Publications: 2011 – 2021

2021

2021

Volpatti, L.R., Facklam, A.L., Cortinas, A.B., Lu, Y., Matragna, M.A., MacIsaac, C., Hill, M.C., Langer, R., Anderson, D.G. Microgel encapusalted nanoparticles for glucose-responsive insulin therapy.Biomaterials 2021. DOI: 10.1016/j.biomaterials.2020.120458. PMID: 33197650

Edwards, D., Ausiello, D., Salzman, J., Devlin, T., Langer, R., Beddingfield, B., Fears, A., Doyle-Meyers, L., Redmann, R., Killeens, S., Maness, N., Roy, C. Exhaled aerosol increases with COVID-19 infection, age and obesity. Proceedings of the National Academies of Sciences, 2021. DOI: 10.1073/pnas.2021830118

Abramson, A., Della, D., Kong, Y.L., Zhou, J., Gao, Y., Collins, J., Tamang, S., Wainer, J., McManus, R.,Hayward, A., Frederiksen, M.R., Water, J.J., Jensen, B., Roxhed, N., Langer, R., Traverso, G. Ingestible transiently anchoring electronics for microstimulation and conductive signaling. Science Advances, 6:35, eaaz0127, 2021. DOI: 10.1126/sciadv.aaz0127

Tang, Z., Kong, N., Zhang, X., Liu,Y. Ping Hu, P., Mou, S.,Liljeström, P., Shi, P.J., Tan, W., Kim, J.S., Cao, Y., Langer, R., Leong, K., O Farokhzad, O., Tao, W. A materials science perspective on tackling COVID-19, Nature Review Materials, 1:14, 2020. 1–14. DOI: 10.1038/s41578-020-00247-y PMCID: PMC7556605. PMID: 33078077

Li, W., Qiu, J., Li, X., Aday, S., Zhang, J., Conley, G., Xu, J., Langer, R., Mannix, R., Karp, J.M., Joshi, N. BBB pathophysiology independent delivery of siRNA in traumatic brain injury. Science Advances, 2020. DOI: 10.1101/2020.06.26.173393

Kirtane, A.R., Verma, M., Karandikar, P., Furin, J., Langer, R., Traverso, G. Nanotechnology for global health: A focus on treating infectious diseases. Nature Nanotechnology, 16: 369-389, 2021.DOI: 10.1038/s41565-021-00866-8

Van der Ven, C.F.T., Tibitt, M.W., Conde, J., Van Mil, A., Hjortnaes, J., Doevendans, P.F.M., Sluijter, J.P.G., Aikawa, E., Langer, R.S. Controlled delivery of gold nanoparticle-coupled miRNA therapeutics via an injectable self-healing hydrogel. Nanoscale, (13), 20451, 2021. DOI: https://doi.org/10.1039/D1NR04973A

McLean, W.J., Hinton, A.S., Herby, J., Yang-Hood, A., Schrader, A.D., Ohlemiller, K.K., Salt, A.N., Hartsock, J.J., Wilson, S., Lucchino, D., King, S., Jackson, L.E., Rosenbloom, J., Atiee, G., Bear, M., Runge, C., Gifford, R., Rauch, S., Lee, D., Langer, R., Karp, J., Loose, C., LeBel, C. Improved speech intelligibility in subjects with stable sensorineural hearing loss following intratympanic dosing of FX-322. Otology & Neurotology, 42: e849-857, 2021.

Mitchell, M., Billingsley, M., Haley, R., Wechsler, M., Peppas, N.A., Langer, R. Engineering precision nanoparticles for drug discovery. Nature Reviews Drug Discovery, (2):101-124, 2021. PMID: 33277608 PMCID: PMC7717100. DOI: 10.1038/s41573-020-0090-8

Caffarel-Salvador, E., Kim, S., Soares, V., Tian, R.Y., Stern, S.R., Minahan, D., Yona, R., Lu, X., Zakaria, F.R., Collins, J., Wainer, J., Jessica Wong.J., McManus, R., Tamang, S., Shane McDonnell, S., Ishida, K.,Hayward, A. Xiewen Liu, X., Hubàlek, F., Fels, F.,Vegge, A., Revsgaard Frederiksen, M., Rahbek U., Yoshitake, T., Fujimoto, J., Roxhed, N., Langer, R., Traverso, G. A microneedle platform for buccal macromolecule delivery. Science Advances, 7, 4, eabe2620, 2021. DOI: 10.1126/sciadv.abe2620

Sadeghi, I., Byrne, J., Shakur, R., Langer, R. Addressing global health challenges through novel materials in drug delivery. Journal of Controlled Release, 331: 503-514, 2021. PMID: 33516755PMCID: PMC7842133 DOI: 10.1016/j.jconrel.2021.01.035

Reker, D., Rybakova, Y., Kirtane, A., Cao, R., Yang, J.W., Navamajiti, N., Gardner, A., Zhang, R., Esfandiary, T., L’Heureux, J., Von Erlach, T., Smekalova, E., Leboef, D., Hess, K., Lopes, A., Rogner, J., Collins, J., Tamang, S., Ishida, K., Chamberlain, P., Yun, D., Lytton-Jean, A., Soule, C., Cheah, J., Hayward, A., Langer, R., Traverso, G. Computationally guided high-throughput design of self-assembling drug nanoparticles. Nature Nanotechnology, 2021. DOI:10.1038/s41565-021-00870-y

Mirvakili, S., Langer, R. Wireless on-demand drug delivery. Nature Electronics, 2021. DOI: 10.1038/s41928-021-00614-9

Dong, Y., Hou, X., Zaks, T., Langer, R. Lipid nanoparticles for mRNA delivery. Nature Reviews Materials, 2021, DOI: 10.1038/s41578-021-00358-0

Talebian, S., Rodrigues, T., das Neves, J., Sarmento, B., Langer, R., Conde, J. Facts and figures about nanotechnology in the past 20 years. ACS Nano, 2021. DOI: 10.1021/acsnano.1c03992

Abramson, A., Frederiksen, M., Vegge, A., Jense, B., Poulsen, M., Mouridsen, B., Jespersen, M., Kirk, R., Windum, J.,Hubalek, F., Water, J., Fels, J., Gunnarson, S., Ley, M., Bohn, A., Straarup, E., Lu, X., Wainer, J., Collins, J., Tamang, S., Ishida, K., Hayward, A., Herskind,P., Buckley, S., Roxhed, N., Langer, R., Rahbek, U., Traverso, G. Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors. Nature Biotechnology, 2021. DOI: 10.1038/s41587-021-01024-0

Yang, K., O’Cearbhaill, E.D., Liu, S.S., Zhou, A., Chitnis, G.D., Hamilos, A.E., Xu, J., Verma, M.K.S., Giraldo, J.A., Kudo, Y., Lee, E.A., Lee, Y., Pop, R., Langer, R., Melton, D.A., Greiner, D.L., Karp, J.M.A therapeutic convection enhanced macroencapsulation device for enhancing β cell viability and insulin secretion. Proceedings of National Academy of Sciences, 2021. 118 (37) e2101258118; DOI/10.1073/pnas.2101258118 PMID: 34504013

Langer, R., Gupta, A., Andresen, J., Manan, R. Nucleic acid delivery for therapeutic applications. Advanced Drug Delivery Reviews, 2021. https://doi.org/10.1016/j.addr.2021.113834 PMID: 34492233

Hou, X., Zaks, T., Langer, R., Dong, Y. Lipid nanoparticles for mRNA delivery. Nature Review Materials, 2021. https://doi.org/10.1038/s41578-021-00358-0

Ragelle, H., Rahimian, S., Guzz, E., Westenskow, Tibbit, M., Schwach, G, Langer, R. Additive manufacturing in drug delivery: innovative drug product design and opportunities for industrial application. Advanced Drug Delivery Review, 178:113990., 2021. DOI: 10.1016/j.addr.2021.113990 PMID: 34600963

Dong, Y., Hou, X., Zaks, T., Langer, R. Lipid nanoparticles for mRNA delivery. Nature Reviews Materials, 2021, DOI: 10.1038/s41578-021-00358-0

France, M.M., del Rio, T., Travers, H., Raftery, E., Langer, R., Traverso, G., Schoellhammer, C.M. Platform for the delivery of unformulated RNA in vivo. Journal of Pharmaceutical Sciences, 2021. DOI: https://doi.org/10.1016/j.xphs.2021.12.008

2020

2020

Raman, R., Hua, T., Gwynne, D., Collins, J., Tamang, S., Zhou, J., Esfandiary, T., Soares, V., Pajovic, S., Hayward, A., Langer, R., Traverso, G. Light-degradable hydrogels as dynamic triggers for gastrointestinal applications. Science Advances, 6:eaay0065, 2020. PMID32010768; PMC6968934; DOI: 10.1126/sciadv.aay0065

Yu, J., Wang, J., Zhang, Y., Chen, G., Mao, W., Ye, Y., Kahkoska, A., Buse, J., Langer, R., Gu, Z. Glucose-responsive smart insulin patch for blood glucose regulation in mice and pigs, Nature Biomedical Engineering, 499–506, 2020. DOI:10.1038/s41551-019-0508-y

Sarmadi, M., Behrens, A.M., McHugh, K.J., Contreras, H., Tochka, Z., Lu, X., Langer, R., Jaklenec, A. Modeling, design, and machine learning-based framework for optimal injectability of microparticle-based drug formulations. Science Advances, 2020. DOI: 10.1126/sciadv.abb6594

Volpatti, L., Matranga, M.A., Cortinas, A.B., Delcassian, D., Daniel, K., Langer, R., Anderson, D., Glucose-responsive nanoparticles for rapid and extended self-regulated insulin delivery, ACS Nano, 14 (1): 488-497, 2020. DOI: 10.1021/acsnano.9b06395. PMID: 31765558

Mirvakili, S., Sim, D., Hunter, I., Langer, R. Actuation of untethered pneumatic artificial muscles and soft robots using magnetically induced liquid-to-gas phase transitions. Science Robotics, 5(41):eaaz4239. DOI: 10.1126/scirobotics.aaz42392020. PMID: 33022626

Mirvakili, S., Ngo, Q.P., Langer, R. Polymer nanocomposite microactuators for on-demand chemical release via high-frequency magnetic field excitation. Nano Letters, 2020, 4816-4822 DOI: 10.1021/acs.nanolett.0c00648 PMC7349659. PMID: 32479730

Srinivasan, S., Ramadi. K., Vicario, F., Gwynne, D., Hayward, A., Lagier, D., Langer, R., Frassica, J., Baron, R., Traverso, G. A rapidly deployable individualized system for augmenting ventilator capacity. Science Translational Medicine, 2020. PMID32424018; PMC7259824; DOI: 10.1126/scitranslmed.abb9401

Wood, M., Langer, R., Roberts, T. Advances in oligonucleotide drug delivery. Nature Reviews Drug Discovery, 2020. DOI: 10.1038/s41573-020-0075-7

Lu, X., Miao, L., Gao, W., Chen, Z., McHugh, K., Sun, Y., Tochka, Z., Tomasic, S., Sadtler, K., Hyacinthe, A., Huang, Y., Graf, T., Hu, Q., Sarmadi, M., Langer, R., Anderson, D., Jaklenec, A. Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy. Science Translational Medicine, 2020. DOI: 10.1126/scitranslmed.aaz6606

Sadtler, K., Collins, J., Byrne, J., Langer, R. Parallel evolution of polymer chemistry and immunology: integrating mechanistic biology with materials design. Advanced Drug Delivery Reviews, 2020. doi.org/10.1016/j.addr.2020.06.021

Patel, A, Kaczmarek, J, Bose, S, Kauffman, K, Mir, F, Heartlein, M, DeRosa, F, Langer, R, and Anderson, D, Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium, Advanced Materials, PMID: 30609147 DOI: 10.1002/adma.201805116

Von Erlach, T., Saxton, S., Shi, Y., Minahan, D., Reker, D., Javid. F., Lee, Y.L., Schoellhammer, C., Esfandiary, T., Cleveland, C., Booth, L. Lin, J. Levy, H., Blackburn, S., Hayward, A., Langer, R., Traverso, G. Robotically handled whole-tissue culture system for the screening of oral drug formulations. Nature Biomedical Engineering, 4, 544–559, 2020. DOI:10.1038/s41551-020-0545-6

Reker, D., Shi, Y., Kirtane, A.R.., Hess, K., Zhong, G.J., Crane, E., Lin, C., Langer, R., Traverso, G. Machine learning uncovers food-and-excipient-drug interactions. Cell Reports, 30, 3710–3716, 2020. DOI:10.1016/j.celrep.2020.02.094 PMID: 32187543 PMCID: PMC7179333

Li, J., Liang, Y.J., Laken, S., Langer, R., Traverso, G. Clinical opportunities for continuous biosensing and closed-loop therapies. Trends in Chemistry, 2 (4): 319-340, 2020. DOI:10.1016/j.trechm.2020.02.009

Rudra, A., Li, J., Shakur, R., Bhagchandani, S., Langer, R. Trends in therapeutic conjugates: bench to clinic, Bioconjugate Chemistry, 31 (3), 462-473, 2020. DOI: 10.1021/acs.bioconjchem.9b00828

Verma, M., Chu, J., Salama, J., Faiz, M., Eweje, F., Gwynne, D., Lopes, A., Hess, K., Soares, V., Steiger, C., McManus, R., Koeppen, R., Hua, T., Hayward, A., Collins, J., Tamang, S.M., Ishida, K., Miller, J., Katz, S., Slocum, A.H., Sulkowski, M.S., Thomas, D.L., Langer, R., Traverso, G. Development of a long-acting direct-acting antiviral system for Hepatitis C virus treatment in swine. Proceedings of the National Academies of Sciences, 117 (22) 11987-11994, 2020. DOI: 10.1073/pnas.2004746117

Sarmadi, M., Behrens, A., Kevin J. McHugh, K., Contreras, H., Tochka, Z., Lu, X., Langer, R., Jaklenec, A. Modeling, design, and machine learning-based framework for optimal injectability of microparticle-based drug formulations. Science Advances, 6:8, eabb6594, 2020. DOI: 10.1126/sciadv.abb6594

Haley RM, Gottardi R, Langer R, Mitchell MJ. Cyclodextrins in drug delivery: applications in gene and combination therapy. Drug Delivery Translational Research, 10:661- 677, 2020. PMID32077052 DOI:10.1007/s13346-020-00724-5

Wei, T., Cheng, Q., Farbiak, L., Anderson, D.G., Langer, R.,. Siegwart, D.J. Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing . ACS Nano, 2020, DOI: 10.1021/acsnano.0c04707 NIHMSID:1665693; PMID:32697075

Saunders N.R.M., Paolini M.S., Fenton O.S., Poul L., Devalliere J., Mpambani F., Darmon A., Bergere M., Jibault O., Germain M., Langer R. A Nanoprimer To Improve the Systemic Delivery of siRNA and mRNA. Nano Letters, 20:4264-4269, 2020. PMID32357299; DOI: 10.1021/acs.nanolett.0c00752

Ramadi, K., Dagdeviren, C., Bhagchandani, P.; Nunez-Lopez, C., Kim, M. Langer, R., Graybiel, A., Cima, M. Simultaneous recording and marking of brain microstructures. Journal of Neural Engineering, 17 :044001, 2020. DOI:10.1088/1741-2552/aba161

Bose, S., Volpatti, L., Thiono, D., Yesilyurt, V., McGladrigan, C., Tang, Y., Facklam, A., Wang, A., Jhunjhunwala, S, Veiseh, O., Hollister-Lock, J., Bhattacharya, C., Weir, G., Greiner, D., Langer, R., Anderson, D. A retrievable implant for the long-term encapsulation and survival of therapeutic xenogeneic cells. Nature Biomedical Engineering, 4: 814-826, 2020. DOI:10.1038/s41551-020-0538-5

Steiger, C., Phan, N., Sun, H., Huang, H., Hess, K., Lopes, A., Korzenik, J., Langer, R., Traverso, G. Controlled delivery of bile acids to the colon. Clinical and Translational Gastroenterology, 11: e00229, 2020. https://doi.org/10.14309/ctg.0000000000000229

Schwerdt, H., Amemori, K., Gibson, D., Stanwicks, L., Yoshia, T., Bichot, N., Amemori, S., Desimone, R., Langer, R., Cima, M., Graybiel, A. Dopamine and beta-band oscillations differentially linked to striatal value and motor control, Science Advances, 6:39, eabb9226, 2020. DOI: 10.1126/sciadv.abb9226

Krohn-Grimberghe, M., Mitchell, M., Schloss, M., Khan, O., Courties, G., Guimares, P., Rohde, D., Cremer, S., Kowalski, P., Sun, Y., Tan, M., Webster, J., Wang, K., Iwamoto, Y., Schmidt, S., Wojtkiewicz, Nayar, R., Frodermann, V., Hulsmans, M., Chung, A., Hoyer, F., Swirski, F., Langer, R., Anderson, D., Nahrendorf, M. Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche. Nature Biomedical Engineering, 4: 1076-1089, 2020. PMID: 33020600. PMCID: PMC7655681; DOI:10.1038/s41551-020-00623-7

Raman, R., Rousseau, E.B., Wade, M. ,Tong, A., Cotler, M.J., Kuang, J., Aponte Lugo, A., Zhang, E., Graybiel, A.M., White, F.M, Langer, R., Cima, M.J. Platform for micro-invasive membrane e-free biochemical sampling of brain interstitial fluid, Science Advances, 2020, DOI: 10.1126/sciadv.abb0657

Chu, C. K,, Joseph, A.J., Limjoco, M.D., Yang, J., Bose, S., Thapa, L.S., Langer, R., Anderson, D.G.Chemical tuning of fibers drawn from extensible hyaluronic acid networks. Journal of the American Chemical Society, 46: 42, 19715-19721, 2020. DOI: 10.1021/jacs.0c09691.

