., Kohane, D.S., Park, Y.J., Bartlett, R.H., Langer, R. and Yang, V.C., Injectable microparticle-gel system for prolonged and localized lidocaine release. II:  In vivo anesthetic effects, J. Biomed. Mat. Rsch, 70:  459-466, 2004.

Anderson, D., Burdick, J. and Langer, R., Smart biomaterials, Science, 305:  1923-1924, 2004.

Levenberg, S. and Langer, R., Advances in Tissue Engineering, in Current Topics in Developmental Biology., 2004, 61: 113-134, G.P. Schatten, eds., Elsevier Academic Press.

Ijima, H., Wang, Y. and Langer, R., Spheroid formation and expression of liver specific functions of primary rat hepatocytes co-cultured with bone marrow cells, Biochem. Eng. Journal, 20:  223-228, 2004.

Khademhosseini, A., Suh, K.Y., Jon, S., Eng, G., Yeh, J., Chen, G.J. and Langer, R., A soft lithographic approach to fabricate patterned microfluidic channels, Analytical Chemistr, 76:  3675-3681, 2004.

Stevens, M., Qanadilo, H., Langer, R., Martin, I. and Shastri, V.P., FGF-2 in combination with TGF-b1 enhances periosteum derived chondrogenesis in vitro, J. Orthop. Res., 22:  1114-1119, 2004.

Meinel, L., Kareourgiou, V., Hofmann, S., Fajardo, R., Snyder, B., Li, C., Zichner, L., Langer, R., Vunjak-Novakovic, G. and Kaplan, D., Engineering bone-like tissue using human bone marrow stromal cells in 3D silk scaffolds, J. Biomed. Mat. Res., 71:  25-34, 2004.

Stevens, M., Marini, R., Martin, I., Langer, R. and Shastri, V., FGF-2 enhances TGF-beta1-induced periosteal chondrogenesis, J. of Orthopaedic Rsch., 22:  1114-1119, 2004.

Suh, K-Y., Khademhosseini, A., Yoo, P.J. and Langer, R., Patterning and separating infected bacteria using host parasite and virus antibody interactions, Biomedical Mircodevices, 6:  223-229, 2004.

Seidel, J., Pei, M., Gray, M.L., Langer, R., Freed, L. and Vunjak-Novakovic, G., Long term culture of tissue engineered cartilage in a perfused chamber with mechanical stimulation, Biorheology, 41:  445-458, 2004.

Grayson, A., Voskerician, G., Lynn, A., Anderson, J., Cima, M. and Langer R., Differential degradation rates in vivo and in vitro of biocompatibile poly(lactic acid) and poly(glycolic acid) homo- and co-polymers for a polymeric drug-delivery microchip, J of Biomat. Science, 15:  1281-1304, 2004.

Marini, R., Stevens, M., Langer, R. and Shastri, V.P., Hydraulic elevation of the periosteum:  A novel technique for periosteal harvest, J. Invest. Surg., 17:  229-233, 2004.

Anderson, D.G., Peng, W., Akinc, A., Hossain, N., Kohn, A., Padera, R., Langer, R and Sawicki, J.A., A polymer library approach to suicide gene therapy for cancer, Proceedings of the National Academy of Sciences, 101:  16028-16033, 2004.

Levenberg, S., Khademhosseini, A. & Langer, R. in Handbook of Stem Cells (ed. Lanza, R.) 737-746 (Elsevier Academic Press, 2004)

Haining, W.N., Anderson, D. G., Little, S.R., von Bergwelt-Baildon, M., Cardoso, P.A., Alves, P., Kosmatopoulos, K., Nadler, L., Langer, R. and Kohane, D.S., pH-triggered microparticles for peptide vaccination, Journal of Immunology, 173:  2578 – 2585, 2004.

Shawgo, R., Voskerician, G., Duc, H.L.H., Li, Y., Lynn, A., McEwan, M., Langer, R., Anderson, J. and Cima, M., Repeated in vivo electrochemical activation and the biological effects of microelectromechanical system drug delivery devices, J. of Biomed. Mats. Rsch., 71A:  559-568, 2004.

Meinel, L., Kaplan, D., Langer, R, Karageorgious, V, Zichner, L. and Vunjak-Novakovic, G., Engineering cartilage-like tissue using human mesenchymal stem cells and silk protein scaffolds, Biotechnology and Bioengineering, 88:  379-391, 2004.

Grovender, E., Kellogg, B., Singh, J., Blom, D., Ploegh, H., Wittrup, K.D., Langer, R. and Ameer, G., Single chain antibody fragment based adsorbent for the extracorporeal removal of b2-microglobulin, Kidney International, 65:  310-322, 2004.

Li, Y., Shawgo, R., Tyler, B., Henderson, P.T., Vogel, J.S., Rosenberg, A., Storm, P.B., Langer, R., Brem, H. and Cima, M.J., In vivo release from a drug delivery MEMS device, Journal of Controlled Release, 100:  211-219, 2004.

Mahmood, T. and Langer, R., Adhesion-mediated signal transduction in human articular chondrocytes:  The influence of biomaterial chemistry and tenascin-C, Experimental Cell Research, 301: 179-188, 2004.

Domb, A., Teomim, D., Golenser, J., Langer, R., Israel, Z., “Biodegradable polyanhydrides”, in Biodegradable Polymers, ed. R. Arshady, p. 145-146, 2004, Citrus Books, London, UK.

Jaffar, S., Nam, K.T., Khademhosseini, A., Xing, J., Langer, R., Belcher, A., Layer-by-layer surface modification and patterned electrostatic deposition of quantum dots, Nano Letters, 4: 1421-1425, 2004.

2003

2003

Lahann, J., Mitragotri, S., Tran, T., Kaido, H., Sundaran, J., Hoffer, S., Somorjai, G. A. and Langer, R. “Reversible switching of surfaces”, Science; 299: 371-374, 2003.

Lee, P., Langer, R., Shastri, V. ” Novel microemulsion enhancer formulation for simultaneous transdermal delivery of hydrophilic and hydrophobic drugs”, Pharmaceutical Research; 20: 264-269, 2003.

Sundaram, M., Qi, Y., Shriver, Z., Liu, D., Zhao, G., Venkataraman, G., Langer, R., Sasiskharan, R. “Rational design of low molecular weight heparins with improved in vivo activity”, PNAS; 100: 651-656, 2003.

Langer, R. “Where a pill won’t reach”, Scientific American; 288: 50-57, 2003.

Voskerician, G., Shive, M., Shawgo, R., Von Recum, H., Anderson, J., Cima, M., Langer, R. “Biocompatibility and biofouling of MEMS drug delivery device”, Biomaterials; 24: 1959-1967, 2003.

LaVan, D., George, P.M, Langer, R. “Simple three-dimensional microfabrication of electrodeposited structures”, Angewandte Chemie; 42: 1262-1265, 2003.

Yu, B., Kim, K.H., So, P.T.C., Blankschtein, D., Langer, R. “Visualization of oleic acid-induced transdermal diffusion pathways using two-photon fluorescence microscopy.”, Journal of Invest. Derm.; 120: 448-455, 2003.

Fu, K., Harrell, R., Zinski, K., Um, C., Frazier, J., Lotan, N., Burke, P., Klibanov, A., Langer, R. “A potential approach for decreasing the burst effect of protein from PLGA microspheres”, Journal of Pharm. Sci.; 92: 1582-1591, 2003.

Nashat, A. and Langer, R. “Temporal characteristics of activation, deactivation and restimulation of signal transduction following depolarization in the pheochromocytoma cell line PC12”, Molec. & Cell. Biol.; 23: 4788-4795, 2003.

Baroli, B., Shastri, V.P., Langer, R. “A method to protect sensitive molecules from a light-induced polymerizing environment”, Journal of Pharm. Sci.; 92: 1186-1195, 2003.

Kohane, D.S., Smith, S.E., Louis, D.N., Colombo, G., Ghoroghchian, P., Hunfeld, N.G.M., Berde, C.B. and Langer, R. “Prolonged duration local anesthesia from tetrodotoxin-enhanced localanesthetic microspheres”, Pain; 104: 415-421, 2003.

Akinc, A., Lynn, D., Anderson, D. and Langer, R. “Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery”, J. Am. Chem. Soc.; 125: 5316-5323, 2003.

Anderson, D.G., Lynn, D.M., Langer, R. “Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery”, Angewandte Chemie; 42: 3153-3158, 2003.

Radisic, M., Euloth, M., Yang, L., Langer, R., Freed, L., Vunjak-Novakovic, G. “High density seeding of myocyte cells for tissue engineering”, Biotechnology & Bioengineering; 82: 403-414, 2003.

Wang, Y., Kim, Y., Langer, R. “In vivo degradation characteristics of poly(glycerol sebacate)”, Journal of Biomedical Materials Research; 66A: 192-197, 2003.

Shastri, V., Hildgen, P., Langer, R. “In situ pore formation by differential polymer degradation”, Biomaterials; 24: 3133-3137, 2003.

Valente, A., Langer, R., Stone, H., Edwards, D.A. “Recent advances in the evelopment of an inhaled insulin product”, BioDrugs; 17: 9-17, 2003.

Putnam, D., Zelikin, A., Izumrudov, V.A. and Langer, R. “Polyhistidine-PEG: DNA nanocomposites for gene delivery”, Biomaterials; 24: 4425-4433, 2003.

Levenberg, S., Huang, N.F., Lavik, E., Rogers, A.B., Itskovitz-Eldor, J., Langer, R. ” Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds”, PNAS; 100: 12741-12746, 2003.

Grayson, A., Choi, I., Tyler, B., Wang, P., Brem, H., Cima, M.J. and Langer, R. ” Multi-pulse drug delivery from a resorbable polymeric microchip device”, Nature Materials; 2: 767-772, 2003.

Kohane, D.S., Anderson, D.G., Yu, C. and Langer, R. “pH-triggered release of macromolecules from spray-dried polymethacrylate microparticles”, Pharm. Research; 20: 1533-1538, 2003.

Suh, K., Lahann, J. and Langer, R. “Fabrication of elastomeric stamps with polymer-reinforced sidewalls via chemically selective vapor deposition polymerization of poly(p-xylylene)”, App. Phys. Ltrs.; 83: 4250-4252, 2003.

Flynn, N.T., Tran, T., Cima, M. and Langer, R. “Long term stability of self-assembled monolayers in biological media”, Langmuir; 19: 10909-10915, 2003.

LaVan, D., McGuire, T. and Langer, R. “Small-scale systems for in vivo drug delivery”, Nature Biotech.; 21: 1184-1191, 2003.

Yu, B., Blankschtein, D., Langer, R. “Evaluation of fluorescent probe surface intensities as an indicator of transdermal permeant distributions using wide-area two-photon fluorescence microscopy”, Journal of Pharm. Sci.; 92: 2354-2365, 2003.

Shastri, V., Hildgen, P., Langer, R. “In situ pore formation by differential polymer degradation”, Biomaterials; 24: 3133-3137, 2003.

Moses, M., Brem, H., and Langer, R. “Advancing the field of drug delivery: Taking aim at cancer”, Cancer Cell; 4: 337-341, 2003.

Jon, S., Anderson, D.G. and Langer, R. “Degradable poly(amino alcohol esters) as potential DNA vectors with low cytotoxicity”, Biomacromolecules; 4: 1759-1762, 2003.

Jon, S., Seong, J., Khademhosseini, A., Tran, T., Laibinis, P. and Langer, R. “Construction of nonbiofouling surfaces by polymeric self-assembled monolayers”, Langmuir; 19: 9989-9993, 2003

Lee, H., Cusick, R., Pollock, J., Utsunomiya, H., Ma, P., Langer, R., Vacanti, J. “Effect of Implantation Site on Hepatocytes Heterotopically Transplanted on Biodegradable Polymer Scaffolds”, Tissue Engineering; 9: 1227-1232, 2003.

Akinc, A., Anderson, D.G., Lynn, D.M., Langer, R. “Synthesis of poly(ß-amino esters) optimized for highly effective gene delivery”, Bioconj. Chem.; 14: 979-988, 2003.

Langer, R. and Peppas, N. “Advances in Biomaterials, Drug Delivery, and Bionanotechnology”, AIChE Journal; 49: 2990-3006, 2003.

Brant, M. “Sci-Fi War Uniforms?”, Newsweek, U.S. Edition; P E2-E4, February 24, 2003.

Berhm, D. “Technology Licensing Office has terrific year, “super Week”, MIT TechTalk; March 19, 2003.

Schwartz, P. “Speakers cite promise of biotech field”, The Daily Gazette, NY; P B9, April 4, 2003.

Aoki, N. “The Crusader”, The Boston Globe Magazine; P 12, May 25, 2003.

Weston, H. “Changing the World”, The Boston Globe Magazine; P 4 , June 29th, 2003.

McManus, R. “MIT’s Langer Offers “Blue Sky” view of Biomaterial Potential”, National Institute of Health; LV-15: 1, 6, 2003.

Thomson, E. “Stem cells “seeded” on polymer scaffold”, MIT TechTalk; October 22, 2003.

Bourzac, K. “Stem cells grown into tissues”, The Boston Globe ; October 28, 2003.

Linda Villarosa “How Much Of the Body Is Replaceable?”, New York Times; Late Edition – Final, SecF, P5, Col 5, November 11, 2003.

Henry, C. “Surface Science, Switchable Surface, Monolayer bends on command, reversibly changes properties”, Chemichal & Engineering News; 81 3 p. 6, 2003.

Thomson, E. “MIT, California Schools receive $50M grant for Army research”, MIT TechTalk; September 10, 2003.

Berhm, D. “Langer wins two prestigious prizes for biomedical advances”, MIT TechTalk; December 3, 2003.

Mishra, R. “Prizes Honor Local Scientists”, The Boston Globe; E2, December 2, 2003.

2002

2002

Kohane, D., Lipp, M., Kinney, R., Anthony, D., Louis, D., Lotan, N., Langer, R. “Biocompatibility of lipid-protein sugar particles containing bupivacaine in the epineurium”, J. Biomat. Research; 59: 450-459, 2002.

LaVan, D., Lynn, D., Langer, R. “Moving smaller in drug delivery and discovery”, Nature Drug Discovery; 1: 77-84, 2002.

Carrier, R., Rupnick, M., Langer, R., Schoen, F., Freed, L., Vunjak-Novakovic, G. “Perfusion improves tissue architecture of engineered cardiac muscle”, Tissue Engineering; 8: 175-188, 2002.

Zelikin, A., Shastri, V., Lynn, D., Farhadi, J., Martin, I., Langer, R. “Erodible conducting polymers for potential biomedical applications”, Angewandte Chemie, Int. Ed.; 41: 141-144, 2002.

Teng, Y.D., Lavik, E.B., Qu, X., Park, K., Ourednik, J., Zurakowsi, D., Langer, R., Snyder, E.Y. “Functional Recovery Following Traumatic Spinal Cord Injury Mediated by a Unique Polymer Scaffold Seeded with Neural Stem Cells”, Proc. Nat. Acad. Sci; 99: 3024-3029, 2002.

Terahara, T., Mitragotri, S., Langer, R. “Porous resins as a cavitation enhancer for low-frequency sonophoresis”, J. Pharm. Sci.; 91: 753-759, 2002.

Terahara, T., Mitragotri, S., Kost, J., Langer, R. “Dependence of Low-frequency Sonophoresis on Ultrasound Parameters; Distance of the Horn, Intensity, and Frequency”, Int. Journal Pharm. 235: 35-42, 2002.

Carrier, R., Rupnick, M., Langer, R., Schoen, F., Freed, L., Vunjak-Novakovic, G. “Effects of oxygen on engineered cardiac muscle”, Biotechnology and Bioengineering; 78: 617-625, 2002.

Cannizzaro, S. and Langer, R., “Biomaterials: Synthetic and engineering strategies”, Biomimetic materials and design: Biointerfacial Strategies, tissue engineering and targeted drug delivery, Eds: A.K. Dillow and A.M. Lowman, Marcel Dekker, Inc., NY, 251-281, 2002.

Blunk, T., Sieminski, A., Gooch, K., Courter, D., Hollander, A., Nahir, A.M., Langer, R., Vunjak-Novakovic, G., Freed, L. “Differential effects of growth factors on tissue-engineered cartilage”, Tissue Engineering; 8: 73-84, 2002.

Levenberg, S., Golub, J., Amit, M., Eldor, J., Langer, R. “Endothelial Cells Derived from Human Embryonic Stem Cells”, PNAS; 99: 4391-4396, 2002.

Akinc, A., Langer, R. “Measuring the pH environment of DNA delivered using nonviral vectors: Implications for lysosomal trafficking”, Biotechnology and Bioengineering; 78: 503-508, 2002.

Lendlein, A. and Langer, R. “Biodegradable, Elastic Thermoplastic Shape Memory Polymers with Adjustable Properties for Potential Biomedical Applications”, Science; 296: 1673 – 1676, 2002.

Lahann, J., Langer, R. “Novel Poly(p-xylylenes): Thin Films with Tailored Chemical and Optical Properties”, Macromolecules; Vol:35, 11: 4380-4386, 2002.

Wang, Y., Ameer, G.A., Sheppard, B.J., Langer, R. “A Tough Biodegradable Elastomer”, Nature Biotech; 20: 602-606, 2002.

Grovender, E., Ameer, G., Cooney, C., Langer, R. “Immunoadsorption Model for a Novel Fluidized-Bed Blood Detoxification Device”, AIChE Journal; 48:2357-2365, 2002.

Kohane, D., Plesnila, N., Thomas, S., Le, D., Langer, R., Moskowitz, M. “Lipid-sugar particles for intracranial drug delivery: Safety and biocompatibility”, Brain Research, 946: 206-213, 2002.

Katti, D.S., Lakshmi, S., Langer, R., Laurencin, C.T. “Toxicity, biodegradation and elimination of polyanhydrides”, Advanced Drug Delivery; 54: 933-961, 2002.

Kumar, N., Langer, R.S., Domb, A.J. “Polyanhydrides: An overview”, Advanced Drug Delivery Reviews; 54: 889-910, 2002.

Madry, H., Padera., R., Seidel, J., Langer, Robert, Freed, L.E., Trippel, S.B., Vunjak-Novakovic, G. “Gene transfer of human insulin-like growth factor IcDNA enhances tissue engineering of cartilage”, Human Gene Therapy, 13: 1621-1630, 2002.

Yu, B., Kim, K.H., So, P.T.C., Blankschtein, D., Langer, R. “Topographic heterogeneity in transdermal transport revealed by high speed two-photon microscopy: determination of representative skin sample sizes”, J. of Invest. Derm.; 118: 1085-1088, 2002.

Zelikin, A., Putnam, D., Shastri, P., Langer, R., Izumrudov, V. “Aliphatic ionenes as gene delivery agents: elucidation of structure – function relationship through modification of charge density and polymer length”, Bioconj. Chem., 13: 548-553, 2002.

Potineni, A., Lynn, D., Langer, R., Amiji, M. “Poly(ethylene oxide)-modified poly(b-amino ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery”, J. of Controlled Release; 86: 223-234, 2002.

Lahann, J. Rodon, T., Balcells, M., Jensen, K., Lee, C.J.Y. and Langer, R. “Reactive Polymer Coatings: A platform for patterning proteins and mammalian cells onto a broad range of materials”, Langmuir; 18: 3632-3638, 2002.

2001

2001

Papadaki, M., Mahmood, T., Gupta, P., Classe, M., Grijpma, D., Riesle, J., van Blitterswijk, C., Langer, R. “The Different Behaviors of Skeletal Muscle Cells and Chondrocytes on PEGT/PBT Block Copolymers are Related to the Surface Properties of the Substrate”, Journal of Biomedical Materials Research; 54: 47-58, 2001.

