Publications: 2020-



Raman, R., Hua, T., Gwynne, D., Collins, J., Tamang, S., Zhou, J., Esfandiary, T., Soares, V., Pajovic, S., Hayward, A., Langer, R., Traverso, G. Light-degradable hydrogels as dynamic triggers for gastrointestinal applications. Science Advances, 6:eaay0065, 2020. PMID32010768; PMC6968934; DOI: 10.1126/sciadv.aay0065

Yu, J., Wang, J., Zhang, Y., Chen, G., Mao, W., Ye, Y., Kahkoska, A., Buse, J., Langer, R., Gu, Z. Glucose-responsive smart insulin patch for blood glucose regulation in mice and pigs, Nature Biomedical Engineering, 499–506, 2020. DOI:10.1038/s41551-019-0508-y

Sarmadi, M., Behrens, A.M., McHugh, K.J., Contreras, H., Tochka, Z., Lu, X., Langer, R., Jaklenec, A. Modeling, design, and machine learning-based framework for optimal injectability of microparticle-based drug formulations. Science Advances, 2020.

Volpatti, L., Matranga, M.A., Cortinas, A.B., Delcassian, D., Daniel, K., Langer, R., Anderson, D., Glucose-responsive nanoparticles for rapid and extended self-regulated insulin delivery, ACS Nano, 14 (1): 488-497, 2020. DOI: 10.1021/acsnano.9b06395. PMID: 31765558

Mirvakili, S., Sim, D., Hunter, I., Langer, R. Magnetically induced thermal pneumatic artificial muscles. Science Robotics, 2020.

Yang, K., O’Cearbhaill, E., Liu S., Zhou, A., Hamilos, A., Chitnis, G., Xu, J., Giraldo, J., Verma, M., Pop, R., Langer, R., Melton, D.,. Greiner, D., Karp, J. SUbA therapeutic convection enhanced macroencapsulation device for enhancing β cell viability and insulin secretion. Science Advances,

Mirvakili, S., Ngo, Q.P., Langer, R. Polymer nanocomposite microactuators for on-demand chemical release via high-frequency magnetic field excitation. Nano Letters, 2020, 4816-4822 DOI: 10.1021/acs.nanolett.0c00648 PMC7349659; PMID: 32479730

Srinivasan, S., Ramadi. K., Vicario, F., Gwynne, D., Hayward, A., Lagier, D., Langer, R., Frassica, J., Baron, R., Traverso, G. A rapidly deployable individualized system for augmenting ventilator capacity. Science Translational Medicine, 2020. PMID32424018; PMC7259824; DOI: 10.1126/scitranslmed.abb9401

Roberts, T., Langer, R., Wood, M. Advances in oligonucleotide drug delivery. Nature Reviews Drug Discovery, 2020. DOI: 10.1038/s41573-020-0075-7

Lu, X., Miao, L., Gao, W., Chen, Z., McHugh, K., Sun, Y., Tochka, Z., Tomasic, S., Sadtler, K., Hyacinthe, A., Huang, Y., Graf, T., Hu, Q., Sarmadi, M., Langer, R., Anderson, D., Jaklenec, A. Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy. Science Translational Medicine, 2020. DOI: 10.1126/scitranslmed.aaz6606

Sadtler, , Collins, J., Byrne, J., Langer, R. Parallel evolution of polymer chemistry and immunology: integrating mechanistic biology with materials design. Advanced Drug Delivery Reviews, 2020.

Patel, A, Kaczmarek, J, Bose, S, Kauffman, K, Mir, F, Heartlein, M, DeRosa, F, Langer, R, and Anderson, D, Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium, Advanced Materials, PMID: 30609147 DOI: 1002/adma.201805116

Von Erlach, T., Saxton, S., Shi, Y., Minahan, D., Reker, D., Javid. F., Lee, Y.L., Schoellhammer, C., Esfandiary, T., Cleveland, C., Booth, L. Lin, J. Levy, H., Blackburn, S., Hayward, A., Langer, R., Traverso, G. Robotically handled whole-tissue culture system for the screening of oral drug formulations. Nature Biomedical Engineering, 4, 544–559, 2020. DOI:10.1038/s41551-020-0545-6