2019

2019

Verma, M., Furin, J., Langer, R., Traverso, G. Making the case: developing innovative adherence solutions for the treatment of tuberculosis. BMJ Global Health, 4:e001323. Doi:10.1136/bmjgh-2018-001323, 2019.

Glinel, K., Behrens, A., Langer, R., Jaklenec, A., Jonas, A., Nanofibrillar Patches of Commensal Skin Bacteria. Biomacromolecules, 20: 102-108, 2019. DOI: 1021/acs.biomac.8b00735 PMID: 29979873

Patel, A, Kaczmarek, J, Bose, S, Kauffman, K, Mir, F, Heartlein, M, DeRosa, F, Langer, R, and Anderson, D, Inhaled nanoformulated mRNA polyplexes for protein production in lung epithelium, Adavanced Materials, 2019. PMID: 30609147 DOI: 1002/adma.201805116

Ayoob, A., Peppi, M., Tandon, V., Langer, R., Borenstein, J., Intracochlear drug delivery: Fluorescent tracer evaluation for quantification of distribution in the cochlear partition, European Journal of Pharmaceutical Sciences, 126: 49-58, 2019.

Babaee, S., Pajovic, S., Kirtane, A., Shi, J., Caffarel-Salvador, E., Hess, K., Collins, J., Tamang, S., Wahane, A., Hayward, A., Mazdiyasni, H., Langer, R. and Traverso, G., Temperature responsive biometamaterials for gastrointestinal applications, Science Translational Medicine, 11: eaau8581, 2019.

Verma, M., Vishwanath, K., Eweje, F., Roxhed, N., Grant, T., Castaneda, M., Steiger, C., Mazdiyasni, H., Bensel, T., Minahan, D., Soares,V., Lopes, A., Hess, K., Cleveland, C., Fulop, D., Hayward, A., Collins, J., Tamang, S., Hua, T., Ikeanyi, C., Zeidman, G., Mule, E., Boominathan, S., Popova, E., Bellinger, A., Collins, D., Leibowitz, D., Batra, S., Ahuja, S., Bajiya, M., Batra, S., Sarin, R., Agarwal, U., Khaparde, S., Gupta, K., Gupta, D., Bhatnagar, A., Chopra, K., Sharma, N., Khanna, A., Chowdhury, J., Stoner, R., Slocum, A., Cima, M., Furin, J., Langer, R., Traverso, G., A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment. Science Translational Medicine, 11: eaau6267, 2019.

Abramson, A., Caffarel-Salvador, E., Khang, M., Dellal, D. Silverstein, D., Gao, Y., Frederiksen, M., Vegge, A., Hubalek, F., Water, J., Friderichsen, A., Fels, J., Kirk, R., Cleveland, C., Collins, J., Tamang, S., Hayward, A., Landh, T., Buckley, S., Roxhed, N., Rahbek, U., Langer, R., and Traverso, G., An ingestible self orienting systems for oral delivery of macromolecules, Science, 363: 611-615, 2019.

Chauhan, V., Chen, I., Tong, R., Ng, M., Martin, J., Naxerova, K., Wu, M., Huang, P., Boucher, Y., Kohane, D., Langer, R. and Jain, R., Reprogramming the microenvironment with tumor selective angiotensin blockers enhances cancer immunotherapy, Proceedings of the National Academy of Sciences, doi.org/10.1073/pnas.1819889116, 2019.

Anderson, D., Spanoudaki, V., Doloff, J., Huang, W., Norcross, S., Langer, R., Simultaneous spatiotemporal tracking and oxygen sensing of transient implants in vivo using hot-spot MRI and machine learning, Proceedings of the National Academy of Sciences, 116: 4861-4870, 2019.

Chen, I., Chauhan, V., Posada, J., Ng, M., W., M., Adstamongkonkul, P., Huang, P., Lindeman, N., Langer, R., and Jain, R., Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration and improves immunotherapy in metastatic breast cancer, Proceedings of the National Academy of Sciences, 116: 4558-4566, 2019.

Riley, R., June, C., Langer, R., Mitchell, M. Delivery technologies for cancer immunotherapy. Nature Reviews Drug Discovery 18:175-197, 2019.

Langer, R. Controlling the movement of molecules. Quarterly Reviews of Biophysics, 52, E5. doi:10.1017/S0033583519000040, 2019.

Larson, B., Yu, S., Park, H., Estes, B., Moutos, F., Bloomquist, C., Wu, P., Welter, J., Langer, R., Guilak, F., Freed, L., Cartilaginous and osteochondral tissue formation by human mesenchymal stem cells on three-dimensionally woven scaffolds, Biomaterials, 2019.

Farah, S., Doloff, J., Müller, P., Sadraei, A., Han, H-J., Olafson, K., Vyas, K., Tam, H-H., Hollister-Locke, J., Griffin, M., Meng, A., McGarrigle, J., Oberholzer, J., Weir, G., Greiner, D.L., Langer, R., Anderson^,D.G., Long-Term Implant Fibrosis Prevention in Rodents and Non-Human Primates Using Crystallized Drug Formulations, Nature Materials, 18: 892-904, 2019.

Langer, R. Chemical and biological approaches to regenerative medicine and tissue engineering. Molecular Frontiers Journal, 3:2, 2019.

Larson, B., Yu, S., Park, H., Estes, B., Moutos, F., Bloomquist, C., Wu, P., Welter, J., Langer, R., Guilak, F., Freed, L., Chondrogenic, hypertrophic, and osteochondral differentiation of human mesenchymal stem cells on three-dimensionally woven scaffolds, Tissue Engineering and Regenerative Medicine, 2019.

Raman, R., Langer, R., Biohybrid design gets personal: new materials for patient-specific therapy, Advanced Materials, 2019.

McAvoy, M., Tsosie, J, Vyas, K, Khan, O, Sadtler, K, Langer, R., Anderson, D. Flexible multielectrode array for skeletal muscle conditioning, acetylcholine receptor stabilization and epimysial recording after critical peripheral nerve injury. Theranostics, 9 (23): 7099-7107, 2019. DOI: 7150/thno.35436 PMID: 31660089 PMCID: PMC6815960

Miao, L., Li, L., Huang, Y., Delcassian, D., Chahal, J., Han, J., Shi, Y., Sadtler, K., Gao, W., Lin, J., Doloff, J., Langer, R., Anderson, D., Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation. Nature Biotechnology, 37, 1174-1185, 2019. DOI: 10.1038/s41587-019-0247-3

Pang, Y., Liu, J., Moussa, Z., Collins, J., McDonnell, S., Hayward, A., Jajoo, K., Langer, R., Traverso, G. Endoscopically-injectable shear-thinning hydrogels facilitating polyp removal. Advance Science (Weinh), 6 (19): 1901041, 2019. DOI: 10.1002/advs.201901041 PMCID: PMC6774062 PMID: 31592420

Cotler, M., Rousseau, E., Ramadi, K., Fang, J., Graybiel, A., Langer, R., Cima, M. Steerable microinvasive probes for localized drug delivery to deep tissue, Small, 2019.

Traverso, G., Abramson, A., Caffarel-Salvador, E., Soares, V., Minahan, D., Lu, X., Tian, R., Dellal, D., Gao, Y., Kim, S., Wainer, J., Collins, J., Tamang, S., Hayward, A., Yoshitake, T., Lee, H., Fujimoto, J., Fels, J., Frederiksen, M., Rahbek, U., Roxhed, N., Langer, R., A luminal unfolding microneedle injector for oral delivery of macromolecules, Nature Medicine, 25: 1512-1518, 2019.

Anselmo, A,C., Xu, X., Buerkli, S., Zeng, Y., Tangm W., McHugh,K.J., Behrens, A.M., Rosenberg, E., Duan, A.R., Sugarman, J.L., Zhuang, J., Collins, J., Lu, X., Graf, T., Tzengm S.Y., Rose, S., Acolatse, S., Nguyenm T.D., Le, X., Guerra, A.S., Freed, L.E., Weinstock, S.B., Sears, C.B., Nikolic, B., Woodm L., Welkhoff, P.A., Oxley, J.D., Moretti, D., Zimmermann, M.B., Langer, R., Jaklenec, A. A heat-stable microparticle platform for oral micronutrient delivery. ScienceTranslational Medicine, PMID31723037; DOI:10.1126/scitranslmed.aaw3680

Mirvakili, S.M., Broderick, K., Langer, R. A new approach for micro-fabrication of printed circuit boards with ultra-fine traces, ACS Appl. Mater. Interfaces, 2019, 11 (38), 35376-35381 DOI: 10.1021/acsami.9b08761

Kirtane, A., Hua, T., Hayward, A., Bajpayee, A., Wahane, A., Lopes, A., Bensel, T., Ma, L., Stanczyk, F., Brooks, S., Gwynne, D., Wainer, J., Collins, J., Tamang, S., Langer, R., Traverso, G., A once a month oral contraceptive, Science Translational Medicine, 2019 DOI: 10.1126/scitranslmed.aay2602

Lee, M.; Duarte, C.; Eguiluz, VM; Heller, D., Langer, R.; Meekan, M., Sikes, H., Srivastava, M.; Strano, M.; Wilson, R. Can fish and cell phones teach us about our health?, ACS Sensors, 2019, 4(10), 2566-2570 DOI: 10.1021/acssensors.9b00947 PMID: 31576740

Smekalova, E., Gerashchenko, M., O’Connor, P., Whittaker, C., Kauffman, K., Fefilova, A., Zatsepin, T., Bogorad, R., Baranov, P., Langer, R., Gladyshev, V., Anderson, D., Koteliansky, V, In vivo RNAi mediated eIF3m knockdown is associated with alterations in ribosome biogenesis, but has limited affect on mRNA translation, Molecular Therapy –Nucleic Acids, 2019org/10.1016/j.omtn.2019.11.009. PMID: 31855834 PMCID: PMC6926209

Fenton, O., Tibbitt, M., Appel, E., Jhunjuhnwala, S., Webber, M., R. Langer. Injectable polymer-nanoparticle hydrogels for local immune cell recruitment, Biomacromolecules, 2019. 20(12), 4430-4436 DOI: 10.1021/acs.biomac.9b01129

Beh, C., Farah, S., Langer, R., Jaklenec, A. (2019) Chapter 12: Methods for Sterilization of Biopolymers for Biomedical Applications. In A.J. Domb, K.R. Kunduru, and S. Farah (eds). Biomaterials Science Series No. 5. Antimicrobial Materials for Biomedical Applications (5^th edition). Royal Society of Chemistry, London, United Kingdom

Bouthillette, M., Beccati, D., Akthakul, A., Ramadurai, N., Nashat, A., Langer, R., Anderson, R.R., Sakamoto, F.H. A crosslinked polymer skin barrier film for moderate to severe atopic dermatitis: A pilot study in adults. Journal of the American Academy of Dermatolology, 82:895-901, 2019. PMID31589946; DOI: 10.1016/j.jaad.2019.09.073

McHugh, K.J., Jing, L., Severt ,S.Y., Cruz, M., Sarmadi ,M., Jayawardena ,H.S.N., Perkinson, C.F., Larusson, F., Rose S., Tomasic, S,. Graf, T., Tzeng, S.Y., Sugarman,, J.L., Vlasic, D., Peters, M., Peterson, N,. Wood L., Tang, W., Yeom, J., Collins, J., Welkhoff, P.A., Karchin, A., Tse, M., Gao, M,. Bawendi, M.G. Langer, R., Jaklenec, A. Biocompatible near infrared quantum dots delivered to the skin by microneedle patches record vaccination. Science Translational Medicine, 2019. PMID31852802 DOI: 10.1126/scitranslmed.aay7162

2018

2018

Kauffman, K., Oberli, M., Dorkin, J. R., Hurtado, J., Kaczmarek, J., Bhadani, S., Wycokoff, J., Langer, R., Jaklenec, A. and Anderson, D., Rapid single cell analysis and discovery of vectored mRNA transfection in vivo and with a loxP-flanked tdTomato reporter mouse, Molecular Therapy Nucleic Acids, 10: 55-63, 2018.

Mikulskis, P., Hook, A., Dundas, A., Irvine, D., Sanni, O., Anderson, D., Langer, R., Alexander, M., Williams, P., Winkler, D. Prediction of broad-spectrum pathogen attachment to coating materials for biomedical devices, ACS Applied Materials and Interfaces, 10: 139-149, 2018.

Tong, Z., Martyn, K., Yang, A., Yin, X., Mead, B., Joshi, N., Sherman, N., Langer, R. and Karp, J., Towards a defined ECM and small molecule based monolayer culture system for the expansion of mouse and human intestinal stem cells, Biomaterials, 154: 60-73, 2018.

Bisso, P., Tai, M., Katepalli, H., Bertrand, N., Blankschtein, D., Langer, R., Molecular rotors for universal quantitation of nanoscale hydrophobic interfaces in microplate format, Nano Letters, 18: 618-628, 2018.

Kowalski, P., Palmiero, U., Huang, Y., Rudra, A., Langer, R. and Anderson, D., Ionizable amino-polyesters synthesized via ring opening polymerization of tertiary amino-alcohols for tissue selective mRNA delivery, Advanced Materials, 30: 1801151, 2018.

Li, Z., Behrens, A., Ginat, N., Tzeng, S., Lu, X., Sivan, S., Langer, R. and Jaklenec, A., Probiotics: Biofilm inspired encapsulation of probiotics for the treatment of complex infections, Advanced Materials, 30: 1803925, 2018.

Shankar, G., Kirtane, A., Miller, J., Mazdiyasni, H., Rogner, J., Tai, T., Williams, E., Higuchi, F., Jurati, T., Tateishi, K., Koerner, M., Tummala, S., Fink, A., Penson, T., Schmidt, S., Wojtkiewicz, G., Baig, A., Francis, J., Rinne, M., Batten, J., Batchelor, T., Brastianos, P., Curry, W., Barker, F., Jordan, J., Iafrate, J., Chi, A., Lennerz, J., Meyerson, M., Langer, R., Wakimoto, H., Traverso, G. and Cahill, D., Proceedings of the National Academy of Sciences, 36: E8388-E8394, 2018.

Chertok, B. and Langer, R., Circulating magnetic microbubbles for localized real time control of drug delivery by ultrasonography guided magnetic targeting and ultrasound, Theranostics, 8: 341-357, 2018.

Kirtane, A., Abouzid, O., Minahan, D., Bensel, T., Hill, A.L., Selinger, C., Bershteyn, A., Craig, M., Mo, S.S., Mazdiyasni, H., Cleveland, C., Rogner, J., Lee, Y., Booth, L., Javid, F., Wu, S., Grant, G., Bellinger, A., Nikolic, B., Hayward, A., Wood, L., Eckhoff, P.A., Nowak, M., Langer, R., Traverso, G., Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy, Nature Communications, 9(2), DOI:10.1038/s41467-017-02294-6, 2018.

Dagdeviren, C., Ramadi, K., Joe, P., Spencer, K., Schwerdt, H., Shimazu, H., Delcasso, S., Amemori, K-I., Lopez, C., Graybiel, A., Cima, M., Langer, R., Miniaturized neural system for chronic, local intracerebral drug delivery, Science Translational Medicine, 10(425), eaan2742, 2018.

Ragelle, H., Tibbitt, M., Wu, S., Castillo, M., Cheng, G., Gangadharan, S., Anderson, D., Cima, M. and Langer, R., Surface tension-assisted additive manufacturing, Nature Communications, 9(1184), DOI: 10.1038/s41467-018-03391-w, 2018.

Jonas, A., Glinel, K., Behrens, A., Anselmo, A., Langer, R. and Jaklenec, A., Controlling the Growth of Staphylococcus epidermidis by Layer-by-Layer Encapsulation, ACS Applied Materials & Interfaces DOI: 1021/acsami.8b01988, 2018.