Gooch, K.J., Kwon, J.H., Blunk, T., Langer, R., Freed, L.E., Vunjak-Novakovic, G. “Effects of mixing intensity on tissue-engineered cartilage”, Biotech. and Bioeng.; 72, 4: 402-407, 2001.

Putnam, D., Gentry, C., Pack, D., Langer, R. “Polymer-based gene delivery with low cytotoxicity by a unique balance of side chain termini”, PNAS; 98: 3, 1200-1205, 2001.

Lendlein, A, Schmidt, A.M., Langer, R. “AB-Polymer networks based on oligio (?-caprolactone) segments showing shape memory properties”, PNAS; 98: 3, 842-847, 2001.

Niklason, L., Langer, R. “Prospects for Organ and Tissue Replacements”, J. Am. Med. Assoc.; 285: 573-576, 2001.

Tang, H., Mitragotri, S., Blankschtein, D., Langer, R. “Theoretical description of transdermal transport of hydrophilic permeants: application to low-frequency sonophoresis”, J. Pharm. Sci.; 90, 543-566, 2001.

Martin, I., Shastri, V., Padera, R., Yang, J., Mackay, A., Langer, R., Vunjak-Novakovic, G., Freed, L. “Selective differentiation of mammalian bone marrow stromal cells cultured on three-dimensional polymer foams”, Journal of Biomedical Materials Research; 55: 229-235, 2001.

Niklason, L., Abbott, W., Gao, J., Klagges, B., Hirschi, K., Ulubayram, K., Conroy, N., Jones, R., Vasanwala, A., Sanzgiri, S., Langer, R. “Morphologic and mechanical characteristics of engineered bovine arteries”, J. Vasc.Surg.; 33: 628-638, 2001.

Lesniak, M., Langer, R., Brem, H. “Drug delivery to tumors of the central nervous system”, Current Neurology & Neuroscience Reports; 1, 210-216, 2001.

Yu, B., Dong, C., So, P.T.C., Blankschtein, D., Langer, R. “In vitro visualization and quantification of oleic acid induced changes in transdermal transport using two-photon fuorescence microscopy”, Journal of Investigative Dermatology; 117 (1): 16, 2001.

Ameer, G., Grovender, E., Ploegh, H., Ting, D., Owen, W., Rupnick, M., Langer, R. “A novel immunoadsorption device for removing b2 microglobulin from whole blood.”, Kidney International; 59, 1544-1550, 2001.

David M. Lynn, Mansoor M. Amiji, and Robert Langer”pH-Responsive Polymer Microspheres: Rapid Release of Encapsulated Material Within the Range of Intracellular pH”, Angewandte Chemie International Edition; 40, 1707, 2001.

Mathiowitz, E., Jacob, J., Jong, Y., Spano, W., Guemonprez, R., Klibanov, A., Langer, R. “Novel desiccants based on polymeric blends”, Journal of Applied Polymer Science; 80, 317-327, 2001.

Lavik, E., Hrkach, J., Lotan, N., Nazarov, R., Langer, R. “A Simple Synthetic Route to the Formation of a Block Copolymer of Poly(lactic-co-glycolic acid) and Polylysine for the Fabrication of Functionalized, Degradable Structures for Biomedical Applications”, Journal of Biomedical Materials Research; 58, 291-294, 2001.

Lahann, J., Hocker, H., Langer, R. “Synthesis of Amino [2.2]paracyclophanes, Beneficial Monomers for Bioactive Coating of Medical Implant Materials”, Angewandte Chemie International Edition; 40, 726-728, 2001.

Hirosue, S., Muller, B., Mulligan R., Langer, R. “Plasmid DNA encapsulation and release from solvent diffusion nanospheres”, Journal of Controlled Release; 70: 231-242, 2001.

Lendlein, A, Schmidt, A.M., Langer, R. “AB-Polymer networks based on oligio(e-caprolactone) segments showing shape memory properties”, Proc. Nat. Acad. Sci; 98: 3, 842-847, 2001.

Choi, W.S., Krishnamurthy, G.G., Edwards, D.A. Langer, R., Klibanov, A.M. “Inhalation delivery of proteins from ethanol suspensions”, Proc. Nat. Acad. Sci.; 98: 11103-11107, 2001.

Mathiowitz, E., Jacob, J., Jong, Y., Hekal, T., Spano, W., Guemonprez, R., Klibanov, A., Langer, R. “Novel desiccants based on designed polymeric blends”, Journal of Applied Polymer Science; 80, 317-327, 2001.

Choi, I., Langer, R. “Surface-Initiated Polymerization of L-Lactide: Coating of Solid Substrates with a Biodegradable Polymer”, Macromolecules; 34: 5361-5363, 2001.

Grovendor, E., Cooney, C., Langer, R., Ameer, G. “Modeling the Mixing Behavior of a Novel Fluidized Extracorporeal Immunoadsorber”, Chemical Engineering Science; 56, 5437-5441, 2001.

Perez, C., Sanchez, A., Putnam, D., Ting, D., Langer, R., Alonso, M.J. “Poly(lactic acid)-poly(ethylene glycol) nanoparticles as new carriers for the delivery of plasmid DNA”, Journal of Controlled Release; 75: 211-224, 2001.

Lahann, J., Choi, I., Lee, J., Jensen, K., Langer, R. “A New Method Toward Microengineered Surfaces Based on Reactive Coating”, Angewandte Chemie; 40: 3166-3169, 2001.

Lynn, D., Mansoor, A., Langer, R. “pH-responsive polymer microsphere: Rapid release of encapsulated material within the range of intracellular pH”, Angewandte Chemie; 40: 1707-1710, 2001.

Lynn, D., Anderson, D., Putnam, D., Langer, R. “Accelerated discovery of synthetic transfection vectors: Parallel synthesis and screening of a degradable polymer library”, Journal of the American Chemical Society; 123, 8155-8156, 2001.

Langer, R. “Perspectives: Drug delivery – drugs on target”, Science; 293:58-59, 2001.

Lahann, J. and Langer, R. “Surface-initiated ring opening polymerization of e-Caprolactone from a patterned poly[(hydroxymethyl)-p-xylylene]”, Macromolec. Rapid Comm.; 22: 968-971, 2001.

Lahann, J. and Langer, R. “Microengineered surfaces for biomedical applications based on a polymeric active ester”, Polymer Reprints, 42: 113-114, 2001.

Publications: 2011 – 2021

2021

2021

Kirtane, A.R., Verma, M., Karandikar, P., Furin, J., Langer, R., Traverso, G. Nanotechnology for global health: A focus on treating infectious diseases. Nature Nanotechnology, 16: 369-389, 2021.DOI: 10.1038/s41565-021-00866-8

Mitchell, M., Billingsley, M., Haley, R., Wechsler, M., Peppas, N.A., Langer, R. Engineering precision nanoparticles for drug discovery. Nature Reviews Drug Discovery, (2):101-124, 2021. PMID: 33277608 PMCID: PMC7717100. DOI: 10.1038/s41573-020-0090-8

Caffarel-Salvador, E., Kim, S., Soares, V., Tian, R.Y., Stern, S.R., Minahan, D., Yona, R., Lu, X., Zakaria, F.R., Collins, J., Wainer, J., Jessica Wong.J., McManus, R., Tamang, S., Shane McDonnell, S., Ishida, K.,Hayward, A. Xiewen Liu, X., Hubàlek, F., Fels, F.,Vegge, A., Revsgaard Frederiksen, M., Rahbek U., Yoshitake, T., Fujimoto, J., Roxhed, N., Langer, R., Traverso, G. A microneedle platform for buccal macromolecule delivery. Science Advances, 7, 4, eabe2620, 2021. DOI: 10.1126/sciadv.abe2620

Sadeghi, I., Byrne, J., Shakur, R., Langer, R. Addressing global health challenges through novel materials in drug delivery.  Journal of Controlled Release, 331: 503-514, 2021. PMID: 33516755PMCID: PMC7842133 DOI: 10.1016/j.jconrel.2021.01.035

Reker, D., Rybakova, Y., Kirtane, A., Cao, R., Yang, J.W., Navamajiti, N., Gardner, A., Zhang, R., Esfandiary, T., L’Heureux, J., Von Erlach, T., Smekalova, E., Leboef, D., Hess, K., Lopes, A., Rogner, J., Collins, J., Tamang, S., Ishida, K., Chamberlain, P., Yun, D., Lytton-Jean, A., Soule, C., Cheah, J., Hayward, A., Langer, R., Traverso, G. Computationally guided high-throughput design of self-assembling drug nanoparticles. Nature Nanotechnology, 2021. DOI:10.1038/s41565-021-00870-y

Mirvakili, S., Langer, R. Wireless on-demand drug delivery. Nature Electronics, 2021. DOI: 10.1038/s41928-021-00614-9

Talebian, S., Rodrigues, T., das Neves, J., Sarmento, B., Langer, R., Conde, J. Facts and figures about nanotechnology in the past 20 years.  Nature Nanotechnology, 2021. DOI: 10.1021/acsnano.1c03992

Abramson, A., Frederiksen, M., Vegge, A., Jense, B., Poulsen, M., Mouridsen, B., Jespersen, M., Kirk, R., Windum, J.,Hubalek, F., Water, J., Fels, J., Gunnarson, S., Ley, M., Bohn, A., Straarup, E., Lu, X., Wainer, J., Collins, J., Tamang, S., Ishida, K., Hayward, A., Herskind,P., Buckley, S., Roxhed, N., Langer, R., Rahbek, U., Traverso, G. Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors. Nature Biotechnology, 2021. DOI: 10.1038/s41587-021-01024-0

Yang, K., O’Cearbhaill, E.D., Liu, S.S., Zhou, A., Chitnis, G.D., Hamilos, A.E., Xu, J., Verma, M.K.S., Giraldo, J.A., Kudo, Y., Lee, E.A., Lee, Y., Pop, R., Langer, R., Melton, D.A., Greiner, D.L., Karp, J.M.A therapeutic convection enhanced macroencapsulation device for enhancing β cell viability and insulin secretion. Proceedings of National Academy of Sciences, 2021. 118 (37) e2101258118; DOI/10.1073/pnas.2101258118 PMID: 34504013

Langer, R., Gupta, A., Andresen, J., Manan, R. Nucleic acid delivery for therapeutic applications. Advanced Drug Delivery Reviews, 2021. https://doi.org/10.1016/j.addr.2021.113834 PMID: 34492233

Hou, X., Zaks, T., Langer, R., Dong, Y. Lipid nanoparticles for mRNA delivery. Nature Review Materials, 2021. https://doi.org/10.1038/s41578-021-00358-0

Ragelle, H., Rahimian, S., Guzz, E., Westenskow, Tibbit, M., Schwach, G, Langer, R. Additive manufacturing in drug delivery: innovative drug product design and opportunities for industrial application. Advanced Drug Delivery Review, 178:113990., 2021. DOI: 10.1016/j.addr.2021.113990 PMID: 34600963

Dong, Y., Hou, X., Zaks, T., Langer, R. Lipid nanoparticles for mRNA delivery. Nature Reviews Materials, 2021, DOI: 10.1038/s41578-021-00358-0

France, M.M., del Rio, T., Travers, H., Raftery, E., Langer, R., Traverso, G., Schoellhammer, C.M. Platform for the delivery of unformulated RNA in vivo. Journal of Pharmaceutical Sciences, in press. DOI: https://doi.org/10.1016/j.xphs.2021.12.008

 

2020

2020

Raman, R., Hua, T., Gwynne, D., Collins, J., Tamang, S., Zhou, J., Esfandiary, T., Soares, V., Pajovic, S., Hayward, A., Langer, R., Traverso, G. Light-degradable hydrogels as dynamic triggers for gastrointestinal applications. Science Advances, 6:eaay0065, 2020. PMID32010768; PMC6968934; DOI: 10.1126/sciadv.aay0065

Yu, J., Wang, J., Zhang, Y., Chen, G., Mao, W., Ye, Y., Kahkoska, A., Buse, J., Langer, R., Gu, Z. Glucose-responsive smart insulin patch for blood glucose regulation in mice and pigs, Nature Biomedical Engineering, 499–506, 2020. DOI:10.1038/s41551-019-0508-y

Sarmadi, M., Behrens, A.M., McHugh, K.J., Contreras, H., Tochka, Z., Lu, X., Langer, R., Jaklenec, A. Modeling, design, and machine learning-based framework for optimal injectability of microparticle-based drug formulations.  Science Advances, 2020.  DOI: 10.1126/sciadv.abb6594

Volpatti, L., Matranga, M.A., Cortinas, A.B., Delcassian, D., Daniel, K., Langer, R., Anderson, D., Glucose-responsive nanoparticles for rapid and extended self-regulated insulin delivery, ACS Nano, 14 (1): 488-497, 2020. DOI: 10.1021/acsnano.9b06395. PMID: 31765558

Mirvakili, S., Sim, D., Hunter, I., Langer, R. Actuation of untethered pneumatic artificial muscles and soft robots using magnetically induced liquid-to-gas phase transitions. Science Robotics, 5(41):eaaz4239. DOI: 10.1126/scirobotics.aaz42392020. PMID: 33022626

Mirvakili, S., Ngo, Q.P., Langer, R. Polymer nanocomposite microactuators for on-demand chemical release via high-frequency magnetic field excitation. Nano Letters, 2020, 4816-4822 DOI: 10.1021/acs.nanolett.0c00648 PMC7349659. PMID: 32479730

Srinivasan, S., Ramadi. K., Vicario, F., Gwynne, D., Hayward, A., Lagier, D., Langer, R., Frassica, J., Baron, R., Traverso, G. A rapidly deployable individualized system for augmenting ventilator capacity. Science Translational Medicine, 2020. PMID32424018; PMC7259824; DOI: 10.1126/scitranslmed.abb9401

Wood, M., Langer, R., Roberts, T. Advances in oligonucleotide drug delivery. Nature Reviews Drug Discovery, 2020. DOI: 10.1038/s41573-020-0075-7

Lu, X., Miao, L., Gao, W., Chen, Z., McHugh, K., Sun, Y., Tochka, Z., Tomasic, S., Sadtler, K., Hyacinthe, A.,  Huang, Y., Graf, T., Hu, Q., Sarmadi, M., Langer, R., Anderson, D., Jaklenec, A. Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy.  Science Translational Medicine, 2020. DOI: 10.1126/scitranslmed.aaz6606

Sadtler, K., Collins, J., Byrne, J., Langer, R. Parallel evolution of polymer chemistry and immunology: integrating mechanistic biology with materials design. Advanced Drug Delivery Reviews, 2020. doi.org/10.1016/j.addr.2020.06.021

Patel, A, Kaczmarek, J, Bose, S, Kauffman, K, Mir, F, Heartlein, M, DeRosa, F, Langer, R, and Anderson, D, Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium, Advanced Materials, PMID: 30609147 DOI: 10.1002/adma.201805116

Von Erlach, T., Saxton, S., Shi, Y., Minahan, D., Reker, D., Javid. F., Lee, Y.L., Schoellhammer, C., Esfandiary, T., Cleveland, C., Booth, L. Lin, J. Levy, H., Blackburn, S., Hayward, A., Langer, R., Traverso, G. Robotically handled whole-tissue culture system for the screening of oral drug formulations. Nature Biomedical Engineering, 4, 544–559, 2020. DOI:10.1038/s41551-020-0545-6

Reker, D., Shi, Y., Kirtane, A.R.., Hess, K., Zhong, G.J., Crane, E., Lin, C., Langer, R., Traverso, G. Machine learning uncovers food-and-excipient-drug interactions. Cell Reports,  30, 3710–3716, 2020. DOI:10.1016/j.celrep.2020.02.094 PMID: 32187543 PMCID: PMC7179333

Li, J., Liang, Y.J., Laken, S., Langer, R., Traverso, G. Clinical opportunities for continuous biosensing and closed-loop therapies. Trends in Chemistry, 2 (4): 319-340, 2020. DOI:10.1016/j.trechm.2020.02.009

Rudra, A., Li, J., Shakur, R., Bhagchandani, S., Langer, R. Trends in therapeutic conjugates: bench to clinic, Bioconjugate Chemistry, 31 (3), 462-473, 2020. DOI: 10.1021/acs.bioconjchem.9b00828

Verma, M., Chu, J., Salama, J., Faiz, M., Eweje, F., Gwynne, D., Lopes, A., Hess, K., Soares, V., Steiger, C., McManus, R., Koeppen, R., Hua, T., Hayward, A., Collins, J., Tamang, S.M., Ishida, K., Miller, J., Katz, S., Slocum, A.H., Sulkowski, M.S., Thomas, D.L., Langer, R., Traverso, G. Development of a long-acting direct-acting antiviral system for Hepatitis C virus treatment in swine.  Proceedings of the National Academies of Sciences, 117 (22) 11987-11994, 2020. DOI: 10.1073/pnas.2004746117

Sarmadi, M., Behrens, A., Kevin J. McHugh, K., Contreras, H., Tochka, Z., Lu, X., Langer, R., Jaklenec, A.  Modeling, design, and machine learning-based framework for optimal injectability of microparticle-based drug formulations.  Science Advances, 6:8, eabb6594, 2020. DOI: 10.1126/sciadv.abb6594

Haley RM, Gottardi R, Langer R, Mitchell MJ. Cyclodextrins in drug delivery: applications in gene and combination therapy. Drug Delivery Translational Research, 10:661- 677, 2020. PMID32077052 DOI:10.1007/s13346-020-00724-5

Wei, T., Cheng, Q., Farbiak, L., Anderson, D.G., Langer, R.,. Siegwart, D.J. Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing .  ACS Nano, 2020, DOI: 10.1021/acsnano.0c04707 NIHMSID:1665693; PMID:32697075

Saunders N.R.M., Paolini M.S., Fenton O.S., Poul L., Devalliere J., Mpambani F., Darmon A., Bergere M., Jibault O., Germain M., Langer R. A Nanoprimer To Improve the Systemic Delivery of siRNA and mRNA. Nano Letters, 20:4264-4269, 2020. PMID32357299; DOI: 10.1021/acs.nanolett.0c00752

Ramadi, K., Dagdeviren, C., Bhagchandani, P.; Nunez-Lopez, C., Kim, M. Langer, R., Graybiel, A., Cima, M. Simultaneous recording and marking of brain microstructures.  Journal of Neural Engineering, 17 :044001, 2020.  DOI:10.1088/1741-2552/aba161

Bose, S., Volpatti, L., Thiono, D., Yesilyurt, V., McGladrigan, C., Tang, Y., Facklam, A., Wang, A., Jhunjhunwala, S, Veiseh, O., Hollister-Lock, J., Bhattacharya, C., Weir, G., Greiner, D., Langer, R., Anderson, D. A retrievable implant for the long-term encapsulation and survival of therapeutic xenogeneic cells. Nature Biomedical Engineering, 4: 814-826, 2020.  DOI:10.1038/s41551-020-0538-5

Steiger, C., Phan, N., Sun, H., Huang, H., Hess, K., Lopes, A., Korzenik, J., Langer, R., Traverso, G. Controlled delivery of bile acids to the colon. Clinical and Translational Gastroenterology, 11: e00229, 2020. https://doi.org/10.14309/ctg.0000000000000229

Tang,  Z., Kong, N., Zhang, X.,  Liu,Y. Ping Hu, P., Mou, S.,Liljeström, P., Shi, P.J.,  Tan, W., Kim,  J.S., Cao,  Y., Langer, R., Leong,  K., O Farokhzad, O., Tao, W. A materials science perspective on tackling COVID-19, Nature Review Materials, 5: 847–860, 2020.