Reker, D., Shi, Y., Kirtane, A.R.., Hess, K., Zhong, G.J., Crane, E., Lin, C., Langer, R., Traverso, G. Machine learning uncovers food-and-excipient-drug interactions. Cell Reports, 30, 3710–3716, 2020. DOI:1016/j.celrep.2020.02.094 PMID: 32187543 PMCID: PMC7179333

Li, J., Liang, Y.J., Laken, S., Langer, R., Traverso, G. Clinical opportunities for continuous biosensing and closed-loop therapies. Trends in Chemistry, 2 (4): 319-340, 2020. DOI:10.1016/j.trechm.2020.02.009

Rudra, A., Li, J., Shakur, R., Bhagchandani, S., Langer, R. Trends in therapeutic conjugates: bench to clinic, Bioconjugate Chemistry, 31 (3), 462-473, 2020. DOI: 10.1021/acs.bioconjchem.9b00828

Verma, M., Chu, J., Salama, J., Faiz, M., Eweje, F., Gwynne, D., Lopes, A., Hess, K., Soares, V., Steiger, C., McManus, R., Koeppen, R., Hua, T., Hayward, A., Collins, J., Tamang, S.M., Ishida, K., Miller, J., Katz, S., Slocum, A.H., Sulkowski, M.S., Thomas, D.L., Langer, R., Traverso, G. Development of a long-acting direct-acting antiviral system for Hepatitis C virus treatment in swine. Proceedings of the National Academies of Sciences, 117 (22) 11987-11994, 2020. DOI: 10.1073/pnas.2004746117

Sarmadi, M., Behrens, A., Kevin J. McHugh, K., Contreras, H., Tochka, Z., Lu, X., Langer, R., Jaklenec, A. Modeling, design, and machine learning-based framework for optimal injectability of microparticle-based drug formulations. Science Advances, 6:8, eabb6594, 2020. DOI: 10.1126/sciadv.abb6594

Haley RM, Gottardi R, Langer R, Mitchell MJ. Cyclodextrins in drug delivery: applications in gene and combination therapy. Drug Delivery Translational Research, 10:661- 677, 2020. PMID32077052 DOI:10.1007/s13346-020-00724-5

Wei, T., Cheng, Q., Farbiak, L., Anderson, D.G., Langer, R., Siegwart, D.J. Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing. ACS Nano, 2020, DOI: 10.1021/acsnano.0c04707

Saunders N.R.M., Paolini M.S., Fenton O.S., Poul L., Devalliere J., Mpambani F., Darmon A., Bergere M., Jibault O., Germain M., Langer R. A Nanoprimer to Improve the Systemic Delivery of siRNA and mRNA. Nano Letters, 20:4264-4269, 2020. PMID32357299; DOI: 10.1021/acs.nanolett.0c00752

Ramadi, K., Dagdeviren, C., Bhagchandani, P.; Nunez-Lopez, C., Kim, M. Langer, R., Graybiel, A., Cima, M. Simultaneous recording and marking of brain microstructures. Journal of Neural Engineering, 17: 044001, 2020. DOI:10.1088/1741-2552/aba161

Bose, S., Volpatti, L., Thiono, D., Yesilyurt, V., McGladrigan, C., Tang, Y., Facklam, A., Wang, A., Jhunjhunwala, S, Veiseh, O., Hollister-Lock, J., Bhattacharya, C., Weir, G., Greiner, D., Langer, R., Anderson, D. A retrievable implant for the long-term encapsulation and survival of therapeutic xenogeneic cells. Nature Biomedical Engineering, 4: 814-826, 2020. DOI:10.1038/s41551-020-0538-5

Schwerdt, H., Amemori, K., Gibson, D., Stanwicks, L., Yoshia, T., Bichot, N., Amemori, S., Desimone, R., Langer, R., Cima, M., Graybiel, A. Dopamine and beta-band oscillations differentially linked to striatal value and motor control, Science Translation Medicine, in press.