McHugh, K., Jing, L., Behrens, A., Jayawardena, S., Tang, W., Gao, M., Langer, R. and Jaklenec, A., Biocompatible semiconductor quantum dots as cancer imaging agents, Advanced Materials, 30(18), 1706356, 2018.

Langer, R., Kirtane, A., Schoellhammer, C., and Traverso, G., Convergence for translation, Angewandte Chemie, 57: 2156-4163, 2018.

Kauffman, K, Oberli, M, Dorkin, JH, Kaczmarek, J, Bhadani, S, Wyckoff, J, Langer, R, Jaklenec, A, Anderson, D, Rapid, single-cell analysis and discovery of vectored mRNA transfection in vivo with a loxP flanked tdTomato reporter mouse, Molecular Therapy – Nucleic Acids, 10: 55–63, 2018.

Sharma, U, Concagh, D, Core, L, Kuang, Y, You, C, Pham, Q, Zugates, G, Busold, R, Webber, S, Merlo, J, Langer, R, Whitesides, G, Palasis, M, The development of bioresorbable composite polymeric implants with high mechanical strength, Nature Materials, 17: 96–103, 2018.

Kang, S., Ji, Z., Tseng, L., Turner, S., Villanueva, D., Johnson, R., Albano, A., Langer, R., Design and synthesis of waterborne polyurethanes, Advanced Materials, 30(18), 1706237, 2018.

Yin, H., Song, C., Sureshy, S., Kwan, S., Wu, Q., Walsh, S., Ding, J., Bogorad. R.L., Zhu, L.J., Wolfe, S.A., Koteliansky, V., Xue, W., Langer, R. and Anderson, D.G., Partial DNA-guided Cas9 enables genome editing with reduced off-target activity, Nature Chemical Biology, 14: 311-316, 2018.

Ramadi, K., Dagdeviren, C., Spencer, K., Joe, P., Cotler, M., Rousseau, E., Nunez-Lopez, C., Graybiel, A., Langer, R., Cima, M., Focal, remote-controlled, chronic chemical modulation of brain microstructures, Proceedings of the National Academy of Sciences, 115: 7254-7259, 2018.

Guimaraes, P.P.G., Gaglione, S., Sewastianik, T., Carrasco, R.D., Langer, R. and Mitchell, M.J., Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy, ACS Nano, 12(2): 912-931, 2018.

Mead, B.E., Ordovas-Montanes, J., Braun, A.P., Levy, L.E., Bhargava, P., Szucs, M.J., Ammendolia, D.A., MacMullan, M.A., Yin, X., Hughes, T.K., Wadsworth II, M.H., Ahmad, R., Rakoff-Nahoum, S., Carr, S.A., Langer, R., Collins, J.J., Shalek, A.K. and Karp, J.M., Harnessing single-cell genomics to improve the physiological fidelity of organoid derived cell types, BMC Biology, 16:62, 2018

Ferber, S., Behrens, A.M., McHugh, K.J., Rosenberg, E.M., Linehan, A.R., Sugarman, J.L., Jayawardena, H.S.N., Langer, R., Jaklenec, A., Evaporative cooling hydrogel packaging for storing biologics outside of the cold chain, Advanced Healthcare Materials, 1800218, 2018.

Xie, X., Doloff, J., Yesilyurt, V., Sadraei, A., McGarrigle, J., Omami, M., Veiseh, O., Farah, S., Isa, D., Ghani, S., Joshi, I., Vegas, A., Li, J., Wang, W., Bader, A., Tam, H., Tao, J., Chen, H., Yang, B., Williamson, K., Oberholzer, J. Langer, R., Anderson, D., Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer, Nature Biomedical Engineering, 2: 894-906, 2018.

DiCiccio, A., Lee, Y., Glettig, D., Walton, E., de La Serna, E., Montgomery, V., Grant, T., Langer, R. and Traverso, G., Caffeine-catalyzed gels, Advanced Materials, 170: 127-135, 2018.

Mimee, M., Nadeau, P., Hayward, A., Carim, S., Flanagan, S., Jerger, L., Collins, J., McDonnell, S., Swartwout, R., Citorik, R.J., Bulovic, V., Langer, R., Traverso, G., Chandrakasan, A.P. and Lu, T.K., An ingestible bacterial-electronic system to monitor gastrointestinal health., Science, 360(6391): 915-918, 2018.

Bochenek, M., Veiseh, O., Vegas, A., McGarrigle, J., Qi, M., Marchese, E., Omami, M., Doloff, J., Mendoza-Elias, J., Nouramohammadzadeh, M., Khan, A., Yeh, C-C., Xing, Y., Isa, D., Ghani, S., Li, J., Landry, C., Bader, A., Olejenik, K., Chen, M., Hollister-Lock, J., Wang, Y., Greiner, D., Weir, G., Strand, B.L., Rockstad, A., Lacik, I., Langer, R., Anderson, D.G., Oberholzer, J., Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques, Nature Biomedical Engineering, 2: 810-821, 2018.

Fenton, O. S., Olafson, K. N., Pillai, P., Mitchell, M. and Langer, R. Advances in Biomaterials for Drug Delivery. Advanced Materials, 30: 1705328, 2018.

Tzeng, S., McHugh, K., Behrens, A., Rose, S., Sugarman, J., Ferber, S., Langer, R. and Jaklenec, A., Stabilized single injection inactivated polio vaccine elicits a strong neutralizing immune response, PNAS, 115: E5269-E5278, 2018.

Fenton, O., Andresen, J., Paolini, M., Langer, R. (2018). B-Aminoacrylate Synthetic Hydrogels: Easily Accessible and Operationally Simple Biomaterials Networks. Chem. Int. Ed. 57: 16026-16029, 2018.

Islam, M., Xu, Y., Tao, W., Ubellacker, J., Lim, M., Aum, D., Lee, G., Zhou, K., Zope, H., Yu, M., Cao, W., Oswald, J., Dinarvand, M., Mahmoudi, M., Langer, R., Kantoff, P., Farokhzad, O., Zetter, B., Shi, J. Restoration of Tumour-growth Suppression in Vivo via Systemic Nanoparticle-mediated Delivery of PTEN mRNA. Nature Biomedical Engineering. 10.1038/s41551-018-0284-0, 2018.

Khan, O., Kowalski, P., Doloff, J., Tsosie, J., Bakthavatchalu, V., Winn, C., Haupt, J., Jamiel, M., Langer, R. and Anderson, D, Endothelial siRNA delivery in nonhuman primates using ionizable low molecular weight polymeric nanoparticles, Science Advances, 4: eaar8409, 2018.

Ayoob, A.M., Peppi, M., Tandon, V., Langer, R., Borenstein, J.T., A fluorescence-based imaging approach to pharmacokinetic analysis of intracochlear drug delivery, Hearing Research, 368: 41-48, 2018.

Guimaraes, P., Tan, M., Tammela, T., Wu, K., Chung, A., Oberli, M., Wang, K., Spektor, R., Riley, R., Viana, C., Jacks, T., Langer, R. and Mitchell, M., Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes, Journal of Controlled Release, 290: 75-87, 2018.

Stewart, M., Langer, R. and Jensen, K., Intracellular delivery by membrane distruption: Mechanisms, strategies and concepts, Journal of the American Chemical Society, 118: 7409-7531, 2018.

Kowalski, P., Bhattacharya, C., Afewerki, S. and Langer, R., Smart biomaterials: Recent advances and future directions, ACS Biomaterials Science and Engineering, 4: 3809-3817, 2018.

Bisso, P., Gaglione, S., Guimaraes, P., Mitchell, M., and Langer, r., Nanomaterial interactions with human neutrophils, ACS Biomaterials Science and Engineering, 4: 4255-4265, 2018.

2017

2017

Spencer, K., Sy, J., Ramadi, K., Graybiel, A., Langer, R. and Cima, M., Characterization of mechanically matched hydrogel coatings to improve the biocompatibility of neural implants, Scientific Reports, 7: 1952: DOI: 1038/s41598-017-02107-2, 2017.

Abid, A., O’Brien, J., Bensel, T., Cleveland, C., Booth, L., Smith, B., Langer, R., and Traverso, G., Wireless power transfer to millimeter sized gastrointestinal electronics validated in a swine model, Scientific Reports, 7: 46745: DOI: doi:10.1038/srep46745, 2017.

Delcassian, D., Elgueta, E., Ortiz, C., Bochenek, M., Qatachi, O., Chan, C., McGladrigan, C., Hausser, R. Langer, Anderson, D. and Shakesheff, K., Protecting transplanted cell therapies using immunomodulatory materials, Tissue Engineering, Part A., 23: S20, 2017.

Doloff, J., Veiseh, O., Vegas, A., Tam, H., Farah, S., Ma, M., Li, J., Bader, A., Chiu, A., Sadraei, A., Aresta-DaSilva, S., Griffin, M., Jhunjhunwala, S., Webber, M., Siebert, S., Tang, K., Chen, M., Langan, E., Dholokia, N., Thakrar, R., Qi, M., Oberholzer, J., Greiner, D., Langer, R. and Anderson, D., Colony stimulating factor-1 receptor is a central component of foreign body response to biomaterial implants in rodents and non-human primates, Nature Materials, |DOI: 10.1038/nmat4866, 2017.

Mitchell, M., Webster, J., Chung, A., Guimaraes, P., Khan, O. and Langer, R., Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis, Nature Communications, 8: DOI:10.1038/ncomms14179, 2017.

Dahlman, J., Kauffman, K., Xing, Y., Shaw, T., Dlott, C., Mir, F., Langer, R., Anderson, D. and Wang, E., Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics, Proceedings of the National Academy of Sciences, 114: 2060-2065, 2017.

Kim, K., Cha, Y., Han, M., Cha, H., Zoldan, J., Burkart, A., Jung, J., Jang, Y., Kim, C., Jeong, H., Kim, B., Langer, R., Kahn, C. and Guarente, L., Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis, Nature Cell Biology, 19: 445-456, 2017.

Ragelle, H., Naba, A., Larson, B., Zhou, F., Prijic, M., Whittaker, C., Del Rosario, A., Langer, R., Hynes, R. and Anderson, D., Comprehensive proteomic characterization of stem cell-derived extracellular matrices, Biomaterials, 128: 147-159, 2017.

Fay, F., Hansen, L., Hectors, S., Sanchez-Gaytan, B., Zhao, Y., Tang, J., Munitz, J., Alaarg, A., Braza, M., Gianella, A., Aaronson, S., Reiner, T., Kjems, J., Langer, R., Hoeben, F., Janssen, H., Calcagno, C., Strijkers, G., Fayad, Z., Perez-Medina, C. and Mulder, W., Investingating the cellular specificity in tumors of a surface-converting nanoparticle by multimodal imaging, Bioconjugate Chemistry, i28: 1413-1421, 2017.

Slotkin, J., Pritchard, C., Luque, B., Ye, J., Layer, r., Lawrence, M., O’Shea, T., Roy, R., Zhong, H., Vollenweider, I., Edgerton, V., Courtine, G., Woodard, E. and Langer, R., Biodegradable scaffolds promote tissue remodeling and fuctional improvement in non-human primates with acute spinal cord injury, Biomaterials, 123: 63-76, 2017.

Schoellhammer, C., Lauwers, G., Goettel, J., Oberli, M., Cleveland, C., Park, J., Minahan, D., Chen, Y., Anderson, D., Jaklenec, A., Snapper, S., Langer, R. and Traverso, G., Ultrasound-mediated delivery of RNA to colonic mucosa of live mice, Gastroenterology, 152: 1151-1160, 2017.

Oberli, M., Reichmuth, A., Dorkin, J., Mitchell, M., Fenton, O., Jaklenec, A., Anderson, D., Langer, R. and Blankschtein, D., Lipid nanoparticle-assisted mRNA delivery for potent cancer immunotherapy, Nano Letters, 17: 1326-1335, 2017.

Giwa, S., Lewis, J., Alvarez, L., Langer, R., Roth, A., Church, G., Markmann, J., Sachs, D., Chandraker, A., Wertheim, J., Rothblatt, M., Boyden, E., Eidbo, E., Lee, W., Pomahac, B., Brandacher, g., Weinstock, D., Elliott, G., Nelson, D., Acker, J., Uygun, K., Schmalz, B., Weegman, B., Tocchio, A., Fahy, G., Storey, K., Rubinsky, B., Bishof, J., Elliott, J., Woodruff, T., Morris, J., Demirci, U., Brockbank, K., Woods, E., Ben, R., Baust, J., Gao, D., Fuller, B., Rabin, Y., Kravitz, D., Taylor, M., and Toner, M., The promise of organ and tissue preservation to transform medicine, Nature Communications, 35: 530-542, 2017.

Zhang, S., Langer, R., Traverso, G., Nanoparticulate drug delivery systems targeting inflammation for treatment of inflammatory bowel disease, 16: Nano Today, 82-96, 2017.

Tibbitt, M. and Langer, R., Living biomaterials, Accounts in Chemical Research, 50: 508-513, 2017.

Polat, B., Schoellhammer, C., Langer, R. and Blankschtein, D., Combined use of ultrasound and other physical methods of Skin penetration enhancement, in Percutaneous Penetration Enhancers: Physical Methods in Penetration Enhancement, pp. 369-377, 2017, eds: Dragicevic, N. and Maibach, H., Springer Link.

Roper, J., Tammela, T., Cetinbas, N., Akkad, a., Roghanian, A., Rickelt, S., Almeqdadi, M., Wu, K., Oberli, M., Sanchez-Rivera, F., Park, Y., Liang, x., Eng., G., Taylor, M., Azimi, R., Kedrin, D., Neupane, R., Beyaz, S., Sicinska, E., Suarez, Y., Yoo, J., Chen, L., Zuckerbert, L., Katajisto, P., Deshpande, V., Bass, A., Tsichlis, P., Lees, J., Langer, R., Hynes, R., Chen, J., Bhutkar, A., Jacks, T. and Yilmaz, O., In vivo genome editing and orthotopic transplantation models of colorectal cancer and metastasis, Nature Medicine, 35: 569-579, 2017.

Rwei, A., Langer, R. and Kohane, D. Ultrasound-triggered local anaesthesia, Nature Biomedical Engineering, 1: 644-653, 2017.

Langer, R., Advances in chemistry and their implications for studying and treating brain disease, Molecular Frontiers Journal, 1: 2-9, 2017.

Zwang, Y., Jonas, O., Chen, C., Rinne, M., Doench, J., Piccioni, F., Tan, L., Huang, H., Wang, J., Ham, Y., O’Connell, J., Bhola, P., Doshi, M., Whitman, M., Cima, M., Letai, A., Root, D., Langer, R. Gray, N. and Hahn, C., Synergistic interactions with PI3K inhibition that induce apoptosis, eLife, 6: e24523, 2017.

Nadeau, P., El-Damak, D., Glettig, D., Kong, Y., Mo, S., Cleveland, C., Booth, L., Roxhed, N., Langer, R., Chandrakasan, A. and Traverso, G., Prolonged energy harvesting for ingestible devices, Nature Biomedical Engineering, E-pub ahead of time, DOI: 10.1038/s41551-016-0022, 2017.

Yu, D., Khan, O., Suva, M., Dong, B., Panek, W., Xiao, T., Wu, M. Han, Y., Ahmed, A., Balyasnikova, I., Zhang, H., Sun, C., Langer, R., Anderson, D., Lesniak, M., Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression, Proceedings of the National Academy of Sciences, E-pub ahead of time, DOI: 1073/pnas.1701911114, 2017.

Fenton, O., Kauffman, K., Kaczmarek, J., McClellan, R., Jhunjhunwala, S., Tibbitt, M., Zeng, M., Appel, E., Dorkin, J., Mir, F., Yang, J., Oberli, M., Heartlein, M., DeRosa, F., Langer, R. and Anderson, D., Synthesis and biological evaluation of ionizable lipid materials for the in vivo delivery of messenger RNA to B lymphocytes, Advanced Materials, DOI: 1002/adma.201606944, 2017.

Liu, J., Pang, Y., Zhang, S., Cleveland, C., Yin, X., Booth, L., Lin, J., Lee, Y., Mazdiyasni, H., Saxton, S., Kirtane, A., von Erlach, T., Rogner, J., Langer, R. and Traverso, G., Triggerable tough hydrogels for gastric resident dosage forms, Nature Communications, 8: 124: DOI: 1038/s41467-017-00144-z, 2017.

McHugh, K., Nguyen, T., Linehan, A., Yang, D., Behrens, A., Rose, S., Tochka, Z., Tzeng, S., Norman, J., Anselmo, A., Xu, X., Tomasic, S., Taylor, M., Lu, J., Guarecuco, R., Langer, R. and Jaklenec, A., Fabrication of fillable microparticles and other complex 3D microstructures, Science, 357: 1138-1142, 2017.