Schwerdt, H., Amemori, K., Gibson, D., Stanwicks, L., Yoshia, T., Bichot, N., Amemori, S., Desimone, R., Langer, R., Cima, M., Graybiel, A. Dopamine and beta-band oscillations differentially linked to striatal value and motor control, Science Advances, 6:39, eabb9226, 2020. DOI: 10.1126/sciadv.abb9226

Krohn-Grimberghe, M., Mitchell, M., Schloss, M., Khan, O., Courties, G., Guimares, P., Rohde, D., Cremer, S., Kowalski, P., Sun, Y., Tan, M., Webster, J., Wang, K., Iwamoto, Y., Schmidt, S., Wojtkiewicz, Nayar, R., Frodermann, V., Hulsmans, M., Chung, A., Hoyer, F., Swirski, F., Langer, R., Anderson, D., Nahrendorf, M. Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche. Nature Biomedical Engineering, 4: 1076-1089, 2020.  PMID: 33020600. PMCID: PMC7655681; DOI:10.1038/s41551-020-00623-7

Raman, R., Rousseau, E.B., Wade, M. ,Tong, A., Cotler, M.J., Kuang, J., Aponte Lugo, A., Zhang, E., Graybiel, A.M., White, F.M, Langer, R., Cima, M.J. Platform for micro-invasive membrane e-free biochemical sampling of brain interstitial fluid, Science Advances, 2020, DOI: 10.1126/sciadv.abb0657

Chu, C. K,, Joseph, A.J., Limjoco, M.D., Yang, J., Bose, S., Thapa, L.S., Langer, R., Anderson, D.G.Chemical tuning of fibers drawn from extensible hyaluronic acid networks. Journal of the American Chemical Society, 46: 42,  19715-19721, 2020. DOI: 10.1021/jacs.0c09691.

Edwards, D., Ausiello, D., Salzman, J., Devlin, T., Langer, R., Beddingfield, B., Fears, A., Doyle-Meyers, L., Redmann, R., Killeens, S., Maness, N., Roy, C. Exhaled aerosol increases with COVID-19 infection, age and obesity.  Proceedings of the National Academies of Sciences, 2021. DOI: 10.1073/pnas.2021830118

Abramson, A., Della, D., Kong, Y.L., Zhou, J., Gao, Y., Collins, J., Tamang, S., Wainer, J., McManus, R.,Hayward, A., Frederiksen, M.R., Water, J.J., Jensen, B., Roxhed, N., Langer, R., Traverso, G. Ingestible transiently anchoring electronics for microstimulation and conductive signaling. Science Advances, 6:35, eaaz0127, 2021. DOI: 10.1126/sciadv.aaz0127

Tang,  Z., Kong, N., Zhang, X.,  Liu,Y. Ping Hu, P., Mou, S.,Liljeström, P., Shi, P.J.,  Tan, W., Kim,  J.S., Cao,  Y., Langer, R., Leong,  K., O Farokhzad, O., Tao, W. A materials science perspective on tackling COVID-19, Nature Review Materials, 1:14, 2020. 1–14. DOI: 10.1038/s41578-020-00247-y PMCID: PMC7556605. PMID: 33078077

Li, W., Qiu, J., Li, X., Aday, S., Zhang, J., Conley, G., Xu, J., Langer, R., Mannix, R., Karp, J.M., Joshi, N. BBB pathophysiology independent delivery of siRNA in traumatic brain injury. Science Advances, 2020. DOI: 10.1101/2020.06.26.173393

2019

2019

Verma, M., Furin, J., Langer, R., Traverso, G. Making the case: developing innovative adherence solutions for the treatment of tuberculosis. BMJ Global Health, 4:e001323. Doi:10.1136/bmjgh-2018-001323, 2019.

Glinel, K., Behrens, A., Langer, R., Jaklenec, A., Jonas, A., Nanofibrillar Patches of Commensal Skin Bacteria. Biomacromolecules, 20: 102-108, 2019. DOI: 1021/acs.biomac.8b00735 PMID: 29979873

Patel, A, Kaczmarek, J, Bose, S, Kauffman, K, Mir, F, Heartlein, M, DeRosa, F, Langer, R, and Anderson, D, Inhaled nanoformulated mRNA polyplexes for protein production in lung epithelium, Adavanced Materials, 2019. PMID: 30609147 DOI: 1002/adma.201805116

Ayoob, A., Peppi, M., Tandon, V., Langer, R., Borenstein, J., Intracochlear drug delivery: Fluorescent tracer evaluation for quantification of distribution in the cochlear partition, European Journal of Pharmaceutical Sciences, 126: 49-58, 2019.

Babaee, S., Pajovic, S., Kirtane, A., Shi, J., Caffarel-Salvador, E., Hess, K., Collins, J., Tamang, S., Wahane, A., Hayward, A., Mazdiyasni, H., Langer, R. and Traverso, G., Temperature responsive biometamaterials for gastrointestinal applications, Science Translational Medicine, 11: eaau8581, 2019.

Verma, M., Vishwanath, K., Eweje, F., Roxhed, N., Grant, T., Castaneda, M., Steiger, C., Mazdiyasni, H., Bensel, T., Minahan, D., Soares,V., Lopes, A., Hess, K., Cleveland, C., Fulop, D., Hayward, A., Collins, J., Tamang, S., Hua, T., Ikeanyi, C., Zeidman, G., Mule, E., Boominathan, S., Popova, E., Bellinger, A., Collins, D., Leibowitz, D., Batra, S., Ahuja, S., Bajiya, M., Batra, S., Sarin, R., Agarwal, U., Khaparde, S., Gupta, K., Gupta, D., Bhatnagar, A., Chopra, K., Sharma, N., Khanna, A., Chowdhury, J., Stoner, R., Slocum, A., Cima, M., Furin, J., Langer, R., Traverso, G., A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment. Science Translational Medicine, 11: eaau6267, 2019.

Abramson, A., Caffarel-Salvador, E., Khang, M., Dellal, D. Silverstein, D., Gao, Y., Frederiksen, M., Vegge, A., Hubalek, F., Water, J., Friderichsen, A., Fels, J., Kirk, R., Cleveland, C., Collins, J., Tamang, S., Hayward, A., Landh, T., Buckley, S., Roxhed, N., Rahbek, U., Langer, R., and Traverso, G., An ingestible self orienting systems for oral delivery of macromolecules, Science, 363: 611-615, 2019.

Chauhan, V., Chen, I., Tong, R., Ng, M., Martin, J., Naxerova, K., Wu, M., Huang, P., Boucher, Y., Kohane, D., Langer, R. and Jain, R., Reprogramming the microenvironment with tumor selective angiotensin blockers enhances cancer immunotherapy, Proceedings of the National Academy of Sciences, doi.org/10.1073/pnas.1819889116, 2019.

Anderson, D., Spanoudaki, V., Doloff, J., Huang, W., Norcross, S., Langer, R., Simultaneous spatiotemporal tracking and oxygen sensing of transient implants in vivo using hot-spot MRI and machine learning, Proceedings of the National Academy of Sciences, 116: 4861-4870, 2019.

Chen, I., Chauhan, V., Posada, J., Ng, M., W., M., Adstamongkonkul, P., Huang, P., Lindeman, N., Langer, R., and Jain, R., Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration and improves immunotherapy in metastatic breast cancer, Proceedings of the National Academy of Sciences, 116: 4558-4566, 2019.

Riley, R., June, C., Langer, R., Mitchell, M. Delivery technologies for cancer immunotherapy. Nature Reviews Drug Discovery 18:175-197, 2019.

Langer, R. Controlling the movement of molecules. Quarterly Reviews of Biophysics, 52, E5. doi:10.1017/S0033583519000040, 2019.

Larson, B., Yu, S., Park, H., Estes, B., Moutos, F., Bloomquist, C., Wu, P., Welter, J., Langer, R., Guilak, F., Freed, L., Cartilaginous and osteochondral tissue formation by human mesenchymal stem cells on three-dimensionally woven scaffolds, Biomaterials, 2019.

Farah, S., Doloff, J., Müller, P., Sadraei, A., Han, H-J., Olafson, K., Vyas, K., Tam, H-H., Hollister-Locke, J., Griffin, M., Meng, A., McGarrigle, J., Oberholzer, J., Weir, G., Greiner, D.L., Langer, R., Anderson, D.G., Long-Term Implant Fibrosis Prevention in Rodents and Non-Human Primates Using Crystallized Drug Formulations, Nature Materials, 18: 892-904, 2019.

Langer, R. Chemical and biological approaches to regenerative medicine and tissue engineering. Molecular Frontiers Journal, 3:2, 2019.

Larson, B., Yu, S., Park, H., Estes, B., Moutos, F., Bloomquist, C., Wu, P., Welter, J., Langer, R., Guilak, F., Freed, L., Chondrogenic, hypertrophic, and osteochondral differentiation of human mesenchymal stem cells on three-dimensionally woven scaffolds, Tissue Engineering and Regenerative Medicine, 2019.

Raman, R., Langer, R., Biohybrid design gets personal: new materials for patient-specific therapy, Advanced Materials, 2019.

McAvoy, M., Tsosie, J, Vyas, K, Khan, O, Sadtler, K, Langer, R., Anderson, D. Flexible multielectrode array for skeletal muscle conditioning, acetylcholine receptor stabilization and epimysial recording after critical peripheral nerve injury. Theranostics, 9 (23): 7099-7107, 2019. DOI: 7150/thno.35436 PMID: 31660089 PMCID: PMC6815960

Miao, L., Li, L., Huang, Y., Delcassian, D., Chahal, J., Han, J., Shi, Y.,  Sadtler, K.,  Gao, W., Lin, J., Doloff, J., Langer, R., Anderson, D., Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation. Nature Biotechnology, 37, 1174-1185, 2019.  DOI: 10.1038/s41587-019-0247-3

Pang, Y., Liu, J., Moussa, Z., Collins, J., McDonnell, S., Hayward, A., Jajoo, K., Langer, R., Traverso, G. Endoscopically-injectable shear-thinning hydrogels facilitating polyp removal. Advance Science (Weinh), 6 (19): 1901041, 2019. DOI: 10.1002/advs.201901041 PMCID: PMC6774062 PMID: 31592420

Cotler, M., Rousseau, E., Ramadi, K., Fang, J., Graybiel, A., Langer, R., Cima, M. Steerable microinvasive probes for localized drug delivery to deep tissue, Small, 2019.

Traverso, G., Abramson, A., Caffarel-Salvador, E., Soares, V., Minahan, D., Lu, X., Tian, R., Dellal, D., Gao, Y., Kim, S., Wainer, J., Collins, J., Tamang, S., Hayward, A., Yoshitake, T., Lee, H., Fujimoto, J., Fels, J., Frederiksen, M., Rahbek, U., Roxhed, N., Langer, R., A luminal unfolding microneedle injector for oral delivery of macromolecules, Nature Medicine, 25: 1512-1518, 2019.

Anselmo, A,C., Xu, X., Buerkli, S., Zeng, Y., Tangm W., McHugh,K.J., Behrens, A.M., Rosenberg, E., Duan, A.R., Sugarman, J.L., Zhuang, J., Collins, J., Lu, X., Graf, T., Tzengm S.Y., Rose, S., Acolatse, S., Nguyenm T.D., Le, X., Guerra, A.S., Freed, L.E., Weinstock, S.B., Sears, C.B., Nikolic, B., Woodm L., Welkhoff, P.A., Oxley, J.D., Moretti, D., Zimmermann, M.B., Langer, R., Jaklenec, A. A heat-stable microparticle platform for oral micronutrient delivery. ScienceTranslational Medicine, PMID31723037; DOI:10.1126/scitranslmed.aaw3680

Mirvakili, S.M., Broderick, K., Langer, R. A new approach for micro-fabrication of printed circuit boards with ultra-fine traces, ACS Appl. Mater. Interfaces, 2019, 11 (38), 35376-35381 DOI: 10.1021/acsami.9b08761

Kirtane, A., Hua, T., Hayward, A., Bajpayee, A., Wahane, A., Lopes, A., Bensel, T., Ma, L., Stanczyk, F., Brooks, S., Gwynne, D., Wainer, J., Collins, J., Tamang, S., Langer, R., Traverso, G., A once a month oral contraceptive, Science Translational Medicine, 2019 DOI: 10.1126/scitranslmed.aay2602

Lee, M.; Duarte, C.; Eguiluz, VM; Heller, D., Langer, R.; Meekan, M., Sikes, H., Srivastava, M.; Strano, M.; Wilson, R. Can fish and cell phones teach us about our health?, ACS Sensors, 2019, 4(10), 2566-2570 DOI: 10.1021/acssensors.9b00947 PMID: 31576740

Smekalova, E., Gerashchenko, M., O’Connor, P., Whittaker, C., Kauffman, K., Fefilova, A., Zatsepin, T., Bogorad, R., Baranov, P., Langer, R., Gladyshev, V., Anderson, D., Koteliansky, V, In vivo RNAi mediated eIF3m knockdown is associated with alterations in ribosome biogenesis, but has limited affect on mRNA translation, Molecular TherapyNucleic Acids, 2019org/10.1016/j.omtn.2019.11.009. PMID: 31855834 PMCID: PMC6926209

Fenton, O., Tibbitt, M., Appel, E., Jhunjuhnwala, S., Webber, M., R. Langer. Injectable polymer-nanoparticle hydrogels for local immune cell recruitment, Biomacromolecules, 2019. 20(12), 4430-4436 DOI: 10.1021/acs.biomac.9b01129

Beh, C., Farah, S., Langer, R., Jaklenec, A. (2019) Chapter 12: Methods for Sterilization of Biopolymers for Biomedical Applications. In A.J. Domb, K.R. Kunduru, and S. Farah (eds). Biomaterials Science Series No. 5.  Antimicrobial Materials for Biomedical Applications (5th edition). Royal Society of Chemistry, London, United Kingdom

Bouthillette, M., Beccati, D., Akthakul, A., Ramadurai, N., Nashat, A., Langer, R., Anderson, R.R., Sakamoto, F.H. A crosslinked polymer skin barrier film for moderate to severe atopic dermatitis: A pilot study in adults. Journal of the American Academy of Dermatolology, 82:895-901, 2019. PMID31589946; DOI: 10.1016/j.jaad.2019.09.073

McHugh, K.J., Jing, L., Severt ,S.Y., Cruz, M., Sarmadi ,M., Jayawardena ,H.S.N., Perkinson, C.F., Larusson, F., Rose S., Tomasic, S,. Graf, T., Tzeng, S.Y., Sugarman,, J.L., Vlasic, D., Peters, M., Peterson, N,. Wood L., Tang, W., Yeom, J., Collins, J., Welkhoff, P.A., Karchin, A., Tse, M., Gao, M,. Bawendi, M.G. Langer, R., Jaklenec, A. Biocompatible near infrared quantum dots delivered to the skin by microneedle patches record vaccination. Science Translational Medicine, 2019. PMID31852802 DOI: 10.1126/scitranslmed.aay7162

2018

2018

Kauffman, K., Oberli, M., Dorkin, J. R., Hurtado, J., Kaczmarek, J., Bhadani, S., Wycokoff, J., Langer, R., Jaklenec, A. and Anderson, D., Rapid single cell analysis and discovery of vectored mRNA transfection in vivo and with a loxP-flanked tdTomato reporter mouse, Molecular Therapy Nucleic Acids, 10: 55-63, 2018.

Mikulskis, P., Hook, A., Dundas, A., Irvine, D., Sanni, O., Anderson, D., Langer, R., Alexander, M., Williams, P., Winkler, D. Prediction of broad-spectrum pathogen attachment to coating materials for biomedical devices, ACS Applied Materials and Interfaces, 10: 139-149, 2018.

Tong, Z., Martyn, K., Yang, A., Yin, X., Mead, B., Joshi, N., Sherman, N., Langer, R. and Karp, J., Towards a defined ECM and small molecule based monolayer culture system for the expansion of mouse and human intestinal stem cells, Biomaterials, 154: 60-73, 2018.

Bisso, P., Tai, M., Katepalli, H., Bertrand, N., Blankschtein, D., Langer, R., Molecular rotors for universal quantitation of nanoscale hydrophobic interfaces in microplate format, Nano Letters, 18: 618-628, 2018.

Kowalski, P., Palmiero, U., Huang, Y., Rudra, A., Langer, R. and Anderson, D., Ionizable amino-polyesters synthesized via ring opening polymerization of tertiary amino-alcohols for tissue selective mRNA delivery, Advanced Materials, 30: 1801151, 2018.

Li, Z., Behrens, A., Ginat, N., Tzeng, S., Lu, X., Sivan, S., Langer, R. and Jaklenec, A., Probiotics: Biofilm inspired encapsulation of probiotics for the treatment of complex infections, Advanced Materials, 30: 1803925, 2018.

Shankar, G., Kirtane, A., Miller, J., Mazdiyasni, H., Rogner, J., Tai, T., Williams, E., Higuchi, F., Jurati, T., Tateishi, K., Koerner, M., Tummala, S., Fink, A., Penson, T., Schmidt, S., Wojtkiewicz, G., Baig, A., Francis, J., Rinne, M., Batten, J., Batchelor, T., Brastianos, P., Curry, W., Barker, F., Jordan, J., Iafrate, J., Chi, A., Lennerz, J., Meyerson, M., Langer, R., Wakimoto, H., Traverso, G. and Cahill, D., Proceedings of the National Academy of Sciences, 36: E8388-E8394, 2018.

Chertok, B. and Langer, R., Circulating magnetic microbubbles for localized real time control of drug delivery by ultrasonography guided magnetic targeting and ultrasound, Theranostics, 8: 341-357, 2018.

Kirtane, A., Abouzid, O., Minahan, D., Bensel, T., Hill, A.L., Selinger, C., Bershteyn, A., Craig, M., Mo, S.S., Mazdiyasni, H., Cleveland, C., Rogner, J., Lee, Y., Booth, L., Javid, F., Wu, S., Grant, G., Bellinger, A., Nikolic, B., Hayward, A., Wood, L., Eckhoff, P.A., Nowak, M., Langer, R., Traverso, G., Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy, Nature Communications, 9(2), DOI:10.1038/s41467-017-02294-6, 2018.

Dagdeviren, C., Ramadi, K., Joe, P., Spencer, K., Schwerdt, H., Shimazu, H., Delcasso, S., Amemori, K-I., Lopez, C., Graybiel, A., Cima, M., Langer, R., Miniaturized neural system for chronic, local intracerebral drug delivery, Science Translational Medicine, 10(425), eaan2742, 2018.

Ragelle, H., Tibbitt, M., Wu, S., Castillo, M., Cheng, G., Gangadharan, S., Anderson, D., Cima, M. and Langer, R., Surface tension-assisted additive manufacturing, Nature Communications, 9(1184), DOI: 10.1038/s41467-018-03391-w, 2018.

Jonas, A., Glinel, K., Behrens, A., Anselmo, A., Langer, R. and Jaklenec, A., Controlling the Growth of Staphylococcus epidermidis by Layer-by-Layer Encapsulation, ACS Applied Materials & Interfaces DOI: 1021/acsami.8b01988, 2018.

McHugh, K., Jing, L., Behrens, A., Jayawardena, S., Tang, W., Gao, M., Langer, R. and Jaklenec, A., Biocompatible semiconductor quantum dots as cancer imaging agents, Advanced Materials, 30(18), 1706356, 2018.

Langer, R., Kirtane, A., Schoellhammer, C., and Traverso, G., Convergence for translation, Angewandte Chemie, 57: 2156-4163, 2018.

Kauffman, K, Oberli, M, Dorkin, JH, Kaczmarek, J, Bhadani, S, Wyckoff, J, Langer, R, Jaklenec, A, Anderson, D, Rapid, single-cell analysis and discovery of vectored mRNA transfection in vivo with a loxP flanked tdTomato reporter mouse, Molecular Therapy – Nucleic Acids, 10: 55–63, 2018.

Sharma, U, Concagh, D, Core, L, Kuang, Y, You, C, Pham, Q, Zugates, G, Busold, R, Webber, S, Merlo, J, Langer, R, Whitesides, G, Palasis, M, The development of bioresorbable composite polymeric implants with high mechanical strength, Nature Materials, 17: 96–103, 2018.