Abramson, A., Della, D., Kong, Y.L., Zhou, J., Gao, Y., Collins, J., Tamang, S., Wainer, J., McManus, R., Hayward, A., Frederiksen, M.R., Water, J.J., Jensen, B., Roxhed, N., Langer, R., Traverso, G. Ingestible transiently anchoring electronics for microstimulation and conductive signaling. Science Advances, in press, 2020.

Tang, Z., Kong, N., Zhang, X., Liu,Y. Ping Hu, P., Mou, S., Liljeström, P., Shi, P.J.,  Tan, W., Kim,  J.S., Cao,  Y., Langer, R., Leong,  K., O Farokhzad, O., Tao, W. Responding to COVID-19: What can materials scientists do?  Nature Review Materials, 2020, in press.

Raman, R., Rousseau, E.B., Wade, M. ,Tong, A., Cotler, M.J., Kuang, J., Aponte Lugo, A., Zhang, E., Graybiel, A.M., White, F.M, Langer, R., Cima, M.J. Platform for micro-invasive membrane-free biochemical sampling of brain interstitial fluid, Science Advances, 2020, in press.

Yin, H., Bogorad, R., Barnes, C., Zhuang, I., Nonaka, H., Ruda, V., Kuchimanchi, S., Nechev, L., Akinc, A., Zerial, M., Langer, R., Anderson, D. and Koteliansky, V., Efficient multiplex knockdown mediated control of organ size and its application for rapid analyses of molecular interactions in vivo, Proceedings of the National Academy of Sciences,

Han, M., Cha, Y., Jeong, H., Zoldan, J., Burkart, A., Kim, C., Kim, H., Cho, S., Kim, B., Langer, R., Kahn, R., Cha, H., Guarente, L. and Kim, K., Metabolic control of human pluripotent stem cell fate and function by deacetylase SIRT2, Science, submitted.

Taylor, L., Arner, K., Kolewe, M., Pritchard, C., Hendy, G., Langer, R. and Ghosh, F., Tissue stabilization in vitro using surface modification of poly(glycerol-co-sebacic acid) membranes in adult porcine retinal explants, Biomaterials, submitted.

Mizrahi, B., Khoo, X., Chiang, H., Sher, K., Feldman, R., Irusta, S., Langer, R. and Kohane, D., Multi-armed prepolymer for antifouling coatings, Journal of the American Chemical Society, submitted.

Fenton, O., Kauffman, K., McClellan, R., Appel, E., Dorkin, J., Tibbitt, M., Heartlein, M., DeRosa, F., Langer, R. and Anderson, D., Bioinspired alkenyl amino alcohol ionizable lipid materials for highly potent in vivo mRNA delivery, Journal of the American Chemical Society, submitted.

Indolfi, L., Ligorio, M., Ting, D., Xega, K., Tzafriri, A., Bersani, F., Aceto, N., Deshpande, V., Ferrone, C., Haber, D., Langer, R., Clark, J. and Edelman, E., A local drug delivery platform to enhance cytotoxic effects of chemotherapy in pancreatic cancer, Proceedings of the National Academy of Sciences, submitted.

Lin, J., Dargazany, R., Zhang, S., Jafari, M., Lee, Y., Hurowitz, H., Langer, R. and Traverso, G., Corona molecular dynamics of poly(ethylene glycol)-coated nanoparticles, Nano Letters, submitted.

Kahn, O., Tsosie, J., Spanoudaki, V., Zaia, E., Chiu, A., Tang, K., Siebert, S., Bader, A., Aresta-Dasilva, S., Langan, E., Langer, R., Anderson, D., Implant surface modifications modulate blood vessel geometry and vascular organization at the material-host interface, Journal of the American Chemical Society, submitted

McAvoy, M., Tsosie, J, Vyas, K, Khan, O, Sadtler, K, Anderson, D, and Langer, R, Stretchable Multielectrode Array for Skeletal Muscle Conditioning, Acetylcholine Receptor Stabilization and Epimysial Recording After Critical Peripheral Nerve Injury, Biomaterials, submitted.

Ferreira, M., Neubert, J., Atala, A., Breuer, C., Collins, S., Keating, A., Langer, R., Rapoza, M., Reeve, B., Russell, A., Roberts, M., Parsons-Wingerter, P., Stoudemire, J., Gobel, D., Harper, L., Hunsberger, J., Naughton, G., Moldovan, N., Solorzano, R., Pereira, T., Roadmap to ending the organ shortage: Research strategies, challenges and opportunities, Nature Biotechnology, submitted.