Bakh, N., Cortinas, A., Weiss, M. Langer, R., Anderson, D., Gu, Z., Dutta, S. and Strano, M., Glucose responsive insulin by molecular and physical design, Nature Chemistry, 937–943, 2017.

Abramson, A., Langer, R., Traverso, G, and Caffarel-Salvador, E., Oral delivery of biologics using drug-device combinations, Current Opinion in Pharmacology, 8-13, 2017.

Dagdeviren, C, Javid, F, Joe, P, von Erlach, Bensel, T, Wei, Z, Saxton, S, Cleveland, C, Booth, L, McDonnell, S, Collins, J, Hayward, A, Langer, R, Traverso, G, Flexible piezoelectric devices for gastrointestinal motility sensing, Nature Biomedical Engineering 1: 807-817, 2017.

Mitchell, M., Jain, R. and Langer, R., Engineering and physical sciences in oncology: Challenges and opportunities, Nature Reviews Cancer, 659-675, 2017.

Yin, H, Song, C-Q, Suresh, S, Wu, Q, Walsh, S, Rhym, L.H., Mintzer, E, Bolukbasi, M.F., Zhu, L.J., Kauffman, K, Mou, H, Oberholzer, A, Ding, J, Kwan, S-Y, Bogorad, R, Zatsepin, T, Koteliansky, V, Wolfe, S.A., Xue, W, Langer, R, Anderson, D.G., Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing, Nature Biotechnology, 35: 1179-1187, 2017.

Schoellhammer, C., Chen, Y., Cleveland, C., Minahan, D., Bensel, T., Park, J., Saxton, S., Lee, Y., Booth., L., Langer, R. and Traverso, G., Defining optimal permeant characteristics for ultrasound mediated gastrointestinal delivery, Journal of Controlled Release, 268: 113-119, 2017.

Schwerdt, H., Shimazu, H., Amemori, K., Amemori, S., Tierney, P., Gibson, D., Hong, S., Yoshida, T., Langer, R., Cima, M. and Graybiel, A., Long-term dopamine neurochemical monitoring in primates, Proceedings of the National Academy of Sciences, 14: 13260-13265, 2017.

Bertrand, N., Grenier, P., Mahmoudi, M., Lima, E., Appel, E., Dormont, F., Lim, J., Karnik, R., Langer, R. and Farokhzad, O., Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics, Nature Communications, 8: 77, 2017.

Mahmoudi, M., Yu, M., Serpooshan, V., Wu, J., Langer, R., Lee, R., Karp, J. and Farokhzad, O, Multiscale technologies for treatment of ischemic cardiomyopathy, Nature Nanotechnology, 12: 845–855, 2017.

Kakkar, A., Traverso, G., Farokhzad, O., Weissleder, R. and Langer, R., Evolution of macromolecular complexity in drug delivery systems, Nature Reviews Chemistry, 1(0063), doi: 10.1038/s41570-017-0063, 2017.

Aday, S., Zoldan, J., Besnier, M., Carreto, L., Saif, J., Fernandes, R., Santos, T., Bernardino, L., Langer, R., Emanueli, C. and Ferreira, L., Synthetic microparticles conjugated with VEGF₁₆₅ improve the survival of endothelial progenitor cells via microRNA-17 inhibition, Nature Communications, 8(747), oi:10.1038/s41467-017-00746-7, 2017.

Jung, K., Heishi, T., Khan, O., Kowalski, P., Incio, J., Rahbari, N., Chung, E., Clark, J., Willett, Luster, A., Yun, S., Langer, R., Anderson, D., Padera, T., Jain, R. and Fukumura, D., Ly6C(low) monocytes drive immunosuppression and confer resistance to anti-VEGFR2 therapy in colorectal cancer, Journal of Clinical Investigation, 127(8): 3039-3051, 2017.

Doloff, J., Saraei, A., Farah, F., Bortell, R., Brehm, M., Greiner, D., Anderson, D., Langer, R., Development of a humanized mouse model that recapitulates the fibrotic response to biomaterial implants, The Journal of Immunology, 198(1): 206.3, 2017.

Schneider, C., Langer, R., Loveday, D., Hair, D., Applications of ethylene vinyl acetate copolymers (EVA) in drug delivery systems, Journal of Controlled Release, 262: 284-295, 2017.

McLean, W.J., Yin, X., Lu, L., Lenz, D.R., Mclean, D., Langer, R., Karp, J.M. and Edge, A.S.B.,Clonal expansion of Lgr5-positive cells from mammalian cochlea and high-purity generation of sensory hair cells, Cell Reports, 18(8): 1917-1929, 2017.

2016

2016

Vegas, A., Veiseh, O., Doloff, J., Ma, M., Tam, H., Bratlie, K., Li, J., Bader, A., Langan, E., Olejnik, K., Fenton, P., Kang, J., Hollister-Locke, J., Bochenek, M., Chiu, A., Siebert, S., Tang, K., Jhunjhunwala, S., Aresta-Dasilva, S., Dholakia, N., Thakrar, R., Vietti, T., Chen, M., Cohen, J., Siniakowicz, K., Qi, M., McGarrigle, J., Lyle, S., Harlan, D., Greiner, D., Oberholzer, J., Weir, G. Langer, R. and Anderson, D., Combinatorial development of hydrogels that mitigate the foreign body response in primates, Nature Biotechnology, 34: 345-352, 2016. PMCID: PMC4904301

Yin, H., Song, C., Dorkin, J., Zhu, L., Li, Y., Wu, Q., Park, A., Yang, J., Suresh, S., Bizhanova, A., Gupta, A., Bolukbasi, M., Walsh, S., Bogorad, R., Gao, G., Weng, Z., Dong, Y., Koteliansky, V., Wolfe, S., Langer, R., Xue, W., and Anderson, D., Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo, Nature Biotechnology, 34: 328-333, 2016.

Dong, Y., Dorkin, J., Wang, W., Chang, P., Webber, M., Tang, B., Abutbul-Ionita, I., Danino, D., DeRosa, F, Heartlein, M. and Langer, R., Poly(glycoamidoamine) brushes formulated nanomaterials for systemic mRNA delivery in vivo, Nano Letters, 16: 842-848, 2016.

Xue, Y., Xu, X., Zhang, X., Farokhzad, O. and Langer, R., Preventing diet-induced obesity in mice by inducing adipose tissue transformation and angiogenesis using targeting nanoparticles with drug delivery amplification, Proceedings of the National Academy of Sciences, 113: 5552-5557, 2016. PMCID: PMC4878518

Webber, M., Appel, E., Meijer, E. and Langer, R., Supramolecular biomaterials, Nature Materials, 15: 13-26, 2016. PMC Exempt – Review

Tibbitt, Mark, Dahlman, J. and Langer, R., Emerging frontiers in drug delivery, Journal of the American Chemical Society, 138: 704-717, 2016. PMC Exempt – Review

Vegas, A., Veiseh, O., Gurtler, M., Millman, J., Pagliuca, F., Bader, A., Doloff, J., Li, J., Chen, M., Olejnik, K., Tam, H., Jhunjhunwala, S., Langan, E., Aresta-Dasilva, S., Gandham, S., McGarrigle, J., Bochenek, M., Hollister-Lock, J., Oberholzer, J., Greiner, D., Weir, G., Melton, D, Langer, R. and Anderson, D., Long-term glycemic control using polymer encapsulated human stem cell-derived beta cells in immune-competent mice, Nature Medicine, 22: 306-211, 2016. PMCID: PMC4825868

Tzeng, S., Guarecuco, R., McHugh, K., Rose, S., Rosenberg, E., Zeng, Y., Langer, R. and Jaklenec, A., Thermostabilization of inactivated polio vaccine in PLGA-based microspheres for pulsatile release, Journal of Controlled Release, 233: 101-113, 2016. PMCID: PMC4925381

Stewart, M., Sharei, A., Ding, X., Sahay, G., Langer, R., and Jensen, K., In vitro and ex vivo strategies for intracellular delivery, Nature, 538: 183-192, 2016.

Yu, A., Chen, H. Chan, D., Agmon, G., Stapleton, L., Sevit, A., Tibbitt, M., Acosta, J., Zhang, T., Franzia, P., Langer, R., and Appel, E., Scalable manufacturing of biomimetic moldable hydrogels for industrial applications, Proceedings of the National Academy of Sciences, 113: 14255-14260, 2016.

Lee, H., Ahsen, O., Liang, K., Wang, Z., Cleveland, C., Booth, L., Potsaid, B., Jayaraman, V., Cable, A., Mashimo, H., Langer, R., Traverso, G. and Fujimoto, J., Circumferential optical coherence tomography angiography imaging of the swine esophagus using a micromoto balloon catheter, Biomedical Optics Express, 7: 2927-2942, 2016. PMCID: PMC4986804

Yin, H., Bogorad, R., Barnes, C., Walsh, S., Zhuang, I., Nonaka, H., Ruda, V., Kuchimanchi, S., Nechev, L., Akinc, A., Xue, W., Zerial, M., Langer, R., Anderson, D. and Koteliansky, V., RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver, Journal of Hepatology, 64: 899-907, 2016.

Oudin, M., Jonas, O., Kosciuk, T., Broye, L., Wyckoff, J., Riquelme, D., Lamar, J., Asokan, S., Whittaker, C., Ma, D., Langer, R., Cima, M., Wisinski, K., Hynes, R., Lauffenburger, D., Keely, P., Bear, J. and Gertler, F., Tumor cell-driven extracellular matrix remodeling enables haptotaxis during metastatic progression, Cancer Discovery, 6: 516-531, 2016. PMCID: PMC4854754

Yun, S., Budatha, M., Dahlman, J., Coon, B., Cameron, R., Langer, R., Anderson, D., Baillie, G. and Schwartz, M., Integrin a5-PDE4D interaction regulates endothelial inflammatory signaling, Nature Cell Biology, 18: 1043-1053, 2016.

Webber, M., Appel, E., Vinciguerra, B., Cortinas, A., Thapa, L., Jhunjhunwala, S., Isaacs, L., Langer, R. and Anderson, G., Supramolecular PEGylation of biopharmaceuticals, Proceedings of the National Academy of Sciences, 113: 14189-14194, 2016.

Fischer, K., Morgan, K., Hearon, K., Sklaviadis, D., Tochka, Z., Fenton, O., Anderson, D., Langer, R. and Freed, L., Poly(limonene thioether) scaffold for tissue engineering, Advanced Healthcare Materials, 5: 813-821, 2016.

Kimball, A., Javorsky, E., Ron, E., Crowley, W. and Langer, R., A novel approach to administration of peptides in women: Systemic absorption of a GnRH agonist via transvaginal ring delivery system, Journal of Controlled Release, 233: 19-28, 2016. Exempt from PMC—Non-NIH/PHS Funding

Yu, B., Kang, S., Akthakul, A., Ramadurai, N., Pilkenton, M. Sakamoto, F., Gilchrest, B., Anderson, R. and Langer, R., An elastic second skin, Nature Materials, 15: 911-918, 2016. Exempt from PMC—Non-NIH/PHS Funding.

Moss, J. and Langer, R., Drug delivery modalities, Principles of pharmacology: The pathophysiologic basis of drug therapy, Fourth Edition, Chap. 55, pp. 979-985, Golan, E., Armstrong, E., Armstrong, A. eds; Wolters Kluwer, 2016, PMCID: Exempt from PMC—Book Chapter.

Chahal, J., Khan, O., Cooper, C., McPartlan, J., Tsosie, J., Tilley, L., Sidik, S., Lourido, S., Langer, R., Bavari, A., Ploegh, H. and Anderson, D., Dendrimer-RNA nanoparticles generate protective immunity against lethal ebola, H1N1 influenza and toxoplasma gondii challenges with a single dose, Proceedings of the National Academy of Sciences, 113: E4133-E4142, 2016.

Lee, Y., Zhang, S., Lin, J., Langer, R. and Traverso, G., A janus mucoadhesive and omniphobic device for gastrointestinal retention, Advanced Healthcare Materials, 5: 1141-1146, 2016. NIHMSID 842081 (PMCID Pending)

Sager, H., Dutta, P., Dahlman, J., Courties, G., Heidt, T., Vinegoni, C., Borodovsky, A, Fitzgerald, K., Sun, Y., Wojtkiewicz, G., Iwamoto, Y., Khan, O., Xing, Y., Shaw, T., Libby, P., Langer, R., Weissleder, R., Sirski, F., Anderson, D. and Nahrendorf, M., RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction, Science Translational Medicine, 8: 342ra80, 2016. PMCID: PMC5125383.

Lu, Y., Langer, R. and Gu, Z., Bio-responsive materials, Nature Reviews Materials, 2: 1-17, 2016. PMC Exempt – Review.

Adlington, K., Nguyen, N., Eaves, E., Yang, J., Chang, C., Li, J., Gower, A., Stimpson, A., Anderson, D., Langer, R., Davies, M., Hook, A., Williams, P., Alexander, M. and Irvine, D., Application of targeted molecular and material property optimization to bacterial attachment resistant (meth)acrylate polymers, Biomacromolecules, 17: 2830-2838, 2016.

Morgan, K., Sklaviadis, D., Tochka, Z., Fischer, K., Hearon, K., Morgan, T., Langer, R. and Freed, L., Multi-material tissue engineering scaffold with hierarchical pore architecture, Advanced Functional Materials, 26: 5873-5883, 2016. PMCID: PMC5142531

Khademhosseini, A. and Langer, R., A decade of progress in tissue engineering, Nature Protocols, 11: 1775-1781, 2016. PMC Exempt – Review.

Kirtane, A., Langer, R. and Traverso, G., Past, present and future drug delivery systems for antiretrovirals, Journal of Pharmaceutical Sciences, 105: 3471-3482, 2016. PMC Exempt – Review.

Bellinger, A., Jafari, M., Grant, T., Zhang, S., Slater, H., Wenger, E., Mo, S., Lee, Y., Mazdiyasni, H., Kogan, L., Barman, R., Cleveland, C., Booth, L., Bensel, T., Minahan, D., Hurowitz, H., Tai, T., Daily, J., Nikolic, B., Wood, L., Eckhoff, P., Langer, R. and Traverso, G., Oral, ultra-long-lasting drug delivery: Application toward malaria elimination goals, Science Translational Medicine, 4: 365ra157, 2016. PMCID: PMC5264553

Yang, Y., Andersson, P., Hosaka, K., Zhang, Y., Cao, R., Iwamoto, H., Yang, X., Nakamura, M., Wang, J., Zhuang, R., Morikawa, H., Xue, Y., Braun, H., Beyaert, R., Samani, N., Nakae, S., Hams, E., Dissing, S., Fallong, P., Langer, R., and Cao, Y., The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumor-associated macrophages, Nature Communications, DOI: 10.1038/ncomms11385, 2016. PMCID: PMC4859070

Chen, X., Wu, B., Jayawardana, K., Hao, N., Jayawardena, S., Langer, R., Jaklenec, A. and Yan, M., Magnetic multivalent trehalose glycopolymer nanoparticles for the detection of mycobacteria, Advanced Healthcare Materials, E-pub ahead of time, DOI:10.102/adhm.201600071, 2016. PMCID: PMC5242184

Zhao, X., Hwang, N., Bichara, D., Saris, D., Malda, J., Vacanti, J., Pomerantseva, I., Sundback, C., Langer, R., Anderson, D. and Randolph, M., Chondrogenesis by bone marrow-derived mesenchymal stem cells grown in chondrocyte-conditioned medium for auricular reconstruction, Journal of Tissue Engineering and Regenerative Medicine, E-pub ahead of time DOI: 10.1002/term.2171, 2016. Exempt from PMC—Non-NIH/PHS Funding.

Patel, A., Tibbitt, M., Celiz, M., Davies, M., Langer, R., Denning, C., Alexander, M. and Anderson, D., High throughput screening for discovery of materials that control stem cell fate, Current Opinion in Solid State and Materials Science, E-pub ahead of time, DOI:10.1016/j.cossms.2016.02.002, 2016.

Lu, Y., Aimetti, A., Langer, R. and Gu, Z., Bioresponsive materials, Nature Reviews Materials, E-pub ahead of time, DOI: 10.1038/natrevmats.2016.75, 2016. PMC Exempt – Review.