Kang, S., Ji, Z., Tseng, L., Turner, S., Villanueva, D., Johnson, R., Albano, A., Langer, R., Design and synthesis of waterborne polyurethanes, Advanced Materials, 30(18), 1706237, 2018.

Yin, H., Song, C., Sureshy, S., Kwan, S., Wu, Q., Walsh, S., Ding, J., Bogorad. R.L., Zhu, L.J., Wolfe, S.A., Koteliansky, V., Xue, W., Langer, R. and Anderson, D.G., Partial DNA-guided Cas9 enables genome editing with reduced off-target activity, Nature Chemical Biology, 14: 311-316, 2018.

Ramadi, K., Dagdeviren, C., Spencer, K., Joe, P., Cotler, M., Rousseau, E., Nunez-Lopez, C., Graybiel, A., Langer, R., Cima, M., Focal, remote-controlled, chronic chemical modulation of brain microstructures, Proceedings of the National Academy of Sciences, 115: 7254-7259, 2018.

Guimaraes, P.P.G., Gaglione, S., Sewastianik, T., Carrasco, R.D., Langer, R. and Mitchell, M.J., Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy, ACS Nano, 12(2): 912-931, 2018.

Mead, B.E., Ordovas-Montanes, J., Braun, A.P., Levy, L.E., Bhargava, P., Szucs, M.J., Ammendolia, D.A., MacMullan, M.A., Yin, X., Hughes, T.K., Wadsworth II, M.H., Ahmad, R., Rakoff-Nahoum, S., Carr, S.A., Langer, R., Collins, J.J., Shalek, A.K. and Karp, J.M., Harnessing single-cell genomics to improve the physiological fidelity of organoid derived cell types, BMC Biology, 16:62, 2018

Ferber, S., Behrens, A.M., McHugh, K.J., Rosenberg, E.M., Linehan, A.R., Sugarman, J.L., Jayawardena, H.S.N., Langer, R., Jaklenec, A., Evaporative cooling hydrogel packaging for storing biologics outside of the cold chain, Advanced Healthcare Materials, 1800218, 2018.

Xie, X., Doloff, J., Yesilyurt, V., Sadraei, A., McGarrigle, J., Omami, M., Veiseh, O., Farah, S., Isa, D., Ghani, S., Joshi, I., Vegas, A., Li, J., Wang, W., Bader, A., Tam, H., Tao, J., Chen, H., Yang, B., Williamson, K., Oberholzer, J. Langer, R., Anderson, D., Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer, Nature Biomedical Engineering, 2: 894-906, 2018.

DiCiccio, A., Lee, Y., Glettig, D., Walton, E., de La Serna, E., Montgomery, V., Grant, T., Langer, R. and Traverso, G., Caffeine-catalyzed gels, Advanced Materials, 170: 127-135, 2018.

Mimee, M., Nadeau, P., Hayward, A., Carim, S., Flanagan, S., Jerger, L., Collins, J., McDonnell, S., Swartwout, R., Citorik, R.J., Bulovic, V., Langer, R., Traverso, G., Chandrakasan, A.P. and Lu, T.K., An ingestible bacterial-electronic system to monitor gastrointestinal health., Science, 360(6391): 915-918, 2018.

Bochenek, M., Veiseh, O., Vegas, A., McGarrigle, J., Qi, M., Marchese, E., Omami, M., Doloff, J., Mendoza-Elias, J., Nouramohammadzadeh, M., Khan, A., Yeh, C-C., Xing, Y., Isa, D., Ghani, S., Li, J., Landry, C., Bader, A., Olejenik, K., Chen, M., Hollister-Lock, J., Wang, Y., Greiner, D., Weir, G., Strand, B.L., Rockstad, A., Lacik, I., Langer, R., Anderson, D.G., Oberholzer, J., Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques, Nature Biomedical Engineering, 2: 810-821, 2018.

Fenton, O. S., Olafson, K. N., Pillai, P., Mitchell, M. and Langer, R. Advances in Biomaterials for Drug Delivery. Advanced Materials, 30: 1705328, 2018.

Tzeng, S., McHugh, K., Behrens, A., Rose, S., Sugarman, J., Ferber, S., Langer, R. and Jaklenec, A., Stabilized single injection inactivated polio vaccine elicits a strong neutralizing immune response, PNAS, 115: E5269-E5278, 2018.

Fenton, O., Andresen, J., Paolini, M., Langer, R. (2018). B-Aminoacrylate Synthetic Hydrogels: Easily Accessible and Operationally Simple Biomaterials Networks. Chem. Int. Ed. 57: 16026-16029, 2018.

Islam, M., Xu, Y., Tao, W., Ubellacker, J., Lim, M., Aum, D., Lee, G., Zhou, K., Zope, H., Yu, M., Cao, W., Oswald, J., Dinarvand, M., Mahmoudi, M., Langer, R., Kantoff, P., Farokhzad, O., Zetter, B., Shi, J. Restoration of Tumour-growth Suppression in Vivo via Systemic Nanoparticle-mediated Delivery of PTEN mRNA. Nature Biomedical Engineering. 10.1038/s41551-018-0284-0, 2018.

Khan, O., Kowalski, P., Doloff, J., Tsosie, J., Bakthavatchalu, V., Winn, C., Haupt, J., Jamiel, M., Langer, R. and Anderson, D, Endothelial siRNA delivery in nonhuman primates using ionizable low molecular weight polymeric nanoparticles, Science Advances, 4: eaar8409, 2018.

Ayoob, A.M., Peppi, M., Tandon, V., Langer, R., Borenstein, J.T., A fluorescence-based imaging approach to pharmacokinetic analysis of intracochlear drug delivery, Hearing Research, 368: 41-48, 2018.

Guimaraes, P., Tan, M., Tammela, T., Wu, K., Chung, A., Oberli, M., Wang, K., Spektor, R., Riley, R., Viana, C., Jacks, T., Langer, R. and Mitchell, M., Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes, Journal of Controlled Release, 290: 75-87, 2018.

Stewart, M., Langer, R. and Jensen, K., Intracellular delivery by membrane distruption: Mechanisms, strategies and concepts, Journal of the American Chemical Society, 118: 7409-7531, 2018.

Kowalski, P., Bhattacharya, C., Afewerki, S. and Langer, R., Smart biomaterials: Recent advances and future directions, ACS Biomaterials Science and Engineering, 4: 3809-3817, 2018.

Bisso, P., Gaglione, S., Guimaraes, P., Mitchell, M., and Langer, r., Nanomaterial interactions with human neutrophils, ACS Biomaterials Science and Engineering, 4: 4255-4265, 2018.

 

2017

2017

Spencer, K., Sy, J., Ramadi, K., Graybiel, A., Langer, R. and Cima, M., Characterization of mechanically matched hydrogel coatings to improve the biocompatibility of neural implants, Scientific Reports, 7: 1952: DOI: 1038/s41598-017-02107-2, 2017.

Abid, A., O’Brien, J., Bensel, T., Cleveland, C., Booth, L., Smith, B., Langer, R., and Traverso, G., Wireless power transfer to millimeter sized gastrointestinal electronics validated in a swine model, Scientific Reports, 7: 46745: DOI: doi:10.1038/srep46745, 2017.

Delcassian, D., Elgueta, E., Ortiz, C., Bochenek, M., Qatachi, O., Chan, C., McGladrigan, C., Hausser, R. Langer, Anderson, D. and Shakesheff, K., Protecting transplanted cell therapies using immunomodulatory materials, Tissue Engineering, Part A., 23: S20, 2017.

Doloff, J., Veiseh, O., Vegas, A., Tam, H., Farah, S., Ma, M., Li, J., Bader, A., Chiu, A., Sadraei, A., Aresta-DaSilva, S., Griffin, M., Jhunjhunwala, S., Webber, M., Siebert, S., Tang, K., Chen, M., Langan, E., Dholokia, N., Thakrar, R., Qi, M., Oberholzer, J., Greiner, D., Langer, R. and Anderson, D., Colony stimulating factor-1 receptor is a central component of foreign body response to biomaterial implants in rodents and non-human primates, Nature Materials, |DOI: 10.1038/nmat4866, 2017.

Mitchell, M., Webster, J., Chung, A., Guimaraes, P., Khan, O. and Langer, R., Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis, Nature Communications, 8: DOI:10.1038/ncomms14179, 2017.

Dahlman, J., Kauffman, K., Xing, Y., Shaw, T., Dlott, C., Mir, F., Langer, R., Anderson, D. and Wang, E., Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics, Proceedings of the National Academy of Sciences, 114: 2060-2065, 2017.

Kim, K., Cha, Y., Han, M., Cha, H., Zoldan, J., Burkart, A., Jung, J., Jang, Y., Kim, C., Jeong, H., Kim, B., Langer, R., Kahn, C. and Guarente, L., Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis, Nature Cell Biology, 19: 445-456, 2017.

Ragelle, H., Naba, A., Larson, B., Zhou, F., Prijic, M., Whittaker, C., Del Rosario, A., Langer, R., Hynes, R. and Anderson, D., Comprehensive proteomic characterization of stem cell-derived extracellular matrices, Biomaterials, 128: 147-159, 2017.

Fay, F., Hansen, L., Hectors, S., Sanchez-Gaytan, B., Zhao, Y., Tang, J., Munitz, J., Alaarg, A., Braza, M., Gianella, A., Aaronson, S., Reiner, T., Kjems, J., Langer, R., Hoeben, F., Janssen, H., Calcagno, C., Strijkers, G., Fayad, Z., Perez-Medina, C. and Mulder, W., Investingating the cellular specificity in tumors of a surface-converting nanoparticle by multimodal imaging, Bioconjugate Chemistry, i28: 1413-1421, 2017.

Slotkin, J., Pritchard, C., Luque, B., Ye, J., Layer, r., Lawrence, M., O’Shea, T., Roy, R., Zhong, H., Vollenweider, I., Edgerton, V., Courtine, G., Woodard, E. and Langer, R., Biodegradable scaffolds promote tissue remodeling and fuctional improvement in non-human primates with acute spinal cord injury, Biomaterials, 123: 63-76, 2017.

Schoellhammer, C., Lauwers, G., Goettel, J., Oberli, M., Cleveland, C., Park, J., Minahan, D., Chen, Y., Anderson, D., Jaklenec, A., Snapper, S., Langer, R. and Traverso, G., Ultrasound-mediated delivery of RNA to colonic mucosa of live mice, Gastroenterology, 152: 1151-1160, 2017.

Oberli, M., Reichmuth, A., Dorkin, J., Mitchell, M., Fenton, O., Jaklenec, A., Anderson, D., Langer, R. and Blankschtein, D., Lipid nanoparticle-assisted mRNA delivery for potent cancer immunotherapy, Nano Letters, 17: 1326-1335, 2017.

Giwa, S., Lewis, J., Alvarez, L., Langer, R., Roth, A., Church, G., Markmann, J., Sachs, D., Chandraker, A., Wertheim, J., Rothblatt, M., Boyden, E., Eidbo, E., Lee, W., Pomahac, B., Brandacher, g., Weinstock, D., Elliott, G., Nelson, D., Acker, J., Uygun, K., Schmalz, B., Weegman, B., Tocchio, A., Fahy, G., Storey, K., Rubinsky, B., Bishof, J., Elliott, J., Woodruff, T., Morris, J., Demirci, U., Brockbank, K., Woods, E., Ben, R., Baust, J., Gao, D., Fuller, B., Rabin, Y., Kravitz, D., Taylor, M., and Toner, M., The promise of organ and tissue preservation to transform medicine, Nature Communications, 35: 530-542, 2017.

Zhang, S., Langer, R., Traverso, G., Nanoparticulate drug delivery systems targeting inflammation for treatment of inflammatory bowel disease, 16: Nano Today, 82-96, 2017.

Tibbitt, M. and Langer, R., Living biomaterials, Accounts in Chemical Research, 50: 508-513, 2017.

Polat, B., Schoellhammer, C., Langer, R. and Blankschtein, D., Combined use of ultrasound and other physical methods of Skin penetration enhancement, in Percutaneous Penetration Enhancers: Physical Methods in Penetration Enhancement, pp. 369-377, 2017, eds: Dragicevic, N. and Maibach, H., Springer Link.

Roper, J., Tammela, T., Cetinbas, N., Akkad, a., Roghanian, A., Rickelt, S., Almeqdadi, M., Wu, K., Oberli, M., Sanchez-Rivera, F., Park, Y., Liang, x., Eng., G., Taylor, M., Azimi, R., Kedrin, D., Neupane, R., Beyaz, S., Sicinska, E., Suarez, Y., Yoo, J., Chen, L., Zuckerbert, L., Katajisto, P., Deshpande, V., Bass, A., Tsichlis, P., Lees, J., Langer, R., Hynes, R., Chen, J., Bhutkar, A., Jacks, T. and Yilmaz, O., In vivo genome editing and orthotopic transplantation models of colorectal cancer and metastasis, Nature Medicine, 35: 569-579, 2017.

Rwei, A., Langer, R. and Kohane, D. Ultrasound-triggered local anaesthesia, Nature Biomedical Engineering, 1: 644-653, 2017.

Langer, R., Advances in chemistry and their implications for studying and treating brain disease, Molecular Frontiers Journal, 1: 2-9, 2017.

Zwang, Y., Jonas, O., Chen, C., Rinne, M., Doench, J., Piccioni, F., Tan, L., Huang, H., Wang, J., Ham, Y., O’Connell, J., Bhola, P., Doshi, M., Whitman, M., Cima, M., Letai, A., Root, D., Langer, R. Gray, N. and Hahn, C., Synergistic interactions with PI3K inhibition that induce apoptosis, eLife, 6: e24523, 2017.

Nadeau, P., El-Damak, D., Glettig, D., Kong, Y., Mo, S., Cleveland, C., Booth, L., Roxhed, N., Langer, R., Chandrakasan, A. and Traverso, G., Prolonged energy harvesting for ingestible devices, Nature Biomedical Engineering, E-pub ahead of time, DOI: 10.1038/s41551-016-0022, 2017.

Yu, D., Khan, O., Suva, M., Dong, B., Panek, W., Xiao, T., Wu, M. Han, Y., Ahmed, A., Balyasnikova, I., Zhang, H., Sun, C., Langer, R., Anderson, D., Lesniak, M., Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression, Proceedings of the National Academy of Sciences, E-pub ahead of time, DOI: 1073/pnas.1701911114, 2017.

Fenton, O., Kauffman, K., Kaczmarek, J., McClellan, R., Jhunjhunwala, S., Tibbitt, M., Zeng, M., Appel, E., Dorkin, J., Mir, F., Yang, J., Oberli, M., Heartlein, M., DeRosa, F., Langer, R. and Anderson, D., Synthesis and biological evaluation of ionizable lipid materials for the in vivo delivery of messenger RNA to B lymphocytes, Advanced Materials, DOI: 1002/adma.201606944, 2017.

Liu, J., Pang, Y., Zhang, S., Cleveland, C., Yin, X., Booth, L., Lin, J., Lee, Y., Mazdiyasni, H., Saxton, S., Kirtane, A., von Erlach, T., Rogner, J., Langer, R. and Traverso, G., Triggerable tough hydrogels for gastric resident dosage forms, Nature Communications, 8: 124: DOI: 1038/s41467-017-00144-z, 2017.

McHugh, K., Nguyen, T., Linehan, A., Yang, D., Behrens, A., Rose, S., Tochka, Z., Tzeng, S., Norman, J., Anselmo, A., Xu, X., Tomasic, S., Taylor, M., Lu, J., Guarecuco, R., Langer, R. and Jaklenec, A., Fabrication of fillable microparticles and other complex 3D microstructures, Science, 357: 1138-1142, 2017.

Bakh, N., Cortinas, A., Weiss, M. Langer, R., Anderson, D., Gu, Z., Dutta, S. and Strano, M., Glucose responsive insulin by molecular and physical design, Nature Chemistry, 937–943, 2017.

Abramson, A., Langer, R., Traverso, G, and Caffarel-Salvador, E., Oral delivery of biologics using drug-device combinations, Current Opinion in Pharmacology, 8-13, 2017.

Dagdeviren, C, Javid, F, Joe, P, von Erlach, Bensel, T, Wei, Z, Saxton, S, Cleveland, C, Booth, L, McDonnell, S, Collins, J, Hayward, A, Langer, R, Traverso, G, Flexible piezoelectric devices for gastrointestinal motility sensing, Nature Biomedical Engineering 1: 807-817, 2017.

Mitchell, M., Jain, R. and Langer, R., Engineering and physical sciences in oncology: Challenges and opportunities, Nature Reviews Cancer, 659-675, 2017.

Yin, H, Song, C-Q, Suresh, S, Wu, Q, Walsh, S, Rhym, L.H., Mintzer, E, Bolukbasi, M.F., Zhu, L.J., Kauffman, K, Mou, H, Oberholzer, A, Ding, J, Kwan, S-Y, Bogorad, R, Zatsepin, T, Koteliansky, V, Wolfe, S.A., Xue, W, Langer, R, Anderson, D.G., Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing, Nature Biotechnology, 35: 1179-1187, 2017.

Schoellhammer, C., Chen, Y., Cleveland, C., Minahan, D., Bensel, T., Park, J., Saxton, S., Lee, Y., Booth., L., Langer, R. and Traverso, G., Defining optimal permeant characteristics for ultrasound mediated gastrointestinal delivery, Journal of Controlled Release, 268: 113-119, 2017.

Schwerdt, H., Shimazu, H., Amemori, K., Amemori, S., Tierney, P., Gibson, D., Hong, S., Yoshida, T., Langer, R., Cima, M. and Graybiel, A., Long-term dopamine neurochemical monitoring in primates, Proceedings of the National Academy of Sciences, 14: 13260-13265, 2017.

Bertrand, N., Grenier, P., Mahmoudi, M., Lima, E., Appel, E., Dormont, F., Lim, J., Karnik, R., Langer, R. and Farokhzad, O., Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics, Nature Communications, 8: 77, 2017.

Mahmoudi, M., Yu, M., Serpooshan, V., Wu, J., Langer, R., Lee, R., Karp, J. and Farokhzad, O, Multiscale technologies for treatment of ischemic cardiomyopathy, Nature Nanotechnology, 12: 845–855, 2017.

Kakkar, A., Traverso, G., Farokhzad, O., Weissleder, R. and Langer, R., Evolution of macromolecular complexity in drug delivery systems, Nature Reviews Chemistry, 1(0063), doi: 10.1038/s41570-017-0063, 2017.

Aday, S., Zoldan, J., Besnier, M., Carreto, L., Saif, J., Fernandes, R., Santos, T., Bernardino, L., Langer, R., Emanueli, C. and Ferreira, L., Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition, Nature Communications, 8(747), oi:10.1038/s41467-017-00746-7, 2017.

Jung, K., Heishi, T., Khan, O., Kowalski, P., Incio, J., Rahbari, N., Chung, E., Clark, J., Willett, Luster, A., Yun, S., Langer, R., Anderson, D., Padera, T., Jain, R. and Fukumura, D., Ly6C(low) monocytes drive immunosuppression and confer resistance to anti-VEGFR2 therapy in colorectal cancer, Journal of Clinical Investigation, 127(8): 3039-3051, 2017.

Doloff, J., Saraei, A., Farah, F., Bortell, R., Brehm, M., Greiner, D., Anderson, D., Langer, R., Development of a humanized mouse model that recapitulates the fibrotic response to biomaterial implants, The Journal of Immunology, 198(1): 206.3, 2017.

Schneider, C., Langer, R., Loveday, D., Hair, D., Applications of ethylene vinyl acetate copolymers (EVA) in drug delivery systems, Journal of Controlled Release, 262: 284-295, 2017.