Hlavaty, K., Booty, M., Stockman, A., Tian, L., How, E., Subramanya, D., Venkitaraman, A., Yee, C., Ozay, E., Pryor, O., Smith, C., Volk, K., Blagovic, K., Vicente-Suarez, I., Yarar, D., Myint, M., Merino, A., Chow, J., Pomerance, L., Abdeljawad, T., An, H., Stokes, B., Liu, S., Mao, S., Heimann, M., von Adrian, U., Jensen, K., Langer, R., Knoetgen, H., Trumpfheller, C., Bernstein, H., Sharei, A., Loughhead, S., Microfluidic squeezing enables antigen presentation by diverse immune cell types to elicit CD8+ T cell responses, Nature Biomedical Engineering, submitted.

Ramadi, K., Bashyam, A., Frangieh, C., Rousseau, E., Cotler, M., Langer, R., Graybiel, A., Cima, M., Computationally guided intracerebral drug delivery via chronically implanted microdevices, Cell Reports, submitted.

Talebian, S., das Neves, J., Sarmento, B., Langer, R., Conde, J. Facts and figures about nanotechnology in the past 20 years. Nature Nanotechnology, submitted.

Volpatti, L., Facklam, A., Cortinas, A., Matranga, M., Hill, M. Langer, R., Anderson, D. Microgel encapsulated nanoparticles for glucose-responsive insulin delivery. Biomaterials, submitted

Kirtane, A.R. , Karavasili, C., Wahane, A. , Dao Le, T.H., Hua, T., Scala, C., Lopes, A., Hess, K., Collins, J., Tamang, S., Ishida, K., Rajesh, N., Phan, N., Li, J., Hayward, A., Langer, R., Traverso, G. Molecular gastronomy-inspired drug delivery systems for paediatric applications. Nature Communications, submitted.

Schwerdt, H., Amemori, K., Gibson, D., Stanwicks, L., Yoshia, T., Bichot, N., Amemori, S., Desimone, R., Langer, R., Cima, M., Graybiel, A. Dopamine and beta-band oscillations differentially linked to striatal value and motor control, Science Translation Medicine,

Li, W., Qiu, J., Li, X., Aday, S., Zhang, J., Conley, G., Xu, J., Langer, R., Mannix, R., Karp, J.M., Joshi, N. BBB pathophysiology independent delivery of siRNA in traumatic brain injury. Science Advances, submitted.

Caffarel-Salvador, E., Kim, S., Soares, V., Tian, R.Y., Stern, S.R., Minahan, D., Yona, R., Lu, X., Zakaria, F.R., Collins, J., Wainer, J., Wong. J., McManus, R., Tamang, S., McDonnell, S., Ishida, K., Hayward, A. Liu, X., Hubàlek, F., Vegge, A., Frederiksen, M., Rahbek U., Yoshitake, T., Fujimoto, J., Roxhed, N., Langer, R., Traverso, G., A microneedle platform for buccal macromolecule delivery. Science Advances, submitted.

McLean, W.J., Hinton, A.S., Herby, J., Yang-Hood, A., Schrader, A.D., Ohlemiller, K.K., Salt, A.N., Hartsock, J.J., Wilson, S., Lucchino, D., King, S., Jackson, L.E., Rosenbloom, J., Atiee, G., Bear, M., Runge, C., Gifford, R., Rauch, S., Lee, D., Langer, R., Karp, J., Loose, C., LeBel, C. Improved speech intelligibility in subjects with stable sensorineural hearing loss following intratympanic dosing of FX-322. Otology & Neurotology, submitted.

Sadtler, K., MacIsaac, C., Zepeda, F., Langer, R., Anderson, D.G. The clotting cascade: a link between scar formation and the foreign body response. Science Translational Medicine, submitted.

Mitchell, M., Billingsley, M., Haley, R., Wechsler, M., Peppas, N.A., Langer, R. Engineering precision nanoparticles for drug discovery. Nature Reviews Drug Discovery, submitted.