Jhunjhunwala, S., Alvarez, D., Aresta-DaSilva, S., Tang, K., Tang, B, Greiner, D., Newburger, P., von Andrian, U., Langer, R. and Anderson, D., Splenic progenitors aid in maintaining high neutrophil numbers at sites of sterile chronic inflammation, Journal of Leukocyte Biology, E-pub ahead of time, DOI: 10.1189/jlb.1HI0615-248RR, 2016. PMCID: PMC4945357

Jonas, O., Kosciuk, T., Cima, M., Flaherty, K. and Langer, R., Parrallel in vivo assessment of drug phenotypes at various time points during systemic BRAF inhibition reveals tumor adaptation and altered treatment vulnerabilities, Clinical Cancer Research, E-pub ahead of time, DOI: 10.1158/1078-0432.CCR-15-2722, 2016.

Farah, S., Anderson, D. and Langer, R., Physical and mechanical properties of PLA and their functions in widespread applications: A comprehensive review, Advanced Drug Delivery Reviews, E-pub ahead of time, DOI: 10.1016/j.addr2016.06.012, 2016. PMC Exempt – Review.

Chertok, B., Langer, R. and Anderson, D., Spatial control of gene expression by nanocarriers using heparin masking and ultrasound-targeted microbubble destruction, ACS Nano, E-pub ahead of time, DOI: 10.1021/acsnano.6b01199, 2016. PMCID: PMC5240524

Kollmannsperger, A., Sharei, A., Raulf, A., Heilemann, M., Langer, R., Jensen, K., Wieneke, R. and Tampe, R., Live-cell protein labeling with nanometer precision by cell squeezing, Nature Communications, DOI: 10.1038/ncomms10372, 2016.

Chu, H., Kohane, D. and Langer, R., RNA therapeutics: The potential treatment for myocardial infarction, Regenerative Therapy, 4: 83-91, 2016.

Hong, A., Tseng, Y., Cowley, G., Jonas, O., Cheah, J., Kynnap, B., Doshi, M., Oh, C., Meyer, S., Church, A., Gill, S., Bielski, C., Keskula, P., Imamovic, A., Howell, S., Kryukov, G., Clemons, P., Tsherniak, A., Vazquez, F., Crompton, B., Shamji, A., Rodriguez-Galindo, C., Janeway, K., Roberts, C., Stegmaier, K., van Hummelen, P., Cima, M., Langer, R., Garraway, L., Schreiber, S., Root, D., Hahn, W. and Boehm, J., Integrated genetic and pharmacologic interrogation of rare cancers, Nature Communications, DOI: 10.1038/ncomms11987, 2016. PMCID: PMC49179.

Anselmo, A., McHugh, K., Webster, J., Langer, R. and Jaklenec, A., Layer-by-layer encapsulation of probiotics for delivery to the microbiome, Advanced Materials, E-pub ahead of time, DOI: 10.1002/adma.201603270, 2016, PMID: 27616140, 2016.

Tam, H., Melo, M., Kang, M., Pelet, J., Ruda, V., Foley, M., Hu, J., Crampton, J., Baldeon, A., Sanders, R., Moore, J., Crotty, S., Langer, R., Anderson, D., Chakraborty, A. and Irvine, D., Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination, Proceedings of the National Academy of Sciences, 113: E6639-E6648, 2016, DOI: 10.1073/pnas.1606050113, 2016. PMCID: PMC5086995

2015

2015

Langer, R. and Weissleder, R., Scientific discovery and the future of medicine: Nanotechnology, Journal of the American Medical Association, 312: 135-136, 2015.

Veiseh, O., Tang, B., Whitehead, K., Anderson, D. and Langer, R., Managing diabetes with nanomedicine: Challenges and opportunities, Nature Reviews Drug Discovery, 14: 45-57, 2015Traverso, G., Schoellhammer, C., Schroeder, A., Maa, R., Lauwers, G., Polat, B., Anderson, D., Blankschtein, D. and Langer, R., Microneedles for drug delivery via the gastrointestinal tract, Journal of Pharmaceutical Sciences, 104: 362-367, 2015.

Traverso, G. and Langer, R., Perspective: Special delivery for the gut, Nature, 519: S19, 2015.

Chou, D., Webber, M., Tang, B., Lin, A., Thapa, L., Deng, D., Truong, J., Cortinas, A., Langer, R. and Anderson, D., Glucose responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates, Proceedings of the National Academy of Sciences,111: 2401-2406, 2015.

Appel, E., Larson, B., Luly, K., Kim, J. and Langer, R., Non-cell-adhesive substrates for printing arrayed biomaterials, Advanced Healthcare Materials, 4: 501-505, 2015.

Webber, M., Anderson, D. and Langer, R., Engineering synthetically modified insulin for glucose-responsive diabetes therapy, Expert Review of Endocrinology and Metabolism, 10: 483-489, 2015.

Jonas, O., Landry, H., Fuller, J., Santini, J., Baselga, J., Tepper, R., Cima, M. and Langer, R., An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors, Science Translational Medicine, 7: 284ra57, 2015.

Sanni, O., Chang, C., Anderson, D., Langer, R., Davies, M., Williams, P.M., Willimas, P., Alexander, M. and Hook, A., Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity, Advanced Healthcare Materials, 4: 695-701: 2015.

Khan, O., Zaia, E., Jhunjhunwala, S., Xue, W., Cai, W., Yun, D., Barnes, C., Dahlman, J., Dong, Y., Pelet, J., Webber, M., Tsosie, J., Jacks, T., Langer, R. and Anderson, D., Dendrimer-inspired nanomaterials for the in vivo delivery of siRNA to lung vasculature, Nano Letters, 15: 3008-3016, 2015.

Traverso, G. and Langer, R., Engineering precision, Science Translational Medicine, 7: 289ed6, 2015.

Appel, E., Tibbitt, M., Webber, M., Mattix, B., Veishe, O. and Langer, R., Self-assembled hydrogels utilizing polymer-nanoparticle interactions, Nature Communications, 6: 6295, 2015.

Patel, A., Celiz, A., Rajamohan, D., Anderson, D., Langer, R., Davies, M., Alexander, M., and Denning, C., A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays, Biomaterials, 61: 257-265, 2015.

Maldonado, R., LaMothe, R., Ferrari, J., Zhang, A., Rossi, R., Griset, A., O’Neil, C., Altreuter, D., Johnston, L., Farokhzad, O., Langer, R., Scott, D., von Andrian, U. and Kishimoto, T., Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance, Proceedings of the National Academy of Sciences, 112: E156-E165, 2015.

O’Shea, T., Aimetti, A., Kim, E., Yesilyurt, V. and Langer, R., Synthesis and characterization of a library of in situ curing, nonswelling ethoxylated polyol thiol-ene hydrogels for tailorable macromolecule delivery, Advanced Materials, 27: 65-72, 2015.

Sydlik, S., Jhunjhunwala, S., Webber, M., Anderson, D. and Langer, R., In vivo compatibility of graphene oxide of differing oxidation states, ACS Nano, s9: 3866-3874, 2015.

Veiseh, O., Doloff, J., Ma, M., Vegas, A., Tam, H., Bader, A., Li, J., Langan, E., Wyckoff, J., Loo, W., Jhunjhunwala, S., Chiu, A., Siebert, S., Tang, K., Hollister-Lock, H., Aresta-Dasilva, S., Bochenek, M., Mendoza-Elias, J., Wang, Y., Qi, M., Lavin, D., Dholakia, N., Thakrar, R., Wier, G., Oberholzer, J., Greiner, D., Langer, R. and Anderson, D., Size and shape dependent foreign body immune response to materials implanted in rodents and non-human primates, Nature Materials, 14: 643-651, 2015.

Tong, R. and Langer, R., Nanomedicine targeting the tumor microenvironment, The Cancer Journal: The Journal of Principles and Practice of Oncology, 21: 314-215, 2015.

Veiseh, O. and Langer, R., A smart insulin patch, Nature, 524: 39-40, 2015.

Zhang, S., Ermann, J., Succi, M., Zhou, A., Hamilton, M., Cao, B., Korzenik, J., Glickman, J., Vemula, P., Glimcher, L., Traverso, G., Langer, R. and Karp, J., An inflammation-targeted hydrogel as a novel approach for drug delivery in inflammatory bowel disease, Science Translational Medicine, 7: 300ra128, 2015.

Celiz, Z., Smith J., Patel, A., Hook, A., Rajamohan, D., George, V., Flatt, L., Patel, M., Epa, V. Singh, T., Langer, R., Anderson, D., Allen, N., Hay, D., Winkler, D., Barrett, D., Davies, M., Young, L., Denning, C. and Alexander, M., Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation, Advanced Materials, 27: 4006-4012, 2015.

Zhang, S., Bellinger, A., Glettig, D., Barman, R., Lee, Y-A., Zhu, J., Cleveland, C., Montgomery, V., Gu, L., Nash, L., Maitland, D., Langer, R. and Traverso, R., A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices, Nature Materials, 10: 1065-1071, 2015. PMID: 26213897; PMCID: 4772966.

White, K., Lu, Y., Annis, S., Hale, A., Chau, N., Dahlman, J., Hemann, C., Opotowsky, A., Vargas, S., Rosas, I., Perrella, M., Osorio, J., Haley, K., Graham, B., Kumar, R., Saggar, R., Saggar, R., Wllance, W., Ross, D., Khan, O., Bader, A., Gochuico, B., Matar, M., Polach, K., Johannessen, N., Prosser, H., Anderson, D., Langer, R., Zweier, J., Bindoff, L., Systrom, D., Waxman, A. Jin, R. and Chan, S., Genetic and hypoxic alterations of tehh microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension, EMBO Molecular Medicine, 7: 695-713, 2015.

Stary, G., Olive, A., Radovic-Moreno, A., Gondek, D., Alvarez, D, Basto, P., Perro, M., Vrbanac, V., Tager, A., Shi, J., Yethon, J., Farokhzad, O., Langer, R. Starnbach, M. and von Andrian, U., A mucosal vaccine against chlamydia trachomatis generates two synergistic waves of protective memory T cells, Science, 348: 1331, 2015.

McHugh, K., Guarecuco, R., Langer, R. and Jaklenec, A., Single-injection vaccines: Progress, challenges and opportunities, Journal of Controlled Release, 219: 596-609, 2015.

Appel, E., Tibbitt, M., Greer, J., Fenton, O., Kreuels, K., Anderson, D. and Langer, R., Exploiting electrostatic interactions in polymer nanoparticle hydrogels, ACS Macro Letters, 4: 848-852, 2015.

Schoellhammer, C., Schroeder, A., Maa, R., Brugge, W., Lauwers, G., Anderson, D., Blankschtein, D., Langer, R. and Traverso, G., Ultrasound-mediated gastrointestinal drug delivery, Science Translational Medicine, 7: 310ra168, 2015.

Wang, Q., Cheng, H., Peng, H., Zhou, H. Li, P. and Langer, R., Non-genetic engineering of cells for drug delivery and cell-based therapy, Advanced Drug Delivery Reviews, 91: 125-140, 2015.

Chung, B., Toth, M., Kamaly, N., Sei, Y., Becraft, J. Mulder, W., Fayad, Z., Farokhzad, O., Kim, YT and Langer, R., Nanomedicines for endothelial disorders, Nano Today, 10: 759-776, 2015.

O’Shea, T., Webber, M., Aimetti, A. and Langer, R., Covalent incorporation of trehalose within hydrogels for enhanced long-term functional stability and controlled release of biomacromolecules, Advanced Healthcare Materials, 4: 1802-1812, 2015.

Sanchez-Gaytan, B., Fay, F., Lobatto, M., Tang, J., Ouimet, M., Kim, Y., van der Staay, S., van Rijs, S., Priem, B., Zhang, L., Fisher, E., Moore, K., Langer, R., Fayad, Z. and Mulder, W., HDL-mimetic PLGA nanoparticle to target atherosclerotic plaque macrophage, Bioconjugate Chemistry, 26: 443-451, 2015.

Yesilyurt, V., Webber, M., Appel, E., Godwin, C., Langer, R. and Anderson, D., Injectable self-healing glucose-responsive hydrogels with pH-regulated mechanical properties, Advanced Materials, 28: 86-91, 2015.

Rwei, A., Lee, J., Zhan, C., Liu, Q., Ok, M., Shankarappa, S., Langer, R. and Kohane, D., Repeatable and adjustable on-demand sciatic nerve block with phototriggerable liposomes, Proceedings of the National Academy of Sciences, 112: 15719-15724, 2015.

Brandl, F., Bertrand, N., Lima, E. and Langer, R., Nanoparticles with photoinduced precipitation for the extraction of pollutants from water and soil, Nature Communications, DOI: 10.1038/ncomms8765, 2015.

Szeto, G., Van Egeren, D., Worku, H., Sharei, A., Alejandro, B., Park, C., Frew, K., Brefo, M., Mao, S., Heimann, M., Langer, R., Jensen, K. and Irvine, D., Microfluidic squeezing for intracellular antigen laoding in polyclonal B-cells as cellular vaccines, Scientific Reports, DOI:10.1038/srep10276, 2015.

Jhunjhunwala, S., Aresta-Dasilva, S., Tang, K., Alvarez, D., Webber, M., Tang, B., Lavin, D., Veiseh, O., Doloff, J., Bose, S. Vegas, A., Ma, M., Sahay, G., Chiu, A., Bader, A., Langan, E., Siebert, S., Li, J., Greiner, D., Newburger, P., von Andrian, U., Langer, R. and Anderson, D., Neutrophil responses to sterile implant materials, Plos One, DOI: 10.1371/journal.pone.0137550, 2015.

Traverso, G., Ciccarelli, G., Hughes, T., Boettcher, T., Barman, R., Langer, R. and Siston, A., Physiologic status monitoring via the gastrointestinal tract, PLOS ONE, DOI: 10.1371/journal.pone.0141666, 2015.

Sharei, A., Trifonova, R., Jhunjhunwala, S., Hartoularos, G., Eyerman, A., Lytton-Jean, A., Angin, M., Sharma, S., Poceviciute, R., Mao, S., Heimann, M., Liu, S., Talkar, T., Khan, O., Addo, M., von Andrian, U., Anderson, D., Langer, R., Lieberman, J. and Jensen, K., Ex vivo cytosolic delivery of functional macromolecules to immune cells, PLOS One, DOI: 10.1371/journal.pone.0118803, 2015.

2014

2014

Lim, J., Bertrand, N., Valencia, P., Rhee, M., Langer, R., Jon, S., Farokhzad, O. and Karnik, R., Parallel Microfluidic Synthesis of Size-Tunable Polymeric Nanoparticles using 3D flow focusing towards in vivo study, Nanomedicine: Nanotechnology, Biology and Medicine, 10: 401-409, 2014. PMID: 23969105.

Yin, X., Farin, H., van Es, J., Clevers, H., Langer, R. and Karp, J., Niche-independent high-purity culture of Lgr5+ intestinal stem cells and their progeny, Nature Methods, 11: 106-112, 2014. NIHMSID: 548435.

Lang, N., Pereira, J., Lee, Y., Friehs, I., Vasilyev, N., Feins, E., Ablasser, K., O’Cearbhaill, E., Xu, C., Fabozzo, A., Padera, R., Wasserman, S., Freudenthall, F., Ferreira, L., Langer, R., Karp, J. and del Nido, P., A blood-resistant surgical glue for minimally invasive repair of vessels and heart defects, Science Translational Medicine 6: 218ra6, 2014 (cover article).

Epa, V., Hook, A., Chang, C. Yang, J., Langer, R. Anderson, D., Willimas, P, Davies, M., Alexander, M. and Winkler, D., Modelling and prediction of bacterial attachment to polymers, Advanced Funcational Materials, 24: 2085-2093, 2014.

Foradori, M., Chen, Q., Fernandez, C., Harper, J., Li, X., Tsang, P., Langer, R. and Moses, M., Matrilin-1 is an inhibitor of neovascularization, J. Biol. Chem., 289: 14301-14309, 2014

Guo, Liang, Ma, M., Zhang, N., Langer, R., and Anderson, D., Stretchable polymeric multielectrode array for conformal neural interfacing, Advanced Materials, 26: 1427-1433, 2014.

Pereira, M., Sundback, C., Lang, N., Cho, W., Pomerantseva, I., Ouyang, B., Tao, S., McHugh, K., Mwizerwa, O., Vemula, P., Mochel, M., Carter, D., Borenstein, J., Langer, R., Ferreira, L., Karp, J. and Masiakos, P., Combined surface micropatterning and reactive chemistry maximizes tissue adhesion with minimal inflammation, Advanced Healthcare Materials, 3: 565-571, 2014.

Timko, B., Arruebo, M., Shankarappa, S., McAlvin, J., Okonkwo, O., Mizrahi, B., Stefanescu, C., Gomez, L., Zhu, J., Zhu, A., Santamaria, J., Langer, R. and Kohane, D., Near-infrared actuated devices for remotely controlled drug delivery, Proceedings of the National Academy of Sciences, 111: 1349-1354, 2014.