McLean, W.J., Yin, X., Lu, L., Lenz, D.R., Mclean, D., Langer, R., Karp, J.M. and Edge, A.S.B.,Clonal expansion of Lgr5-positive cells from mammalian cochlea and high-purity generation of sensory hair cells, Cell Reports, 18(8): 1917-1929, 2017.

2016

2016

Vegas, A., Veiseh, O., Doloff, J., Ma, M., Tam, H., Bratlie, K., Li, J., Bader, A., Langan, E., Olejnik, K., Fenton, P., Kang, J., Hollister-Locke, J., Bochenek, M., Chiu, A., Siebert, S., Tang, K., Jhunjhunwala, S., Aresta-Dasilva, S., Dholakia, N., Thakrar, R., Vietti, T., Chen, M., Cohen, J., Siniakowicz, K., Qi, M., McGarrigle, J., Lyle, S., Harlan, D., Greiner, D., Oberholzer, J., Weir, G. Langer, R. and Anderson, D., Combinatorial development of hydrogels that mitigate the foreign body response in primates, Nature Biotechnology, 34:  345-352, 2016. PMCID: PMC4904301

Yin, H., Song, C., Dorkin, J., Zhu, L., Li, Y., Wu, Q., Park, A., Yang, J., Suresh, S., Bizhanova, A., Gupta, A., Bolukbasi, M., Walsh, S., Bogorad, R., Gao, G., Weng, Z., Dong, Y., Koteliansky, V., Wolfe, S., Langer, R., Xue, W., and Anderson, D., Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo, Nature Biotechnology, 34:  328-333, 2016.

Dong, Y., Dorkin, J., Wang, W., Chang, P., Webber, M., Tang, B., Abutbul-Ionita, I., Danino, D., DeRosa, F, Heartlein, M. and Langer, R., Poly(glycoamidoamine) brushes formulated nanomaterials for systemic mRNA delivery in vivo, Nano Letters, 16:  842-848, 2016.

Xue, Y., Xu, X., Zhang, X., Farokhzad, O. and Langer, R., Preventing diet-induced obesity in mice by inducing adipose tissue transformation and angiogenesis using targeting nanoparticles with drug delivery amplification, Proceedings of the National Academy of Sciences, 113:  5552-5557, 2016. PMCID: PMC4878518

Webber, M., Appel, E., Meijer, E. and Langer, R., Supramolecular biomaterials, Nature Materials, 15:  13-26, 2016. PMC Exempt – Review

Tibbitt, Mark, Dahlman, J. and Langer, R., Emerging frontiers in drug delivery, Journal of the American Chemical Society, 138:  704-717, 2016. PMC Exempt – Review

Vegas, A., Veiseh, O., Gurtler, M., Millman, J., Pagliuca, F., Bader, A., Doloff, J., Li, J., Chen, M., Olejnik, K., Tam, H., Jhunjhunwala, S., Langan, E., Aresta-Dasilva, S., Gandham, S., McGarrigle, J., Bochenek, M., Hollister-Lock, J., Oberholzer, J., Greiner, D., Weir, G., Melton, D, Langer, R. and Anderson, D., Long-term glycemic control using polymer encapsulated human stem cell-derived beta cells in immune-competent mice, Nature Medicine, 22:  306-211, 2016. PMCID: PMC4825868

Tzeng, S., Guarecuco, R., McHugh, K., Rose, S., Rosenberg, E., Zeng, Y., Langer, R. and Jaklenec, A., Thermostabilization of inactivated polio vaccine in PLGA-based microspheres for pulsatile release, Journal of Controlled Release, 233:  101-113, 2016. PMCID: PMC4925381

Stewart, M., Sharei, A., Ding, X., Sahay, G., Langer, R., and Jensen, K., In vitro and ex vivo strategies for intracellular delivery, Nature, 538:  183-192, 2016.

Yu, A., Chen, H. Chan, D., Agmon, G., Stapleton, L., Sevit, A., Tibbitt, M., Acosta, J., Zhang, T., Franzia, P., Langer, R., and Appel, E., Scalable manufacturing of biomimetic moldable hydrogels for industrial applications, Proceedings of the National Academy of Sciences, 113: 14255-14260, 2016.

Lee, H., Ahsen, O., Liang, K., Wang, Z., Cleveland, C., Booth, L., Potsaid, B., Jayaraman, V., Cable, A., Mashimo, H., Langer, R., Traverso, G. and Fujimoto, J., Circumferential optical coherence tomography angiography imaging of the swine esophagus using a micromoto balloon catheter, Biomedical Optics Express, 7:  2927-2942, 2016. PMCID: PMC4986804

Yin, H., Bogorad, R., Barnes, C., Walsh, S., Zhuang, I., Nonaka, H., Ruda, V., Kuchimanchi, S., Nechev, L., Akinc, A., Xue, W., Zerial, M., Langer, R., Anderson, D. and Koteliansky, V., RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver, Journal of Hepatology, 64:  899-907, 2016.

Oudin, M., Jonas, O., Kosciuk, T., Broye, L., Wyckoff, J., Riquelme, D., Lamar, J., Asokan, S., Whittaker, C., Ma, D., Langer, R., Cima, M., Wisinski, K., Hynes, R., Lauffenburger, D., Keely, P., Bear, J. and Gertler, F., Tumor cell-driven extracellular matrix remodeling enables haptotaxis during metastatic progression, Cancer Discovery, 6:  516-531, 2016. PMCID: PMC4854754

Yun, S., Budatha, M., Dahlman, J., Coon, B., Cameron, R., Langer, R., Anderson, D., Baillie, G. and Schwartz, M., Integrin a5-PDE4D interaction regulates endothelial inflammatory signaling, Nature Cell Biology, 18: 1043-1053, 2016.

Webber, M., Appel, E., Vinciguerra, B., Cortinas, A., Thapa, L., Jhunjhunwala, S., Isaacs, L., Langer, R. and Anderson, G., Supramolecular PEGylation of biopharmaceuticals, Proceedings of the National Academy of Sciences, 113:  14189-14194, 2016.

Fischer, K., Morgan, K., Hearon, K., Sklaviadis, D., Tochka, Z., Fenton, O., Anderson, D., Langer, R. and Freed, L., Poly(limonene thioether) scaffold for tissue engineering, Advanced Healthcare Materials, 5:  813-821, 2016.

Kimball, A., Javorsky, E., Ron, E., Crowley, W. and Langer, R., A novel approach to administration of peptides in women:  Systemic absorption of a GnRH agonist via transvaginal ring delivery system, Journal of Controlled Release, 233: 19-28, 2016. Exempt from PMC—Non-NIH/PHS Funding

Yu, B., Kang, S., Akthakul, A., Ramadurai, N., Pilkenton, M. Sakamoto, F., Gilchrest, B., Anderson, R. and Langer, R., An elastic second skin, Nature Materials, 15:  911-918, 2016. Exempt from PMC—Non-NIH/PHS Funding.

Moss, J. and Langer, R., Drug delivery modalities, Principles of pharmacology:  The pathophysiologic basis of drug therapy, Fourth Edition, Chap. 55, pp. 979-985, Golan, E., Armstrong, E., Armstrong, A. eds;  Wolters Kluwer, 2016, PMCID: Exempt from PMC—Book Chapter.

Chahal, J., Khan, O., Cooper, C., McPartlan, J., Tsosie,  J., Tilley, L., Sidik, S., Lourido, S., Langer, R., Bavari, A., Ploegh, H. and Anderson, D., Dendrimer-RNA nanoparticles generate protective immunity against lethal ebola, H1N1 influenza and toxoplasma gondii challenges with a single dose, Proceedings of the National Academy of Sciences, 113: E4133-E4142, 2016.

Lee, Y., Zhang, S., Lin, J., Langer, R. and Traverso, G., A janus mucoadhesive and omniphobic device for gastrointestinal retention, Advanced Healthcare Materials, 5:  1141-1146, 2016. NIHMSID 842081 (PMCID Pending)

Sager, H., Dutta, P., Dahlman, J., Courties, G., Heidt, T., Vinegoni, C., Borodovsky, A, Fitzgerald, K., Sun, Y., Wojtkiewicz, G., Iwamoto, Y., Khan, O., Xing, Y., Shaw, T., Libby, P., Langer, R., Weissleder, R., Sirski, F., Anderson, D. and Nahrendorf, M., RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction, Science Translational Medicine, 8: 342ra80, 2016. PMCID: PMC5125383.

Lu, Y., Langer, R. and Gu, Z., Bio-responsive materials, Nature Reviews Materials, 2:  1-17, 2016. PMC Exempt – Review.

Adlington, K., Nguyen, N., Eaves, E., Yang, J., Chang, C., Li, J., Gower, A., Stimpson, A., Anderson, D., Langer, R., Davies, M., Hook, A., Williams, P., Alexander, M. and Irvine, D., Application of targeted molecular and material property optimization to bacterial attachment resistant (meth)acrylate polymers, Biomacromolecules, 17: 2830-2838, 2016.

Morgan, K., Sklaviadis, D., Tochka, Z., Fischer, K., Hearon, K., Morgan, T., Langer, R. and Freed, L., Multi-material tissue engineering scaffold with hierarchical pore architecture, Advanced Functional Materials, 26:  5873-5883, 2016. PMCID: PMC5142531

Khademhosseini, A. and Langer, R., A decade of progress in tissue engineering, Nature Protocols, 11: 1775-1781, 2016. PMC Exempt – Review.

Kirtane, A., Langer, R. and Traverso, G., Past, present and future drug delivery systems for antiretrovirals, Journal of Pharmaceutical Sciences, 105: 3471-3482, 2016. PMC Exempt – Review.

Bellinger, A., Jafari, M., Grant, T., Zhang, S., Slater, H., Wenger, E., Mo, S., Lee, Y., Mazdiyasni, H., Kogan, L., Barman, R., Cleveland, C., Booth, L., Bensel, T., Minahan, D., Hurowitz, H., Tai, T., Daily, J., Nikolic, B., Wood, L., Eckhoff, P., Langer, R. and Traverso, G., Oral, ultra-long-lasting drug delivery:  Application toward malaria elimination goals, Science Translational Medicine, 4:  365ra157, 2016. PMCID: PMC5264553

Yang, Y., Andersson, P., Hosaka, K., Zhang, Y., Cao, R., Iwamoto, H., Yang, X., Nakamura, M., Wang, J., Zhuang, R., Morikawa, H., Xue, Y., Braun, H., Beyaert, R., Samani, N., Nakae, S., Hams, E., Dissing, S., Fallong, P., Langer, R., and Cao, Y., The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumor-associated macrophages, Nature Communications, DOI: 10.1038/ncomms11385, 2016. PMCID: PMC4859070

Chen, X., Wu, B., Jayawardana, K., Hao, N., Jayawardena, S., Langer, R., Jaklenec, A. and Yan, M., Magnetic multivalent trehalose glycopolymer nanoparticles for the detection of mycobacteria, Advanced Healthcare Materials, E-pub ahead of time, DOI:10.102/adhm.201600071, 2016. PMCID: PMC5242184

Zhao, X., Hwang, N., Bichara, D., Saris, D., Malda, J., Vacanti, J., Pomerantseva, I., Sundback, C., Langer, R., Anderson, D. and Randolph, M., Chondrogenesis by bone marrow-derived mesenchymal stem cells grown in chondrocyte-conditioned medium for auricular reconstruction, Journal of Tissue Engineering and Regenerative Medicine, E-pub ahead of time DOI:  10.1002/term.2171, 2016. Exempt from PMC—Non-NIH/PHS Funding.

Patel, A., Tibbitt, M., Celiz, M., Davies, M., Langer, R., Denning, C., Alexander, M. and Anderson, D., High throughput screening for discovery of materials that control stem cell fate, Current Opinion in Solid State and Materials Science, E-pub ahead of time, DOI:10.1016/j.cossms.2016.02.002, 2016.

Lu, Y., Aimetti, A., Langer, R. and Gu, Z., Bioresponsive materials, Nature Reviews Materials, E-pub ahead of time, DOI: 10.1038/natrevmats.2016.75, 2016. PMC Exempt – Review.

Jhunjhunwala, S., Alvarez, D., Aresta-DaSilva, S., Tang, K., Tang, B, Greiner, D., Newburger, P., von Andrian, U., Langer, R. and Anderson, D., Splenic progenitors aid in maintaining  high neutrophil numbers at sites of sterile chronic inflammation, Journal of Leukocyte Biology, E-pub ahead of time, DOI: 10.1189/jlb.1HI0615-248RR, 2016. PMCID:  PMC4945357

Jonas, O., Kosciuk, T., Cima, M., Flaherty, K. and Langer, R., Parrallel in vivo assessment of drug phenotypes at various time points during systemic BRAF inhibition reveals tumor adaptation and altered treatment vulnerabilities, Clinical Cancer Research, E-pub ahead of time, DOI: 10.1158/1078-0432.CCR-15-2722, 2016.

Farah, S., Anderson, D. and Langer, R., Physical and mechanical properties of PLA and their functions in widespread applications:  A comprehensive review, Advanced Drug Delivery Reviews, E-pub ahead of time, DOI: 10.1016/j.addr2016.06.012, 2016. PMC Exempt – Review.

Chertok, B., Langer, R. and Anderson, D., Spatial control of gene expression by nanocarriers using heparin masking and ultrasound-targeted microbubble destruction, ACS Nano, E-pub ahead of time, DOI:  10.1021/acsnano.6b01199, 2016. PMCID: PMC5240524

Kollmannsperger, A., Sharei, A., Raulf, A., Heilemann, M., Langer, R., Jensen, K., Wieneke, R. and Tampe, R., Live-cell protein labeling with nanometer precision by cell squeezing, Nature Communications, DOI: 10.1038/ncomms10372, 2016.

Chu, H., Kohane, D. and Langer, R., RNA therapeutics:  The potential treatment for myocardial infarction, Regenerative Therapy, 4: 83-91, 2016.

Hong, A., Tseng, Y., Cowley, G., Jonas, O., Cheah, J., Kynnap, B., Doshi, M., Oh, C., Meyer, S., Church, A., Gill, S., Bielski, C., Keskula, P., Imamovic, A., Howell, S., Kryukov, G., Clemons, P., Tsherniak, A., Vazquez, F., Crompton, B., Shamji, A., Rodriguez-Galindo, C., Janeway, K., Roberts, C., Stegmaier, K., van Hummelen, P., Cima, M., Langer, R., Garraway, L., Schreiber, S., Root, D., Hahn, W. and Boehm, J., Integrated genetic and pharmacologic interrogation of rare cancers, Nature Communications, DOI: 10.1038/ncomms11987, 2016. PMCID: PMC49179.

Anselmo, A., McHugh, K., Webster, J., Langer, R. and Jaklenec, A., Layer-by-layer encapsulation of probiotics for delivery to the microbiome, Advanced Materials, E-pub ahead of time, DOI: 10.1002/adma.201603270, 2016, PMID: 27616140, 2016.

Tam, H., Melo, M., Kang, M., Pelet, J., Ruda, V., Foley, M., Hu, J., Crampton, J., Baldeon, A., Sanders, R., Moore, J., Crotty, S., Langer, R., Anderson, D., Chakraborty, A. and Irvine, D., Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination, Proceedings of the National Academy of Sciences, 113: E6639-E6648, 2016, DOI: 10.1073/pnas.1606050113, 2016. PMCID: PMC5086995

2015

2015

Langer, R. and Weissleder, R., Scientific discovery and the future of medicine:  Nanotechnology, Journal of the American Medical Association, 312:  135-136, 2015.

Veiseh, O., Tang, B., Whitehead, K., Anderson, D. and Langer, R., Managing diabetes with nanomedicine:  Challenges and opportunities, Nature Reviews Drug Discovery, 14:  45-57, 2015Traverso, G., Schoellhammer, C., Schroeder, A., Maa, R., Lauwers, G., Polat, B., Anderson, D., Blankschtein, D. and Langer, R., Microneedles for drug delivery via the gastrointestinal tract, Journal of Pharmaceutical Sciences, 104:  362-367, 2015.

Traverso, G. and Langer, R., Perspective:  Special delivery for the gut, Nature, 519: S19, 2015.

Chou, D., Webber, M., Tang, B., Lin, A., Thapa, L., Deng, D., Truong, J., Cortinas, A., Langer, R. and Anderson, D., Glucose responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates, Proceedings of the National Academy of Sciences,111:  2401-2406, 2015.

Appel, E., Larson, B., Luly, K., Kim, J. and Langer, R., Non-cell-adhesive substrates for printing arrayed biomaterials, Advanced Healthcare Materials, 4:  501-505, 2015.

Webber, M., Anderson, D. and Langer, R., Engineering synthetically modified insulin for glucose-responsive diabetes therapy, Expert Review of Endocrinology and Metabolism, 10:  483-489, 2015.

Jonas, O., Landry, H., Fuller, J., Santini, J., Baselga, J., Tepper, R., Cima, M. and Langer, R., An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors, Science Translational Medicine, 7: 284ra57, 2015.

Sanni, O., Chang, C., Anderson, D., Langer, R., Davies, M., Williams, P.M., Willimas, P., Alexander, M. and Hook, A., Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity, Advanced Healthcare Materials, 4:  695-701: 2015.

Khan, O., Zaia, E., Jhunjhunwala, S., Xue, W., Cai, W., Yun, D., Barnes, C., Dahlman, J., Dong, Y., Pelet, J., Webber, M., Tsosie, J., Jacks, T., Langer, R. and Anderson, D., Dendrimer-inspired nanomaterials for the in vivo delivery of siRNA to lung vasculature, Nano Letters, 15:  3008-3016, 2015.

Traverso, G. and Langer, R., Engineering precision, Science Translational Medicine, 7: 289ed6, 2015.

Appel, E., Tibbitt, M., Webber, M., Mattix, B., Veishe, O. and Langer, R., Self-assembled hydrogels utilizing polymer-nanoparticle interactions, Nature Communications, 6: 6295, 2015.

Patel, A., Celiz, A., Rajamohan, D., Anderson, D., Langer, R., Davies, M., Alexander, M., and Denning, C., A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays, Biomaterials, 61:  257-265, 2015.

Maldonado, R., LaMothe, R., Ferrari, J., Zhang, A., Rossi, R., Griset, A., O’Neil, C., Altreuter, D., Johnston, L., Farokhzad, O., Langer, R., Scott, D., von Andrian, U. and Kishimoto, T., Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance, Proceedings of the National Academy of Sciences, 112: E156-E165, 2015.

O’Shea, T., Aimetti, A., Kim, E., Yesilyurt, V. and Langer, R., Synthesis and characterization of a library of in situ curing, nonswelling ethoxylated polyol thiol-ene hydrogels for tailorable macromolecule delivery, Advanced Materials, 27:  65-72, 2015.

Sydlik, S., Jhunjhunwala, S., Webber, M., Anderson, D. and Langer, R., In vivo compatibility of graphene oxide of differing oxidation states, ACS Nano, s9:  3866-3874, 2015.

Veiseh, O., Doloff, J., Ma, M., Vegas, A., Tam, H., Bader, A., Li, J., Langan, E., Wyckoff, J., Loo, W., Jhunjhunwala, S., Chiu, A., Siebert, S., Tang, K., Hollister-Lock, H., Aresta-Dasilva, S., Bochenek, M., Mendoza-Elias, J., Wang, Y., Qi, M., Lavin, D., Dholakia, N., Thakrar, R., Wier, G., Oberholzer, J., Greiner, D., Langer, R. and Anderson, D., Size and shape dependent foreign body immune response to materials implanted in rodents and non-human primates, Nature Materials, 14:  643-651, 2015.

Tong, R. and Langer, R., Nanomedicine targeting the tumor microenvironment, The Cancer Journal: The Journal of Principles and Practice of Oncology, 21:  314-215, 2015.

Veiseh, O. and Langer, R., A smart insulin patch, Nature, 524: 39-40, 2015.