Kim, Y., Lobatto, M., Kawahara, T., Chung, B., Mieszawska, A., Sanchez-Gaytan, B., Fay, F., Senders, M., Calcagno, C., Becraft, J., Saung, M., Gordon, R., Stroes, E., Ma, M., Farokhzad, O., Fayad, Z., Mulder, W. and Langer, R., Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis, Proceedings of the National Academy of Sciences 111: 1078-1083, 2014.

Schoellhammer, C., Blankschtein, D., Langer, R., Skin permeabilization for transdermal drug delivery: Recent advances and future prospects, Expert Opinion Drug Delivery, 11: 393-407, 2014. PMID: 24392787.

Sharei, A., Poceviciute, R., Jackson, E., Cho, N., Mao, S., Hartoularos, G., Jang, D., Jhunjhunwala, S., Eyerman, A., Schoettle, T., Langer, R. and Jensen, K., Plasma membrane recovery kinetics of a microfluidic intracellular delivery platform, Integrative Biology, 6: 470-475, 2014.

Dong, Y., Love, K., Dorkin, J., Sirirungruang, S., Zhang, Y., Chen, D., Bogorad, R., Yin, H., Chen, Y., Vegas, A., Alabi, C., Sahay, G., Olejnik, K., Wang, W., Schroeder, A., Lytton-Jean, A., Siegwart, D., Akinc, A., Barnes, C., Barros, S., Carioto, M., Fitzgerald, K., Hettinger, J., Kumar, V., Novobrantseva, T., Qin, J., Querbes, W., Kotelianski, V., Langer, R. and Anderson, D. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates, Proceedings of the National Academy of Sciences, 111: 3955-3960, 2014.

Hook, A., Chang, C-Y., Scurr, D., Langer, R., Anderson, D., Williams, P., Davies, M. and Alexander, M., Thermally switchable polymers achieve controlled Escherichia coli detachment, Advanced Healthcare Materials, 3: 1020-1025, 2014.

Upadhyay, U., Tyler, B., Patt, Y., Wicks, R., Spencer, K., Scott, A., Masi, B., Hwang, L., Grossman, R., Cima, M., Brem, H. and Langer, R., Intracranial microcapsule chemotherapy delivery for the localized treatment of roden metastatic breast adenocarcinoma in the brain, Proceedings of the National Academy of Sciences, 111, 16071-16076, 2014.

Zhu, X., Radovic-Moreno, A., Wu, J., Langer, R., and Shi, J., Nanomedicine in the management of microbial infection: Overview and perspectives, Nano Today, 9: 478-498, 2014.

Barhoumi, A., Wang, W., Zurakowski, D., Langer, R. and Kohane, D., Photothermally targeted thermosensitive polymer-masked nanoparticles, Nano Letters, 14: 3697-3701, 2014.

Celiz, A., Smith, J., Langer, R., Anderson, D., Winkler, D., Barrett, D., Davies, M., Young, L., Denning, C. and Alexander, M., Materials for stem cell factories of the future, Nature Materials, 13: 570-579, 2014.

Dahlman, J., Barnes, C., Khan, O., Thiriot, A., Jhunjunwala, S., Shaw, T., Xing, Y., Sage, H., Sahay, G., Speciner, L., Bader, A., Bogorad, R., Yin, H., Racie, T., Dong, Y., Jiang, S., Seedorf, D., Dave, A., Sandu, K., Webber, M., Novobrantseva, T., Ruda, V., Lytton-Jean, A., Levins, C., Kalish, B., Mudge, D., Perez, M., Abezgauz, L., Dutta, P., Smith, L., Charisse, K., Kieran, M., Fitzgerald, K., Nahrendorf, M., Danino, D., Tuder, R., von Andrian, U., Akinc, A., Schroeder, A., Panigrahy, D., Kotelianski, V., Langer, R. and Anderson, D., In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight, Nature Nanotechnology, 9: 648-655, 2014.

Chan, K., Li, R., Chapman, J., Trac, E., Kobler, J., Zeitels, S., Langer, R. and Karajanagi, S., Functionalizable hydrogel microparticles of tunable size and stiffness for soft tissue filler applications, Acta Biomaterialia, 10: 2563-2573, 2014. NIHMSID: 589854.

Dahlman, J., Tammela, T., Khan, O., Sood, S., Dave, A., Cai, W., Chirino, L., Yang, G., Bronson, R., Crowley, D., Sahay, G., Schroeder, A., Langer, R., Anderson, D., and Jacks, T., Small RNA combination therapy for lung cancer, Proceedings of the National Academy of Sciences, 111: E3553-E3561, 2014

Aday, S., Zoldan, J., Carreto, L., Santos, T., Bernardino, L., Malva, J., Langer, R. and Ferreira, L., VEGF165-bound beads modulate endothelial cell survivial and mirna expression, Journal of Tissue Engineering and Regenerative Medicine, 8: 191-192, 2014.

Ilyinskii, P., Roy, C., O’Neil, C., Browning, E., Pittet, L., Altreuter, D., Alexis, F., Tonti, E., Shi, J., Basto, P., Iannacone, M., Radovic-Moreno, A., Langer, R., Farokhzad, O., von Andrian, U., Johnston, L and Kishimoto, T., Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release, Vaccine, 32: 2882-2895, 2014. NIHMSID: 589859.

Lim, J. Swami, A., Gilson, L., Chopra, S., Choi, S., Wu, J., Langer, R., Farokhzad, O. and Karnik, R., Ultra-high throughput synthesis of nanoparticles with homogeneous size distribution using a coaxial turbulent jet mixer, ACS Nano, 8: 6056-6065, 2014.

Cima, M., Lee, H., Daniel, K., Tanenbaum, L., Mantzavinou, A., Spencer, K., Ong, Q., Sy, J., Santini, J., Schoellhammer, C., Blankschtein, D. and Langer, R., Single compartment drug delivery, Journal of Controlled Release, 190: 157-171, 2014.

Webber, M., Khan, O., Sydlik, S., Tang, B. and Langer, R., A perspective on the clinical translation of scaffolds for tissue engineering, Annals of Biomedical Engineering, 43: 641-656, 2014.

Lee, J., Jeong, K., Hashimoto, M., Kwon, A., Rwei, A., Shankarappa, S., Tsui, J. and Kohane, D., Synthetic ligand-coated magnetic nanoparticles for microfluidic bacterial separation from blood, Nano Letters, 14: 1-5, 2014.

Whitehead, K., Dorkin, R., Vegas, A., Chang, P., Veiseh, O., Matthews, J., Fenton, O., Zhang, Y., Olejnik, K., Yesilyurt, V., Chen, D., Barros, S., Klebanov, B., Novobrantseva, T., Langer, R. and Anderson, D., Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity, Nature Communications, 5: 4277, 2014

Celiz, A., Smith, J., Patel, A., Langer, R., Anderson, D., Barrett, D., Young, L., Davies, M., Denning, C and Alexander, M., Chemically diverse polymer microarrays and high throughput surface characterization: A method for discovery of materials for stem cell culture, Biomaterials Science, 2: 1604-1611, 2014.

Li, L., Tong, R., Chu, H., Wang, W., Langer, R and Kohane, D., Aptamer photo-regulation in vivo, Proceedings of the National Academy of Sciences, 111: 17099-17103, 2014.

Laulicht, B., Traverso, G., Deshpande, V., Langer, R. and Karp, Jeffrey, Simple battery armor to protect against gastrointestinal injury from accidental ingestion, Proceedings of the National Academy of Sciences ,111: 16490-16495, 2014.

Barth, H., Crafoord, S., O’Shea, T., Pritchard, C., Langer, R., Ghosh, F., A new model for in vitro testing of vitreous substitute candidates, Graefe’s Archive for Clinical and Experimental Ophthalmology, 252: 1581-1592, 2014. PMCID: PMC Exempt—Non-NIH/PHS Funding.

Mitragotri, S., Burke, P. and Langer, R., Overcoming the challenges in administering biopharmaceutical drugs: Formulation and delivery strategies, Nature Reviews Drug Discovery, 13: 655-672, 2014.

Dahlman, J., Kauffman, K., Langer, R. and Anderson, D., Nanotechnology for in vivo targeted siRNA delivery, Advances in Genetics, 88: 37-69, 2014.

Chen, S., Xue, Y., Wu, X., Cong, L., Bhutkar, A., Bell, E., Zhang, F., Langer, R. and Sharp, P., Global microRNA depletion suppresses tumor angiogenesis, Genes and Development, 28: 1054-1067, 2014.

De la Fuente, M., Langer, R., and Alonso, M., Nanotechnology approaches for cancer immunotherapy and immunomodulation, in Nano-oncologicals: New targeting and delivery approaches, 2014, Ch. 8. pp 215-242, Alonso, M. and Garcia-Fuentes, M. eds., Springer, New York.

Platt, R., Chen, S., Zhou, Y., Yim. M., Swiech, L., Kempton, H., Dahlman, J. Parnas, O., Eisenhaure, T., Jovanovic, M., Graham, D., Jhunjhunwala, S., Xavier, R., Langer, R., Anderson, D., Hacohen, N., Regev, A., Feng, G., Sharp, P., Zhang, F., CRISPR-Cas9 knockin mice for genome editing and cancer modeling, Cell, 159: 440-455, 2014.

Dong, Y., Eltoukhy, A., Alabi, C., Khan, O., Veiseh, O., Dorkin, J., Sirirungruang, S., Yin, H., Tang, B., Pelet, J., Chen, D., Gu, Z., Xue, Y., Langer, R. and Anderson, D., Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo, Advanced Healthcare Materials, 3: 1392-1397, 2014.

2013

2013

Eltoukhy A. A., Chen, D., Alabi, C. A., Langer R. and Anderson D. G., Degradable terpolymers with alkyl side chains demonstrate enhanced gene delivery potency and nanoparticle stability, Advanced Materials, 25: 1487-1493, 2013. PMID: 23293063.

Fisher, O. Z., Larson, B. L., Hill, P. S., Graupner, D., Nguyen-Kim, M-T., Kehr, N-S., Cola, L., Langer, R. and Anderson D. G. Melanin-like hydrogels derived from gallic macromers, Advanced Materials, 24: 3032-3036, 2013 PMCID: Exempt from PMC—Non-NIH/PHS Funding

Hook, A., Chang, C., Yang, J., Atkinson, S., Langer, R., Anderson, D., Davies, M., Williams, P. and Alexander, M., Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays, Advanced Materials, 25: 2542-2547, 2013. PMID: 23417823, PMCID: PMC 3736217.

Neal, R., Jean, A., Park, H., Wu, P., Hsiao, J., Engelmayr, G., Langer, R. and Freed, L., 3D elastomeric scaffolds designed with cardiac-mimetic structural and mechanical features, Tissue Engineering, 19: 793-807, 2013. PMCID: 23190320, PMCID: PMC3566675.

Langer, R., Fuller, J. and Levin, M. Chapter III.1.10 Entrepreneurship in Biomaterials, in Biomaterials Science, 2013, 3rd Ed., pp. 1459-1472, Ratner, D., Hoffman, S. and Schoen, F. eds., Elsevier Inc., Academic Press.

Ma, M., Guo, L, Anderson, D. and Langer, R., Bio-inspired polymer composite actuator and generator driven by water gradients, Science, 339: 186-189, 2013. PMID: 23307738, PMCID: PMC3635810.

Langer, R., A personal account of translating discoveries in an academic lab, Nature Biotechnology, 31: 487-489, 2013. PMID: 23752424. PMC Exempt – Review.

Karagiannis, E., Urbanska, A., Sahay, G., Pelet, J., Jhunjhunwala, S., Langer, R., Anderson, D., Rational design of a biomimetric cell penetrating peptide library, ACS Nano, 7: 8616-8626, 2013.

Sharei, Armon, Zoldan, Janet, Adamo, Andrea., Sim, Woo-Young, Cho, Nahyun, Jackson, Emily, Mao, Shirley, Schneider, Sabine, Han, Min-Joon, Lytton-Jean, Abigail, Basto, Pamela A., Jhunjhunwala, Siddharth, Lee, Jungmin, Heller, Daniel A., Kang, Jeon Woong, Hartoularos, George C, Kim, Kwang-Soo, Anderson, Daniel G, Langer, Robert, Jensen, Klavs F., A vector-free microfluidic platform for intracellular delivery, Proceedings of the National Academy of Sciences, 110: 2082-2087, 2013. PMCID: PMC3568376.

Heller, D., Levi, Y., Pelet, J., Doloff, J., Wallas, J., Pratt, G., Jiang, S., Sahay, G., Schroeder, A., Schroeder, J.E., Chyan, Y., Zurenko, C., Querbes, W., Manzano-Garcia, Kohane, D., Langer, R., and Anderson, D., Modular ‘click-in-emulsion’ bone-targeted nanogels, Advanced Materials, 25: 1449-1454, 2013. PMID: 23280931.

Hashimoto, M., Langer, R. and Kohane, D., Benchtop fabrication of microfluidic systems based on curable polymers with improved solvent compatibility, Lab on a Chip, 13: 252-259, 2013. PMID: 23192674.

Sharei, A., Cho, N., Mao, S., Jackson, E., Poceviciute, R., Adamo, A., Zoldan, J., Langer, R. and Jensen, K., Cell squeezing as a robust microfluidic intracellular delivery platform, Journal of Visualized Experiments, 81, e50980, 2013.

Sahay, G., Querbes, W., Alabi, C., Eltoukhy, A., Sarkar, S., Zurenko, C., Karagiannis, E., Love, K., Chen, D., Zoncu, R., Buganim, Y., Schroeder, A., Langer, R. and Anderson, D., Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling, Nature Biotechnology, 31: 653-658, 2013. PMID: 23792629, PMID: PMC3814166.

Hook, A., Scurr, D., Burley, J., Langer, R., Anderson, D., Davies, M. and Alexander, M., Analysis and prediction of defects in UV photo-initiated polymer microarrays, Journal of Materials Chemistry B, 1: 1035-1043, 2013.

Langer, R., Biomaterials and biotechnology: From the discovery of the first angiogenesis inhibitors to the development of controlled drug delivery systems and the foundation of tissue engineering, Journal of Biomedical Materials Research, 101A: 2449-2455, 2013. PMID: 23723136.

Alabi, C., Love, K., Sahay, G., Yin H., Luly, K., Langer, R., and Anderson, D., Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery, Proceedings of the National Academy of Sciences, 110: 12881-12886, 2013. PMID: 23882076, PMCID: PMC3740846.

Bonner, D., Zhao, X., Buss, H., Langer, R., Hammond, P., Crosslinked linear polyethylenimine enhances delivery of DNA to the cytoplasm, Journal of Controlled Release, 167: 101-107, 2013. PMID: 22995755.

Celiz, A., Hook A., Scurr, D., Anderson, D., Langer, R., Davies, M. and Alexander, M., ToF-SIMS imaging of a polymer microarray prepared using ink-jet printing of acrylate monomers, Surface and Interface Analysis, 45: 202-205, 2013.

Chertok, B., Webber, M., Succi, M. and Langer, R., Drug Delivery Interfaces in the 21st Century: From Science Fiction Ideas to Viable Technologies, Molecular Pharmacology, 10: 3531-3543, 2013. PMID: 23915375.

Dang, T., Thai, A., Cohen, J., Slosberg, J., Siniakowicz, D., Doloff, J., Ma, M., Hollister-Lock, J., Tang, K., Gu, Z., Cheng, H., Weir, G., Langer, R. and Anderson, D., Enhanced function of immune-isolated islets in diabetes therapy by co-encapsulation with an anti-inflammatory drug, Biomaterials, 34: 5792-5801, 2013. PMID: 23660251.

Gabriel, D., Monteiro, I., Huang, D., Langer, R. and Kohane, D., A photo-triggered layered surface coating producing reactive oxygen species, Biomaterials, 34: 9763-9769, 2013. PMID: 24074838.

Gianella, A., Janssen, H., Hoben, F., Jarzyna, P. Cormode, D., Costa, K., Rao, S., Langer, R., Farokhzad, O. and Mulder, W., Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform, ChemComm, 49: 9392-9394, 2013. PMID: 23877789, PMCID: PMC3786364.

Gu, M., Vegas, A., Anderson, D., Langer, R., Kilduff, C. and Belfort, G., Combinatorial synthesis with high throughput discovery of protein-resistant membrane surfaces, Biomaterials, 34: 6133-6138, 2013. PMID: 23706542. NIHMS# 548463.

Gu, Z., Aimetti, A., Wang, Q., Dang, T., Zhang, Y., Veiseh, O., Cheng, H., Langer, R. and Anderson, D., Injectable nano-network for glucose mediated insulin delivery, ACS Nano, 7: 4194-4201, 2013. PMID: 23638642.

Haq, R., Yokoyama, S., Hawryluk, E., Jonsson, G., McHenry, K., Porter, D., Tran, T., Love, K., Langer, R., Anderson, D., Garraway, L., Duncan, L., Morton, D., Hoon, D., Song, J. and Fisher, D., BCL2A1 is a lineage-specific anti-apoptotic melanoma oncogene that confers resistance to BRAF inhibition, Proceedings of the National Academy of Sciences, 110: 4321-4326, 2013. PMID: 23447565, PMCID: PMC3600451.

Wang, J., Boutin, K., Abdulhadi, O., Personnat, L., Shazly, T., Langer, R., Chanick, C. and Borenstein, J., Fully biodegradable airway stents using amino alcohol-based poly(ester amide) elastomers, Advanced Healthcare Materials, 2: 1329-1336, 2013. PMID: 23526787. PMCID: PMC Exempt—Non-NIH/PHS Funding.

Hook, A., Scurr, D., Anderson, D., Langer, R., Williams, P., Davies, M., and Alexander, M., High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry, Surface and Interface Analysis, 45: 181-184, 2013. PMID: 23450147, PMCID: PMC3579490.

Jiang, S., Eltoukhy, A., Love, K., Langer, R., Anderson, D., Lipidoid-Coated Iron Oxide Nanoparticles for Efficient DNA and siRNA delivery, Nano Letters, 13: 1059-1064, 2013. PMID: 23394319.

Johnstone, T., Kulak, N., Pridgen, E., Farokhzad, O., Langer, R. and Lippard, S., Nanoparticle encapsulation of mitaplatin and the effect thereof on in vivo properties, ACS Nano, 7: 5675-5683, 2013. PMID: 23697579, PMCID: PMC3722263.

Scurr, D., Hook, A., Burley, J., Williams, P., Anderson, D., Langer, R., Davices, M. and Alexander, M., Strategies for MCR image analysis of large hyperspectral data-sets, Surface and Interface Analysis (Special Issue): 45, 466-470, 2013.

Kamaly, N., Fredman, G., Subramanian, M., Gadde, S., Pesic, A., Cheung, L., Fayad, Z., Langer, R., Tabas, I. and Farokhzad, O., Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles, Proceedings of the National Academy of Sciences, 110: 6506-6511, 2013. PMID: 23533277, PMCID: PMC3631648.

Karagiannis, E., Urbanska, A., Sahay, G., Pelet, J., Jhunjhunwala, S., Langer, R., and Anderson, D., Rational design of a biomimetic cell penetrating peptide library, ACS Nano, 7: 8616-8626, 2013. PMID: 24047542.

Khoo, X., Simons, E., Chiang, H., Hickey, J., Sabharwal, V., Pelton, S., Rosowski, J., Langer, R., Kohane, D., Formulations for trans-tympanic antibiotic delivery, Biomaterials, 34: 1281-1288, 2013. PMID: 23146430, PMCID: PMC3511665.

Kim, Y., Fay, F., Cormode, D., Sanchez-Gaytan, B., Tang, J., Hennessy, E., Ma, M., Moore, K., Farokhzad, O., Fisher, E., Mulder, W., Langer, R., Fayad, Z., Single Step Reconstitution of Multifunctional High-Density Lipoprotein-Derived Nanomaterials Using Microfluidics, ACS Nano, 7: 9975-9983, 2013. PMID: 24079940.

Kolewe, M., Park., H., Gray, C., Ye, X., Langer, R. and Freed, L., 3D structural patterns in scalable, elastomeric scaffolds guide engineered, Advanced Materials, 25: 4459-4465, 2013. PMID: 23765688.

Lim, D., Barhoumi, A., Wylie, R., Reznor, G., Langer, R. and Kohane, D., Enhanced photothermal effect of plasmonic nanoparticles coated with reduced graphene oxide, Nano Letters, 13: 4075-4079, 2013. PMID: 23899267.

Mieszawska, A., Kim, Y., Gianella, A., van Rooy, I., Priem, B., Labarre, M., Ozcan, C., Cormode, D., Petrov, A., Langer, R., Farokhzad, O., Fayad, Z. and Mulder, W., Synthesis of polymer-lipid nanoparticles for image-guided delivery of dual modality therapy, Bioconjugate Chemistry, 24: 1429-1434, 2013. PMID: 23957728, PMCID: PMC3810168.

Mizrahi, B., Shankarappa, S., Hickey, J., Dohlman, J., Timko, B., Whitehead, K., Lee, J., Langer, R., Anderson, D. and Kohane, D., A stiff injectable biodegradable elastomer, Advanced Functional Materials, 23: 1527-1533, 2013. PMID: 23667350, PMCID: PMC3646576.

Pereira, M., Ouyang, B., Sundback, C., Langer, N., Friehs, I., Mureli, S., Pomerantseva, I., McFadden, J, Mochel, M., Mwizerwa, O., del Nido, P., Sarkar, D., Masiakos, P., Langer, R., Ferreira, L. and Karp, J., A highly tunable biocompatible and multifunctional biodegradable elastomer, Advanced Materials, 25: 1209-1215, 2013. PMID: 24106240.

Saigal, R., Cimetta, E., Tandon, N., Zhou, J., Langer, R., Young, M., Vunjak-Novakovic, G. and Redenti, S., Electrical stimulation via a biocompatible conductive polymer directs retinal progenitor cell differentiation, Conf. Proc. IEEE Eng. Med. Biol. Soc., 2013: 1627-1631, 2013. PMID: 24110015.

Hubbell, J. and Langer, R. Translating materials design to the clinic, Nature Materials, 12: 963-966, 2013.

Xu, X., Xie, K., Zhang, X., Pridgen, E., Park, G., Cui, D., Shi, J., Wu, J., Kantoff, P., Lippard, S., Langer, R., Walker, G. and Farokhzad, O., Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug, Proceedings of the National Academy of Sciences, 110: 18638-18643, 2013.

Pridgen, E., Alexis, F., Kuo, T., Levy-Nissenbaum, E., Karnik, R., Blumberg, R., Langer, R. and Farokhzad, O., Transepithelial transport of Fc-targeted nanoparticles by the neonatal Fc receptor for oral delivery, Science Translational Medicine, 5: 213ra167, 2013. PMID: 24285486; NIHMSID#565166.

Valencia, P., Pridgen, E., Rhee, M., Langer, R., Farokhzad, O., and Karnik, R., Microfluidic platform for combinatorial synthesis and optimization of targeted nanoparticles for cancer therapy, ACS Nano, 7: 10671-10680, 2013.

Valencia, P., Pridgen, E., Perea, B., Gadde, S., Sweeny, C., Kantoff, P., Bander, N., Lippard, S., Langer, R., Karnik, R. and Farokhzad, O., Synergistic cytotoxicity of irinotecan and cisplatin in dual drug targeted polymeric nanoparticles, Nanomedicine (Long), 8: 687-698, 2013. PMID23075285; PMCID3694785; 10.2217/nnm.12.134.

2012

2012

Schroeder, A., Heller, D., Winslow, M., Dahlman, J., Pratt, G., Langer, R., Jacks, Tyler and Anderson, D., Treating metastatic cancer with nanotechnology, Nature Reviews Cancer, 12: 39-50, 2012.

Tekin, H., Sanchez, J., Landeros, C., Dubbin, K., Langer, R. and Khademhosseini, A., Controlling spatial organization of multiple cell types in defined 3D geometries, Advanced Materials, 24: 5543-5547, 2012. PMID: 22941804.

Hrkach, J., von Hoff, D., Ali, M., Andrianova, E., Auer, J., Campbell, T., De Witt, D., Figa, M., Figueiredo, M., Horhota, A., Low, S, McDonnell, K., Peeke, E, Retnarajan, B., Sabnis, A., Schnipper, E., Song, J., Song, Y., Summan, J., Tompsett, D., Trojano, G., Van Geen Hoven, T., Wright, J., LoRusso, P., Kantoff, P., Bander, N., Sweeney, C., Farokhzad, O., Langer, R. and Zale, S., Preclinical development and clinical translation of a PSMA targeted docetaxel nanoparticle with a differentiated pharmacological profiles, Science Translational Medicine, 4, 128ra39, 2012.

Kost, J. and Langer, R., Responsive polymeric delivery systems, Advanced Drug Delivery Reviews, 64: 327-341, 2012.

Li, J., Song, J., Bell, R., Tran, T., Haq, R., Liu, H., Love, K., Langer, R., Anderson, D., Larue, L. and Fisher, D., YY1 regulates melanocyte development and function by cooperating with MITF, PLOS Genetics, 8, e1002688, 2012.

Lee, J., Sharei, A., Sim, W., Adamo, A., Langer, R., Jensen, K. and Bawendi, M., Nonendocytic delivery of functional engineered nanoparticles into the cytoplasm of live cells using a novel, high-throughput microfluidic device, Nano Letters, 12: 6322-6327, 2012.

Bellan, L., Kniazeva, T., Kim, W., Epshteyn, A., Cropek, D., Langer, R. and Borenstein, J., Fabrication of a hybrid microfluidic system incorporating both lithographically patterned microchannels and a 3D fiber-formed microfluidic network, Advanced Healthcare Materials, 1: 164-167, 2012. PMID: 22708076.

Eltoukhy,A., Siegwart, D., Alabi, C., Rajan, J., Langer, R. and Anderson, D., Effect of Molecular weight of amine end-modified poly(beta-amino ester)s on gene delivery efficiency and toxicity, Biomaterials, 33: 3594-3603, 2012. PMICD: PMC3326358

Alabi, C. A., Sahay, G., Langer, R. and Anderson, D. G., Development of siRNA-probes for studying intracellular trafficking of siRNA nanoparticles, Integrative Biology, 5: 224-230, 2012, PMID: 23014672, PMCID: PMC3524365.

Hook, A., Chang, C., Yang, J., Luckett, J., Cockayne, A., Atkinson, S., Mei, Y., Bayston, R., Irvine, D., Langer, R., Anderson, D., Williams, P., Davies, M. and Alexander, M., Combinatorial discovery of polymers resistant to bacterial attachment, Nature Biotechnology, 30: 868-875, 2012. PMID22885723; PMCID3796337; 10.1038/nbt.2316.

Seto, J., Polat, B., VanVeller, B., Lopez, R., Langer, R. and Blankschtein, D., Fluorescent penetration enhancers for transdermal applications, Journal of Controlled Release, 158: 85-92, 2012.

Lee, H., Lytton-Jean, A., Chen, Y., Love, K., Park, A., Karagiannis, E., Sehgal, A., Querbes, W., Zurenko, C., Jayaraman, M., Peng, C., Charisse, K., Borodovsky, A., Manoharan, M., Donahoe, J., Truelove, J., Nahrendorf, M., Langer, R. and Anderson, D., Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery, Nature Nanotechnology, 7: 389-393, 2012.

Valencia, P., Farokhzad, O., Karnik, R., Langer, R., Microfluidic technologies for accelerating the clinical translation of nanoparticles, Nature Nanotechnology, 7: 623-629, 2012. PMID: 23042546.

Polat, B., Deen, W., Langer, R., Blankschtein, D., A physical mechanism to explain the delivery of chemical penetration enhancers into skin during transdermal sonosphoresis: Insight into the observed synergism, Journal of Controlled Release, 158: 250-260, 2012.

Siegwart, D., Leiendecker, M., Langer, R. and Anderson, D., Automated ARGET ATRP accelerates catalyst optimization for the synthesis of thiol-fuctionalized polymers, Macromolecules, 45: 1254-1261, 2012.

Jaklenec, A, Stamp, A., Deweerd, E., Sherwin, A and Langer, R., Progress in tissue engineering and stem cell industry “Are we there yet?”, Tissue Engineering, 18: 155-166, 2012.

Vacanti, N. M., Chen, H., Hill, P. S., Guerreiro, J. D. T., Dang, T. T., Ma, M. L., Watson, S., Hwang, N. S., Langer, R. and Anderson, D. G., Localized delivery of dexamethasone from electrospun fibers reduces the foreign body response, Biomacromolecules, 13: 3031-3038, 2012.

Shankarappa, S., Tsui, J, Kim, K, Reznor, G., Dohlman, J., Langer, R. and Kohane, D., Prolonged nerve blockade delays the onset of neuropathic pain, Proceedings of the National Academy of Sciences, 109: 17555-17560, 2012.

Farra, R., Sheppard, N., McCabe, L., Neer, R., Anderson, J., Santini, J., Cima, M. and Langer, R., First in-human testing of a wirelessly controlled drug delivery microchip, Science Translational Medicine, 4: 122ra21, 2012.

Nguyen, D., Mahone, K., Chikh, G., Kim, P., Chung, H., Vicari, A., Love, K., Goldberg, M., Chen, S., Krieg, A., Chen, J., Langer, R. and Anderson, D., Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery, Proceedings of the National Academy of Sciences, 109: E797-E803, 2012. PMID22421433; PMCID3325698; 10.1073/pnas.1121423109.

Schroeder, A., Goldberg, M., Kastrup, C. Wang, Y., Jiang, S., Joseph, B., Levins, C., Kannan, S., Langer, R. and Anderson, D., Remotely-activated protein-producing nanoparticles, Nano Letters, 12, 2685-2689, 2012.

Sun, S., Wang, M., Knupp, S., Soto-Feliciano, Y., Hu, X., Kaplan, D., Langer, R., Anderson, D. and Xu, Q., Combinatorial library of lipidoids for in vitro DNA delivery, Bioconjugate Chemistry, 23: 135-140, 2012.

Langer, R. and Tirrell, D., Introduction and Overview, in Polymer Science: A comprehensive Reference, 2012, Vol. 9 pp. 1-2, Matyjaszewski, K. and Moller. eds., Elsevier BV, Amsterdam, Netherlands.

Mieszawska, A., Gianella, A., Cormode, D., Zhao, Y., Meijerink, A., Langer, R., Farokhzad, O., Fayad, Z. and Mulder, W., Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging, ChemComm, 448: 5835-5837, 2012.

Cho, S-W., yang, F., Son, S.M., Park, H. J., Green, J. J., Bogatyrev, S., Mei, Y., Park, S., Langer, R. and Anderson, D. G. Therapeutic angiogensis using genetically engineered human enddothelial cells, Journal of Controlled Release, 160: 515-524, 2012.

Tian, B., Liu, J., Dvir., T., Jin., L., Tsui, J., Qing, Q., Suo, Z., Langer, R., Kohane, D. and Lieber, C., Macroporous nanowire nanoelectronic scaffolds for synthetic tissues, Nature Materials, 11: 986-994, 2012.

Urbanska, A., Karajiannis, E., Guajardo, G., Langer, R. and Anderson, D., Therapeutic effect of orally administered oxaliplatin for colorectal biomaterials, Biomaterials, 33: 4752-4761, 2012.

Schoellhammer, C., Polat, B., Hart, D., Blankschtein, D. and Langer, R., Rapid skin permeabilization by the simultaneous application of dual-frequency, high-intensity ultrasound, Journal of Controlled Release, 163: 154-160, 2012.

Cho, W., Ankrum, J., Guo, Dagang, Chester, S., Yang, S., Kashyap, A., Campbell, G., Wood, R., Rijal, R., Karnik, R., Langer, R. and Karp, J., Microstructed barbs on the North American porcupine quill enable easy tissue penetration and difficult removal, Proceedings of the National Academy of Sciences, early addition eprint, doi: 10.1073/pnas.1216441109, 2012.

Cohen-Karni, T., Langer, R. and Kohane, D., The smartest materials: The future of nanoelectronics in medicine, ACS Nano, 6: 6541-6545, 2012. PMID: 22850578.

Bratlie, K. M., York, R. L., Invernale, M. A., Langer, R. and Anderson D.G., Materials for diabetes therapeutics Advanced Healthcare Materials, 1: 267-84, 2012. PMCID: Exempt from PMC—Non-NIH/PHS Funding

Radovic-Moreno, A., Lu, T., Puscasu, V., Yoon, C., Langer, R. and Farokhzad, O., Surface charge-switching polymeric nanoparticles for bacterial cell wall-targeted delivery of antibiotics, ACS Nano, 6: 42779-4287, 2012.

Laulicht, B., Langer, R. and Karp, J., Quick release medical tape, Proceedings of the National Academy of Sciences, 109: 18803-18808, 2012.

Novobrantseva, T., Borodovsky, A., Wong, J., Klebanov, B., Zafari, M., Yucius, K. Ge, P., Ruda, v., Querbes, Q., Milstein, S, Speciner, L, Duncan, R., Basha, G., Cullis, P., Akinc, A., Sullivan, J., Jayaprakash, N., Jayaraman, M., Bogorad, R., Love, K., Whitehead, K., Levins, C., Manoharan, M., Swirski, P., Weissleder, R., Langer, R., Anderson, R., de Fougerolles, A., Nahrendorf, M. and Koteliansky, V., Systemic RNAi-mediated gene silencing in non-human primate and rodent myeloid cells, Molecular Therapy Nucleic Acids, 1: e4, doi:10.1038/mtna.2011.3, 2012.