Zhang, S., Ermann, J., Succi, M., Zhou, A., Hamilton, M., Cao, B., Korzenik, J., Glickman, J., Vemula, P., Glimcher, L., Traverso, G., Langer, R. and Karp, J., An inflammation-targeted hydrogel as a novel approach for drug delivery in inflammatory bowel disease, Science Translational Medicine, 7:  300ra128, 2015.

Celiz, Z., Smith J., Patel, A., Hook, A., Rajamohan, D., George, V., Flatt, L., Patel, M., Epa, V. Singh, T., Langer, R., Anderson, D., Allen, N., Hay, D., Winkler, D., Barrett, D., Davies, M., Young, L., Denning, C. and Alexander, M., Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation, Advanced Materials, 27:  4006-4012, 2015.

Zhang, S., Bellinger, A., Glettig, D., Barman, R., Lee, Y-A., Zhu, J., Cleveland, C., Montgomery, V., Gu, L., Nash, L., Maitland, D., Langer, R. and Traverso, R., A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices, Nature Materials, 10: 1065-1071, 2015. PMID: 26213897; PMCID: 4772966.

White, K., Lu, Y., Annis, S., Hale, A., Chau, N., Dahlman, J., Hemann, C., Opotowsky, A., Vargas, S., Rosas, I., Perrella, M., Osorio, J., Haley, K., Graham, B., Kumar, R., Saggar, R., Saggar, R., Wllance, W., Ross, D., Khan, O., Bader, A., Gochuico, B., Matar, M., Polach, K., Johannessen, N., Prosser, H., Anderson, D., Langer, R., Zweier, J., Bindoff, L., Systrom, D., Waxman, A. Jin, R. and Chan, S., Genetic and hypoxic alterations of tehh microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension, EMBO Molecular Medicine, 7: 695-713, 2015.

Stary, G., Olive, A., Radovic-Moreno, A., Gondek, D., Alvarez, D, Basto, P., Perro, M., Vrbanac, V., Tager, A., Shi, J., Yethon, J., Farokhzad, O., Langer, R. Starnbach, M. and von Andrian, U., A mucosal vaccine against chlamydia trachomatis generates two synergistic waves of protective memory T cells, Science, 348: 1331, 2015.

McHugh, K., Guarecuco, R., Langer, R. and Jaklenec, A., Single-injection vaccines:  Progress, challenges and opportunities, Journal of Controlled Release, 219: 596-609, 2015.

Appel, E., Tibbitt, M., Greer, J., Fenton, O., Kreuels, K., Anderson, D. and Langer, R., Exploiting electrostatic interactions in polymer nanoparticle hydrogels, ACS Macro Letters, 4:  848-852, 2015.

Schoellhammer, C., Schroeder, A., Maa, R., Brugge, W., Lauwers, G., Anderson, D., Blankschtein, D., Langer, R. and Traverso, G., Ultrasound-mediated gastrointestinal drug delivery, Science Translational Medicine, 7:  310ra168, 2015.

Wang, Q., Cheng, H., Peng, H., Zhou, H. Li, P. and Langer, R., Non-genetic engineering of cells for drug delivery and cell-based therapy, Advanced Drug Delivery Reviews, 91:  125-140, 2015.

Chung, B., Toth, M., Kamaly, N., Sei, Y., Becraft, J. Mulder,  W., Fayad, Z., Farokhzad, O., Kim, YT and Langer, R., Nanomedicines for endothelial disorders, Nano Today, 10:  759-776, 2015.

O’Shea, T., Webber, M., Aimetti, A. and Langer, R., Covalent incorporation of trehalose within hydrogels for enhanced long-term functional stability and controlled release of biomacromolecules, Advanced Healthcare Materials, 4:  1802-1812, 2015.

Sanchez-Gaytan, B., Fay, F., Lobatto, M., Tang, J., Ouimet, M., Kim, Y., van der Staay, S., van Rijs, S., Priem, B., Zhang, L., Fisher, E., Moore, K., Langer, R., Fayad, Z. and Mulder, W., HDL-mimetic PLGA nanoparticle to target atherosclerotic plaque macrophage, Bioconjugate Chemistry, 26:  443-451, 2015.

Yesilyurt, V., Webber, M., Appel, E., Godwin, C., Langer, R. and Anderson, D., Injectable self-healing glucose-responsive hydrogels with pH-regulated mechanical properties, Advanced Materials, 28:  86-91, 2015.

Rwei, A., Lee, J., Zhan, C., Liu, Q., Ok, M., Shankarappa, S., Langer, R. and Kohane, D., Repeatable and adjustable on-demand sciatic nerve block with phototriggerable liposomes, Proceedings of the National Academy of Sciences, 112:  15719-15724, 2015.

Brandl, F., Bertrand, N., Lima, E. and Langer, R., Nanoparticles with photoinduced precipitation for the extraction of pollutants from water and soil, Nature Communications, DOI:  10.1038/ncomms8765, 2015.

Szeto, G., Van Egeren, D., Worku, H., Sharei, A., Alejandro, B., Park, C., Frew, K., Brefo, M., Mao, S., Heimann, M., Langer, R., Jensen, K. and Irvine, D., Microfluidic squeezing for intracellular antigen laoding in polyclonal B-cells as cellular vaccines, Scientific Reports, DOI:10.1038/srep10276, 2015.

Jhunjhunwala, S., Aresta-Dasilva, S., Tang, K., Alvarez, D., Webber, M., Tang, B., Lavin, D., Veiseh, O., Doloff, J., Bose, S. Vegas, A., Ma, M., Sahay, G., Chiu, A., Bader, A., Langan, E., Siebert, S., Li, J., Greiner, D., Newburger, P., von Andrian, U., Langer, R. and Anderson, D., Neutrophil responses to sterile implant materials, Plos One, DOI: 10.1371/journal.pone.0137550, 2015.

Traverso, G., Ciccarelli, G., Hughes, T., Boettcher, T., Barman, R., Langer, R. and Siston, A., Physiologic status monitoring via the gastrointestinal tract, PLOS ONE, DOI: 10.1371/journal.pone.0141666, 2015.

Sharei, A., Trifonova, R., Jhunjhunwala, S., Hartoularos, G., Eyerman, A., Lytton-Jean, A., Angin, M., Sharma, S., Poceviciute, R., Mao, S., Heimann, M., Liu, S., Talkar, T., Khan, O., Addo, M., von Andrian, U., Anderson, D., Langer, R., Lieberman, J. and Jensen, K., Ex vivo cytosolic delivery of functional macromolecules to immune cells, PLOS One, DOI: 10.1371/journal.pone.0118803, 2015.

2014

2014

Lim, J., Bertrand, N., Valencia, P., Rhee, M., Langer, R., Jon, S., Farokhzad, O. and Karnik, R., Parallel Microfluidic Synthesis of Size-Tunable Polymeric Nanoparticles using 3D flow focusing towards in vivo study, Nanomedicine: Nanotechnology, Biology and Medicine, 10:  401-409, 2014. PMID: 23969105.

Yin, X., Farin, H., van Es, J., Clevers, H., Langer, R. and Karp, J., Niche-independent high-purity culture of Lgr5+ intestinal stem cells and their progeny, Nature Methods, 11:  106-112, 2014. NIHMSID: 548435.

Lang, N., Pereira, J., Lee, Y., Friehs, I., Vasilyev, N., Feins, E., Ablasser, K., O’Cearbhaill, E., Xu, C., Fabozzo, A., Padera, R., Wasserman, S., Freudenthall, F., Ferreira, L., Langer, R., Karp, J. and del Nido, P., A blood-resistant surgical glue for minimally invasive repair of vessels and heart defects, Science Translational Medicine 6:  218ra6, 2014 (cover article).

Epa, V., Hook, A., Chang, C. Yang, J., Langer, R. Anderson, D., Willimas, P, Davies, M., Alexander, M. and Winkler, D., Modelling and prediction of bacterial attachment to polymers, Advanced Funcational Materials, 24:  2085-2093, 2014.

Foradori, M., Chen, Q., Fernandez, C., Harper, J., Li, X., Tsang, P., Langer, R. and Moses, M., Matrilin-1 is an inhibitor of neovascularization, J. Biol. Chem., 289:  14301-14309, 2014

Guo, Liang, Ma, M., Zhang, N., Langer, R., and Anderson, D., Stretchable polymeric multielectrode array for conformal neural interfacing, Advanced Materials, 26:  1427-1433, 2014.

Pereira, M., Sundback, C., Lang, N., Cho, W., Pomerantseva, I., Ouyang, B., Tao, S., McHugh, K., Mwizerwa, O., Vemula, P., Mochel, M., Carter, D., Borenstein, J., Langer, R., Ferreira, L., Karp, J. and Masiakos, P., Combined surface micropatterning and reactive chemistry maximizes tissue adhesion with minimal inflammation, Advanced Healthcare Materials, 3:  565-571, 2014.

Timko, B., Arruebo, M., Shankarappa, S., McAlvin, J., Okonkwo, O., Mizrahi, B., Stefanescu, C., Gomez, L., Zhu, J., Zhu, A., Santamaria, J., Langer, R. and Kohane, D., Near-infrared actuated devices for remotely controlled drug delivery, Proceedings of the National Academy of Sciences, 111:  1349-1354, 2014.

Kim, Y., Lobatto, M., Kawahara, T., Chung, B., Mieszawska, A., Sanchez-Gaytan, B., Fay, F., Senders, M., Calcagno, C., Becraft, J., Saung, M., Gordon, R., Stroes, E., Ma, M., Farokhzad, O., Fayad, Z., Mulder, W. and Langer, R., Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis, Proceedings of the National Academy of Sciences 111:  1078-1083, 2014.

Schoellhammer, C., Blankschtein, D., Langer, R., Skin permeabilization for transdermal drug delivery: Recent advances and future prospects, Expert Opinion Drug Delivery, 11:  393-407, 2014. PMID: 24392787.

Sharei, A., Poceviciute, R., Jackson, E., Cho, N., Mao, S., Hartoularos, G., Jang, D., Jhunjhunwala, S., Eyerman, A., Schoettle, T., Langer, R. and Jensen, K., Plasma membrane recovery kinetics of a microfluidic intracellular delivery platform, Integrative Biology, 6:  470-475, 2014.

Dong, Y., Love, K., Dorkin, J., Sirirungruang, S., Zhang, Y., Chen, D., Bogorad, R., Yin, H., Chen, Y., Vegas, A., Alabi, C., Sahay, G., Olejnik, K., Wang, W., Schroeder, A., Lytton-Jean, A., Siegwart, D., Akinc, A., Barnes, C., Barros, S., Carioto, M., Fitzgerald, K., Hettinger, J., Kumar, V., Novobrantseva, T., Qin, J., Querbes, W., Kotelianski, V., Langer, R. and Anderson, D. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates, Proceedings of the National Academy of Sciences, 111:  3955-3960, 2014.

Hook, A., Chang, C-Y., Scurr, D., Langer, R., Anderson, D., Williams, P., Davies, M. and Alexander, M., Thermally switchable polymers achieve controlled Escherichia coli detachment, Advanced Healthcare Materials, 3:  1020-1025, 2014.

Upadhyay, U., Tyler, B., Patt, Y., Wicks, R., Spencer, K., Scott, A., Masi, B., Hwang, L., Grossman, R., Cima, M., Brem, H. and Langer, R., Intracranial microcapsule chemotherapy delivery for the localized treatment of roden metastatic breast adenocarcinoma in the brain, Proceedings of the National Academy of Sciences, 111, 16071-16076, 2014.

Zhu, X., Radovic-Moreno, A., Wu, J., Langer, R., and Shi, J., Nanomedicine in the management of microbial infection:  Overview and perspectives, Nano Today, 9:  478-498, 2014.

Barhoumi, A., Wang, W., Zurakowski, D., Langer, R. and Kohane, D., Photothermally targeted thermosensitive polymer-masked nanoparticles, Nano Letters, 14:  3697-3701, 2014.

Celiz, A., Smith, J., Langer, R., Anderson, D., Winkler, D., Barrett, D., Davies, M., Young, L., Denning, C. and Alexander, M., Materials for stem cell factories of the future, Nature Materials, 13:  570-579, 2014.

Dahlman, J., Barnes, C., Khan, O., Thiriot, A., Jhunjunwala, S., Shaw, T., Xing, Y., Sage, H., Sahay, G., Speciner, L., Bader, A., Bogorad, R., Yin, H., Racie, T., Dong, Y., Jiang, S., Seedorf, D., Dave, A., Sandu, K., Webber, M., Novobrantseva, T., Ruda, V., Lytton-Jean, A., Levins, C., Kalish, B., Mudge, D., Perez, M., Abezgauz, L., Dutta, P., Smith, L., Charisse, K., Kieran, M., Fitzgerald, K., Nahrendorf, M., Danino, D., Tuder, R., von Andrian, U., Akinc, A., Schroeder, A., Panigrahy, D., Kotelianski, V., Langer, R. and Anderson, D., In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight, Nature Nanotechnology, 9: 648-655, 2014.

Chan, K., Li, R., Chapman, J., Trac, E., Kobler, J., Zeitels, S., Langer, R. and Karajanagi, S., Functionalizable hydrogel microparticles of tunable size and stiffness for soft tissue filler applications, Acta Biomaterialia, 10: 2563-2573, 2014. NIHMSID: 589854.

Dahlman, J., Tammela, T., Khan, O., Sood, S., Dave, A., Cai, W., Chirino, L., Yang, G., Bronson, R., Crowley, D., Sahay, G., Schroeder, A., Langer, R., Anderson, D., and Jacks, T., Small RNA combination therapy for lung cancer, Proceedings of the National Academy of Sciences, 111:  E3553-E3561, 2014

Aday, S., Zoldan, J., Carreto, L., Santos, T., Bernardino, L., Malva, J., Langer, R. and Ferreira, L., VEGF165-bound beads modulate endothelial cell survivial and mirna expression, Journal of Tissue Engineering and Regenerative Medicine, 8:  191-192, 2014.

Ilyinskii, P., Roy, C., O’Neil, C., Browning, E., Pittet, L., Altreuter, D., Alexis, F., Tonti, E., Shi, J., Basto, P., Iannacone, M., Radovic-Moreno, A., Langer, R., Farokhzad, O., von Andrian, U., Johnston, L and Kishimoto, T., Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release, Vaccine, 32:  2882-2895, 2014. NIHMSID: 589859.

Lim, J. Swami, A., Gilson, L., Chopra, S., Choi, S., Wu, J., Langer, R., Farokhzad, O. and Karnik, R., Ultra-high throughput synthesis of nanoparticles with homogeneous size distribution using a coaxial turbulent jet mixer, ACS Nano, 8:  6056-6065, 2014.

Cima, M., Lee, H., Daniel, K., Tanenbaum, L., Mantzavinou, A., Spencer, K., Ong, Q., Sy, J., Santini, J., Schoellhammer, C., Blankschtein, D. and Langer, R., Single compartment drug delivery, Journal of Controlled Release, 190:  157-171, 2014.

Webber, M., Khan, O., Sydlik, S., Tang, B. and Langer, R., A perspective on the clinical translation of scaffolds for tissue engineering, Annals of Biomedical Engineering, 43:  641-656, 2014.

Lee, J., Jeong, K., Hashimoto, M., Kwon, A., Rwei, A., Shankarappa, S., Tsui, J. and Kohane, D., Synthetic ligand-coated magnetic nanoparticles for microfluidic bacterial separation from blood, Nano Letters, 14:  1-5, 2014.

Whitehead, K., Dorkin, R., Vegas, A., Chang, P., Veiseh, O., Matthews, J., Fenton, O., Zhang, Y., Olejnik, K., Yesilyurt, V., Chen, D., Barros, S., Klebanov, B., Novobrantseva, T., Langer, R. and Anderson, D., Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity, Nature Communications, 5:  4277, 2014

Celiz, A., Smith, J., Patel, A., Langer, R., Anderson, D., Barrett, D., Young, L., Davies, M., Denning, C and Alexander, M., Chemically diverse polymer microarrays and high throughput surface characterization:  A method for discovery of materials for stem cell culture, Biomaterials Science, 2:  1604-1611, 2014.

Li, L., Tong, R., Chu, H., Wang, W., Langer, R and Kohane, D., Aptamer photo-regulation in vivo, Proceedings of the National Academy of Sciences, 111: 17099-17103, 2014.

Laulicht, B., Traverso, G., Deshpande, V., Langer, R. and Karp, Jeffrey, Simple battery armor to protect against gastrointestinal injury from accidental ingestion, Proceedings of the National Academy of Sciences ,111:  16490-16495, 2014.

Barth, H., Crafoord, S., O’Shea, T., Pritchard, C., Langer, R., Ghosh, F., A new model for in vitro testing of vitreous substitute candidates, Graefe’s Archive for Clinical and Experimental Ophthalmology, 252: 1581-1592, 2014. PMCID: PMC Exempt—Non-NIH/PHS Funding.

Mitragotri, S., Burke, P. and Langer, R., Overcoming the challenges in administering biopharmaceutical drugs:  Formulation and delivery strategies, Nature Reviews Drug Discovery, 13:  655-672, 2014.

Dahlman, J., Kauffman, K., Langer, R. and Anderson, D., Nanotechnology for in vivo targeted siRNA delivery, Advances in Genetics, 88:  37-69, 2014.

Chen, S., Xue, Y., Wu, X., Cong, L., Bhutkar, A., Bell, E., Zhang, F., Langer, R. and Sharp, P., Global microRNA depletion suppresses tumor angiogenesis, Genes and Development, 28:  1054-1067, 2014.

De la Fuente, M., Langer, R., and Alonso, M., Nanotechnology approaches for cancer immunotherapy and immunomodulation, in Nano-oncologicals:  New targeting and delivery approaches, 2014, Ch. 8. pp 215-242, Alonso, M. and Garcia-Fuentes, M. eds., Springer, New York.

Platt, R., Chen, S., Zhou, Y., Yim. M., Swiech, L., Kempton, H., Dahlman, J. Parnas, O., Eisenhaure, T., Jovanovic, M., Graham, D., Jhunjhunwala, S., Xavier, R., Langer, R., Anderson, D., Hacohen, N., Regev, A., Feng, G., Sharp, P., Zhang, F., CRISPR-Cas9 knockin mice for genome editing and cancer modeling, Cell, 159:  440-455, 2014.

Dong, Y., Eltoukhy, A., Alabi, C., Khan, O., Veiseh, O., Dorkin, J., Sirirungruang, S., Yin, H., Tang, B., Pelet, J., Chen, D., Gu, Z., Xue, Y., Langer, R. and Anderson, D., Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo, Advanced Healthcare Materials, 3:  1392-1397, 2014.

2013

2013

Eltoukhy A. A., Chen, D., Alabi, C. A., Langer R. and Anderson D. G., Degradable terpolymers with alkyl side chains demonstrate enhanced gene delivery potency and nanoparticle stability, Advanced Materials, 25:  1487-1493, 2013. PMID: 23293063.

Fisher, O. Z., Larson, B. L., Hill, P. S., Graupner, D., Nguyen-Kim, M-T., Kehr, N-S., Cola, L., Langer, R. and Anderson D. G. Melanin-like hydrogels derived from gallic macromers, Advanced Materials, 24:  3032-3036, 2013 PMCID: Exempt from PMC—Non-NIH/PHS Funding

Hook, A., Chang, C., Yang, J., Atkinson, S., Langer, R., Anderson, D., Davies, M., Williams, P. and Alexander, M., Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays, Advanced Materials, 25:  2542-2547, 2013. PMID: 23417823, PMCID: PMC 3736217.

Neal, R., Jean, A., Park, H., Wu, P., Hsiao, J., Engelmayr, G., Langer, R. and Freed, L., 3D elastomeric scaffolds designed with cardiac-mimetic structural and mechanical features, Tissue Engineering, 19:  793-807, 2013. PMCID: 23190320, PMCID: PMC3566675.