Epa, V. C., Yang, J., Mei, Y., Hook, A. L., Langer, R., Anderson, D. G., Davies, M., Alexander, M. R. and Winkler, D. A., Modelling human embryoid body cell adhesions to a combinatorial library of polymer surfaces, Journal of Materials Chemistry, 22: 20902-20906, 2012.

Kang, S. M., Hwang, N.S, Yeom, J., Park, S. Y., Messersmith, P. B., Choi, I. S., Langer, R., Anderson, D. G. and Lee, H., One-step multipurpose surface functionalization by adhesive catecholamine, Advanced Functional Materials, 22: 2949-2955, 2012.

Smith, R., Zhang, Z., Bouchard, M., Li, J., Lapp, H., Brotske, G., Lucchino, D., Weaver, D., Roth, L., Coury, A., Biggerstaff, J., Sukavaneshvar, S., Langer, R. and Loose, C., Vascular catheters with a non-leaching poly-sulfobetaine surface modification reduce thrombus formation and microbial attachment, Science Translational Medicine, 4: 153ra132, 2012.

Alabi, C., Love, K., Sahay, g., Stutzman, T., Young, W., Langer, R. and Anderson, D., FRET-labeled siRNA probes for tracking assembly and disassembly of siRNA nanocomplexes, ACS Nano, 6: 6133-6141, 2012. PMCID:PMC3404193

Wang, A., Langer, R. and Farokhzad, O., Nanoparticle delivery of cancer drugs, Annual Reviews of Medicine, 63: 185-198, 2012.

Salvador-Morales, C., Valencia, P. Thakkar, A., Swanson, E. and Langer, R., Recent developments in multifunctional hybrid nanoparticles: Opportunities and challenges in cancer therapy, Frontiers in Bioscience, (Elite Edition): 4: 529-545, 2012. PMID: 22201893.

Stevenson, C., Santini, J. and Langer, R., Reservoir based drug delivery systems utilizing microtechnology, Advanced Drug Delivery Reviews, 64: 1590-1602, 2012.

Tong, R., Hemmati, H., Langer, R. and Kohane, D., Photoswitchable nanoparticles for triggered tissue penetration and drug delivery, Journal of the American Chemical Society, 134: 8848-8855, 2012.

Xiao, Z., Levy-Nissenbaum, F. Alexis, Teply, B., Chanm J., Shi, J., Digga, E., Cheng, J. Langer, R., and Farokhzad, O., Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake projection, ACS Nano, 6: 694-704, 2012.t

De Sousa, F., Lima, A., Denadai, A., Anconi, C., De Almeida, W., Novato, W., Dos Santos, H., Drum, C., Langer, R. and Sinisterra, Superstructure based on b-CD of self-assembly induced by a small guest molecule, Phys. Chem. Chem. Phys., 14: 1934-1944, 2012.

Kastrup, C., Nahrendorf, M., Figueiredo, J., Lee, H., Kambhampati, S., Lee, T., Cho, S., Gorbatov, R., Iwamoto, Y., Dang, T., Dutta, P., Yeon, J., Cheng, H., Pritchard, C., Vegas, A., Siegel, C., MacDougall, S., Okonkwo, M., Thai., A., Stone, J., Coury, A., Weissleder, R., Langer, R. and Anderson, D., Painting blood vessels and atherosclerotic plaques with an adhesive drug depot, Proceedings of the National Academy of Sciences, 109: 21444-21449, 2012.

Cohen-Karni, T., Jeong, K., Tsui, J., Reznor, G., Mustata, M., Wanunu, M., Graham, A., Marks, C., Bell, D., Langer, R. and Kohane, D., Nanocomposite gold-silk nanofibers, Nano Letters, 12: 5403-5406, 2012.

Cheng, H., Byrska-Bishop, M., Zhang, C. T., Kastrup, C. J., Hwang, N. S., Tai, A. K., Lee, W. W., Xu, X. Y., Nahrendorf, M., Langer, R. and Anderson, D. G., Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell-selectin interaction kinetics, Biomaterials33: 5004-5012, 2012. PMCID: PMC366278

Kim, Y., Chung, B., Ma, M., Mulder, W., Fayad, Z., Farokhzad, O. and Langer, R., Mass production and size control of lipid-polymer hybrid nanoparticles through controlled microvortices, Nano Letters, 12: 3587-3591, 2012.

2011

2011

Chan, E., Karp, J. and Langer, R., A “self-pinning” adhesive based on responsive surface wrinkles, Journal of Polymer Science Part B: Polymer Physics, 49: 40-44, 2011. PMID: 21293787, PMCID: PMC3031119.

Dvir, T., Timko, B., Kohane, D. and Langer, R., Nanotechnological strategies for engineering complex tissues, Nature Nanotechnology, 6: 13-22, 2011. PMID: 21151110, PMCID: PMC Exempt—Review.

Timko, BP, Whitehead, K., Gao,W., Kohane, D., Farokhzad, O., Anderson, D. and Langer, R., Advances in drug delivery, Annual Review of Materials Research, 41: 1-20, 2011.

Siegwart, D. Whitehead, K., Nuhn, L., Cheng, H., Jiang, S., Ma, M., Vegas, A. Fenton, P., Love, K., Levins, C., Sahay, G., Lee, H., Collins, S., Li, Y.F., Jang, J., Langer, R., Anderson, D.G., High-throughput synthesis of chemically diverse core-shell nanoparticles for intracellular delivery; Proceedings of the National Academy of Sciences, 108: 12996-3001, 2011.

Rhee, M., Valencia, P., Rodriguez, M., Langer, R., Farokhzad, O. and Karnik, R., Synthesis of size tunable polymeric nanoparticles enabled by 3D hydrodynamic flow focusing in single layer microchannels, Advanced Materials, 23: H79-H83, 2011.

Radovic-Moreno, A., Yuet, K., Langer, R. and Farokhzad, O., Perspectives on nanotechnology in Interventional Techniques in Uro-oncology, ch. 7, p.102., Arya, M., Ahmed, H., Scardino, P. Emberston, M, eds. Wiley-Blackwell Publishers, Hoboken, NJ, 2011.

Kraehenbuehl, T., Ferreira, L., Hayward, L., Nahrendorf, M., Vasile, E., van der Vlies, A., Weissleder, R., Langer, R. and Hubbell, J., Human embryonic stem cell-based microvascular grafts for cardiac tissue preservation after myocardial infarction, Biomaterials, 32: 1102-1109, 2011. PMID: 21035182.

Belfort, G., Zhou, M., Liu, H., Venkiteshwaran, A., Kilduff, J., Langer, R. and Anderson, D., High throughput discovery of new fouling-resistant surfaces, Journal of Materials Chemistry, 21: 693-704, 2011.

Liu, W., Ma., M., Bratlie, K., Dang, T., Langer, R. and Anderson, D., Real time in vivo detection of biomaterials-induced reactiveloxygen species, Biomaterials, 32: 1796-1801, 2011.

Polat, B., Hart, D., Langer, R. and Blankschtein, D., Ultrasound mediated transdermal drug delivery: Mechanism, scope and emerging trends, Journal of Controlled Release, 152: 330-348, 2011.

Lopez, R., Seto, J., Blankschtein, D. and Langer, R., Enhancing the transdermal delivery of nanoparticles using ultrasound and sodium lauryl sulfate, Biomaterials, 32: 933-941, 2011. PMID: 20971504, PMCID: PMC2991545.

Pritchard CD, O’Shea TM, Siegwart DJ, Calo E, Anderson DG, Reynolds FM, Thomas JA, Slotkin JR, Woodard EJ, Langer R., An injectable thiol-acrylate poly(ethylene glycol) hydrogel for sustained release of methylprednisolone sodium succinate, Biomaterials, 32: 587-597, 2011, PMID: 20880573.

Kaji, H., Camci-Unal, G., Khademhosseini, A. and Langer, R., Engineering systems for the generation of patterned co-cultures for controlling cell-cell interactions, Biochimica et Biophysica Acta, 1810: 239-250, 2011. PMID: 20655984, PMCID: PMC3026923.

Polat, B., Seto, J., Blankschtein, D. and Langer, R., Effect of sodium lauryl sulfate on skin structural perturbation when utilized simultaneously with low-frequency sonophoresis, Journal of Pharmaceutical Sciences, 100: 1387-1397, 2011.

Hwang, N. ,Im, S., Wu, P., Bichara, D., Zhao, Z, Randolph, M. Langer, R. and Anderson, D., Chondrogenic priming adipos-enchymal stem cells for cartilage tissue regeneration, Pharmaceutical Research, 28: 1395-1405, 2011.

Valencia, P., Hanewich-Hollatz, M., Gao, W., Karim, F., Langer, R. Karnik, R and Farokhzad, O., Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles, Biomaterials, 32: 6226-6233, 2011.

Tekin, H., Ozaydin-Ince, G., Tsinman, T., Gleason, K., Langer, R., Khademhosseini, A. and Demirel, M., Responsive microgrooves for formation of harvestable tissue constructs, Langmuir, 27: 5671-5679, 2011.

Scott, A., Tyler, B., Masi, B., Upadhyay, U., Patta, Y., Grossman, R., Basaldella, L, Langer, R., Brem, H. and Cima, M., Intracranial microcapsule drug delivery device for the treatment of an experimental gliosarcoma model, Biomaterials, 32: 2532-2539, 2011. PMID: 21220172, PMCID: PMC Exempt—Non-NIH/PHS Funding.

Whitehead, K., Dahlman, J., Langer, R. and Anderson, D., Silencing or Stimulation? siRNA delivery and the immune system, in Annual Review of Chemical and Biomolecular Engineering, 2011, Vol. 2 pp. 77-96, Prausnitz, J., Doherty, M., and Segalman, R. eds., Annual Reviews, Palo Alto, CA.

Karajanagi, S., Yoganathan, R., Mammucari, R., Park, H., Cox, J., Zeitels, S., Langer, R. and Foster, N., Application of a dense gas technique for sterilizing soft biomaterials, Biotechnology and Bioengineering, 108: 1716-1725, 2011. PMID: 21337339.

Polat, E., Lin, S., Mendenhalll, J., VanVeller, B. Langer, R. and Blankschtein, D., Experimental and molecular dynamics investigation into the amphiphilic nature of sulforhodamine B., J. Phy. Chem B., 115: 1394-14032, 2011. PMID: 21222449

Karajanagi, S., Lopez-Guerra, G., Park, H., Kobler, J., Galindo, M., Aanestad, J., Mehta, D., Kumai, Y., Giordano, N., d’Almeida, A., Heaton, J., Langer, R., Herera, V., Faquin, W., Hillman, R., and Zeitels, M., Assessment of canine vocal fold function after injection of a new biomaterial designed to treat phonatory mucosal scarring, Annals of Otology, Rhinology, and Laryngology, 120: 175-184, 2011.

Moghimi, S, Peer, D. and Langer, R., Reshaping the future of nanopharmaceuticals: ad iudicium, ACS Nano, 5: 8454-8458, 2011.

Sharp, P. and Langer, R., Promoting convergence in biomedical science, Science, 333: 527, 2011. PMID21798916; PMC Excempt-non-peer review paper; 10.1126/science.1205008.

Cheng, H., Hill, P., Siegwart, D., Vacanti, N., Lytton-Jean, A., Cho, S., Ye, A., Langer, R., and Anderson, D., A novel family of biodegradable poly(ester amide) elastomers, Advanced Materials, 23: H95-H100, 2011.

Hook, A., Yang, J., Chen, X., Robert, C., Mei, Y., Anderson, D., Langer, R., Alexander, M. and Davies, M., Polymers with hydro-responsive topography identified using high throughput AFM of an acrylate microarray, Soft Matter, 7: 7194-7197, 2011.

Bonner, D., Leung, C. Chen-Liang, j., Chingozha, L, Langer, R. and Hammond, P., Intracellular trafficking of polyamidoamine-poly(ethylene glycol) block copolymers in DNA delivery, Bioconjugate Chemistry, 22: 1519-1525, 2011.

Kraehenbuehl, T., Langer, R. and Ferreira, L., Three-dimensional biomaterials for the study of human pluripotent stem cells, Nature Methods, 8: 731-736, 2011.

Tekin, H., Tsinman, T., Sanchez, J., Jones, B., Camci-Unal, G., Nichol, J. Langer, R. and Khademhosseini, A., Responsive micromolds for sequential patterning of hydrogel microstructures, Journal of the American Chemical Society, 133: 12944-12947, 2011.

Wang, L., Jeong, K., Chiang, H., Zurakowski, D., Behlau, I., Chodosh, J., Dohlman, C., Langer, R. and Kohane, D., Hydroxyapatite for kertoprosthesis biointegration, Investigative Ophthalmology and Visual Science, 52: 7392-7399, 2011.

Kohane, D. and Langer, R., Drug delivery and translation, Drug Delivery and Translational Research, 1: 4-6, 2011.

Jeong, K., Wang, L., Stefanescu, C., Lawlor, M., Polat, J., Dohlman, C., Langer, R. and Kohane, D., Polydopamine coatings enhance biointegration of a model polymeric implant, Soft Matter, 7: 8305 – 8312, 2011.

Urtti, A., Vuorimaa, E., Ketola, T., Hanzlikova, M., Green, J., Lemmetyinen, H., Langer, R. and Anderson, D., Poly (beta) amino ester – DNA complexes: Time resolved fluorescence and cellular tranfection studies, Journal of Controlled Release, 154: 171-176, 2011.

Zoldan, J. Karagiannis, E., Lee, C., Anderson, D., Langer, R. and Levenberg, S. The influence of scaffold elasticity on germ layer specification of human embryonic stem cells, Biomaterials, 32: 9612-9621, 2011.

Zoldan, J., Lytton-Jean, A., Karagiannis, E., Deiorio-Haggar, K., Bellan, L., Langer, R. and Anderson, D., Directing human embryonic stem cell differentiation by non-viral delivery of siRNA in 3D culture, Biomaterials, 32: 7793-7800, 2011.

Karp, J. and Langer, R., Dry solution to a sticky problem, Nature: 477: 42-43, 2011

Gubskaya, A., Kholodovych, V., Bonates, T., Welsh, W., Langer, R., Kohn, J. and Anderson, D., Logical analysis of data in structure-activity investigation of polymeric gene delivery, Macromolecular Theory and Simulations, 20: 275-285, 2011

Cao, Yihai, Arbiser, J., D’Amato, R., D’Amore, P., Ingber, D., Kerbel, R., Klagsbrun, M., Lim, S., Moses, M., Zetter, B., Dvorak, H., Langer, R., Forty-year journey of angiogenesis translational research, Science Translational Medicine, 3: 114rv3, 2011.

Tekin, H., Sanchez, J., Tsinman, T., Langer, R. and Khademhosseini, A., Thermoresponsive platforms for tissue engineering and regenerative medicine, AIChE Journal, 57: 3249-3258, 2011.

Dvir, T., Liao, R., Bauer, M., Schroeder, A., Tsui, J. and Langer, R., Nanoparticles for targeting the infarcted heart, Nano Letters, 11: 4411-4414, 2011.

Saha, K., Mei, Y., Reisterer, C., Pyzocha, N., Yang, J., Muffat, J., Davies, M., Alexander, M., Langer, R., Anderson, D., Jaenisch, R., Surface engineered substrates for improved human pluripotent stem cell culture under fully defined conditions, Proceedings of the National Academy of Sciences, 108: 18714-18719, 2011.

Malavia, N., Zurakowski, D., Schroeder, A., Princiotto, A., Laury, A., Barash, H., Sodroski, J., Langer, R., Madani, N. and Kohane, D, Liposomes for HIV prophylaxis Biomaterials, 32: 8663-8668, 2011.

Dvir, T., Timko, B., Brigham, M., Naik, S., Karajanagi, S., Levy, O., Jin, H., Parker, K., Langer, R. and Kohane, D., Nanowired three-dimensional cardiac patches, Nature Nanotechnology, 6: 720-725, 2011.

Wang, J., Kniazeva, T., Campbell, C., Langer, R., Ustin, J., Borenstein, J., Biodegradable microfluidic scaffolds with tunable degradation properties from alcohol-based poly(ester amide) elastomers, Materials Research Society Symposium Proceedings, 1299:3-8, 2011. 10.1557/opl.2011.377. PMCID: PMC Exempt—Non-NIH/PHS Funding.

Dan, T., Bratlie, K., Bogatyrev, S., Chen, X., Langer, R., and Anderson, D., Spatiotemporal effects of a controlled release anti-inflammatory drug on the cellular dynamics of host response, Biomaterials, 32: 4464-4470, 2011.