Langer, R., Fuller, J. and Levin, M. Chapter III.1.10 Entrepreneurship in Biomaterials, in Biomaterials Science, 2013, 3rd Ed., pp. 1459-1472, Ratner, D., Hoffman, S. and Schoen, F. eds., Elsevier Inc., Academic Press.

Ma, M., Guo, L, Anderson, D. and Langer, R., Bio-inspired polymer composite actuator and generator driven by water gradients, Science, 339: 186-189, 2013. PMID: 23307738, PMCID: PMC3635810.

Langer, R., A personal account of translating discoveries in an academic lab, Nature Biotechnology, 31:  487-489, 2013. PMID: 23752424.  PMC Exempt – Review.

Karagiannis, E., Urbanska, A., Sahay, G., Pelet, J., Jhunjhunwala, S., Langer, R., Anderson, D., Rational design of a biomimetric cell penetrating peptide library, ACS Nano, 7: 8616-8626, 2013.

Sharei, Armon, Zoldan, Janet, Adamo, Andrea., Sim, Woo-Young, Cho, Nahyun, Jackson, Emily, Mao, Shirley, Schneider, Sabine, Han, Min-Joon, Lytton-Jean, Abigail, Basto, Pamela A., Jhunjhunwala, Siddharth, Lee, Jungmin, Heller, Daniel A., Kang, Jeon Woong, Hartoularos, George C, Kim, Kwang-Soo, Anderson, Daniel G, Langer, Robert, Jensen, Klavs F., A vector-free microfluidic platform for intracellular delivery, Proceedings of the National Academy of Sciences, 110: 2082-2087, 2013.  PMCID: PMC3568376.

Heller, D., Levi, Y., Pelet, J., Doloff, J., Wallas, J., Pratt, G., Jiang, S., Sahay, G., Schroeder, A., Schroeder, J.E., Chyan, Y., Zurenko, C., Querbes, W., Manzano-Garcia, Kohane, D., Langer, R., and Anderson, D., Modular ‘click-in-emulsion’ bone-targeted nanogels, Advanced Materials, 25:  1449-1454, 2013. PMID: 23280931.

Hashimoto, M., Langer, R. and Kohane, D., Benchtop fabrication of microfluidic systems based on curable polymers with improved solvent compatibility, Lab on a Chip, 13:  252-259, 2013. PMID: 23192674.

Sharei, A., Cho, N., Mao, S., Jackson, E., Poceviciute, R., Adamo, A., Zoldan, J., Langer, R. and Jensen, K., Cell squeezing as a robust microfluidic intracellular delivery platform, Journal of Visualized Experiments, 81, e50980, 2013.

Sahay, G., Querbes, W., Alabi, C., Eltoukhy, A., Sarkar, S., Zurenko, C., Karagiannis, E., Love, K., Chen, D., Zoncu, R., Buganim, Y., Schroeder, A., Langer, R. and Anderson, D., Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling, Nature Biotechnology, 31:  653-658, 2013. PMID: 23792629, PMID: PMC3814166.

Hook, A., Scurr, D., Burley, J., Langer, R., Anderson, D., Davies, M. and Alexander, M., Analysis and prediction of defects in UV photo-initiated polymer microarrays, Journal of Materials Chemistry B, 1: 1035-1043, 2013.

Langer, R., Biomaterials and biotechnology:  From the discovery of the first angiogenesis inhibitors to the development of controlled drug delivery systems and the foundation of tissue engineering, Journal of Biomedical Materials Research, 101A:  2449-2455, 2013. PMID: 23723136.

Alabi, C., Love, K., Sahay, G., Yin H., Luly, K., Langer, R., and Anderson, D., Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery, Proceedings of the National Academy of Sciences, 110: 12881-12886, 2013. PMID: 23882076, PMCID: PMC3740846.

Bonner, D., Zhao, X., Buss, H., Langer, R., Hammond, P., Crosslinked linear polyethylenimine enhances delivery of DNA to the cytoplasm, Journal of Controlled Release, 167: 101-107, 2013. PMID: 22995755.

Celiz, A., Hook A., Scurr, D., Anderson, D., Langer, R., Davies, M. and Alexander, M., ToF-SIMS imaging of a polymer microarray prepared using ink-jet printing of acrylate monomers, Surface and Interface Analysis, 45: 202-205, 2013.

Chertok, B., Webber, M., Succi, M. and Langer, R., Drug Delivery Interfaces in the 21st Century: From Science Fiction Ideas to Viable Technologies, Molecular Pharmacology, 10: 3531-3543, 2013. PMID: 23915375.

Dang, T., Thai, A., Cohen, J., Slosberg, J., Siniakowicz, D., Doloff, J., Ma, M., Hollister-Lock, J., Tang, K., Gu, Z., Cheng, H., Weir, G., Langer, R. and Anderson, D., Enhanced function of immune-isolated islets in diabetes therapy by co-encapsulation with an anti-inflammatory drug, Biomaterials, 34: 5792-5801, 2013. PMID: 23660251.

Gabriel, D., Monteiro, I., Huang, D., Langer, R. and Kohane, D., A photo-triggered layered surface coating producing reactive oxygen species, Biomaterials, 34: 9763-9769, 2013. PMID: 24074838.

Gianella, A., Janssen, H., Hoben, F., Jarzyna, P. Cormode, D., Costa, K., Rao, S., Langer, R., Farokhzad, O. and Mulder, W., Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform, ChemComm, 49: 9392-9394, 2013. PMID: 23877789, PMCID: PMC3786364.

Gu, M., Vegas, A., Anderson, D., Langer, R., Kilduff, C. and Belfort, G., Combinatorial synthesis with high throughput discovery of protein-resistant membrane surfaces, Biomaterials, 34: 6133-6138, 2013. PMID: 23706542.  NIHMS# 548463.

Gu, Z., Aimetti, A., Wang, Q., Dang, T., Zhang, Y., Veiseh, O., Cheng, H., Langer, R. and Anderson, D., Injectable nano-network for glucose mediated insulin delivery, ACS Nano, 7: 4194-4201, 2013. PMID: 23638642.

Haq, R., Yokoyama, S., Hawryluk, E., Jonsson, G., McHenry, K., Porter, D., Tran, T., Love, K., Langer, R., Anderson, D., Garraway, L., Duncan, L., Morton, D., Hoon, D., Song, J. and Fisher, D., BCL2A1 is a lineage-specific anti-apoptotic melanoma oncogene that confers resistance to BRAF inhibition, Proceedings of the National Academy of Sciences, 110: 4321-4326, 2013. PMID: 23447565, PMCID: PMC3600451.

Wang, J., Boutin, K., Abdulhadi, O., Personnat, L., Shazly, T., Langer, R., Chanick, C. and Borenstein, J., Fully biodegradable airway stents using amino alcohol-based poly(ester amide) elastomers, Advanced Healthcare Materials, 2:  1329-1336, 2013. PMID: 23526787. PMCID: PMC Exempt—Non-NIH/PHS Funding.

Hook, A., Scurr, D., Anderson, D., Langer, R., Williams, P., Davies, M., and Alexander, M., High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry, Surface and Interface Analysis, 45: 181-184, 2013. PMID: 23450147, PMCID: PMC3579490.

Jiang, S., Eltoukhy, A., Love, K., Langer, R., Anderson, D., Lipidoid-Coated Iron Oxide Nanoparticles for Efficient DNA and siRNA delivery, Nano Letters, 13: 1059-1064, 2013. PMID: 23394319.

Johnstone, T., Kulak, N., Pridgen, E., Farokhzad, O., Langer, R. and Lippard, S., Nanoparticle encapsulation of mitaplatin and the effect thereof on in vivo properties, ACS Nano, 7: 5675-5683, 2013. PMID: 23697579, PMCID: PMC3722263.

Scurr, D., Hook, A., Burley, J., Williams, P., Anderson, D., Langer, R., Davices, M. and Alexander, M., Strategies for MCR image analysis of large hyperspectral data-sets, Surface and Interface Analysis (Special Issue):  45, 466-470, 2013.

Kamaly, N., Fredman, G., Subramanian, M., Gadde, S., Pesic, A., Cheung, L., Fayad, Z., Langer, R., Tabas, I. and Farokhzad, O., Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles, Proceedings of the National Academy of Sciences, 110: 6506-6511, 2013. PMID: 23533277, PMCID: PMC3631648.

Karagiannis, E., Urbanska, A., Sahay, G., Pelet, J., Jhunjhunwala, S., Langer, R., and Anderson, D., Rational design of a biomimetic cell penetrating peptide library, ACS Nano, 7:  8616-8626, 2013. PMID: 24047542.

Khoo, X., Simons, E., Chiang, H., Hickey, J., Sabharwal, V., Pelton, S., Rosowski, J., Langer, R., Kohane, D., Formulations for trans-tympanic antibiotic delivery, Biomaterials, 34: 1281-1288, 2013. PMID: 23146430, PMCID: PMC3511665.

Kim, Y., Fay, F., Cormode, D., Sanchez-Gaytan, B., Tang, J., Hennessy, E., Ma, M., Moore, K., Farokhzad, O., Fisher, E., Mulder, W., Langer, R., Fayad, Z., Single Step Reconstitution of Multifunctional High-Density Lipoprotein-Derived Nanomaterials Using Microfluidics, ACS Nano, 7:  9975-9983, 2013. PMID: 24079940.

Kolewe, M., Park., H., Gray, C., Ye, X., Langer, R. and Freed, L., 3D structural patterns in scalable, elastomeric scaffolds guide engineered, Advanced Materials, 25: 4459-4465, 2013. PMID: 23765688.

Lim, D., Barhoumi, A., Wylie, R., Reznor, G., Langer, R. and Kohane, D., Enhanced photothermal effect of plasmonic nanoparticles coated with reduced graphene oxide, Nano Letters, 13: 4075-4079, 2013. PMID: 23899267.

Mieszawska, A., Kim, Y., Gianella, A., van Rooy, I., Priem, B., Labarre, M., Ozcan, C., Cormode, D., Petrov, A., Langer, R., Farokhzad, O., Fayad, Z. and Mulder, W., Synthesis of polymer-lipid nanoparticles for image-guided delivery of dual modality therapy, Bioconjugate Chemistry, 24: 1429-1434, 2013. PMID: 23957728, PMCID: PMC3810168.

Mizrahi, B., Shankarappa, S., Hickey, J., Dohlman, J., Timko, B., Whitehead, K., Lee, J., Langer, R., Anderson, D. and Kohane, D., A stiff injectable biodegradable elastomer, Advanced Functional Materials, 23: 1527-1533, 2013. PMID: 23667350, PMCID: PMC3646576.

Pereira, M., Ouyang, B., Sundback, C., Langer, N., Friehs, I., Mureli, S., Pomerantseva, I., McFadden, J, Mochel, M., Mwizerwa, O., del Nido, P., Sarkar, D., Masiakos, P., Langer, R., Ferreira, L. and Karp, J., A highly tunable biocompatible and multifunctional biodegradable elastomer, Advanced Materials, 25:  1209-1215, 2013. PMID: 24106240.

Saigal, R., Cimetta, E., Tandon, N., Zhou, J., Langer, R., Young, M., Vunjak-Novakovic, G. and Redenti, S., Electrical stimulation via a biocompatible conductive polymer directs retinal progenitor cell differentiation, Conf. Proc. IEEE Eng. Med. Biol. Soc., 2013: 1627-1631, 2013. PMID: 24110015.

Hubbell, J. and Langer, R. Translating materials design to the clinic, Nature Materials, 12:  963-966, 2013.

Xu, X., Xie, K., Zhang, X., Pridgen, E., Park, G., Cui, D., Shi, J., Wu, J., Kantoff, P., Lippard, S., Langer, R., Walker, G. and Farokhzad, O., Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug, Proceedings of the National Academy of Sciences, 110:  18638-18643, 2013.

Pridgen, E., Alexis, F., Kuo, T., Levy-Nissenbaum, E., Karnik, R., Blumberg, R., Langer, R. and Farokhzad, O., Transepithelial transport of Fc-targeted nanoparticles by the neonatal Fc receptor for oral delivery, Science Translational Medicine, 5:  213ra167, 2013. PMID: 24285486; NIHMSID#565166.

Valencia, P., Pridgen, E., Rhee, M., Langer, R., Farokhzad, O., and Karnik, R., Microfluidic platform for combinatorial synthesis and optimization of targeted nanoparticles for cancer therapy, ACS Nano, 7:  10671-10680, 2013.

Valencia, P., Pridgen, E., Perea, B., Gadde, S., Sweeny, C., Kantoff, P., Bander, N., Lippard, S., Langer, R., Karnik, R. and Farokhzad, O., Synergistic cytotoxicity of irinotecan and cisplatin in dual drug targeted polymeric nanoparticles, Nanomedicine (Long), 8:  687-698, 2013. PMID23075285; PMCID3694785; 10.2217/nnm.12.134.

2012

2012

Schroeder, A., Heller, D., Winslow, M., Dahlman, J., Pratt, G., Langer, R., Jacks, Tyler and Anderson, D., Treating metastatic cancer with nanotechnology, Nature Reviews Cancer, 12:  39-50, 2012.

Tekin, H., Sanchez, J., Landeros, C., Dubbin, K., Langer, R. and Khademhosseini, A., Controlling spatial organization of multiple cell types in defined 3D geometries, Advanced Materials, 24:  5543-5547, 2012. PMID: 22941804.

Hrkach, J., von  Hoff, D., Ali, M., Andrianova, E., Auer, J., Campbell, T., De Witt, D., Figa, M., Figueiredo, M., Horhota, A., Low, S, McDonnell, K., Peeke, E, Retnarajan, B., Sabnis, A., Schnipper, E., Song, J., Song, Y., Summan, J., Tompsett, D., Trojano, G., Van Geen Hoven, T., Wright, J., LoRusso, P., Kantoff, P., Bander, N., Sweeney, C., Farokhzad, O., Langer, R. and Zale, S., Preclinical development and clinical translation of a PSMA targeted docetaxel nanoparticle with a differentiated pharmacological profiles, Science Translational Medicine, 4, 128ra39, 2012.

Kost, J. and Langer, R., Responsive polymeric delivery systems, Advanced Drug Delivery Reviews, 64:  327-341, 2012.

Li, J., Song, J., Bell, R., Tran, T., Haq, R., Liu, H., Love, K., Langer, R., Anderson, D., Larue, L. and Fisher, D., YY1 regulates melanocyte development and function by cooperating with MITF, PLOS Genetics, 8, e1002688, 2012.

Lee, J., Sharei, A., Sim, W., Adamo, A., Langer, R., Jensen, K. and Bawendi, M., Nonendocytic delivery of functional engineered nanoparticles into the cytoplasm of live cells using a novel, high-throughput microfluidic device, Nano Letters, 12:  6322-6327, 2012.

Bellan, L., Kniazeva, T., Kim, W., Epshteyn, A., Cropek, D., Langer, R. and Borenstein, J., Fabrication of a hybrid microfluidic system incorporating both lithographically patterned microchannels and a 3D fiber-formed microfluidic network, Advanced Healthcare Materials, 1:  164-167, 2012. PMID: 22708076.

Eltoukhy,A., Siegwart, D., Alabi, C., Rajan, J., Langer, R. and Anderson, D., Effect of Molecular weight of amine end-modified poly(beta-amino ester)s on gene delivery efficiency and toxicity, Biomaterials, 33:  3594-3603, 2012.  PMICD: PMC3326358

Alabi, C. A., Sahay, G., Langer, R. and Anderson, D. G., Development of siRNA-probes for studying intracellular trafficking of siRNA nanoparticles, Integrative Biology, 5:  224-230, 2012, PMID: 23014672, PMCID: PMC3524365.

Hook, A., Chang, C., Yang, J., Luckett, J., Cockayne, A., Atkinson, S., Mei,  Y., Bayston, R., Irvine, D., Langer, R., Anderson, D., Williams, P., Davies, M. and Alexander, M., Combinatorial discovery of polymers resistant to bacterial attachment, Nature Biotechnology, 30:  868-875, 2012. PMID22885723; PMCID3796337; 10.1038/nbt.2316.

Seto, J., Polat, B., VanVeller, B., Lopez, R., Langer, R. and Blankschtein, D., Fluorescent penetration enhancers for transdermal applications, Journal of Controlled Release, 158: 85-92, 2012.

Lee, H., Lytton-Jean, A., Chen, Y., Love, K., Park, A., Karagiannis, E., Sehgal, A., Querbes, W., Zurenko, C., Jayaraman, M., Peng, C., Charisse, K., Borodovsky, A., Manoharan, M., Donahoe, J., Truelove, J., Nahrendorf, M., Langer, R. and Anderson, D., Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery, Nature Nanotechnology, 7:  389-393, 2012.

Valencia, P., Farokhzad, O., Karnik, R., Langer, R., Microfluidic technologies for accelerating the clinical translation of nanoparticles,  Nature Nanotechnology, 7:  623-629, 2012. PMID: 23042546.

Polat, B., Deen, W., Langer, R., Blankschtein, D., A physical mechanism to explain the delivery of chemical penetration enhancers into skin during transdermal sonosphoresis:  Insight into the observed synergism, Journal of Controlled Release, 158: 250-260, 2012.

Siegwart, D., Leiendecker, M., Langer, R. and Anderson, D., Automated ARGET ATRP accelerates catalyst optimization for the synthesis of thiol-fuctionalized polymers, Macromolecules, 45: 1254-1261, 2012.

Jaklenec, A, Stamp, A., Deweerd, E., Sherwin, A and Langer, R., Progress in tissue engineering and stem cell industry “Are we there yet?”, Tissue Engineering, 18:  155-166, 2012.

Vacanti, N. M., Chen, H., Hill, P. S., Guerreiro, J. D. T., Dang, T. T., Ma, M. L., Watson, S., Hwang, N. S., Langer, R. and Anderson, D. G., Localized delivery of dexamethasone from electrospun fibers reduces the foreign body response, Biomacromolecules,  13: 3031-3038, 2012.

Shankarappa, S., Tsui, J, Kim, K, Reznor, G., Dohlman, J., Langer, R. and Kohane, D., Prolonged nerve blockade delays the onset of neuropathic pain, Proceedings of the National Academy of Sciences,  109: 17555-17560, 2012.

Farra, R., Sheppard, N., McCabe, L., Neer, R., Anderson, J., Santini, J., Cima, M. and Langer, R., First in-human testing of a wirelessly controlled drug delivery microchip, Science Translational Medicine, 4:  122ra21, 2012.

Nguyen, D., Mahone, K., Chikh, G., Kim, P., Chung, H., Vicari, A., Love, K., Goldberg, M., Chen, S., Krieg, A., Chen, J., Langer, R. and Anderson, D., Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery, Proceedings of the National Academy of Sciences, 109:  E797-E803, 2012. PMID22421433; PMCID3325698; 10.1073/pnas.1121423109.

Schroeder, A., Goldberg, M., Kastrup, C. Wang, Y., Jiang, S., Joseph, B., Levins, C., Kannan, S., Langer, R. and Anderson, D., Remotely-activated protein-producing nanoparticles, Nano Letters, 12, 2685-2689, 2012.

Sun, S., Wang, M., Knupp, S., Soto-Feliciano, Y., Hu, X., Kaplan, D., Langer, R., Anderson, D. and Xu, Q., Combinatorial library of lipidoids for in vitro DNA delivery, Bioconjugate Chemistry, 23: 135-140, 2012.

Langer, R. and Tirrell, D., Introduction and Overview, in Polymer Science:  A comprehensive Reference, 2012, Vol. 9 pp. 1-2, Matyjaszewski, K. and Moller. eds., Elsevier BV, Amsterdam, Netherlands.

Mieszawska, A., Gianella, A., Cormode, D., Zhao, Y., Meijerink, A., Langer, R., Farokhzad, O., Fayad, Z. and Mulder, W., Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging, ChemComm, 448:  5835-5837, 2012.

Cho, S-W., yang, F., Son, S.M., Park, H. J., Green, J. J., Bogatyrev, S., Mei, Y., Park, S., Langer, R. and Anderson, D. G.  Therapeutic angiogensis using genetically engineered human enddothelial cells, Journal of Controlled Release, 160: 515-524, 2012.

Tian, B., Liu, J., Dvir., T., Jin., L., Tsui, J., Qing, Q., Suo, Z., Langer, R., Kohane, D. and Lieber, C., Macroporous nanowire nanoelectronic scaffolds for synthetic tissues, Nature Materials, 11: 986-994, 2012.

Urbanska, A., Karajiannis, E., Guajardo, G., Langer, R. and Anderson, D., Therapeutic effect of orally administered oxaliplatin for colorectal biomaterials, Biomaterials, 33: 4752-4761, 2012.

Schoellhammer, C., Polat, B., Hart, D., Blankschtein, D. and Langer, R., Rapid skin permeabilization by the simultaneous application of dual-frequency, high-intensity ultrasound, Journal of Controlled Release, 163:  154-160, 2012.

Cho, W., Ankrum, J., Guo, Dagang, Chester, S., Yang, S., Kashyap, A., Campbell, G., Wood, R., Rijal, R., Karnik, R., Langer, R. and Karp, J., Microstructed barbs on the North American porcupine quill enable easy tissue penetration and difficult removal, Proceedings of the National Academy of Sciences, early addition eprint, doi: 10.1073/pnas.1216441109, 2012.

Cohen-Karni, T., Langer, R. and Kohane, D., The smartest materials:  The future of nanoelectronics in medicine, ACS Nano, 6:  6541-6545, 2012. PMID: 22850578.

Bratlie, K. M., York, R. L., Invernale, M. A., Langer, R. and Anderson D.G., Materials for diabetes therapeutics Advanced Healthcare Materials, 1: 267-84, 2012. PMCID: Exempt from PMC—Non-NIH/PHS Funding

Radovic-Moreno, A., Lu, T., Puscasu, V., Yoon, C., Langer, R. and Farokhzad, O., Surface charge-switching polymeric nanoparticles for bacterial cell wall-targeted delivery of antibiotics, ACS Nano, 6: 42779-4287, 2012.

Laulicht, B., Langer, R. and Karp, J., Quick release medical tape, Proceedings of the National Academy of Sciences, 109:  18803-18808, 2012.

Novobrantseva, T., Borodovsky, A., Wong, J., Klebanov, B., Zafari, M., Yucius, K. Ge, P., Ruda, v., Querbes, Q., Milstein, S, Speciner, L, Duncan, R., Basha, G., Cullis, P., Akinc, A., Sullivan, J., Jayaprakash, N., Jayaraman, M., Bogorad, R., Love, K., Whitehead, K., Levins, C., Manoharan, M., Swirski, P., Weissleder, R., Langer, R., Anderson, R., de Fougerolles, A., Nahrendorf, M. and Koteliansky, V., Systemic RNAi-mediated gene silencing in non-human primate and rodent myeloid cells, Molecular Therapy Nucleic Acids, 1: e4, doi:10.1038/mtna.2011.3, 2012.

Epa, V. C., Yang, J., Mei, Y., Hook, A. L., Langer, R., Anderson, D. G., Davies, M., Alexander, M. R. and Winkler, D. A.,  Modelling human embryoid body cell adhesions to a combinatorial library of polymer surfaces, Journal of Materials Chemistry, 22: 20902-20906, 2012.

Kang, S. M., Hwang, N.S, Yeom, J., Park, S. Y., Messersmith, P. B., Choi, I. S., Langer, R., Anderson, D. G. and Lee, H.,  One-step multipurpose surface functionalization by adhesive catecholamine, Advanced Functional Materials, 22: 2949-2955, 2012.

Smith, R., Zhang, Z., Bouchard, M., Li, J., Lapp, H., Brotske, G., Lucchino, D., Weaver, D., Roth, L., Coury, A., Biggerstaff, J., Sukavaneshvar, S., Langer, R. and Loose, C., Vascular catheters with a non-leaching poly-sulfobetaine surface modification reduce thrombus formation and microbial attachment, Science Translational Medicine, 4:  153ra132, 2012.

Alabi, C., Love, K., Sahay, g., Stutzman, T., Young, W., Langer, R. and Anderson, D., FRET-labeled siRNA probes for tracking assembly and disassembly of siRNA nanocomplexes, ACS Nano, 6:  6133-6141, 2012. PMCID:PMC3404193

Wang, A., Langer, R. and Farokhzad, O., Nanoparticle delivery of cancer drugs, Annual Reviews of Medicine, 63:  185-198, 2012.

Salvador-Morales, C., Valencia, P. Thakkar, A., Swanson, E. and Langer, R., Recent developments in multifunctional hybrid nanoparticles:  Opportunities and challenges in cancer therapy, Frontiers in Bioscience, (Elite Edition): 4:  529-545, 2012. PMID: 22201893.

Stevenson, C., Santini, J. and Langer, R., Reservoir based drug delivery systems utilizing microtechnology, Advanced Drug Delivery Reviews, 64:  1590-1602, 2012.

Tong, R., Hemmati, H., Langer, R. and Kohane, D., Photoswitchable nanoparticles for triggered tissue penetration and drug delivery, Journal of the American Chemical Society, 134:  8848-8855, 2012.

Xiao, Z., Levy-Nissenbaum, F. Alexis, Teply, B.,  Chanm J., Shi, J., Digga, E., Cheng, J. Langer, R., and Farokhzad, O., Engineering of targeted nanoparticles for cancer therapy using internalizing  aptamers isolated by cell-uptake projection, ACS Nano, 6:  694-704, 2012.t

De Sousa, F., Lima, A., Denadai, A., Anconi, C., De Almeida, W., Novato, W., Dos Santos, H., Drum, C., Langer, R. and Sinisterra, Superstructure based on b-CD of self-assembly induced by a small guest molecule, Phys. Chem. Chem. Phys., 14:  1934-1944, 2012.

Kastrup, C., Nahrendorf, M., Figueiredo, J., Lee, H., Kambhampati, S., Lee, T., Cho, S., Gorbatov, R., Iwamoto, Y., Dang, T., Dutta, P., Yeon, J., Cheng, H., Pritchard, C., Vegas, A., Siegel, C., MacDougall, S., Okonkwo, M., Thai., A., Stone, J., Coury, A., Weissleder, R., Langer, R. and Anderson, D., Painting blood vessels and atherosclerotic plaques with an adhesive drug depot, Proceedings of the National Academy of Sciences, 109:  21444-21449, 2012.

Cohen-Karni, T., Jeong, K., Tsui, J., Reznor, G., Mustata, M., Wanunu, M., Graham, A., Marks, C., Bell, D., Langer, R. and Kohane, D., Nanocomposite gold-silk nanofibers, Nano Letters, 12:  5403-5406, 2012.

Cheng, H., Byrska-Bishop, M., Zhang, C. T., Kastrup, C. J., Hwang, N. S., Tai, A. K., Lee, W. W., Xu, X. Y., Nahrendorf, M., Langer, R. and Anderson, D. G., Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell-selectin interaction kinetics, Biomaterials33:  5004-5012, 2012.  PMCID: PMC366278

Kim, Y., Chung, B., Ma, M., Mulder, W., Fayad, Z., Farokhzad, O. and Langer, R., Mass production and size control of lipid-polymer hybrid nanoparticles through controlled microvortices, Nano Letters, 12:  3587-3591, 2012.

2011

2011

Chan, E., Karp, J. and Langer, R., A “self-pinning” adhesive based on responsive surface wrinkles, Journal of Polymer Science Part B:  Polymer Physics, 49:  40-44, 2011. PMID: 21293787, PMCID: PMC3031119.

Dvir, T., Timko, B., Kohane, D. and Langer, R., Nanotechnological strategies for engineering complex tissues, Nature Nanotechnology, 6:  13-22, 2011. PMID: 21151110, PMCID: PMC Exempt—Review.

Timko, BP, Whitehead, K., Gao,W., Kohane, D., Farokhzad, O., Anderson, D. and Langer, R.,  Advances in drug delivery, Annual Review of Materials Research, 41:  1-20, 2011.

Siegwart, D. Whitehead, K., Nuhn, L., Cheng, H., Jiang, S., Ma, M., Vegas, A. Fenton, P., Love, K., Levins, C., Sahay, G., Lee, H., Collins, S., Li, Y.F., Jang, J., Langer, R., Anderson, D.G., High-throughput synthesis of chemically diverse core-shell nanoparticles for intracellular delivery; Proceedings of the National Academy of Sciences, 108: 12996-3001, 2011.

Rhee, M., Valencia, P., Rodriguez, M., Langer, R., Farokhzad, O. and Karnik, R., Synthesis of size tunable polymeric nanoparticles enabled by 3D hydrodynamic flow focusing in single layer microchannels, Advanced Materials, 23:  H79-H83, 2011.

Radovic-Moreno, A., Yuet, K., Langer, R. and Farokhzad, O., Perspectives on nanotechnology in Interventional Techniques in Uro-oncology, ch. 7, p.102., Arya, M., Ahmed, H., Scardino, P. Emberston, M, eds. Wiley-Blackwell Publishers, Hoboken, NJ, 2011.

Kraehenbuehl, T., Ferreira, L., Hayward, L., Nahrendorf, M., Vasile, E., van der Vlies, A., Weissleder, R., Langer, R. and Hubbell, J., Human embryonic stem cell-based microvascular grafts for cardiac tissue preservation after myocardial infarction, Biomaterials, 32:  1102-1109, 2011. PMID: 21035182.

Belfort, G., Zhou, M., Liu, H., Venkiteshwaran, A., Kilduff, J., Langer, R. and Anderson, D., High throughput discovery of new fouling-resistant surfaces, Journal of Materials Chemistry, 21:  693-704, 2011.

Liu, W., Ma., M., Bratlie, K., Dang, T., Langer, R. and Anderson, D., Real time in vivo detection of biomaterials-induced reactiveloxygen species, Biomaterials, 32:  1796-1801, 2011.

Polat, B., Hart, D., Langer, R. and Blankschtein, D., Ultrasound mediated transdermal drug delivery:  Mechanism, scope and emerging trends, Journal of Controlled Release, 152:  330-348, 2011.

Lopez, R., Seto, J., Blankschtein, D. and Langer, R., Enhancing the transdermal delivery of nanoparticles using ultrasound and sodium lauryl sulfate, Biomaterials, 32:  933-941, 2011. PMID: 20971504, PMCID: PMC2991545.

Pritchard CD, O’Shea TM, Siegwart DJ, Calo E, Anderson DG, Reynolds FM, Thomas JA, Slotkin JR, Woodard EJ, Langer R., An injectable thiol-acrylate poly(ethylene glycol) hydrogel for sustained release of methylprednisolone sodium succinate, Biomaterials, 32:  587-597, 2011, PMID: 20880573.

Kaji, H., Camci-Unal, G., Khademhosseini, A. and Langer, R., Engineering systems for the generation of patterned co-cultures for controlling cell-cell interactions, Biochimica et Biophysica Acta, 1810: 239-250, 2011. PMID: 20655984, PMCID: PMC3026923.

Polat, B., Seto, J., Blankschtein, D. and Langer, R., Effect of sodium lauryl sulfate on skin structural perturbation when utilized simultaneously with low-frequency sonophoresis, Journal of Pharmaceutical Sciences, 100:  1387-1397, 2011.

Hwang, N. ,Im, S., Wu, P., Bichara, D., Zhao, Z, Randolph, M. Langer, R. and Anderson, D., Chondrogenic priming adipos-enchymal stem cells for cartilage tissue regeneration, Pharmaceutical Research, 28: 1395-1405, 2011.

Valencia, P., Hanewich-Hollatz, M., Gao, W., Karim, F., Langer, R. Karnik, R and Farokhzad, O., Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles, Biomaterials, 32:  6226-6233, 2011.

Tekin, H., Ozaydin-Ince, G., Tsinman, T., Gleason, K., Langer, R., Khademhosseini, A. and Demirel, M., Responsive microgrooves for formation of harvestable tissue constructs, Langmuir, 27:  5671-5679, 2011.

Scott, A., Tyler, B., Masi, B., Upadhyay, U., Patta, Y., Grossman, R., Basaldella, L, Langer, R., Brem, H. and Cima, M., Intracranial microcapsule drug delivery device for the treatment of an experimental gliosarcoma model, Biomaterials, 32: 2532-2539, 2011. PMID: 21220172, PMCID: PMC Exempt—Non-NIH/PHS Funding.

Whitehead, K., Dahlman, J., Langer, R. and Anderson, D., Silencing or Stimulation?  siRNA delivery and the immune system, in Annual Review of Chemical and Biomolecular Engineering, 2011, Vol. 2 pp. 77-96, Prausnitz, J., Doherty, M., and Segalman, R. eds., Annual Reviews, Palo Alto, CA.

Karajanagi, S., Yoganathan, R., Mammucari, R., Park, H., Cox, J., Zeitels, S., Langer, R. and Foster, N., Application of a dense gas technique for sterilizing soft biomaterials, Biotechnology and Bioengineering, 108:  1716-1725, 2011.  PMID:  21337339.

Polat, E., Lin, S., Mendenhalll, J., VanVeller, B. Langer, R. and Blankschtein, D., Experimental and molecular dynamics investigation into the amphiphilic nature of sulforhodamine B., J. Phy. Chem B., 115:  1394-14032, 2011. PMID: 21222449

Karajanagi, S., Lopez-Guerra, G., Park, H., Kobler, J., Galindo, M., Aanestad, J., Mehta, D., Kumai, Y., Giordano, N., d’Almeida, A., Heaton, J., Langer, R., Herera, V., Faquin, W., Hillman, R., and Zeitels, M., Assessment of canine vocal fold function after injection of a new biomaterial designed to treat phonatory mucosal scarring, Annals of Otology, Rhinology, and Laryngology, 120:  175-184, 2011.

Moghimi, S, Peer, D. and Langer, R., Reshaping the future of nanopharmaceuticals:  ad iudicium, ACS Nano, 5:  8454-8458, 2011.

Sharp, P. and Langer, R., Promoting convergence in biomedical science, Science, 333: 527, 2011. PMID21798916; PMC Excempt-non-peer review paper; 10.1126/science.1205008.

Cheng, H., Hill, P., Siegwart, D., Vacanti, N., Lytton-Jean, A., Cho, S., Ye, A., Langer, R., and Anderson, D., A novel family of biodegradable poly(ester amide) elastomers, Advanced Materials, 23: H95-H100, 2011.

Hook, A., Yang, J., Chen, X., Robert, C., Mei, Y., Anderson, D., Langer, R., Alexander, M. and Davies, M., Polymers with hydro-responsive topography identified using high throughput AFM of an acrylate microarray, Soft Matter, 7: 7194-7197, 2011.

Bonner, D., Leung, C. Chen-Liang, j., Chingozha, L, Langer, R. and Hammond, P., Intracellular trafficking of polyamidoamine-poly(ethylene glycol) block copolymers in DNA delivery, Bioconjugate Chemistry, 22:  1519-1525, 2011.

Kraehenbuehl, T., Langer, R. and Ferreira, L., Three-dimensional biomaterials for the study of human pluripotent stem cells, Nature Methods, 8: 731-736, 2011.

Tekin, H., Tsinman, T., Sanchez, J., Jones, B., Camci-Unal, G., Nichol, J. Langer, R. and Khademhosseini, A., Responsive micromolds for sequential patterning of hydrogel microstructures, Journal of the American Chemical Society, 133:  12944-12947, 2011.

Wang, L., Jeong, K., Chiang, H., Zurakowski, D., Behlau, I., Chodosh, J., Dohlman, C., Langer, R. and Kohane, D., Hydroxyapatite for kertoprosthesis biointegration, Investigative Ophthalmology and Visual Science, 52:  7392-7399, 2011.

Kohane, D. and Langer, R., Drug delivery and translation, Drug Delivery and Translational Research, 1:  4-6, 2011.

Jeong, K., Wang, L., Stefanescu, C., Lawlor, M., Polat, J., Dohlman, C., Langer, R. and Kohane, D., Polydopamine coatings enhance biointegration of a model polymeric implant, Soft Matter, 7:  8305 – 8312, 2011.

Urtti, A., Vuorimaa, E., Ketola, T., Hanzlikova, M., Green, J., Lemmetyinen, H., Langer, R. and Anderson, D., Poly (beta) amino ester – DNA complexes:  Time resolved fluorescence and cellular tranfection studies, Journal of Controlled Release, 154:  171-176, 2011.

Zoldan, J. Karagiannis, E., Lee, C., Anderson, D., Langer, R. and Levenberg, S. The influence of scaffold elasticity on germ layer specification of human embryonic stem cells, Biomaterials, 32:  9612-9621, 2011.

Zoldan, J., Lytton-Jean, A., Karagiannis, E., Deiorio-Haggar, K., Bellan, L., Langer, R. and Anderson, D., Directing human embryonic stem cell differentiation by non-viral delivery of siRNA in 3D culture, Biomaterials, 32: 7793-7800, 2011.

Karp, J. and Langer, R., Dry solution to a sticky problem, Nature: 477: 42-43, 2011

Gubskaya, A., Kholodovych, V., Bonates, T., Welsh, W., Langer, R., Kohn, J. and Anderson, D., Logical analysis of data in structure-activity investigation of polymeric gene delivery, Macromolecular Theory and Simulations, 20:  275-285, 2011

Cao, Yihai, Arbiser, J., D’Amato, R., D’Amore, P., Ingber, D., Kerbel, R., Klagsbrun, M., Lim, S., Moses, M., Zetter, B., Dvorak, H., Langer, R., Forty-year journey of angiogenesis translational research, Science Translational Medicine, 3: 114rv3, 2011.

Tekin, H., Sanchez, J., Tsinman, T., Langer, R. and Khademhosseini, A., Thermoresponsive platforms for tissue engineering and regenerative medicine, AIChE Journal, 57: 3249-3258, 2011.

Dvir, T., Liao, R., Bauer, M., Schroeder, A., Tsui, J. and Langer, R., Nanoparticles for targeting the infarcted heart, Nano Letters, 11: 4411-4414, 2011.

Saha, K., Mei, Y., Reisterer, C., Pyzocha, N., Yang, J., Muffat, J., Davies, M., Alexander, M., Langer, R., Anderson, D., Jaenisch, R., Surface engineered substrates for improved human pluripotent stem cell culture under fully defined conditions, Proceedings of the National Academy of Sciences, 108: 18714-18719, 2011.

Malavia, N., Zurakowski, D., Schroeder, A., Princiotto, A., Laury, A., Barash, H., Sodroski, J., Langer, R., Madani, N. and Kohane, D, Liposomes for HIV prophylaxis Biomaterials, 32:  8663-8668, 2011.

Dvir, T., Timko, B., Brigham, M., Naik, S., Karajanagi, S., Levy, O., Jin, H., Parker, K., Langer, R. and Kohane, D., Nanowired three-dimensional cardiac patches, Nature Nanotechnology, 6:  720-725, 2011.

Wang, J., Kniazeva, T., Campbell, C., Langer, R., Ustin, J., Borenstein, J., Biodegradable microfluidic scaffolds with tunable degradation properties from alcohol-based poly(ester amide) elastomers, Materials Research Society Symposium Proceedings, 1299:3-8, 2011. 10.1557/opl.2011.377. PMCID: PMC Exempt—Non-NIH/PHS Funding.

Dan, T., Bratlie, K., Bogatyrev, S., Chen, X., Langer, R., and Anderson, D., Spatiotemporal effects of a controlled release anti-inflammatory drug on the cellular dynamics of host response, Biomaterials, 32:  4464-4470, 2011.